Baeta Long ali m'gulu la othandizira a hypoglycemic Zingwe zimayikidwa pansi pa khungu. Limagwirira zake zachokera pharmacological zimatha exenatide, amene amachita zolandilira glucagon-ngati peptide-1. Gawo lothandizali lingathandize kupanga insulini musanadye shuga. Nthawi yomweyo, ntchito yamafuta am'magazi a pancreatic beta imachepa pamene misempha yachilengedwe yamagazi ifika.
Dzinalo Losayenerana
Exenatide.
Baeta Long ali m'gulu la othandizira a hypoglycemic
ATX
A10BJ01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa mwa mawonekedwe ngati ufa oyera kuti apange jakisoni wa subcutaneous. Mankhwalawa amatha nthawi yayitali. Powder amagulitsidwa wathunthu ndi zosungunulira. Yotsirizira ndi madzi owoneka bwino okhala ndi chikasu kapena bulawuni. Ufa umakhala ndi 2 mg yogwira ntchito - exenatide, yomwe imathandizidwa ndi sucrose ndi polymer monga zigawo zothandizira.
Zosungunulira zimakhala:
- croscarmellose sodium;
- sodium kolorayidi;
- sodium dihydrogen phosphate mu mawonekedwe a monohydrate;
- madzi osalala a jakisoni.
Zotsatira za pharmacological
Mankhwala ndi a gulu la incretin mimetics - GLP-1. Pamene glucagon-ngati peptide-1 imayatsidwa, exenatide imakulitsa katulutsidwe ka mahomoni a insulin ndi maselo a pancreatic beta chakudya chisanafike. Mankhwalawa amachepetsa kutsuka kwam'mimba ndikalowa m'magazi. Pulogalamu yogwira ya Baeta imakulitsa chidwi cha minyewa pakuchitapo kanthu ka insulin, potero kukonza kusintha kwa glycemic motsutsana ndi maziko a matenda osagwirizana ndi insulin. Kupanga kwa insulini kumayambira pamene kuchuluka kwa shuga m'magazi kumayamba kukhala kwabwinobwino.
Kafukufuku wachipatala awonetsa kuti kuyang'anira exenatide kumachepetsa chilimbikitso komanso kumachepetsa kudya.
Exenatide mu kapangidwe ka mankhwala amasiyana ndi ma cell a insulin, zotumphukira za D-phenylalanine ndi sulfonylurea, alpha-glucosidase blockers komanso thiazolidinediones. Mankhwala amapangitsa kuti magawo a Langerhans a kapamba azigwira ntchito. Pankhaniyi, exenatide amalepheretsa kubisalira kwa glucagon.
Mu maphunziro azachipatala, zidapezeka kuti kuphatikiza kwa exenatide kumachepetsa kudya komanso kumachepetsa kudya, kumalepheretsa m'mimba kufalikira. The yogwira thunthu timapitiriza hypoglycemic zotsatira za antidiabetic wothandizira.
Pharmacokinetics
Mothandizidwa ndi subcutaneous, mankhwalawa amadziunjikira m'magazi popanda kuchita ma cell a chiwindi. Voliyumu yapakati yogawa exenatide ili pafupifupi 28 malita. Chithandizo chogwiritsa ntchito chimachoka m'thupi pogwiritsa ntchito kusefera kwa impso, ndikutsatira proteinolytic cleavage. Mankhwalawa amachotsedwa pakangodutsa milungu 10 kuchokera kutha kwa chithandizo.
Wothandizira hypoglycemic ndikofunikira kuti achepetse kuchuluka kwa shuga m'magazi ndi matenda a shuga a 2.
Zizindikiro Baeta Long
Wothandizira hypoglycemic ndikofunikira kuti achepetse kuchuluka kwa shuga m'magazi ndi matenda a shuga a 2. Ndi zoletsedwa kupereka mankhwalawa mtundu 1 wa shuga. Mankhwalawa amagwiritsidwa ntchito osagwiritsa ntchito njira zingapo zochepetsera kunenepa kwambiri: kuchuluka kwa thupi, chakudya chapadera.
