Mildronate 250 akukhudzidwa ndi metabolic process; Ndi analogue yopanga zachilengedwe yomwe imapezeka m'maselo a thupi la munthu. Chifukwa cha chida ichi, metabolism imabwezeretseka, ntchito ya ziwalo zamkati imayenda bwino.
Panthawi ya MP, njira yolembera mpweya m'maselo imathandizira, yomwe imakonzanso myocardium ndikuthandizira kupewa zovuta zambiri. Pali zoletsa zochepa pakugwiritsira ntchito mankhwalawa, zoyipa sizimapezeka. Mwakuyitanitsa, mlingo wa gawo lalikulu umasungidwa - 250 mg.
Dzinalo Losayenerana
Meldonium.
Chifukwa cha Mildronate, metabolism imabwezeretseka, ntchito ya ziwalo zamkati imayenda bwino.
ATX
C01EB, mankhwala ena ochizira matenda a mtima.
Kutulutsa mafomu ndi kapangidwe kake
Chogulacho chimapezeka mu mawonekedwe olimba komanso amadzimadzi. Chosakaniza chophatikizacho ndi meldonium hydrochloride. Mlingo wake umatha kusiyanasiyana, womwe umakhudzidwa ndi kapangidwe ka mankhwalawa. Mwachitsanzo, 250 mg ndi 500 mg akhoza kukhala mu 1 kapisozi, ndi 100 mg mu 1 ml ya jakisoni yankho. Zina mwazomwe zimapangidwa sizikugwira ntchito. Kuti mupeze chidwi cha mankhwalawo, madzi a jakisoni amawonjezeredwa ku yankho.
Zina mwazinthu zomwe zimapangidwira mu mawonekedwe a makapisozi omwe amagwiritsidwa ntchito kuti apeze zomwe zimafunikira:
- silicon dioxide colloidal;
- wowuma mbatata;
- calcium owawa.
The kapangidwe ka zigamba za mapiritsi Mildronate 250: utoto ndi gelatin.
Kuphatikizika kwa Shell: utoto ndi gelatin.
Chogulitsacho chimaperekedwa m'matumba a 10 ndi 20 ampoules (5 ml iliyonse), komanso 40 ndi 60 makapisozi.
Zotsatira za pharmacological
Ntchito yayikulu yogwira ntchito ndi kusintha kwa kagayidwe kachakudya pama cellular. Kufunika kwake kumachitika ndi ischemia, kuchepa kwa okosijeni komanso mavuto ena omwe amayamba chifukwa cha kusintha kwa michere m'thupi.
Carnitine imapangidwa kudzera pa gamma-butyrobetaine. Chofunikira kwambiri pakuphatikizidwa kwa mankhwalawa ndi mawonekedwe ake a chinthu ichi. Mothandizidwa ndi iye, njira ya kupanga carnitine imaletseka, chifukwa cha kuletsa kwa ntchito ya enzyme gamma-butyrobetaine hydroxylase. Chifukwa cha zochitika izi, kayendedwe ka mafuta acid kudutsa cell membranes kusokonezedwa.
Wothandizirayo amafunsira kulowetsedwa kwa carnitine ndi matumbo a mucous.
Zotsatira zake, ma acid acids samadutsa mwachangu kudzera m'maselo a mtima. Ndi kuperewera kwa okosijeni, makutidwe ndi okosijeni amafuta amathandizidwa.
Zotsatira za njirayi ndi kupangidwa kwa zinthu zapoizoni zomwe zimasokoneza machitidwe a mtima. Poyerekeza zakumbuyo zomwe tafotokozazi, kagayidwe kazakudya kamene kamayamba kuthamanga. Pankhaniyi, kupanga bwino kwa ATP kumachitika.
Mankhwalawa amakhalanso othandizira odwala matenda ashuga, chifukwa amathandizira kutsitsa shuga m'magazi. Ubwino wa chida ndikutha kusintha chizindikiro ichi popanda kuwonjezera kupanga insulin.
