Aries ndi mankhwala zotchulidwa ngati achire mankhwala kupezeka kwa hypercholesterolemia ndi matenda a mtima wodwala. Chofunikira chachikulu cha mankhwalawa ndi simvastatin. Pulogalamuyi yatchula kuti katundu wa lipid-kutsitsa.
Mankhwalawa ali ngati mapiritsi. Wopanga mankhwalawa ndi kampani ya Russia yopanga mankhwala OZON LLC. Mawonekedwe a mapiritsiwo ndiwolondola. Kuphatikizika kwa mapiritsi monga gawo lalikulu lomwe limagwira limaphatikizapo simvastatin mu voliyumu ya 10 kapena 20 mg.
Kuphatikiza pazomwe zimapangidwira mapiritsi, pali mitundu yonse yazinthu zina zowonjezera:
- ascorbic acid;
- citric acid;
- wowuma wa gelatinized;
- lactose;
- titanium dioxide;
- magnesium wakuba;
- talc;
- propylene glycol;
- mafuta a castor;
- wowuma chimanga.
Mankhwalawa amagulitsidwa m'mafakisoni monga mapiritsi omwe amakhala m'matumba a contour, chilichonse chomwe chili ndi zidutswa 10, 20 kapena 50. Ma CD ojambulidwa amaikidwa pakatoni kamatabwa opangidwa ndi makatoni.
Kukhazikitsa kwa mankhwalawa kumachitika pokhapokha ngati pali mankhwala omwe madokotala amakupatsani.
Alumali moyo wa mankhwala 3 zaka. Kusunga kwa mankhwalawa kuyenera kuchitika pamalo otetezedwa ndi dzuwa. Kutentha kosungirako sikuyenera kukhala kwakukulu kuposa +25 degrees Celsius. Malo osungira amayenera kutetezedwa ku chinyezi komanso kuchokera kwa ana.
Tsiku lotha litatha, mankhwalawo amatayidwa.
Pharmacodynamics ndi pharmacokinetics a mankhwala
Mankhwala Ovenkor amatanthauza mankhwala ochepetsa mphamvu ya lipid. Kukonzekera kwa mankhwala kumachitika ndi nayonso mphamvu ya mankhwala omwe amapezeka kuchokera ku fungusic Aspergillusterreus saprophyte bowa.
Lactone yosagwira imapukusidwa, ndikutsatira kaphatikizidwe ka hydroxy acid.
Metabolite yogwira ya simvastatin imalepheretsa 3-hydroxy-3-methyl-glutaryl-CoA reductase.
Ma enzyme omwe atchulidwa amathandizira poyambira momwe HMG-CoA mevalonate amathandizira.
Kusintha kwa HMG-CoA kukhala mevalonate kumaimira gawo loyambirira la cholesterol synthesis. Kugwiritsa ntchito simvastatin sikumapangitsa kuti thupi lizikundana ndi njira zopezera poizoni. HMG-CoA imasinthidwa mosavuta kukhala acetyl-CoA. Pulogalamuyi imakhudzidwa ndi thupi m'thupi la njira zambiri za metabolic.
Kwa simvastatin, zinthu zotsatirazi ndizikhalidwe:
- Kutsitsa plasma milingo ya triglycerides, LDL ndi VLDL, komanso cholesterol yonse.
- Kuwonjezeka kwa ndende ya HDL ndi kuchepa kwa chiwerengero pakati pa lipoproteins otsika kwambiri komanso lipoproteins yapamwamba.
- Kuchepetsa kuchuluka pakati pa cholesterol yathunthu ndi HDL.
Mphamvu ya kugwiritsa ntchito mankhwalawa imawonedwa kale masiku 14 atayamba kugwiritsa ntchito mankhwala a Ovenkor.
Kuti mukwaniritse zochizira zambiri, mumayenera kulandira chithandizo, nthawi yake kuyambira milungu 4 mpaka 6.
Ngati ndi kotheka, dokotala amapitilira nthawi yochizira, yomwe imathandiza kusunga mphamvu ya mankhwalawa. Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumapangitsa kuti mafuta abwinobwino azikhala pang'ono pang'onopang'ono m'thupi la wodwalayo.
Simvastatin ali ndi mayamwidwe ambiri. Kuzungulira kwamphamvu kwa mankhwalawa kumatheka m'thupi pambuyo pa maola 1.3-2.5. Pambuyo maola 12 atatha kugwiritsa ntchito mankhwalawa, kuchepa kwa kuchuluka kwake m'magazi a wodwala ndi 90% kumawonedwa.
Zomwe zimagwira ku Ovenkor zimatha kumanga mapuloteni a plasma. Mlingo wa zomanga mapuloteni umafika mpaka 95%.
Hafu ya moyo wa yogwira mankhwala ndi maola 1.9.
Excretion ya metabolites imachitika ndi matumbo ngati gawo la ndowe. Njira yosagwira ya metabolites imachotsedwa ndi impso mkodzo.
Pafupifupi 60% ya chopondacho chimachotsedwa m'thupi, ndipo pafupifupi 10-15% ya mankhwalawa amuchotsa mkodzo.
