Gluconorm Plus amatanthauza ma multicomponent hypoglycemic othandizira. Chifukwa cha kukhalapo kwa zosakaniza zingapo zogwira ntchito, zotsatira zabwino panthawi ya mankhwala zitha kupezeka mwachangu. Chida chomwe chimaganizidwacho chimasiyana ndi analogi ya dzina lomwelo (Gluconorm) muyeso wokulirapo. Komanso, onse mankhwalawa ali mgulu limodzi.
Dzinalo Losayenerana
Metformin + Glibenclamide.
Gluconorm Plus amatanthauza ma multicomponent hypoglycemic othandizira.
ATX
A10BD02.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mwa mawonekedwe a mapiritsi. Muli zosakaniza: glibenclamide ndi metformin hydrochloride. Mlingo piritsi limodzi, 2,5 ndi 5 mg; 500 mg Kuphatikiza pa kuphatikiza zinthu izi, kapangidwe kake kamaphatikizanso ndi zinthu zothandizanso pamtunduwu wa kumasulidwa:
- ma cellcose a microcrystalline;
- hyprolosis;
- croscarmellose sodium;
- magnesium wakuba.
Mapiritsiwa amakhala ndi zokutira zapadera zomwe zimachepetsa mtengo wa kumasulidwa kwa zinthu zomwe zimagwira. Chifukwa cha izi, kuchuluka kwaukali pazomwe zimapanga mucous m'mimba kumachepa. Mutha kugula malonda mumapaketi okhala ndi miyala 30.
Mankhwala amapezeka mwa mawonekedwe a mapiritsi. Muli zosakaniza: glibenclamide ndi metformin hydrochloride.
Zotsatira za pharmacological
Makina a Gluconorm Plus amatengera kuphatikizika kwa zinthu zosiyanasiyana. Gawo lirilonse limachita mogwirizana ndi mfundo zake, koma nthawi yomweyo limalimbikitsa zotsatira za zinazo. Chifukwa cha zovuta zake, njira zingapo zamunthu mthupi zimaphimbidwa, zomwe zimapangitsa kuchepa kwamphamvu kwa glucose. Chifukwa chake, metformin ndi ya Biguanides. Awa ndi othandizira a hypoglycemic omwe nthawi imodzi amagwiranso ntchito zosiyanasiyana:
- sinthana chiŵerengero cha insulin kuti proinsulin ndi kumangika insulin kuti imamasulidwe, koma njirayi siyoyendetsedwa ndi Gluconorm, koma ndi chifukwa cha zomwe zimachitika thupi likupangika ndi mankhwalawa;
- amachepetsa kuchuluka kwa shuga m'magazi, zomwe zimachitika chifukwa cha kuletsa kwa kapangidwe ka metformin, nthawi yomweyo imayamba kusintha kwa maselo.
Poyerekeza ndi kuwonjezeka kwa kuthamanga kwa shuga, minyewa yamtundu wa insulin imakulirakulira. Nthawi yomweyo, kumasulidwa kwamafuta amafuta achepetsa kumachepetsa. Mafuta oxidation amathanso kuchepa. Kuchuluka kwa triglycerides, otsika kachulukidwe lipoproteins, kumachepera. Chifukwa cha izi, kuchuluka kwa mapangidwe a mafuta amthupi kumachepetsedwa, komwe kumakhudza mwachindunji kulemera kwa munthu. Poyerekeza ndi zakudya zopezeka mokwanira, kudya zakudya zochepa zopatsa mphamvu komanso kuchita masewera olimbitsa thupi, kukula kwa kunenepa kwambiri, komwe ndikofunikira kwambiri kwa odwala matenda ashuga.
