Cholesterol owonjezera ndi vuto. Kukhalapo kwa ziwopsezo zochulukirapo za chinthuchi mthupi ndichimodzi mwazinthu zofunikira kwambiri pakuwonekera kwa kusokonekera kwa mtima ndi pathologies.
Popewa kukula kwamavuto akulu ndi matenda amisala, kupita kwa asing'anga kumapereka odwala omwe amamwa mankhwala ochepetsa lipid.
Kuchita kwa ndalama zotereku ndikofunikira kuti akwaniritse kuchepa kwa cholesterol m'magazi a wodwala.
Njira imodzi yamakono yokhala ndi lipid-kutsitsa kwenikweni ndi mapiritsi ochepetsa cholesterol Novostat.
Pharmacological zochita za Novostat
Mapiritsi a Novostat ndi mankhwala a hypolipidemic omwe ali m'gulu la ma statins. Kugwiritsa ntchito kwake kumathandiza kuchepetsa kuchuluka kwa plasma ya cholesterol yathunthu ndi LDL. Kuphatikiza apo, chithandizo cha Novostat chitha kuchepetsa kuchuluka kwa apolipoprotein B ndi triglycerides.
Kugwiritsa ntchito mankhwalawa kumathandizira kuwonjezeka kosasunthika ku kuchuluka kwa milingo yapamwamba ya lipoproteins.
Chifukwa cha mankhwalawa ndi mankhwalawa, zotsatira zabwino zimawonedwa pakukonzanso kwa ntchito za epithelial pamaso pa zovuta zawo.
Kugwiritsa ntchito mankhwala munthawi ya mankhwalawa kumakongoletsa mkhalidwe wamakhoma wamitsempha, kumathandizira kukonza magawo a magazi. Zomwe zimapangitsa kuti mankhwala azitha kuyendetsa bwino thupi zimatha kuchepetsa kuchepa kwa kufa kwa matenda a mtima
Kuphatikiza apo, mankhwalawa alengeza antioxidant ndi antiproliferative zotsatira.
Mphamvu ya kugwiritsidwa ntchito kwa mankhwalawa imagwirizanitsidwa ndi kuchepa kwa cholesterol yonse chifukwa kuchepa kwa kuchuluka kwa LDL.
Kutsika kwa ma lipoproteins otsika kwambiri kumadalira mlingo ndipo kumadziwika osati ndi kusintha kwa mzere, koma ndi exponential.
Njira yotulutsira ndikupanga mankhwala
Wopangayo amapereka Novostat kwa odwala mwanjira yamapiritsi olimba a opaque gelatin.
Novostat ndi mankhwala opangira.
Pamwambapa miyala inali yoyera. Chisoti chilichonse chimakhala ndi chipewa chachikaso kapena chopepuka cha beige.
M'mapikapu, kutengera ma CD, ma milligram 10, 20, 40 ndi 80 akhoza kukhala. Makapisozi ali ndi zogwirizana ndi atorvastatin. Ichi ndi chinthu chachikulu chomwe chimagwira. Chosakaniza chophatikizira m'mapiritsi amtundu wa atorvastatin calcium trihydrate.
Chiboliboli chilichonse chimakhalanso ndi mitundu ingapo ya zinthu zomwe zimagwira ntchito yothandiza.
Izi ndi izi:
- lactose monohydrate;
- ma cellcose a microcrystalline;
- sodium lauryl sulfate;
- povidone K-17;
- calcium carbonate;
- sodium carboxymethyl wowuma;
- magnesium wakuba.
The kapangidwe kake ka kapangidwe kake ka mankhwala kamakhala ndi izi:
- Utoto wake ndi wachikasu oxide wachikasu.
- Titanium dioxide.
- Gelatin ndiye maziko a kapisozi.
Gawo logwira ntchito ndi chosankha chopikisana mwa 3 hydroxy-3-methylglutaryl coenzyme A-reductases (HMG-CoA reductases. Enzyme iyi ndi gawo lofunikira mu tinthu timene timasinthira 3-hydroxy-3-methylglutaryl-CoA kukhala mevalonate, komwe ndi patsogolo). zitsulo.
Mankhwalawa amagulitsidwa m'mapaketi; kuchuluka kwa mankhwalawo mu phukusi limodzi kumatha kukhala 10 mpaka 300 makapu.
Zizindikiro ndi contraindication kuti mugwiritse ntchito
Pogulitsa mankhwala, phukusi lililonse lili ndi malangizo atsatanetsatane ogwiritsira ntchito.