Chifukwa cha chisonkhezero pakupanga kwa gamma-butyrobetaine, kuchepa kwa chiwopsezo mderalo la malo okhudzidwa ndikupanga myocardial infarction kumadziwika. Chifukwa cha izi, nthawi yobwezeretsa pambuyo pochotsa zizindikiro za pachimake imachepetsedwa.
Patsamba lomwe lili ndi zizindikiro za ischemic, magazi amayenda bwino.
Ngati mtima ukugundika kumayamba, mankhwalawo amathandizanso kuti matenda asinthe. Nthawi yomweyo, pali kuchepa kwa ziwonetsero za angina.
Thupi limalimbana kwambiri ndi kupsinjika kwa thupi. Kuphatikiza apo, kusintha kwamanjenje kwamkati kwamanjenje kumawonedwa, zomwe zimachitika makamaka chifukwa chobwezeretsanso kufalitsa kwa ubongo.
Mutatha kumwa mankhwalawa, matenda amtundu wamkati amawonedwa, zomwe zimachitika chifukwa cha kubwezeretsanso kwa magazi.
Chifukwa cha mankhwala omwe ali ndi meldonium, kuchuluka kwa ogwira ntchito kumawonjezeka, mkhalidwe wamaganizidwe a wodwalayo wabwerera mwakale. Mothandizidwa ndi chida ichi, zizindikiro za kusiyanasiyana ndi kuledzera zimachotsedwa.
Pharmacokinetics
Mfundo zoyenera kuchita komanso kuchuluka kwa kufalikira kwakepi lonse kutengera thupi la MP. Mankhwala mu mawonekedwe amadzimadzi amayamba kugwira ntchito atangopereka magazi / minyewa. Njira yothetsera jakisoni imayendetsedwa kudzera m'mitsempha, intramuscularly ndi parabulbarno. Komanso, bioavailability wa mankhwala oterewa amafikira 100%. Chiwongola dzanja chimachitika nthawi yomweyo ngati chinthucho chilowetsedwa m'magazi. Choyipa chake ndikuchotsedwa kwachangu mthupi (maola 3-6), komwe kumakulitsa pafupipafupi kugwiritsa ntchito.
Mildronate imakonda kupukutidwa; Zotsatira zake, ziwalo ziwiri zothandizidwa zomwe impso zimamasulidwa.
Ngati makapisozi amatengedwa, bioavailability imatsitsidwa ndipo ndi 78%. Peak ntchito ya mankhwala amapezeka pambuyo 60-120 mphindi ndi pakamwa.
Peak ntchito ya mankhwala amapezeka pambuyo 60-120 mphindi ndi pakamwa.
Mtundu wina wa mankhwalawa wayambitsanso katundu: hygroscopic yocheperako, imatha kutentha kwambiri. Posachedwa, njira yotsatira ya meldonium idagwiritsidwa ntchito. Ikatentha, imataya malo, imasintha mawonekedwe ake: chifukwa cha chizolowezi chomeza chinyontho, MP ikudutsa mu mawonekedwe amadzimadzi, amafanana ndi madzi osasunthika.
Zomwe zimayikidwa
Mildronate itha kugwiritsidwa ntchito pazotsatira zotsatirazi:
- matenda a mtima (komanso mankhwala ena); akupanga myocardial infarction, angina pectoris;
- matenda osachiritsika omwe amayamba chifukwa cha kuwonongeka kwa mitsempha: sitiroko, kuperewera kwa magazi ndi mitsempha ya magazi;
- kulephera kwamtima, matenda a mtima, oyambitsidwa ndi kusintha kwatsiku ndi minyewa, komwe nthawi zambiri kumachitika chifukwa cha kusokonekera kwa mahomoni;
- pathological zinthu chifukwa cha kuwonongeka m'magazi a ziwalo masomphenya: hemorrhage, venous thrombosis, retinopathy zosiyanasiyana etiologies;
- kuchira kwa kusiya kusiyanasiyana komwe kumachitika chifukwa cha kuledzera;
- Kuchepetsa magwiridwe.
