Oktolipen ndi mankhwala a mibadwo yotsiriza mwa njira yothetsera kulowetsedwa. Oktolipen wa mtundu wa 2 wa shuga amagwiritsidwa ntchito kuwongolera kagayidwe kazakudya zam'mimba komanso lipid metabolism, kuchepetsa shuga m'magazi ndikutaya mapaundi owonjezera.
Mankhwalawa amagwiritsidwanso ntchito kwambiri pamitundu ina ya matenda ashuga monga mbali ya chithandizo chovuta kwambiri. Oktolipen ali ndi ndemanga zabwino kuchokera kwa anthu odwala matenda ashuga.
Oktolipen amapezekanso mu kapisozi ndi mawonekedwe a piritsi.
Oktolipen
Oktolipen ndi antioxidant wam'mbuyomu omwe amamangirira zopitilira muyeso. Izi zimachitika nthawi ya oxidative decarboxylation ya alpha-keto acid.
Monga coenzyme, mankhwalawa amakhudzidwa ndi decarboxylation ya pyruvic acid ndi alpha-keto acid. Imatha kutsitsa shuga m'magazi, komanso kuonjezera glycogen m'chiwindi ndikugonjetsa insulin kukana. Chifukwa chake, amatha kugwiritsidwa ntchito ngati matenda a shuga a 2.
Thioctic acid ili pafupi ndi mavitamini a B. Izi zili ndi zotsatirazi:
· Imatenga gawo pa lipid ndi chakudya kagayidwe,
· Imasintha mafuta a cholesterol,
· Imayambitsa chiwindi.
Mankhwala ali:
1. Hypocholesterolemic,
2. kupangika
3. kutsika kwa lipid,
4. zotsatira za hypoglycemic.
Mothandizidwa ndi chida trophism ya neurons imakhala bwino, komanso makulidwe azitsulo komanso zovuta za zakumwa zoledzeretsa ndi matenda ashuga zimachepa.
Mankhwala Okolipen amangoperekedwa ndi adokotala okha. Sizoletsedwa kuti tizidzipangira tokha ndi mankhwalawa.
Octolipene mu ampoules ndi chida cholumikizidwa chofunikira popanga njira yovomerezeka. Madziwo amawonekera, amawoneka wobiriwira komanso wachikaso.
Mu 1 millilita wa mankhwalawa ndi thioctic kapena lipic acid 30 mg. Mphepete imodzi imakhala ndi mazana atatu a mgulu.
Zinthu zothandiza ndi:
- disodium edetate,
- ethylenediamine
- madzi osungunuka.
Mankhwalawa amapezeka m'magalasi akuda amtundu wa mamililita 10. Phukusili ndi phukusi la makatoni, mu paketi imodzi - ma ampoules 5.
Mankhwalawa amagulitsidwanso m'mapiritsi a Octolipen 300 ndi mapiritsi a Okolipen 600.
Malangizo ogwiritsira ntchito Oktolipen
Kukonzekera kulowetsedwa, muyenera kuchepetsa 1 kapena 2 ampoules mu 50-250 ml ya 0,9% sodium chloride solution. Njira yothetsera vutoli imayendetsedwa ndi dontho, kudzera m'mitsempha. Amagwiritsidwa ntchito kamodzi patsiku kwa 300-600 mg kwa masabata a 2-4. Chotsatira, muyenera kusinthira pakamwa pamlomo.
Chipangizocho chili ndi photosensitivity, zomwe zikutanthauza kuti ma ampoules ayenera kuchotsedwa nthawi yomweyo asanagwiritse ntchito.
Ndikwabwino kuteteza chidebe ndi yankho kuchokera pakuwala nthawi ya kulowetsedwa, mwachitsanzo, kugwiritsa ntchito zojambulazo kapena matumba oteteza. Njira yokhazikitsidwa imasungidwa m'malo amdima ndipo imagwiritsidwa ntchito maola 6 mutakonzekera.
Ngati dotolo adapereka chithandizo cha mankhwala ndi Oktolipen, ndikofunikira kulingalira mfundo izi:
- mankhwala a lipoic acid angafunike kusintha kwa mapiritsi a mankhwala ena ndi zakudya,
- Ngati mankhwalawa akuphatikizidwa ndi kupewa komanso kuchiza matenda ashuga, ndikofunikira kuwunika kuchuluka kwa shuga m'magazi pogwiritsa ntchito glucometer, ndikusintha muyezo wa othandizira a hypoglycemic,
- The yogwira pophika mankhwala ali chimodzimodzi pochitira mavitamini B, koma si vitamini wowonjezera. Kugwiritsa ntchito mankhwala osakambirana ndi dokotala kumatha kukulitsa mavuto azaumoyo.