Kusadziwika kwina kwa mankhwalawa kosiyanasiyana mwa mitundu ina ya insulin chifukwa cha zochita zina. Chifukwa chake, ndi mankhwala a metformin, palibe zovuta pakapangidwe ka insulin, popeza chinthu ichi chimawonetsa katundu wa hypoglycemic, kupyola maselo a kapamba. Ngakhale kuti gawo ili limaphwanya kagayidwe ka cholesterol, kumachepetsa kuyika kwa LDL, mankhwalawa sachepetsa zomwe zili ndi HDL. Chifukwa cha izi, kulemera kumangoleka kuwonjezera, koma kuchepa kwake kumadziwika pansi pamikhalidwe zingapo.
Katundu wina wa metformin ndi kuthekera kolimbikitsa ma magazi omwe amapangidwa. Chifukwa chake, munthawi ya chithandizo ndi Gluconorm Plus, mphamvu yamagazi ya fibrinolytic imakhala yofanana. Zotsatira zake, ma magazi omwe amapangidwa amawonongeka. Izi zimachitika potseketsa minyewa ya plasminogen activator.
Katundu wina wa metformin ndi kuthekera kolimbikitsa ma magazi omwe amapangidwa.
Gawo lachiwiri logwira ntchito (glibenclamide) ndi gulu la zotumphukira za sulfonylurea. Njira zamtunduwu ndizothandiza kwambiri kuposa mankhwala onse omwe alipo a hypoglycemic. Limagwirira ntchito ya glibenclamide zachokera kuthekera kukopa maselo a pancreatic beta. Mukamacheza ndi ma receptors awo, kutsekedwa kwa potaziyamu ndi njira za calcium zimatseguka.
Zotsatira za izi ndizoyambitsa kwa insulin kumasulidwa. Izi zimachitika chifukwa cholowerera calcium m'maselo. Pomaliza, kutulutsidwa mwamphamvu kwa insulin m'magazi kumadziwika, zomwe zimapangitsa kuchepa kwa shuga. Popeza makina a chinthu ichi, ndikofunikira kuti mugwiritse ntchito mankhwalawa odwala omwe amagwira maselo a beta a kapamba. Kupanda kutero, mphamvu ya glibenclamide imachepetsedwa.
Pharmacokinetics
Metformin imalowa mwachangu. Mlingo wa kuphatikiza kwake m'magazi seramu umawonjezereka mpaka mtengo wake utatha ma 2 maola. Zoyipa zamtunduwu ndizofunikira mwachidule. Pambuyo pa maola 6, kuchepa kwa plasma ndende ya metformin kumayamba, zomwe zimachitika chifukwa cha kutha kwa njira yonyowetsera chakudya m'mimba. Hafu ya moyo wa chinthucho imachepetsedwa. Kutalika kwake kumasiyana kuchokera ku 1.5 mpaka 5 maola.
Kuphatikiza apo, metformin sikugwirizana ndi mapuloteni a plasma. Izi zimatha kudzikundikira mu minyewa ya impso, chiwindi, tiziwalo tamadonthina. Ntchito yaimpso yolakwika ndi chinthu chachikulu chomwe chikuthandizira kuchulukana kwa metformin mthupi, zomwe zimabweretsa kuwonjezeka kwa kuphatikizira kwa gawo ili komanso kuwonjezereka kwa ntchito yake.
Ntchito yaimpso yolakwika ndi chinthu chachikulu chomwe chimathandizira kudziunjikira kwa metformin mthupi, zomwe zimapangitsa kuti chiwonjezere ntchito zake.
Glibenclamide imatenga nthawi yayitali - kwa maola 8-12. Kuchuluka kwa mphamvu kumachitika mu maola 1-2. Katunduyu amakhala womangika ndi mapuloteni amwazi. Njira yosinthira kwa glibenclamide imachitika m'chiwindi, pomwe mapangidwe awiri amapangidwa omwe samawonetsa ntchito za hypoglycemic.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amaloledwa kugwiritsidwa ntchito pochiza odwala omwe ali ndi matenda a shuga a 2 nthawi zina:
- kusowa kwa zotsatira mu chithandizo chomwe chidalembedwa kale cha kunenepa kwambiri, ngati mankhwala atagwiritsidwa ntchito: Metformin kapena Glibenclamide;
- kuchitira mankhwala othandizira, m'malo mwake kuchuluka kwa glucose m'magazi ndikokhazikika ndikuwongolera bwino.
