Yanumet 1000 ndi mankhwala othandiza omwe ali ndi vuto la hypoglycemic. Amagwiritsidwa ntchito pochiza mitundu yosagwirizana ndi matenda a shuga.
Dzinalo Losayenerana
Metformin + Sitagliptin
Yanumet 1000 ndi mankhwala othandiza omwe ali ndi vuto la hypoglycemic.
ATX
A10BD07. Amatanthauzanso mankhwala a m'kamwa.
Kutulutsa mafomu ndi kapangidwe kake
Amapezeka mu mawonekedwe a mapiritsi okhala ndi tulo. Piritsi lililonse lili ndi 64.25 mg wa sitagliptin ndi metformin (1000 mg). Piritsi ili ndi zinthu zochepa zokhazikika zomwe zimapangitsa kuti mayendedwe azigwira bwino ntchito. Kuphatikizidwa kwa metformin m'mitundu yosiyanasiyana ya ndalama kumatha kusiyana 50 mg mpaka 1000 mg.
Ulusi wa kanema umakhala ndi macrogol, utoto.
Zotsatira za pharmacological
Amawerengedwa ngati mankhwala ophatikiza omwe amaphatikiza mitundu iwiri yotsitsa shuga yomwe imakhala yothandizirana. Izi ndizofunikira kusintha kuwongolera kwa odwala pamankhwala a insulin m'magazi.
Sitagliptin ndi choletsa DPP 4. Izi zimagwiritsidwa ntchito kwambiri pochiza anthu omwe ali ndi mtundu II matenda a shuga. Zotsatira zake zimachitika chifukwa chakuti chinthucho chimayambitsa ma insretin. Mankhwala amalimbikitsa plasma ndende ya glucagon-ngati peptide-1 ndi shuga wodalira insulinotropic polypeptide. Zinthu izi ndi gawo la kayendedwe ka shuga.
Metformin imawonjezera kukana kwa wodwala glucose komanso amachepetsa kuyika kwa zinthuzi m'magazi.
Mothandizidwa ndi sitagliptin, kulimba kwa mapangidwe a glucagon m'misempha ya kapamba kumachepa. Kupanga kwa zoletsa ndi kosiyana ndi kukonzekera kwa sulfonylurea, ndichifukwa chake odwala samakhala ochepa chiwonetsero cha hypoglycemia.
Pakukhazikika kwa mankhwalawa, sitagliptin sikuchepetsa mapangidwe ena a glucagon ngati peptides.
Metformin ndi zotsatira za hypoglycemic. Zimawonjezera kukana kwa wodwala ku glucose ndipo kumachepetsa kuyika kwa zinthuzi m'magazi. Kuchulukitsa chidwi cha thupi la munthu kupita ku insulin. Monga sitagliptin, mankhwalawa samayambitsa hypoglycemia mukamagwiritsa ntchito Mlingo wothandizira.
Kugwiritsa ntchito metformin ndiko kwabwino komanso kotetezeka poyerekeza ndi mankhwala ena ochizira matenda a shuga ndi placebo. Thupi silimapangitsa kuti insulin iwonjezeke.
Pharmacokinetics
Bioavailability wa sitagliptin ndi 87%, ndipo zakudya zamafuta sizisintha mu pharmacokinetics.
The bioavailability wa metformin pakudya musanadye mpaka 60%. Ngati mankhwalawa atengedwa ndi chakudya, ndiye kuti kupezeka kwake kumacheperanso. Mfundoyi iyenera kukumbukiridwa popanga njira yolimbikitsira kudya.
Ngati mankhwalawa atengedwa ndi chakudya, ndiye kuti kupezeka kwake kumacheperanso.
Kumangidwa kwa sitagliptin ku mapuloteni mu plasma kuli pafupifupi 38%. Metformin, pang'ono, imagwirizana ndi mapuloteni a plasma. Mwapang'onopang'ono komanso kwa nthawi yochepa, amalowetsedwa m'maselo ofiira a m'magazi.
Ambiri a sitagliptin amachotsedwa mkodzo osasinthika, ndipo metformin imangotuluka kwathunthu kuchokera mthupi momwemo momwe idalandiridwira pakamwa.
Zizindikiro zogwiritsidwa ntchito
Amawonetsedwa ngati kuwonjezera kwa chithandizo chachikulu cha matenda amtundu wa 2 mwa anthu omwe sangathe kukwanitsa glycemia komanso kulemera kwa thupi ndi chithandizo chamankhwala komanso kubwezeretsa katundu wabwinobwino. Itha kuphatikizidwa ndi:
- kukonzekera kwa sulfonylurea;
- Othandizira okhudzana ndi PPAR-γ (monga zowonjezera pazakudya ndi machitidwe);
Itha kugwiritsidwa ntchito ngati mtundu 2 wa shuga limodzi ndi mankhwala a insulin.