Contraindication
Mankhwala omwe amaphatikizidwa ndi anthu omwe ali ndi:
- shuga wodalira insulin;
- Hypersensitivity munthu wowonjezera ndi yogwira zinthu za mankhwala;
- kulephera kwambiri kwaimpso;
- kwambiri mafuta odzola zilonda zam'mimbamo;
- matenda ashuga ketoacidosis;
- ana ochepera zaka 18;
- azimayi oyembekezera komanso oyembekezera.
Kutenga Baetu Long
Mankhwalawa amaperekedwa mwachangu m'matako, mkati mwa khoma lamkati komanso pansi pa khungu pamwamba pa minofu yolimba kapena pamphumi.
Mlingo woyambirira wa mankhwala ukufika 5 mg, pafupipafupi makonzedwe patsiku - 2 zina. Mankhwalawa ayenera kugwiritsidwa ntchito pasanathe mphindi 60 asanayambe kudya. Ndi bwino kupereka jakisoni musanadye chakudya cham'mawa komanso musanadye. Patatha mwezi umodzi chiyambire kumwa mankhwala ndi kulekerera kwabwino, kuchuluka kwa mpaka 10 mg amaloledwa kuyendetsedwa kawiri pa tsiku.
Zotsatira zoyipa Baeta Long
Zotsatira zoyipa zochokera ku mankhwalawa zimatha chifukwa cha kugwiritsa ntchito mosayenera mankhwalawo kapena kuyanjana ndi mankhwala ena mosayenera. Zotsatira zoyipa ziyenera kudziwitsidwa kwa dokotala.
Matumbo
Mukamagwiritsa ntchito Byeta ngati monotherapy, chitukuko cha:
- nseru
- kusanza
- kudzimbidwa
- kutsegula m'mimba kwa nthawi yayitali;
- kudya kwakachepa, anorexia;
- dyspepsia.
Kuphatikiza mankhwala, zomwe zimakhudzidwa zimakhudzidwa ndi chiwopsezo chachikulu cha zilonda zam'mimba ndi duodenum, kutupa kwa kapamba, kukhumudwa kwa masamba, mawonekedwe owawa ndi kuphulika, kusanja, kupindika.
Hematopoietic ziwalo
Ndi kuletsa kwa hematopoietic dongosolo, kuchuluka kwa magazi amachepetsa.
Pakati mantha dongosolo
Kuphwanya dongosolo lamanjenje kumaonekera mwa mawonekedwe a chizungulire, kupweteka mutu, kufooka komanso mawonekedwe a kuwodzera. Nthawi zina, maburashi akunjenjemera amawoneka.
Kuchokera kwamikodzo
Pogwiritsa ntchito munthawi yomweyo ndimankhwala ena, kukulitsa kulephera kwaimpso kapena kufalikira kwake ndikotheka. Kuchuluka kwa seramu creatinine ndende.
Dongosolo la Endocrine
Ndi mankhwala osokoneza bongo, hypoglycemia imayamba. Makamaka ndi kugwiritsidwa ntchito kofanana kwa sulfonylureas.
Ndi mankhwala osokoneza bongo, hypoglycemia imayamba.
Matupi omaliza
Thupi lawo siligwirizana amakhala ndi kukula kwa zotupa khungu, kuyabwa, angioedema, urticaria, kusowa kwa tsitsi, kugwedezeka kwa anaphylactic.
Zokhudza mphamvu pakuwongolera njira
Mankhwala a hypoglycemic samakhudza ntchito yamavuto, luso lamagalimoto abwino ndi mantha amanjenje. Chifukwa chake, munthawi yamankhwala amaloledwa kugwira ntchito ndi maginito ovuta, kuyendetsa galimoto ndi zochitika zina zomwe zimafuna kuthamanga kwambiri kwa kusintha kwakuthupi ndi kwamaganizidwe, kupatsa chidwi.