Musanagwiritse ntchito Novostat, muyenera kukakumana ndi adotolo kuti mukalandire malangizo pazomwe zingachitike pochiritsa thupi lanu pogwiritsa ntchito chida ichi.
Zisonyezero zogwiritsidwa ntchito molingana ndi malangizo ndi machitidwe osiyanasiyana amthupi la wodwalayo.
Zizindikiro zazikulu ndizotsatirazi:
- hypercholesterolemia yoyamba malinga ndi Fredrickson, mtundu IIa;
- kuphatikiza Hyperlipidemia;
- dysbetalipoproteinemia;
- achibale amkati hypertriglyceridemia kugonjetsedwa ndi hypocholisterin zakudya;
- homozygous hypercholesterolemia yochepa mphamvu ya zakudya;
- kupewa chachikulu mtima ndi mtima matenda odwala popanda kukhalapo kwa matenda zizindikiro za matenda a mtima, koma ndi kukhalapo kwa chiopsezo cha chitukuko;
- kupewa kwachiwiri matenda ndi matenda a mtima ndi mtima dongosolo kuti muchepetse anthu, kuchepetsa mwayi wa kugunda kwa mtima ndi sitiroko.
Malinga ndi malangizo, mankhwalawa ali ndi zotsutsana zingapo kuti agwiritse ntchito ngati othandizira.
Mfundo zazikuluzikulu ndi izi:
- Kukhalapo kwa hypersensitivity kwa zigawo zikuluzikulu kapena zothandiza za mankhwalawa.
- Kukhalapo kwa matenda a chiwindi omwe amagwira ntchito mwa wodwala kapena kupezeka kwa kuchuluka kwa chiwindi cha plasma mwa munthu.
- Zaka za wodwalayo ndizosakwana zaka 18.
- Nthawi ya bere ndi nthawi yoyamwitsa.
- Kupezeka kwa tsankho lactose mwa munthu, kuchepa kwa lactase ndi kupezeka kwa shuga-galactose malabsorption.
Chenjezo lowonjezereka liyenera kuonedwa popereka mankhwala kwa odwala omwe amamwa mowa kwambiri, odwala omwe ali ndi mbiri ya matenda a chiwindi, komanso odwala omwe apezeka kuti ali ndi kusokonezeka kwakukulu mu-electrolyte usawa, endocrine ndi metabolic matenda, komanso matenda oopsa.
Kuphatikiza apo, sikulimbikitsidwa kuti mugwiritse ntchito mankhwalawa pambuyo poti muchite opaleshoni yayikulu komanso pamaso pavulala ndi matenda am'matumbo.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwalawa amapangidwira pakamwa. Novostat imaloledwa kutengedwa nthawi iliyonse masana, mosasamala mtundu wa chakudya.
Musanagwiritse ntchito mankhwalawa, ndikulimbikitsidwa kuti mutha kukwaniritsa kuchuluka kwa cholesterol pogwiritsa ntchito zakudya zamagulu ndi mafuta m'thupi. Kuphatikiza apo, tikulimbikitsidwa kuti njira ya mankhwala isanayambike kuchuluka kwa cholesterol m'thupi mwakuwonjezera katundu wambiri m'thupi ndikuchepetsa thupi ngati pali owonjezera.
Popereka mankhwala, mapiritsi amayenera kumwedwa nthawi yomweyo ndi zakudya za hypocholesterol. Wodwala ayenera kutsatira zakudya zopanda cholesterol panthawi yonse ya chithandizo.
Mlingo wa Novostat ukhoza, kutengera zosowa, kusiyana 10 mpaka 80 mg kamodzi patsiku. Mlingo wa wothandizira womwe umagwiritsidwa ntchito umasankhidwa ndi dokotala aliyense payekha, poganizira zotsatira za mayeso ndi machitidwe a thupi la wodwalayo.
Mlingo waukulu womwe umaloledwa kugwiritsidwa ntchito ndi 80 mg tsiku lililonse.
Pa gawo loyambirira la mankhwalawa kapena kuwonjezeka kwa mlingo, plasma cholesterol amayenera kuyang'aniridwa sabata iliyonse iliyonse. Ngati ndi kotheka, malinga ndi zotsatira zakawongoleredwe, kusintha kwa mankhwalawa kumachitika.
Kuphwanya kwa ntchito kwa impso sikukhudza kuchuluka kwa yogwira zigawo za m'magazi, chifukwa chake, ngati izi zimachitika, kusintha kwa mankhwala sikofunikira.
Mukamagwiritsa ntchito mankhwala okalamba, kusintha kwa mankhwalawa sikufunikira kuganizira zaka za wodwalayo.