Contraindication
Zoperewera zambiri zimadziwika momwe chida chomwe chikufunsidwachi sichinagwiritsidwe ntchito:
- tsankho ku chinthu chilichonse chophatikizidwa (zogwira ntchito ndi zosagwira);
- mtundu 1 matenda a shuga;
- kuphwanya kagayidwe kachakudya matenda a shuga;
- gawo loyamba la chikomokere;
- chikomokere;
- kuchepa kwakukulu kwa shuga m'magazi;
- zosiyanasiyana pathological zinthu zomwe zimathandizira kuti minyewa isavutike, imatha kukhala yochepa pang'onopang'ono pakuchepetsa kwamadzimadzi, matenda, mantha;
- matenda aliwonse omwe amayenda ndi kuperewera kwa okosijeni, pakati pawo amayamba kubera;
- lactic acidosis;
- zingapo za pathological zochitika zomwe ndizomwe zimayambitsa kupatsidwa mankhwala a insulin, mu izi, kukondoweza kwa zinthu izi kungapangitse kukula kwa zovuta.
Momwe mungatenge Gluconorm Plus?
Pafupipafupi kotenga mapiritsi ndi kuchuluka kwa zinthu zomwe zimagwira zimatsimikiziridwa payekhapayekha. Mkhalidwe wa wodwala wodwala matenda a shuga, kupezeka kwa matenda ena, komanso msinkhu zimakhudza kusankha kwa mankhwala. Mankhwala amatengedwa ndi chakudya.
Ndi matenda ashuga
Yambirani ntchito ya mankhwalawa ndi mitundu yaying'ono. Tengani piritsi limodzi patsiku. Kuphatikiza apo, ndende ya magawo omwe amagwira ntchito akhoza kukhala osiyana: 2.5 mg + 500 mg; 5 mg + 500 mg. Pang'onopang'ono, kuchuluka kwa metformin ndi glibenclamide kumawonjezeka, koma osaposa 5 mg ndi 500 mg, motsatana. Kusintha kwa kuchuluka kwa mankhwalawa kumachitika pakatha milungu iwiri iliyonse mpaka mkhalidwe wa wodwala ukhazikika.
Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi mapiritsi 4, pomwe Mlingo wa yogwira zosakaniza mu 1 pc: 5 mg ndi 500 mg. Njira ina ndi mapiritsi 6, koma kuchuluka kwa glibenclamide ndi metformin motere: 2.5 mg, 500 mg. Mlingo wowonetsedwa wa mankhwalawa amagawidwa ma Mlingo angapo (2 kapena 3), zonse zimatengera kuchuluka kwa mapiritsi. Kupatula kumakhalapo ngati piritsi 1 limayikidwa patsiku.
Zotsatira zoyipa za Gluconorm Plus
Pali chiwopsezo cha kusokonezeka kwamaonedwe chifukwa cha kutsika kwa glucose.
Matumbo
Kusintha, limodzi ndi mseru, kuchepa kwa chakudya, kupweteka pamimba, kulawa kwachitsulo. Kupezeka kwa zizindikiro za jaundice, hepatitis sichidziwika kwambiri, zochitika za hepatic transaminases zimachulukirachulukira. Izi ndi zotsatira za kusintha kwa chiwindi.
Kusanza limodzi ndi mseru ndi chimodzi mwazotsatira zoyipa za mankhwalawa.
Hematopoietic ziwalo
Zovuta zingapo zoyendetsedwa ndi kusintha kwapangidwe ndi magazi: thrombocytopenia, leukopenia, kuchepa magazi, ndi zina zambiri.