Kugwiritsa ntchito kwa Mildronate pamasewera
Chida choganiziridwa chitha kugwiritsidwa ntchito ndi othamanga omwe ali ndi nkhawa kwambiri yakuchita masewera komanso malingaliro. Komabe, poyesedwa kuti musavutike, meldonium imakhudza zotsatira zake.
Chida chomwe chikufunsidwa chikutha kugwiritsidwa ntchito ndi osewera othamanga kwambiri.
Contraindication
Pali zoletsa zingapo zomwe mankhwala amaletsedwa kugwiritsa ntchito popanda zina:
- zoipa zoyipa zaumunthu payekha pazinthu zina zilizonse zomwe zimapangidwa;
- chizolowezi chowonjezera kukakamira kwachuma, komwe kumachitika chifukwa cha mapangidwe, zotupa za mitsempha, zikuipiraipira.
Ndi chisamaliro
Contraindication zokhudzana ndi chiwindi ndi impso. Popeza kuti ziwalozi zimakhudzidwa ndi metabolism ya meldonium ndi kutuluka kwake, katundu wowonjezerayo amakhumudwitsa kukula kwa zoyipa. Pazifukwa izi, tikulimbikitsidwa kuwunika momwe wodwalayo alili ndi ma pathologies otere.
Momwe mungatenge Mildronate 250
MP ikhoza kuyambitsa chisangalalo chowonjezereka, chifukwa chake tikulimbikitsidwa kuti muzigwiritsa ntchito m'mawa, nthawi yayitali - osachedwa kuposa nkhomaliro. Mlingo wa mankhwala udzakhazikitsidwa payekhapayekha, poganizira kuchuluka kwa matenda, matenda a wodwala. Njira ya chithandizo imathanso kukhala ndi nthawi yosiyana.
Mu matenda a mtima, tengani 500-1000 mg ya mankhwalawa tsiku lililonse kwa masabata 6.
Malangizo ogwiritsira ntchito kutengera ndi matenda:
- matenda a mtima: 500-1000 mg patsiku (logawidwa mu 2 Mlingo), maphunzirowa sapitilira masabata opitilira 6;
- mtima: 500 mg patsiku, nthawi ya mankhwala - mpaka masiku 12;
- subacute komanso matenda a pathological oyambitsidwa ndi kuphwanya kwa mitsempha ya magazi: 500-1000 mg patsiku, mankhwalawa amatha mpaka milungu isanu ndi umodzi, ndipo mawonekedwe osaneneka a matendawa akusonyeza kufunikira kogwiritsa ntchito kuchuluka kochepa kuchokera pamtundu womwe wafotokozedwa (500 mg); kubwezeretsanso mankhwala pambuyo yopuma ndikulimbikitsidwa;
- kuchuluka kwa thupi ndi kuchepa kwa ntchito m'maganizo: 500 mg osaposa 2 kawiri patsiku, maphunziro ake ndi masabata 1.5-2; ngati kuli koyenera, kumachitika mobwerezabwereza, koma osati kale kuposa milungu iwiri;
- muyezo mlingo (500-1000 mg) zotchulidwa kwa othamanga, mankhwalawa amatengedwa osaposa 2 pa tsiku, maphunzirowa amatenga mpaka milungu itatu pakukonzekera kuchita bwino komanso osaposa masiku 14 panthawi yopikisana;
- ndi zakumwa zoledzeretsa: 500 mg kanayi patsiku, mankhwalawa amatengedwa osaposa masiku 10;
- mu ophthalmology: 50 mg kamodzi patsiku, thunthu limayendetsedwa parabulbarly, maphunzirowa amatha mpaka masiku 10.
