Lorista ndi mankhwala ochokera pagulu la angiotensin-2 receptor antagonists (mpikisano). Omalizirawo akutanthauza mahomoni. Zimathandizira vasoconstriction, kupanga aldosterone (adrenal mahomoni) komanso kuchuluka kwa magazi. Angiotensin ndi gawo limodzi la renin-angiotensin.
Ath
Code Lorista anatomical ndi achire mankhwala gulu C09CA01.
Lorista ndi mankhwala ochokera pagulu la otsutsa omwe amalimbikitsa vasoconstriction, kupanga timadzi tamadontho tamadonthoni komanso kuchuluka kwa magazi.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawo amagulitsidwa monga mapiritsi okhala ndi filimu. Potaziyamu losartan ndiye yogwira mankhwala. Zomwe zili piritsi limodzi ndi 12,5 mg, 25 mg, 50 mg kapena 100 mg.
Kuphatikizika kwa mankhwalawa kumaphatikizanso cellactose, wowuma, filimu hypromellose ndi zinthu zina.
Mapiritsiwa amakhala ndi mbali zonse, achikasu kapena zoyera (pamlingo wa 50 ndi 100 mg) ndikuzungulira.
Njira yamachitidwe
Mankhwala amasankha. Zimakhudza ma receptors a AT1 mu impso, minofu yosalala, mtima, mitsempha yamagazi, chiwindi ndi ma adrenal gland, zomwe zimapangitsa kuchepa kwa chiwopsezo cha matenda a angiotensin-2.
Mankhwala ali ndi zotsatirazi pharmacological:
- Kuchulukitsa kukonzanso ntchito.
- Imachepetsa ndende ya aldosterone.
- Imaletsa vasoconstriction (vasoconstriction).
- Sichikukhudza mapangidwe a bradykinin.
- Imachepetsa kukana kwamitsempha yamagazi.
- Imakulitsa kukodzetsa (kuchulukitsa kwa madzi owonjezera mumkodzo mwa kusefa madzi a m'magazi).
- Amachepetsa kuthamanga kwa magazi (makamaka mumizere ya m'mapapo). Amachepetsa kuthamanga kwa magazi komanso kuthamanga. Kutsika kwakukulu kwa kupsinjika kumawonedwa maola a 5-6 mutatha mapiritsi. Ubwino wofunikira wa mankhwalawa ndi kusapezeka kwa matenda achire.
- Amachepetsa kupsinjika pamtima.
- Zimalepheretsa hypertrophy ya minofu ya mtima.
- Amawonjezera kukana kwaumunthu pazolimbitsa thupi. Izi ndizofunikira kwa odwala omwe ali ndi vuto la mtima.
- Sisintha kuchuluka kwa mtima.
Pharmacokinetics
Malinga ndi kafukufuku wa pharmacokinetic, kuyamwa kwa Lorista m'mimba ndi matumbo ang'onoang'ono kumachitika msanga.
Kudya sikukhudzana ndi kuchuluka kwa metabolite yogwira. The bioavailability wa mankhwala pafupifupi 33%. Kamodzi m'magazi, losartan amaphatikiza ndi albin ndipo amagawidwa ziwalo zonse. Ndi gawo la mankhwalawa kudzera m'chiwindi, kagayidwe kake kamachitika.
Hafu ya moyo wa Lorista ndi maola awiri. Ambiri mwa mankhwalawa amachotseredwa ndi bile. Gawo la losartan limayesedwa ndi impso ndi mkodzo. Mbali ya Lorista ndikuti mankhwalawa samalowa mu ubongo.
Kudya sizikhudzanso kuchuluka kwa mankhwala omwe amapezeka.
Zomwe zimathandiza
Mankhwala akuwonetsedwa a:
- matenda oopsa osiyanasiyana magwero;
- lamanzere lamitsempha lamanzere lamanzere (michere yamanzere);
- CHF;
- proteinuria yokhala ndi matenda a shuga a 2 (mankhwalawa amachepetsa chiopsezo cha nephropathy ndi kulephera kwaimpso).
Pa kukakamizidwa kuti atenge
Kumwa mankhwalawa kumakhala koyenera ndi kuthamanga kwa magazi a 140/90 mm Hg. ndi mmwamba. Mankhwalawa nthawi zambiri amalembedwa ngati mukulephera kapena kugwiritsa ntchito ACE zoletsa.
Kumwa mankhwala a Lorista kuli koyenera ndi kuthamanga kwa magazi a 140/90 mm Hg. ndi mmwamba.
Contraindication
Lorist sayenera kupatsidwa ntchito ndi:
- kuthamanga kwa magazi;
- potaziyamu yambiri m'magazi;
- tsankho limodzi ndi zigawo zikuluzikulu za mankhwala;
- wokhala ndi mwana ndi kuyamwa;
- kuchepa kwa thupi;
- malabsorption a galactose kapena shuga;
- tsankho kuti mkaka shuga.