Pakati mantha dongosolo
Kutopa, kupweteka mutu komanso chizungulire, kufooka kwapafupipafupi, kusokonezeka kwa chidwi (kawirikawiri).
Carbohydrate kagayidwe
Hypoglycemia, zomwe zizindikiro zake ndi ukali, chisokonezo, kukhumudwa, kuwona kwamaso, kunjenjemera, kufooka, ndi zina zambiri.
Kuchokera kumbali ya kagayidwe
Lactic acidosis
Pa khungu
Pali zizindikiro za hypersensitivity ku kuwala kwa dzuwa.
Matupi omaliza
Urticaria. Zizindikiro zazikulu: zotupa, kuyabwa, kutentha thupi. Erythema amakula.
Mankhwala angayambitse ziwengo mu kuyimitsidwa ndi zotupa.
Zokhudza mphamvu pakuwongolera njira
Poganizira kuti mankhwalawa amayambitsa kusokonezeka kwa diso, nthawi zina amathandizira kukulitsa kwa hypoglycemia, tikulimbikitsidwa kusamala pakuchita mankhwala ndi Gluconorm Plus mukamayendetsa.
Malangizo apadera
Mankhwalawa amadziwitsidwa mosamala ngati kuphwanya kwambiri kwa chithokomiro, chithokomiro, pathupi, malungo.
Pa chithandizo, tikulimbikitsidwa kuwunika pafupipafupi kuchuluka kwa shuga (pamimba yopanda kanthu ndikatha kudya).
Ndikofunikira kudziwitsa dokotala za matenda ophatikizana ndi ziwalo zoberekera. Pankhaniyi, kusintha kwa mtundu wa chithandizo kungafunike.
Poyerekeza ndi kumbuyo kwa vuto la chiwindi ndi impso, kuchuluka kwa metformin m'magazi kumawonjezeka, zomwe zimachitika chifukwa chakuchepa kwa kuchotsedwa kwa zinthuzi. Zotsatira zake, lactic acidosis imayamba.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Sanapatsidwe.
Cholinga cha Gluconorm Plus kwa ana
Osagwiritsidwa ntchito, chithandizo chokha chachikulire chovomerezeka.
Mankhwalawa sagwiritsidwa ntchito pochiza ana.
Gwiritsani ntchito mu ukalamba
Mankhwala amatengedwa mosamala, makamaka ngati wodwalayo akukumana ndi masewera olimbitsa thupi mopitirira muyeso. Pankhaniyi, chiopsezo cha lactic acidosis chikuwonjezeka.
The ntchito aimpso kuwonongeka
Osatipatsa chithandizo chakuwononga kwambiri chiwalo ichi. Kupanga chilolezo cha Creatinine kumafunika. Ndi kuchepa kwakukulu mu njira ya mankhwalawa kumasokonezedwa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwala ndi contraindicated ngati vuto la chiwindi.
Mankhwala ochulukirapo a Gluconorm Plus
Chida ichi ndi chowopsa ngati chikugwiritsidwa ntchito pophwanya njira yothandizira. Pankhaniyi, hypoglycemia imayamba, popeza njira zotulutsira insulin zimayambitsa. Nthawi yomweyo, glyconeogenesis ndi glucose amagwiritsidwa ntchito moletsa kwambiri. Zotsatira zake, pakuwonjezeka kwa mlingo wa Gluconorm Plus, mavuto amakula.
Therapy imakhudzanso matenda zakudya. Wodwala ayenera kumwa mankhwala okhala ndi mtundu wina uliwonse. Ngati vuto lalikulu la matenda atakula, limodzi ndi chikomokere, chithandizo chimachitika kuchipatala: yankho la dextrose limaperekedwa kudzera m'mitsempha.