Musanadye kapena musanadye
Mankhwalawa amatengedwa pamimba yopanda kanthu kapena theka la ola mutatha kudya.
Mankhwalawa amatha kumwa theka la ola mutatha kudya.
Mlingo wa matenda ashuga
Mildronate amatengedwa mu maphunziro ndi kusokonezeka kwina. Pankhaniyi, ndizovomerezeka kupereka mlingo woyenera wa mankhwalawa. Kutalika kwa maphunzirowa, komanso kuchuluka kwa kugwiritsa ntchito mankhwalawa, kumatsimikiziridwa payekhapayekha.
Zotsatira zoyipa
Zotsatira zoyipa sizimakhala nthawi zambiri.
Pankhaniyi, zotsatira zotsatirazi zimachitika:
- kusunthika kwakumapeto kwa magawo;
- kuphwanya kuchuluka kwa mtima (tachycardia);
- kusangalala boma, chifukwa cha zomwe zimachitika mu dongosolo lamanjenje lalikulu;
- kugaya chakudya
- thupi lawo siligwirizana, kuwonetsedwa ndi kutupa, kuyabwa, zotupa, Hyperemia.
Zokhudza mphamvu pakuwongolera njira
Palibe chidziwitso pakuyendetsa bwino panthawi yamankhwala ndi Mildronate. Zotsatira zoyipa zamankhwala zimagwiritsidwa ntchito nthawi zambiri. Komabe, chifukwa cha kuthekera kwa meldonium kuyambitsa kusokonezeka kwa mtima ndikuchepetsa kupsinjika, chisamaliro chikuyenera kuthandizidwa poyendetsa galimoto.
Mukamamwa Mildronate 250, muyenera kusamala mukamayendetsa galimoto.
Malangizo apadera
Mildronate angagwiritsidwe ntchito ka angina pectoris ndi zina za CCC, koma mankhwalawa si mankhwala oyamba. Pazifukwa izi, MP imagwiritsidwa ntchito limodzi ndi mankhwala ena.
Gwiritsani ntchito mu ukalamba
Chovomerezeka kugwiritsa ntchito chida chofunsidwachi. Komabe, muyenera kuwunika momwe thupi liliri, chifukwa kagayidwe kake muukalamba amachepetsa. Kuphatikiza apo, Mildronate amayambitsa zosokoneza pakugwira ntchito kwa CVS komanso amachepetsa kuthamanga kwa magazi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi oletsedwa kugwiritsidwa ntchito. Izi ndichifukwa chosowa chidziwitso chokhudza chitetezo chake.
Kulemba Mildronate kwa ana 250
Chida chomwe chikufunsidwa sichikugwiritsidwa ntchito. Izi ndichifukwa chosowa chidziwitso chokhudza chitetezo chake.
Amayi oyembekezera kutenga Mildronate amatsutsana.
Bongo
Zizindikiro zomwe zingachitike ndi kuchuluka kwa mankhwalawa:
- kusintha kwakuthwa pamlingo wopanikizika (pansi);
- mutu ndi chizungulire;
- kusokonekera kwa mtima, limodzi ndi kusintha kwa pafupipafupi kwa mtima;
- kumva kufooka.
Chifukwa cha kuwopsa kwa mankhwalawa, zovuta zam'mimba zambiri sizimapezeka. Chotsani zizindikiro ndi mankhwala apamwamba; kusankha chiwembu kumadalira matenda chithunzi.
Kuchita ndi mankhwala ena
Mildronate ikhoza kuphatikizidwa ndi mankhwala ena omwe amakhudza kayendedwe ka mtima ka mtima: ntchito yogaya magazi, antiplatelet, anticoagulant ndi antiarrhythmic mankhwala.
Palibe zizindikiro zoyipa ndi kugwiritsa ntchito munthawi yomweyo ma bronchodilators.
Cardiac glycosides amayamba kugwira ntchito mwachangu motsogozedwa ndi wothandizirayo.