Malangizo apadera
Exenatide osavomerezeka atatha kudya. Sizoletsedwa kupaka jekeseni wamitsempha.
Zinthu zamankhwala zimatha kukhala ndi immunogenicity, chifukwa chomwe thupi la wodwalayo, pamaso pa hypersensitivity, limatha kupanga ma antibodies motsutsana ndi magawo omwe amagwira ntchito. Nthawi zambiri, gawo la ma antibodies linali laling'ono ndipo silinapangitse kuti anaphylactic asinthe. Pakupita milungu makumi asanu ndi atatu a chithandizo cha mankhwala osokoneza bongo, kuchepa kwapang'onopang'ono kwa mayankho a chitetezo cha mthupi kunawonedwa, chifukwa chake, mankhwalawo sanayike pachiwopsezo cha moyo pokhudzana ndikukula kwa anaphylactic.
Sizoletsedwa kupaka jekeseni wamitsempha.
Nthawi zina, ma exenatide amatha kuchepetsa kufalikira kwa minofu ya m'mimba. Chifukwa chake, kugwiritsa ntchito mankhwala komwe kumapangitsa kuti matumbo asamayende bwino kapena kuti athe kuyamwa mwachangu m'mimba, sikulimbikitsidwa.
Pambuyo pakutha kwa mankhwalawa, mankhwala ochititsa chidwi amatha kukhalapo kwa nthawi yayitali, chifukwa kuchuluka kwa plasma kumachepa kwa masabata 10. Ngati atasiya kumwa mankhwalawa, dotolo amupatsanso mankhwala ena, ndikofunikira kuchenjeza katswiri za zam'mbuyo za Baeta. Izi ndizofunikira kupewa kuti anthu asamakumane ndi zinthu zoipa.
Muzochita zamankhwala, panali zochitika za kuchepa thupi msanga (pafupifupi 1.5 makilogalamu pa sabata) pamankhwala omwe amapezeka ndi exenatide. Kuchepa kwambiri kwa thupi kungayambitse mavuto obwera chifukwa cha kusinthasintha kwa mahomoni m'thupi, chiopsezo chowonjezeka cha matenda amtima, kutopa, kukula kwa nkhawa, mwina kugwetsa impso. Ndi kuchepa thupi, ndikofunikira kuwongolera zizindikiritso za cholelithiasis.
Gwiritsani ntchito mu ukalamba
Anthu opitilira zaka zopitilira 60 safunika kusintha njira yochiritsira.
Anthu opitilira zaka zopitilira 60 safunika kusintha njira yochiritsira.
Kupatsa ana
Kugwiritsa ntchito mankhwalawa muubwana ndi koletsedwa chifukwa cha kusowa kwa chidziwitso chokhudza mphamvu ya mankhwalawa pakukula kwa thupi la munthu kufikira zaka 18.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pa mayeso oyeserera a mankhwala a nyama, poizoni wamkati mwa mayiyo ndi mphamvu zake za mwana wosabadwayo zinaululidwa. Pogwiritsa ntchito mankhwalawa ndi amayi apakati, kukomoka kwa mkati, kusokonezeka kwa chitukuko cha ziwalo ndi minyewa pa nthawi ya embryogenis kumatha kuchitika. Chifukwa chake, kugwiritsa ntchito Baeta kwa amayi panthawi yomwe ali ndi pakati ndi koletsedwa.
Pa mankhwala ndi hypoglycemic mankhwala, tikulimbikitsidwa kuletsa kuyamwitsa chifukwa cha kuchuluka kwa hypoglycemia mwa mwana.
The ntchito aimpso kuwonongeka
Pogwiritsa ntchito mankhwalawa odwala omwe ali ndi vuto la aimpso, kuwonjezeka kwa zomwe zimachitika chifukwa cham'mimba thirakiti kunawonedwa. Makamaka ndi creatinine chilolezo pansi pa 30 ml / min. Mwakutero, kayendetsedwe ka Baeta kosagwirizana kwa anthu omwe ali ndi vuto la impso sikuloledwa.