Pankhani ya chithandizo nthawi yomweyo monga Novostat ndi Cyclosporine, mlingo woyambira sayenera kupitirira 10 mg patsiku.
Muyenera kusamala makamaka mukamagwiritsa ntchito mankhwalawa limodzi ndi HIV proteinase inhibitors ndi hepatitis C zoletsa.
Zotsatira zoyipa nthawi ya mankhwala ndi Novostat
Zotsatira zonse zoyipa zomwe zimagwiritsidwa ntchito ngati mugwiritsa ntchito mankhwalawa zitha kugawidwa m'magulu otsatirawa - nthawi zambiri, nthawi zambiri, osati kawirikawiri, kawirikawiri komanso kawirikawiri zomwe zimayamba.
Zotsatira zoyipa zimatha kuthana ndi magazi, chitetezo chamthupi, mantha, kupuma, kugaya, minofu ndi mafupa.
Kuphatikiza apo, zotsatira zoyipa zimatha kukhudza ziwalo za kumva komanso ziwalo zamasomphenya.
Nthawi zambiri, zotsatirazi zotsatila za kumwa mankhwalawa zimayamba:
- Mwazi wamagazi ndi thrombocytopenia.
- Chitetezo cha mthupi - thupi lawo siligwirizana, anaphylactic mantha.
- Kuchokera kumbali ya mantha
- Pa mbali ya ziwalo zamasomphenya - kuchepa kwa kuwona kwamphamvu ndi kusokonezeka kwa malingaliro.
- Amamva ziwalo - tinnitus ndipo, nthawi zina, kumva kumvetsera.
- Kuchokera kupuma dongosolo - nasopharyngitis, nosebleeds, kupweteka kwa m'mimba.
- Kuchokera mmimba dongosolo - kumverera mseru, kugona, kudzimbidwa, dyspepsia, kutsegula m'mimba, kupindika, kusanza, kupweteka pamimba, kupweteka kwapakhosi.
- Pa chiwindi, kukula kwa chiwindi, cholestasis, chiwindi, cholestatic jaundice.
- Integument - alopecia, zotupa pakhungu, kuyabwa kwa khungu, urticaria, erythema multiforme, poyizoni wa epidermal necrolysis.
- Kuchokera ku minculoskeletal system - myalgia, atralgia, kupweteka kwa miyendo, kukokana kwa minofu, kupweteka kumbuyo, kupweteka m'khosi, kufooka kwa minofu.
- Ntchito yobereka - gynecomastia, kusabala.
Mankhwala enieni osokoneza bongo a Novostat osadziwika. Zikatere, chithandizo chamankhwala chimachitika. Hemodialysis siyothandiza chifukwa kupangika kwa ma protein mkati mwa mapuloteni amadzi am'magazi ndi atorvastatin.
Analogs ndi ndemanga za mankhwalawa
Novostat imayenera kusungidwa pamtunda wozungulira osaposa 25 digiri kuposa zero. Malo osungirako ayenera kukhala ouma komanso amdima. Komanso malo osungirako sayenera kupezeka ndi ana ndi ziweto.
Alumali moyo wa mankhwala ndi zaka zitatu. Pambuyo pa nthawi imeneyi, mapiritsi amayenera kutayidwa.
Mtengo wa mankhwalawo ku Russian Federation pakadali pano umatha kusiyanasiyana komanso kutengera dera lomwe likugulitsidwa komanso kampani yomwe ikugulitsa, komanso kuchuluka kwa makapisozi omwe ali phukusi.
Pafupifupi, mtengo wa mankhwala umachokera ku 300 mpaka 600 ma ruble.
Analogs a Novostat pamsika wamafuta ndi:
- Atorvastatin;
- Atoris;
- Torvas
- Liprimar;
- Vazator;
- Tulip;
- Anvistat;
- Lipitor;
- Ator.
Ndemanga za wodwala zokhudza mankhwalawa ndizopanda tanthauzo, zomwe zimachitika makamaka chifukwa cha kuchuluka kwa zotsatira zoyipa zomwe zimagwiritsidwa ntchito ndi mankhwalawa komanso machitidwe a mizimu ya odwala omwe ali ndi cholesterol yayikulu mthupi.
Koma ziyenera kudziwidwa kuti maphunziro azachipatala amatsimikizira kuchuluka kwa mankhwalawa polimbana ndi cholesterol yayikulu mthupi.
Momwe mungachepetse cholesterol akufotokozedwa mu kanema m'nkhaniyi.