Maphunziro azachipatala athunthu pazokhudzana ndi mankhwalawa pa thupi la ana sanachitike, motero mankhwalawa amangolembera achikulire okha. Pankhani yakuphwanya wamagetsi amagetsi a electrolyte, aimpso, chiwindi kukanika komanso kupendekera kwamitsempha yamafungo, kusamala kumafunikira pakumwa.
Momwe angatenge
Mankhwalawa amamwa pakamwa kamodzi patsiku musanadye, nthawi yakudya kapena itatha. Pothamanga kwambiri, mlingo ndi 50 mg / tsiku. Mlingo ukhoza kuwonjezeka mpaka 100 mg.
Mankhwalawa amamwa pakamwa kamodzi patsiku musanadye, nthawi yakudya kapena itatha.
Kuphatikiza apo, pafupipafupi oyang'anira ndi nthawi 1-2 patsiku. Popeza mankhwalawa ali ndi okodzetsa, mukamapatsa mankhwala okodzetsa, Lorista amapatsidwa mlingo wa 25 mg, pang'onopang'ono kuwonjezera mlingo.
Okalamba, odwala omwe ali ndi hemodialysis zida ndi anthu omwe ali ndi vuto la impso amachitika.
Mu CHF, mlingo woyamba wa tsiku ndi tsiku ndi 12,5 mg. Kenako imakwera mpaka 50 mg / tsiku. Sabata iliyonse kwa mwezi umodzi, mlingo woyambayo umakulitsidwa ndi 12,5 mg. Lorista nthawi zambiri imaphatikizidwa ndi othandizira ena omwe amakhudza mtima wamagazi (diuretics, glycosides). Odwala omwe ali ndi chiopsezo chowonjezereka cha ngozi ya pachimake cerebrovascular Lorista ayenera kutenga 50 mg / tsiku.
Kumwa mankhwala a shuga
Pofuna kupewa kuwonongeka kwa impso kwa odwala omwe ali ndi matenda a shuga a 2, mlingo ndi 50-100 mg / tsiku.
Zotsatira zoyipa
Kumbali ya dongosolo la endocrine ndi ziwalo za pachifuwa, kusintha komwe kumachitika sikumawonedwa.
Mukamamwa Lorista, ululu wam'mimba umatha.
Matumbo
Mukamamwa Lorista, zotsatirazi zosavomerezeka ndizotheka:
- kupweteka kwam'mimba
- kuphwanya chopondapo munjira ya m'mimba;
- nseru
- kupweteka kwa dzino
- kamwa yowuma
- kutulutsa;
- kusanza
- kudzimbidwa
- Kuchepetsa thupi mpaka kukomoka;
- kuchuluka kwa kuchuluka kwa ma enzymes a chiwindi m'magazi (kawirikawiri);
- kuchuluka kwa bilirubin m'mwazi.
Woopsa milandu, nthawi ya mankhwala, gastritis ndi hepatitis angayambe.
Hematopoietic ziwalo
Nthawi zina, phenura ndi magazi am'mimba zimachitika.
Kumwa mankhwala kungayambitse magazi m'thupi.
Pakati mantha dongosolo
Mbali yamanjenje, asthenia (kuchepa kwa ntchito, kufooka), kusowa tulo, kupweteka kwa mutu, kusokonezeka kwa chikumbumtima, chizungulire, kusokonekera kwamphamvu mu mawonekedwe a paresthesia (kunging, goosebumps) kapena hypesthesia, migraine, nkhawa, kukomoka, ndi kukhumudwa. Nthawi zina zotumphukira neuropathy ndi ataxia.
Matupi omaliza
Mukamamwa Lorista, mitundu yotsatirayi ya zinthu zoyipa sizingatheke:
- kuyabwa
- zotupa
- urticaria;
- Edema wa Quincke.
Muzovuta kwambiri, kupumira kwam'mimba kumatupa ndikupumira.
Zokhudza mphamvu pakuwongolera njira
Palibe chidziwitso pazokhudzana ndi Lorista pakutha kwa munthu kuyendetsa galimoto ndi kugwiritsa ntchito zida.
Palibe chidziwitso pa zomwe Lorista adachita pagalimoto ya munthu.
Malangizo apadera
Mukamachiritsa Lorista, muyenera kutsatira malangizo awa:
- ngati kuchepa kwa magazi kuzungulira magazi, muyenera kubwezeretsa kapena kuyamba kulandira mankhwalawa;
- kuwunika milingo ya creatinine;
- kuwunika mulingo wa potaziyamu m'magazi.
