Glucophage 850 ndi mankhwala okhala ndi katundu wa hypoglycemic. Mankhwalawa amapangidwira pakamwa. Mankhwalawa ndi a gulu la Biguanides.
Glucophage imathandizira kuchepetsa kuchuluka kwa hyperglycemia ndipo sikumapangitsa kuti thupi la wodwalayo lizioneka ngati ali ndi vuto la hypoglycemia. Chimodzi mwa mankhwalawa ndiko kusowa kwa mphamvu ya yogwira popanga njira zama insulin.
Kugwiritsa ntchito mankhwalawa kumathandizira kuletsa njira za gluconeogeneis ndi glucogenolysis. Kugwiritsa ntchito mankhwala kungathandize kuchepetsa kuyamwa kwa glucose kuchokera m'matumbo a lumen kulowa m'magazi.
Kudya kwa Glucofage 850 mg m'thupi kumabweretsa kukondoweza kwa glycogen kaphatikizidwe ka zochita za mankhwala omwe amapanga pa glucogen synthetase enzyme. Kugwiritsa ntchito Glucofage kumathandizira kukulitsa kuchuluka kwa mayendedwe amitundu yonse yamtundu wa glucose.
Kugwiritsa ntchito mankhwalawa kumawonjezera zina zabwino. Glucophage imatha kukopa metabolid metabolid. Ndi kuyambitsa ntchito yogwira mankhwala m'thupi, kuchuluka kwa cholesterol, LDL ndi TG m'thupi kumachepa.
Kumwa mankhwalawa kumathandizira kuchepetsa kulemera kwa thupi la wodwalayo ngati chizolowezi chimaposa kapena chikakhazikika pamlingo womwewo.
Kufotokozera kwathunthu kwa mankhwalawa, mawonekedwe ake ndi mawonekedwe ake omasulidwa
M'mapiritsi a glucophage, mankhwala othandizira omwe amapanga kwambiri ndi metformin, yomwe imakonzekera mawonekedwe a hydrochloride.
Mankhwalawa amapangidwa ngati mapiritsi, omwe amaphatikizidwa ndi zokutira filimu.
Kuphatikiza pazomwe zimagwiritsidwa ntchito popanga mankhwala, kapangidwe kazinthu kameneka kamagwiritsanso ntchito zinthu zina zomwe zimapatsidwa ntchito zothandizira.
Izi zothandiza zomwe zimapanga glucophage ndi:
- povidone;
- magnesium wakuba.
Utoto wamafilimu wa mankhwalawo umaphatikizanso mu mawonekedwe ake monga hypromellase.
Mapiritsiwo amakhala ndi mawonekedwe a biconvex. Mukuwoneka, gawo lamtanda la phale ndi unyinji wowoneka bwino wokhala ndi khungu loyera.
Mankhwalawa amadzaza m'matumba a 20 mapiritsi. Mapaketi azidutswa atatuwo amayikidwa m'matumba, omwe amakhalanso ndi malangizo ogwiritsira ntchito mankhwala.
Mankhwalawa amagwiritsidwa ntchito pochiza matenda amishuga amitundu iwiri, monga monotherapy komanso pochita zovuta zochizira matenda ashuga a mtundu 2.
Kugwiritsa ntchito glucophage pamaso pa matenda a shuga m'magonedwe kumatha kuchepetsa matendawa. Kugwiritsa ntchito mankhwalawa pofuna kupewa matenda ashuga kupezeka kwa matenda a prediabetes m'thupi kungathandize kuchepetsa mwayi wokhala ndi matenda ashuga.
Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti muzitha kuyendetsa bwino.
Pharmacokinetics ndi pharmacodynamics a mankhwalawa
Mutamwa mankhwalawo, gawo lalikulu la mankhwalawo limatsitsidwa kuchokera kumimba. Mankhwala amaphatikizidwa bwino. The bioavailability wa mankhwala m'thupi la munthu pafupifupi 50-60%.
Pazitali zabwino za mankhwalawa zimapezeka pafupifupi maola 2,5 mutatha kumwa mankhwalawa. Mukamamwa mankhwalawa pakudya, kuchuluka kwa mayamwidwe kumachepa. Pambuyo polowera m'magazi, gawo lofunikalo lamankhwala limagawidwa mwachangu mthupi lonse la wodwalayo.
Pokonzekera kugwiritsira ntchito metformin hydrochloride pazopaka thupi, sizigwirizana ndi mapuloteni okhala m'madzi a m'magazi.
Metformin sikuti imapukusidwa. Ndipo kutulutsa kwa ntchito yogwira kumachitika ndi impso.
Hafu ya moyo wa gawo yogwira ntchito kuchokera mthupi ndi maora pafupifupi 6.5.
Ngati wodwala walephera, impsoyo imakulitsidwa kwambiri, zomwe zimatha kupangitsa kuti thupi lizikundana.