Mankhwalawa adapangidwa kuti agwiritsidwe ntchito ndi anthu omwe ali ndi chiwindi chachikulu.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwalawa adapangidwa kuti agwiritsidwe ntchito ndi anthu omwe ali ndi chiwindi chachikulu.
Bongo
Pochita malonda pambuyo pa malonda, pakhala pali zomwe zimachitika mopitirira muyeso, chithunzi cha chipatala chomwe chinali kusanza kwa kusanza komanso mseru. Pankhaniyi, wodwalayo adalandira mankhwala omwe amayang'ana kwambiri pakuchotsa zizindikiro. Kuti muchepetse vuto la mankhwala osokoneza bongo, osagwiritsa ntchito mankhwalawa. Popanda hypoglycemic kanthu, ndikofunikira kusinthira kulandira chithandizo china, kuwonjezeka kwa payokha kapena kuchuluka kwa kayendetsedwe ka Bayeta kumatsutsana. Kutalika kokwanira kogwiritsa ntchito kawiri pa tsiku.
Kuchita ndi mankhwala ena
Exenatide, akapatsidwa mogwirizana ndi Digoxin, amachepetsa kuchuluka kwambiri kwa seramu yotsirizira ndi 17%, nthawi yoti athe kufikira imawonjezeka ndi maola 2,5. Kuphatikiza apo, chithandizo chophatikizira chotere sichikhudza thanzi la wodwalayo ndipo chiloledwa kuti chigwiritsidwe ntchito.
Ndi makonzedwe apakati pa Baeta Long omwe ali ndi Lovastatin, kuchepa kwa milingo yayikulu kwambiri ya Lovastatin kumawonedwa ndi 28%, nthawi yofika Cmax ikuwonjezeka ndi maola 4. Ndi kusintha kotereku kwamapiritsi a pharmacokinetic, kusintha kwa mankhwalawa kwa mitundu yonse ya mankhwalawa ndikofunikira.
Exenatide, akapatsidwa mogwirizana ndi Digoxin, amachepetsa kuchuluka kwambiri kwa seramu yotsirizira ndi 17%, nthawi yoti athe kufikira imawonjezeka ndi maola 2,5.
Kutenga HMG-CoA reductase inhibitors sikukhudza kagayidwe ka mafuta. Palibe kusintha komwe kukuchitika kwa Exenatide kuphatikiza ndi Metformin, Thiazolidinedione.
Odwala omwe amatenga 5-20 mg ya mlingo wa tsiku ndi tsiku wa Lisinopril kuti achulukitse kuthamanga kwa magazi, pomwe exantide imagwiritsidwa ntchito, nthawi yofika kwambiri ya plasma level ya lisinopril idakulitsidwa. Zosintha pama pharmacological magawo
Akaphatikizidwa ndi warfarin m'maphunziro a malonda otsatsa, milandu yokhudzana ndi kutuluka kwamkati mkati ndikuwonjezereka kwa nthawi kuti ifikire kuchuluka kwa warfarin ndi maola 2 adalemba. Kuphatikiza uku sikulimbikitsidwa ngati mankhwala ophatikiza. Ngati ndi kotheka, pa gawo loyambirira la chithandizo, wodwalayo ayenera kuwongolera kuchuluka kwa coumarin ndi warfarin zotumphukira m'madzi a m'magazi.
Kuyenderana ndi mowa
Mankhwala a Hypoglycemic saloledwa kuti agwiritsidwe ntchito ndi zizindikiro zochoka. Munthawi ya mankhwalawa, ndizoletsedwa kumwa mowa. Mowa wa ethyl umatha kukulitsa mwayi wokhala ndi hypoglycemia ndi zina. Ethanol imasokoneza maselo a chiwindi, imachulukitsa chiopsezo cha kuchepa kwamafuta.