Mlingo wa Gluconorm Plus ukachuluka, lactic acidosis imayamba. Matenda amtunduwu amafunikira chithandizo kuchipatala. Komanso, lactate ndi metformin zimachotsedwa bwino mthupi kudzera mu hemodialysis. Kuti muchotse glibenclamide, njirayi siyabwino, chifukwa chinthu ichi ndichopanda mapuloteni amwazi.
Mankhwala ndi contraindicated ngati vuto la chiwindi.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito molumikizira kwa Gluconorm Plus ndi Miconazole kumathandizira kukulitsa kwa hypoglycemia.
Zinthu zokhala ndi ayodini sizigwiritsidwa ntchito limodzi ndi mankhwalawa. Izi ziyenera kukumbukiridwa popanga kafukufuku wofuna kugwiritsa ntchito kusiyanasiyana kwa zinthu zomwe zili ndi ayodini.
Phenylbutazone amalimbikitsa machitidwe a mankhwala omwe amafunsidwa - amathandizira kutsika kwamphamvu kwamphamvu m'magulu a shuga.
Besontan amachititsa kuti chiwindi chiwonjezeke.
Mankhwala ndi zinthu zingapo zomwe zimafuna kusamala:
- Chlorpromazine;
- GCS;
- beta-adrenergic agonists ndi adrenergic blockers;
- okodzetsa;
- Danazole;
- ACE zoletsa.
Kuyenderana ndi mowa
Zakumwa zomwe zili ndi mowa sizingaphatikizidwe ndi Gluconorm Plus.
Analogi
M'malo mogwira mtima:
- Glibomet;
- Janumet;
- Metglib;
- Glucophage ndi ena.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo wa Gluconorm Plus
Mtengo wapakati: ma ruble 160-180.
Zosungidwa zamankhwala
Mtengo wolimbikitsidwa: mpaka + 25 ° С.
Tsiku lotha ntchito
Katundu wa mankhwalawa amasungidwa kwa zaka ziwiri kuchokera tsiku lotulutsidwa.
Wopanga
Pharmstandard-Tomskkhimfarm OJSC, Russia.
Mukakalamba, mankhwalawa amatengedwa mosamala, makamaka ngati wodwala akumana ndi zochitika zolimbitsa thupi kwambiri.
Ndemanga za Gluconorm Plus
Madokotala
Valiev A.A., endocrinologist, wazaka 45, Vladivostok
Njira yothandiza. Zotsatira zakufuna chithandizo zitha kupezeka nthawi yomweyo, koma zizindikiro zotere zimayenderana ndi chiwopsezo cha zovuta. Kutsika kwamphamvu kwa shuga m'magazi kumabweretsa hypoglycemia, kotero mutha kumwa mankhwala pokhapokha mukaonana ndi dokotala.
Shuvalov E. G., wothandizira, wazaka 39, Pskov
Mankhwalawa amagwira ntchito mwangwiro. Ndiwo wokhawo womwe ungatengedwe ndi shuga yachiwiri. Ndikuwona zovuta zingapo zoyipa, contraindication. Ndimaona mwayi ngati mtengo wotsika mtengo, womwe ndiofunikira, chifukwa odwala nthawi zambiri amayenera kumwa mapiritsi awa.
Odwala
Veronika, wazaka 28, Yaroslavl
Posachedwa ndidapeza matenda ashuga. Ndikuphunzira kukhala naye, ndimafunikira chakudya komanso kuwunika kwa ma glucose ena. Ndidatenganso mankhwalawa, amathandiza msanga, ndipo izi ndizophatikiza, chifukwa mantha anga akulu ndi kutsika kwa maziko a kuchepa kwama glucose.
Anna, wazaka 44, Samara
Mankhwalawa sanakwane. Amapereka mavuto. Mutu, nseru, kuwonongeka kwamaso - Ndinakumana ndi izi zonse pandekha. Dokotala poyamba ankakhulupirira kuti nkhaniyi inali mu mulingo, koma ngakhale mankhwala odekha kwambiri sanathetse vutoli.