Mukamamwa mankhwalawa monga gawo la zovuta mankhwala, muyenera kuwalandira mosamala pazomwe mankhwala Glucofage amatengedwa. Izi ndichifukwa choti mukamamwa mankhwala ena ndi glucophage, mwayi wokhala ndi vuto la hypoglycemic ukuwonjezeka.
Kuyanjana koteroko pakati pa mankhwala kumafuna kusintha kwa mankhwalawa kwa mankhwalawa.
Zizindikiro ndi contraindication kugwiritsa ntchito mankhwalawa
Glucophage amalimbikitsidwa kwa odwala omwe ali ndi mtundu wa shuga wachiwiri, makamaka odwala omwe ali onenepa kwambiri.
Kugwiritsa ntchito mankhwalawa kumalimbikitsidwa pokhapokha pakutha kwa zakudya zopatsa thanzi komanso zolimbitsa thupi.
Mankhwalawa amaloledwa kugwiritsidwa ntchito ndi onse akulu ndi ana omwe ali ndi zaka 10.
Malangizo ogwiritsira ntchito Glucofage amalimbikitsa kumwa mankhwalawa ngati prophylactic ndi wodwala yemwe wapeza matenda a prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa matenda a shuga a mtundu II.
Monga chida chothandizira kupewa, mankhwalawa amayenera kugwiritsidwa ntchito ngati kusintha kwa moyo ndi zakudya sizilola kukwaniritsidwa koyenera kwa shuga mumagazi a magazi.
Monga mankhwala aliwonse, Glucophage imakhala ndi zotsutsana zingapo kuti zigwiritsidwe.
Milandu ikuluikulu pakugwiritsira ntchito mankhwalawa ndi iyi:
- kukhalapo kwa hypersensitivity pazinthu zazikulu kapena zowonjezera zomwe zimapanga mankhwala.
- Kupezeka kwa thupi la wodwala wodwala matenda a shuga, matenda ashuga ketoacidosis, matenda a shuga, kapena kuyambika kwa chikomokere.
- Wodwalayo amatha kulephera kwa impso kapena kugwira bwino impso.
- The zimachitika pachimake zinthu zomwe zimachitika mthupi ndi kuoneka ngati chiwopsezo cha matenda osokonezeka mu ntchito ya impso. Zinthu ngati izi zimaphatikizapo kusowa kwamadzi, kutsegula m'mimba, kapena kusanza.
- Kukula kwa matenda opatsirana owopsa komanso opatsirana m'thupi komwe kumakhudza kugwira ntchito kwa impso.
- Kukhalapo kwa wodwala kwamawonekedwe owopsa kapena matenda opweteka kwambiri omwe angayambitse matenda a minofu hypoxia, mwachitsanzo, kulephera kwa mtima, kulephera kwa mtima komwe kumayenderana ndi kusakhazikika kwa magawo a hemodynamic, kupuma, kugunda kwa mtima.
- Kuchita zodzionetsera zambiri pakagwiritsidwe ntchito ka mankhwala a insulin.
- Kukhalapo kwa kulephera kwa chiwindi ndi khungu la chiwindi.
- Kukhalapo kwa uchidakwa woperewera kwa wodwala, poyizoni wazakumwa ndi zakumwa zoledzeretsa.
- Nthawi ya bere ndi kuyamwitsa.
- Kuchita maphunziro okhudzana ndi kugwiritsa ntchito mankhwala okhala ndi ayodini ngati gawo lolowera.
- Kugwiritsa ntchito zakudya zamafuta ochepa.
Musanagwiritse ntchito mankhwalawa, ndikofunikira kuti mufunsane ndi dokotala.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwalawa adapangira pakamwa.
Amagwiritsidwa ntchito pa monotherapy kapena ngati gawo la zovuta la mankhwala pochiza matenda a shuga a 2.
Mukasinthira kugwiritsa ntchito Glucophage ngati mankhwala okhawo a hypoglycemic, muyenera kusiya kugwiritsa ntchito mankhwala ena omwe ali ndi vuto lofanana ndi la wodwala matenda a shuga a 2.
Popanga monotherapy ndi Glucofage, mankhwalawa amathandizidwa kuti azigwiritsidwa ntchito pazotsatira komanso kukhazikitsa malamulo ena:
- Mulingo woyenera wa mankhwalawa ndi 500 mg 2-3 Mlingo patsiku, mankhwala ayenera kumwedwa mutatha kudya kapena nthawi yomweyo;
- popanga monotherapy, tikulimbikitsidwa masiku 10 aliwonse kuti mupeze kuchuluka kwa glycemia ndikusintha Mlingo wa mankhwalawa malinga ndi zotsatira zake;
- Mukamamwa mankhwala, mlingo uyenera kuchuluka pang'onopang'ono, njira yothandizira mankhwalawa imathandiza kupewa kuwoneka ngati mavuto obwera chifukwa cha ntchito ya m'mimba;
- monga mlingo wokonza, mlingo wa mankhwalawa wofanana ndi 1500-2000 mg patsiku uyenera kugwiritsidwa ntchito;
- Kuti muchepetse mavuto, mankhwalawa azigawika pawiri.