Malangizo ogwiritsira ntchito mankhwalawa
Musanagwiritse ntchito Ovenkor, ndikofunikira kuphunzira malangizo kuti mugwiritse ntchito mwatsatanetsatane, kuwonjezera pa izi, muyenera kudziwa bwino za mtengo wamankhwala ndikuwunika kwa odwala ndi madokotala, ndipo muyenera kuphunziranso kufanana kwa mankhwalawa ngati pakufunika kutero.
Asanayambe kumwa mankhwalawa, wodwalayo amapatsidwa zakudya zoyenera za hypocholesterol.
Popereka mankhwala, tsiku ndi tsiku mlingo ungasiyane 1- mpaka 80 mg.
Mlingo woyambira wabwino ndi 10 mg; mlingo waukulu ndi 80 mg. Kusintha kwa Mlingo kumachitika ndi masabata anayi. Nthawi zambiri, mulingo woyenera kwambiri ndi 20 mg patsiku.
Mlingo wogwira wa Ovenkor pamaso pa matenda a mtima kapena ngati pali vuto lalikulu kwambiri lotengera matendawa kuyambira 20 mpaka 40 mg patsiku. Pa gawo loyambirira la mankhwalawa, muyezo wa 20 mg wa mankhwalawa umagwiritsidwa ntchito ndipo pambuyo pa masabata anayi mlingo umasinthidwa kukhala 40 mg.
Ngati mulingo wa cholesterol wochepera 140 mg / dl wapezeka m'thupi, mlingo wa mankhwalawo umachepetsedwa.
Mlingo wocheperako umagwiritsidwa ntchito ngati wodwala amakhala ndi kulephera kwa impso kapena pochita mankhwala othandizira osakanikirana ndi cyclosporine, Danazole, Gemfibrozil kapena michere ina.
Zizindikiro zogwiritsidwa ntchito molingana ndi malangizo ndi
- kukhalapo kwa hypercholesterolemia;
- kupezeka kwa thupi la IHD kapena prerequisites kuti izi zitheke.
Zoyipa zogwiritsidwa ntchito ndi mankhwalawa ndi:
- Matenda a chiwindi mu mawonekedwe.
- Porphyria.
- Myopathy
- Zaka za odwala zimafika zaka 18.
- Mimba komanso kuyamwa.
- Kukhalapo kwa tsankho.
Chenjezo pamene mukumwa mankhwalawa akuyenera kuwonetsedwa ndi zakumwa zoledzeretsa, kupezeka kwa ochepa matenda oopsa mwa wodwala, panthawi ya mankhwala a immunosuppression. Kuphatikiza apo, kusamala ndikofunikira ngati wodwala ali ndi khunyu komanso matenda am'mimbidwe ya mafupa am'mimba a genesis osadziwika.
Mukamagwiritsa ntchito mankhwalawa, mawonekedwe a zovuta za mankhwalawa amawonetsedwa motere:
- kupweteka pamimba;
- kudzimbidwa, kusefukira kwa msana, mseru, kupweteka kwam'mimba, chiwindi, kufuna kusanza;
- mutu
- zotumphukira neuropathy;
- Chizungulire
- kusowa tulo
- malungo
- kuyabwa
- urticaria;
- kuchuluka kwa mtima, kuchepa magazi, kuchepa kwa potency.
Ngati zizindikiro zoyambirira za zoyipa zapezeka, Ovenor ayenera kusiyidwa.
Mtengo wa mankhwalawa, mawonekedwe ake ndi ndemanga zake za mankhwalawa
Malinga ndi ndemanga yomwe ilipo ya odwala komanso kulandira madokotala, Ovencor ndi njira yothandiza kwambiri yolimbana ndi cholesterol yayikulu mthupi. Chimodzi mwazinthu zothandizira kukwaniritsa zabwino pamakhalidwe azithandizo zimafuna kutsatira kwambiri zakudya. Chowonongeka cha mankhwalawa ndikutukuka komwe kungachitike mwa wodwala pazovuta zosiyanasiyana zomwe zingayambitse kuthetsedwako kwa mankhwalawo.
Mtengo wa Ovenkor pakadali pano ku malo ogulitsa mankhwala ku Russian Federation umachokera ku ruble 300 mpaka 600 pa phukusi, kutengera dera.
Mankhwala otsatirawa ndi fanizo la mankhwalawa:
- Simvastatin.
- Vero-simvastatin.
- Zokor.
- Atherostat.
- Zovatin.
- Avestitin.
- Simvastol.
- Simvakard.
- Simlo.
- Holvasim.
- Zorstat.
Mtengo wa analogues wa mankhwala akuluakulu ungathe kusintha mosiyanasiyana. Chifukwa chake, mwachitsanzo, Simvastatin ili ndi mtengo wa ma ruble 41 pa mapiritsi 30, aliyense ali ndi 10 mg ya mankhwala othandizira, ndipo Vasilip ali ndi mtengo wa ma ruble 124 phukusi lomwe lili ndi mapiritsi 14, lililonse limakhala ndi 10 mg yaomwe yogwira pophika.
Musanasankhe analogue yoyenera m'malo mwa mankhwalawa, muyenera kufunsa dokotala.
Kodi ndichabwino kuti titenge akatswiri a statins anganene mu kanema munkhaniyi.