Analogi
Bayetu Long yotsika kapena yotsika mankhwalawa imatha kutha ndi imodzi mwamankhwala otsatirawa omwe ali ndi vuto lofanana la hypoglycemic:
- Baeta;
- Exenatide;
- Victoza;
- Forsyga;
- NovoNorm.
Kupita kwina mankhwala
Kugulitsa kwaulere kwa mankhwalawa popanda upangiri wa dokotala ndi koletsedwa.
Kodi ndingagule popanda kulandira mankhwala?
Chifukwa chotukuka kwa hypoglycemia mukamamwa popanda chithandizo chamankhwala mwachindunji, simungagule mankhwala popanda mankhwala.
Mtengo
Mtengo wapakati wamankhwala mumsika wamankhwala umasiyana kuchokera pa 5 322 mpaka 11 000 rubles.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kukhala ndi ufa wamankhwala kumalo osiyanitsidwa ndi kuyatsidwa ndi dzuwa, kutentha kwa + 2 ... + 8 ° C. Pambuyo potsegula phukusi, kusungidwa pamatenthedwe mpaka + 30 ° C osaposa milungu 4 kumaloledwa.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Amilin Ohio Electric, USA.
Akaphatikizidwa ndi warfarin, kafukufuku wotsatsa malonda adalemba zochitika za kutuluka mkati.
Ndemanga
Miroslav Belousov, wazaka 36, Rostov-on-Don
Ndili ndi matenda osokoneza bongo omwe amadalira insulin. Ndimatenga Bayetu limodzi ndi jakisoni wa insulin kwa pafupifupi chaka. Mankhwala amatha kuthana ndi ntchito yake - shuga kuchokera 13 mmol amakhala wokhazikika mpaka 6-7 mmol. Panali zododometsa popereka insulin mumzinda, ndinangoyala majekeseni ochulukitsa a Bayeta. Shuga adakhalabe wabwinobwino. Ndimadwala matenda a chiwindi nthawi yomweyo, chifukwa chake ndidakumana ndi adokotala musanagwiritse ntchito mankhwalawa. Baeta sizinakulitse matendawa, motero ndimasiya ndemanga zabwino.
A Evstafy Trofimov, wazaka 44, St. Petersburg
Pakafukufuku wotsatira wa kuchipatala adawonetsa shuga m'magazi. Zizindikiro zidakwera chifukwa cha kupsinjika kwakukulu. Tinapezeka kuti tili ndi matenda ashuga a mtundu 2. Jekeseni wotchulidwa Baeta Long. Ndikosavuta kuyika pansi pa khungu ndi cholembera. Ndakhala ndikupereka mankhwalawa kwa miyezi isanu ndi umodzi. Mankhwalawo pawokha sagwira ntchito. Mukamamwa mankhwala osokoneza bongo, muyenera kudya zakudya zapadera komanso kuchita masewera olimbitsa thupi. Kenako shuga amachepetsedwa kukhala zabwinobwino. Ndinaona kuti nthawi ya chithandizo ndimataya 11 kg yakulemera kwambiri, kuthamanga kwa magazi kumachepa. Ndikofunika kupaka jakisoni mosamalitsa malinga ndi malangizo.
Natalya Solovyova, wazaka 34, Krasnoyarsk
Ndili ndi matenda ashuga a 2. Jakisoni wa Exenatide amayika pafupifupi chaka. Kulemera sikunachepe. Pambuyo jakisoni wamadzulo, chilakolako chimadzuka ndipo mukufuna kudya osasiya. Izi ndi zotsatira zoyipa. Ngati mumadziletsa, ndiye kuti shuga amakhalanso bwinobwino.Ndikupangira anthu omwe ali ndi vuto lofananalo ndi kuchuluka kwa chidwi chofuna kuyenda kuti akwaniritse mayeserowo. M'mawa, shuga ali m'migawo ya 6-7.2 mmol. Chobwereza chokha ndicho mtengo wokwera.