- Mlingo woyenera tsiku lililonse sayenera kupitirira 3000 mg patsiku.
Kuti mukwaniritse bwino pazomwe mukugwiritsa ntchito mankhwalawa, mutha kugwiritsidwa ntchito ngati imodzi mwazinthu zovuta kuzitsatira.
Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito limodzi ndi insulin.
Mukamachita chithandizo chotere, mlingo wa Glucophage wotengedwa uyenera kukhala 500 mg katatu patsiku. Ndipo Mlingo wa mankhwala okhala ndi insulin ya mahomoni amasankhidwa molingana ndi kuchuluka kwa kuchuluka kwa shuga m'magazi a wodwala.
Pochita monotherapy ndi prediabetes, kumwa mankhwalawa akulimbikitsidwa pa mlingo wa 1000-1700 mg patsiku. Mlingo wa tsiku ndi tsiku wa mankhwalawa umayenera kugawidwa mu 2 Mlingo.
Kuchita monotherapy ndi prediabetes kumafuna kuwunika pafupipafupi kwa plasma glycemia.
Kutalika kwa glucophage makonzedwe ndi dokotala. Imwani mankhwalawa osasokoneza.
Zotsatira zoyipa mukamamwa mankhwalawa
Zotsatira zoyipa zomwe zimapezeka pakumwa mankhwalawa zimatha kugawidwa m'magulu angapo kutengera kupezeka kwawo.
Nthawi zambiri, mthupi la wodwala mukamagwiritsa ntchito mankhwala Glucofage, zosokoneza zimatulukira mu kagayidwe kazakudya ndi kagwiridwe ka ntchito m'mimba. Mwina kukula kwa lactic acidosis.
Kugwiritsa ntchito mankhwalawa kwakanthawi kumabweretsa kuchepa kwa mayankho a thupi a wodwala vitamini B12.
Wodwala akaulula zizindikiro za kuchepa kwa magazi m'thupi la megaloblastic, njira zonse zofunika ziyenera kutengedwa nthawi yomweyo kuti muchepetse vuto.
Nthawi zambiri, odwala omwe amagwiritsidwa ntchito ngati mankhwala ochiritsira amakhala akusokoneza malingaliro awo.
Kuchokera m'mimba, mawonekedwe a zoyipa monga:
- Matenda a shuga
- Kumva kupusa.
- Kubweza.
- Ululu m'mimba.
- Kuchepetsa chilako.
Nthawi zambiri, zotsatira zoyipazi zimachitika poyambira kumwa mankhwalawo ndipo nthawi zambiri, zotsatira zake zimatha pang'onopang'ono ndikugwiritsanso ntchito mankhwalawa.
Nthawi zina, mukamamwa mankhwalawa, khungu limakhudzika m'njira zosiyanasiyana zotupa ndi kuyabwa.
Mndandanda wa mankhwalawa, umawerengera za nkhaniyi komanso mtengo wake
Kugulitsidwa kwa Glucophage kuchokera ku matenda a shuga kungachitike ku chipatala chilichonse, pokhapokha ngati wodwala ali ndi malangizo omwe adokotala adamupangira. Mtengo wa mankhwalawa ku Russia umachokera pa 124 mpaka 340 rubles pa phukusi, kutengera dera lomwe lili mdzikolo.
Ndemanga za mankhwalawa zimawonetsa kuti ndi othandizira pa hypoglycemic, omwe, kuphatikiza pa kuwongolera kuchuluka kwa shuga m'magazi am'mwazi, angakhudze mayeso amthupi la wodwalayo ndipo, pamaso pa kunenepa kwambiri, amachepetsa.
Ndemanga zoyipa za mankhwalawa ndizosowa kwambiri ndipo nthawi zambiri mawonekedwe awo amakhudzana ndi kuphwanya kwamalangizo ogwiritsira ntchito mankhwalawa.
Ma fanizo odziwika bwino a mankhwala ndi awa:
- Siofor
- Diaformin OD.
- Glucophage Kutalika.
Nthawi zambiri, Glucophage Long imagwiritsidwa ntchito ngati analog. Mankhwala ali ndi nthawi yayitali yogwira ntchito. Mutha kugula Glucophage Long, ngati analogue ina iliyonse, ku bungwe lililonse lazamankhwala. Kuti mupeze mankhwala amtunduwu, mankhwala a dokotala amafunikiranso. Mtengo wa analogues wa mankhwalawa uli pafupi ndi mtengo wa Glucofage. Kanemayo munkhaniyi afotokoza zamankhwala pambuyo pake.