Zotsatira za pharmacological
Lipoic acid amapangidwa mkati mwa thupi panthawi yopanga okosijeni a keto acid. Kutha kwake kuthetsa mayankho a metabolic ku insulin kwatsimikiziridwa. Lipoic acid amakhudza mwachindunji chiwindi, chofunikira kwa matenda a shuga a 2.
Mankhwalawa amagwiritsidwa ntchito nthawi zambiri mu kunenepa kwambiri ngati mukupezeka matenda a matenda a shuga a 2 kapena popanda matenda otere.
Lipoic acid amakhudza bwino magwero osungiramo mafuta amthupi. Mothandizidwa ndi asidi awa, malo osungirako mafuta amawonongeka ndipo mphamvu zambiri zimamasulidwa. Kuti muchepetse kunenepa, ndikofunikanso kuwonjezera zochitika zolimbitsa thupi ndikutsatira zakudya zamafuta.
Lipoic acid amatenga chakudya chamafuta, koma amawasamutsa kuti asamangogwiritsa minofu, koma minofu ya minofu, komwe amamugwiritsa ntchito kapena kugwira ntchito ngati minofu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito kuchepetsa thupi pokhapokha pazakudya ndi masewera.
Kafukufuku wambiri akuwonetsa kuti thioctic acid ilibe mwachindunji anabolic.
Oktolipen bwino amachepetsa kuchuluka kwa lactic acid mu minofu minofu yomwe imapangika pakulimbitsa thupi. Munthu amapeza mwayi wopirira kupsinjika kwachangu komanso kwanthawi yayitali, komwe kumakhudza thanzi la munthu komanso mawonekedwe ake.
Lipoic acid imachulukitsa kukoka kwa glucose ndimaselo a minofu. Chifukwa chake, ngakhale kuphunzitsidwa pang'ono kumapangitsa kuti zinthu ziziwoneka bwino pakumwa tiyi. Tiyenera kudziwa kuti mukamachita masewera olimbitsa thupi, kagayidwe kam'maselo kamangowonjezereka mofulumira, ndikuwoneka zochuluka zama radicals aulere, zomwe sizimasinthidwa mosavuta ndi lipoic acid.
Contraindication ndi zisonyezo
Oktolipen adalembedwa kwa anthu omwe ali ndi polyneuropathy yokhazikika ya odwala matenda ashuga komanso mowa.
Amasonyezedwanso cirrhosis ndi neuralgia, kuledzera ndi mchere wazitsulo zolemera. Anthu omwe ali ndi chidwi chachikulu ayenera kumwa mankhwalawa mosamala.
Mukamagwiritsa ntchito mankhwalawa, zotsatirazi zimakhala zotsatirazi:
- kutentha kwa mtima, nseru, kusanza,
- kupezeka kwa thupi lawo siligwirizana,
- hypoglycemia.
Zizindikiro za bongo ndi:
- kusanza
- nseru
- mutu.
Ngati mukumwa mankhwala a thioctic acid okwanira 10 mpaka 40 g, mapiritsi oposa khumi a 600 mg, kapena pa mlingo wa zopitilira 50 mg pa kilogalamu ya thupi mu ana, ndiye kuti:
- Psychotor
- kukomoka kwakukulu,
- kusokonezeka kwakukulu kwa acid-base balance ndi lactic acidosis,
- hypoglycemia (mpaka mapangidwe chikomokere),
- pachimake chigoba minofu necrosis,
- hemolysis
- DIC syndrome
- mafupa kuponderezana
- kulephera kwa ziwalo zingapo.
Ngati limodzi la mankhwalawo likugwiritsidwa ntchito ndipo mankhwala osokoneza bongo amachitika, kuchipatala mwachangu ndikugwiritsa ntchito njira zozikidwa pofotokoza mfundo zomwe zingachitike ngati poyizoni mwangozi ndikofunikira. Mutha:
- kusanza
- natsuka m'mimba
- samalani makala.
Chithandizo cha kukomoka kwakukulu, lactic acidosis ndi zotsatira zina zowopsa ziyenera kuchitidwa molingana ndi malamulo a chisamaliro chokwanira komanso kukhala chisonyezo. Sizimabweretsa zotsatira:
- hemoperfusion,
- hemodialysis
- njira zosefera pomwe thioctic acid wachotsedwa.
Kuyanjana kwa mankhwala
Mphamvu ya hypoglycemic ya mankhwalawa imawonjezeka ngati itengedwa ndi insulin ndi mapiritsi amodzimodzi. Izi zimatha kutsitsa magazi kwambiri.