Mildronate ikhoza kuphatikizidwa ndi othandizira omwe amakhudza kugwira ntchito kwa mtima.
Matenda a wodwalayo amawunikidwa nthawi zonse mukamachiza ndi mankhwalawa:
- Nitroglycerin;
- Nifedipine;
- alpha-blockers;
- antihypertensive mankhwala;
- zotumphukira vasodilators.
Kufunika uku kumachitika chifukwa cha chiwopsezo chowonjezeka chochita.
Kuyenderana ndi mowa
Ngakhale kuti mankhwalawa amagwiritsidwa ntchito pochiza munthu yemwe akudwala mowa, sayenera kugwiritsidwa ntchito nthawi yomweyo ndi zakumwa zoledzeretsa, popeza pali kuchepa kwa ntchito ya MP.
Analogi
M'malo mogwira mtima:
- Meldonium;
- Meldonium Organics;
- Cardionate;
- Idrinol
Mutha kusintha Mildronate ndi Meldonium.
M'malo mwa makapisozi ndi yankho, mapiritsi angagwiritsidwe ntchito. Ngati ndi kotheka, kuwerenganso kwa mlingo kumachitika.
Miyezo ya tchuthi Mildronata 250 kuchokera ku pharmacy
Mankhwalawa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Palibe zotheka.
Mtengo wa Mildronate 250
Mtengo wapakati ndi ma ruble 315.
Zosungidwa zamankhwala
Pamalo amdima ndi owuma. Kutentha kovomerezeka - kosapitirira kuposa + 25 ° ะก.
Tsiku lotha ntchito
Mapiritsi amatha kugwiritsa ntchito zaka 4; yankho likhoza kugwiritsidwa ntchito nthawi yayitali - zaka 5 kuchokera tsiku lotulutsidwa.
Mapiritsi amatha kugwiritsa ntchito zaka 4; yankho likhoza kugwiritsidwa ntchito nthawi yayitali - zaka 5 kuchokera tsiku lotulutsidwa.
Wopanga Mildronate 250
Santonica, Lithuania.
Ndemanga za Mildronate 250
Chifukwa cha kuwunika kwa malingaliro a akatswiri ndi ogula, zimatha kuwerengera momwe mankhwalawo amagwirira ntchito.
Omvera zamtima
Kutina M.A., wamtima wazaka 32, Saratov
Mankhwala othandiza; Zotsatira zabwino zimatheka patadutsa masiku 7-10 chiyambireni chithandizo. Mpumulo wina umabwera tsiku loyamba. Gawani zakusokonekera kwa kapangidwe ka makoma amitsempha yamagazi. Zochita zanga, zoyipa odwala sizinakhazikike.
Gerudova, A.I., katswiri wazamtima, wazaka 39, Moscow
Ngakhale kusowa kwa maphunziro athunthu okhudzana ndi chitetezo cha mankhwalawa, zimadziwonetsa kukhala zabwino kwambiri. Kukula kwa zizindikiro zamatenda kumachepa ndi monotherapy. Ngati mankhwala omwe mukufunsidwa amagwiritsidwa ntchito limodzi ndi mankhwala amphamvu, zizindikiro zake zimatha.
Odwala
Alexandra, wazaka 33, Oryol
Mildronate adayikidwa pambuyo pakuchita opaleshoni: dokotala wa opaleshoni adanena kuti ndikofunikira kupewa zovuta. Sindikudziwa kuti mankhwalawo adagwira bwanji pakuchira kwanga, koma ndidachira msanga, palibe mavuto omwe adabuka.
Eugene, wazaka 37, Barnaul
Zovomerezedwa ndikuwonongeka kwamakhalidwe abwino akumva (panali khutu m'makutu). Patatha milungu ingapo zidakhala bwino. Tsopano ndimagwiritsa ntchito mankhwalawo kunyumba ngati zingakhale zovuta zosiyananso.