Odwala omwe ali ndi vuto la chiwindi
Ndi cirrhosis yolimbitsa, kuchuluka kwa losartan m'magazi ndikutheka, chifukwa chake, anthu omwe ali ndi matenda a chiwindi ayenera kuchepetsa kuchuluka kwa mankhwalawa.
Odwala ndi mkhutu aimpso ntchito
Ndi ntchito yosakwanira, Lorista amatengedwa mosamala. Odwala akulangizidwa kuti apereke magazi kuti awunikenso kuti adziwe kuchuluka kwa mankhwala a nayitrogeni.
Mukamagwiritsa ntchito Lorista, muyenera kusiya kuyamwitsa.
Pa mimba ndi mkaka wa m`mawere
Kugwiritsa ntchito mankhwalawa pakubala kwa ana kumawonjezera chiopsezo cha kuwonongeka kwa fetal chifukwa cha kukhudzidwa kwa Lorista pa renin-angiotensin. Mukamagwiritsa ntchito Lorista, muyenera kusiya kuyamwitsa.
Kusankhidwa kwa Lorist kwa ana
Mankhwalawa ali contraind mu ana ndi achinyamata.
Mlingo wokalamba
Kwa anthu okalamba, mlingo woyambirira umafanana ndi muyezo wachipatala. Mapiritsi amatengedwa m'mawa, masana kapena madzulo.
Kuyenderana ndi mowa
Mukamagwiritsa ntchito Lorista, ndikofunikira kuti musiye kumwa mowa.
Mukamagwiritsa ntchito Lorista, ndikofunikira kuti musiye kumwa mowa.
Bongo
Zizindikiro za bongo ndi:
- kukoka kwamtima;
- kupsinjika kwa magazi ndi kusokonezeka kwa magazi;
- kukopa kwa pakhungu.
Nthawi zina bradycardia imayamba. Mwa anthu otere, kugunda kwa mtima kumakhala kochepa kuposa 60 kumenyedwa / mphindi. Thandizo limakhala ndi kukakamiza diuresis ndi kugwiritsa ntchito mankhwala opatsa chidwi. Kuyeretsa magazi ndi hemodialysis sikuthandiza.
Kuchita ndi mankhwala ena
Kugwirizana kwakuipa kwa Lorista ndi:
- mankhwala opangidwa ndi fluconazole;
- Rifampicin;
- Spironolactone;
- NSAIDs;
- Triamteren;
- Amiloridine.
Kusagwirizana bwino kwa Lorista ndi mankhwala opangidwa ndi fluconazole kumadziwika.
Chizindikiro cha Lorista ndikuti chimawonjezera chidwi cha opanga beta-blockers, okodzetsa komanso achifundo.
Analogi
Zofanizira za Lorista zokhala ndi losartan ndi mankhwala monga Presartan, Lozarel, Kardomin-Sanovel, Blocktran, Lozap, Vazotens, Lozartan-Richter, Kozaar ndi Lozartan-Teva.
Zilonda mmalo mwa Lorista zingakhale zovuta mankhwala. Izi zikuphatikiza Lortenza, GT Blocktran, Losartan-N Canon, Lozarel Plus, Gizaar ndi Gizaar Forte.
Palibe mankhwala Lorista Plus. Kukonzekera kovuta, Lozap AM, yokhala ndi losartan ndi amlodipine ikugulitsanso.
Wopanga
Opanga Lorista ndi ma fanifilimu ake ndi Russia, Germany, Slovenia, Iceland (Vazotens), USA, Netherlands, Korea ndi United Kingdom.
Chimodzi mwazomwe opanga Lorista ndi mawonekedwe ake ndi Russia.
Kupita kwina mankhwala
Mankhwala amagulitsidwa kokha ndi mankhwala.
Mtengo wa Lorista
Mtengo wa Lorista umachokera ku ma ruble 130. Mitengo ya analogi imasiyana ndi ma ruble 80. (Losartan) mpaka ma ruble 300. ndi mmwamba.
Kusunga mankhwala a Lorista
Mankhwalawa amasungidwa kutentha kwa firiji (mpaka 30ºC). Malo osungira amayenera kutetezedwa ku chinyezi komanso kuchokera kwa ana.
Tsiku lotha ntchito
Zaka 5 kuyambira tsiku lopangira.
Ndemanga za Lorista
Omvera zamtima
Dmitry, wazaka 55, ku Moscow: "Ndimalemba Lorista kapena fanizo lake kwa odwala anga omwe ali ndi matenda oopsa."
Odwala
Alexandra, wazaka 49, Samara: "Ndimamwa Lorista mu mlingo wa 50 mg kuchokera ku kuthamanga kwa magazi. Mankhwalawa amachepetsa kuthamanga kwa magazi."