Ngati kugwiritsidwa ntchito kophatikizana ndikofunikira, ndiye kuti nthawi zambiri kumayendetsedwa ndikuwunika kuchuluka kwa shuga m'magazi. Pakupatuka kosavomerezeka, mlingo wa insulin kapena othandizira ena a hypoglycemic ayenera kusinthidwa mwachangu.
Ethanol ndi metabolites zimawonjezera mwayi wazotsatira zoyipa. Oktolipen sagwirizana ndi mayankho a dextrose ndi Ringer, komanso mankhwala ndi mayankho omwe amachitika posagwirizana ndi magulu a SH ndi ethanol.
Muyeneranso kusunga mphindi 30 pakati pa kudya Okolipen ndi kumwa mkaka. Kuphatikiza apo, kupuma kotereku kumagwiranso ntchito kwa mankhwala omwe ali ndi:
- chitsulo
- calcium
Kusamala kumafunikanso kuphatikiza Oktolipen ndi mankhwala opangidwa ndi magnesium a odwala matenda ashuga.
Pankhaniyi, ndibwino kugwiritsa ntchito Oktolipen m'mawa, ndikukonzekera ndi magnesium, chitsulo ndi calcium madzulo.
Kuphatikiza apo, mankhwalawa amachepetsa kuuma kwa zochita za cisplatin, ngati njira zimagwiritsidwa ntchito nthawi imodzi.
Mtengo ndi fanizo
Mtengo wa mankhwala Okolipen siwokwezeka kwambiri. Makapisozi okhala ndi 300 mg a chinthu chachikuluchi amafunika ma ruble 310.
Mapiritsi a Octolipen 600 mg atenga pafupi ma ruble 640. M'mafakitala, mutha kupezanso alpha lipoic acid yomwe. Zimawononga zochepa - ma ruble 80 okha. Mtengo wa Tiolept ndi ma ruble pafupifupi 600, Tiogamm amawononga ma ruble 200, Espa-lipon - pafupifupi rubles 800.
Njira sizimasiyana pogwira ntchito ndipo zimasinthidwa wina ndi mzake:
- Tiolepta
- Malipidwe,
- Lipothioxone;
- Alpha lipoic acid,
- Tiogamma
- Thioctacid
- Lipamide
- Neuro lipone
- Espa lipon
- Thiolipone.
Chodziwika kwambiri, tsopano ndi mankhwala a Neyrolipon, ndi njira ina yabwino kwa Oktolipen.
Thioctacid
Thioctic acid ilipo mu yankho la Thioctacid, ndipo thioctate trometamol imagwiritsidwa ntchito piritsi lamapiritsi.
Thioctacid ndi metabolic mankhwala omwe amathandiza kuchepetsa mawonetseredwe a matenda ashuga komanso mowa.
Chidacho chili:
- antioxidant
- achina,
- hepatoprotective kwenikweni.
Thioctacid amateteza kagayidwe kachakudya mu thupi, kofunikira kwa matenda ashuga a 2.
Pali mitundu ya mitundu:
- mapiritsi
- yankho la jakisoni.
Gawo lalikulu la mankhwalawa ndi antioididant amkati. Kupezeka kwa chinthu m'thupi kumapereka:
- kuchotsa shuga,
- matenda a neurophyl,
- kuteteza maselo ku zochita za poizoni,
- kuchepetsedwa chiwonetsero cha matenda.
Ma antioxidant nthawi zambiri amakhala m'thupi mokwanira, ndipo amathandizira magwiridwe antchito ake.
Mankhwala omwe ali mgulu la mankhwala a Thioctacid amachedwa mwachangu komanso mokwanira, ndipo amamuchotsa pang'ono m'thupi pafupifupi theka la ola. Koma kugwiritsa ntchito mankhwalawa ndi chakudya kumakhudza kuyamwa kwa chinthu chachikulu. Bioavailability ndi 20%.
Kwenikweni, metabolism imakwaniritsidwa ndi oxidation ndi conjugation. Kuchotsa zochuluka za mankhwalawa kumachitika ndi impso. Thioctacid nthawi zambiri amalembera odwala matenda ashuga.
Mankhwala oterewa amathandizidwanso kwa matenda a chiwindi. Mwachitsanzo, mankhwala amathandizidwa ndi:
- matenda amatsenga
- aakulu a chiwindi
- kuchepa kwamafuta,
- fibrosis.
Thioctacid imapangitsa kuti ichotse poizoni yemwe amakhala zitsulo.
Mtengo wa mankhwalawa mu ma ampoules ndi ma ruble 1,500, mapiritsi amatengera 1,700 mpaka 3,200 rubles.
Dziwani zomwe zili bwino: Thioctacid kapena Oktolipen, dokotala wopezekapo angakuthandizeni. Ubwino wa lipoic acid kwa anthu odwala matenda ashuga adzajambulidwa mu kanema munkhaniyi.