Contraindication
Zoyipa kuti mutenge Yanumet ndi:
- mphamvu ya thupi ku sitagliptin, metformin hydrochloride ndi magawo ena a mankhwala;
- odwala ndi matenda a shuga a mtundu I;
- chilichonse pachimake zomwe zimakhudza yachilendo ntchito yaimpso;
- kusowa kwamadzi;
- dziko lodetsa nkhawa;
- kulephera kwa mtima ndi kupuma, mayendedwe amtima;
- zakumwa zoledzeretsa ndi uchidakwa;
- nthawi yodyetsa mwana;
- metabolic acidosis, kuphatikizapo matenda ashuga;
- kuyeserera kwa thupi pobweretsa mankhwala a radiopaque.
Ndi chisamaliro
Mosamala, muyenera kupereka mankhwalawa ngati mukulumikizika impso ndi chiwindi ntchito (kutsitsa kwina kumachitika).
Momwe mungatenge Janumet 1000
Mankhwalawa amayenera kumwa kawiri pa tsiku. Piritsi iyenera kumwa ndi zakudya. Sizoletsedwa kuphwanya kapena kupera mankhwala.
Ndi matenda ashuga
Mlingo woyambirira wotsimikizika umatsimikiziridwa ndi dokotala pambuyo pofufuza mosamala za momwe wodwalayo alili. Ngati zotumphukira za sulfonylurea zimatengedwabe, ndiye kuti muyenera kuchepetsa mlingo wa Yanumet kuti hypoglycemia isakule.
Zotsatira zoyipa
Mankhwala angayambitse kuphwanya mayamwidwe a vitamini B12, kusintha kwa kapangidwe ka magazi. Nthawi zina matenda amitsempha yamagazi amayamba.
Janumet angayambitse kusintha kwa magazi.
Matumbo
Munthawi ya mankhwalawa, kutsegula m'mimba, kusowa kwa chakudya, kusokoneza kukoma, kumatulutsa. Kukhumudwa m'mimba nthawi zina kumayamba. Nthawi zambiri, odwala amazindikira kukomoka kwachitsulo pamkamwa.
Zomverera izi zimadutsa pang'onopang'ono. Kuti muchepetse kulimba kwawo, muyenera kumwa mankhwala a analgesic, antispasmodics. Sikoyenera kumwa mankhwalawa omwe si a antiidal.
Kuchokera kumbali ya kagayidwe
Hypoglycemia imachitika kawirikawiri ndipo zimachitika chifukwa chokhazikika pakayendetsedwe kamankhwala osavomerezeka limodzi ndi sulfonylurea analogues. Zizindikiro za hypoglycemia zimawonekera kwambiri komanso zimachuluka. Thukuta lozizira limawoneka wodwalayo, nkhope yake imasunthika, kumatha kumva njala. Kuopsa komanso kusayenerana kwa chikhalidwe kumadziwika. Wozunzika kwambiri, amadzidzimuka.
Kuti muchepetse zizindikiro za vuto loperewera, muyenera kumuthandiza wodwalayo. Milandu yayikulu imayimitsidwa m'chipatala chokha.
Pa khungu
Pafupipafupi pamayambitsa redness ndi kutupa.
Kuchokera pamtima
Kuwonongeka kwa magazi kumakhala kovuta.
Kuchokera pakulimbana ndi zovuta zonse, zotupa pakhungu zimatheka.
Matupi omaliza
Kuchokera pakulimbana ndi zovuta zonse, zotupa pakhungu zimatheka. Kuopsa kotereku kumawonjezeka ndi wokalamba.
Zokhudza mphamvu pakuwongolera njira
Chifukwa Popeza mankhwalawa amatha kuyambitsa hypoglycemia, chifukwa cha nthawi ya mankhwalawa ndibwino kukana kuyendetsa galimoto ndikugwira ntchito ndi zovuta kupanga.
Malangizo apadera
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Panthawi ya bere, chithandizo chovomerezeka chimakhala chokhacho pokhapokha ngati palibe zoopseza zina kwa mwana. Panthawi yamankhwala, mwana wakhanda ayenera kusinthidwa kuti akhale njira yodyetsera.
Kukhazikitsidwa kwa Yanumet kwa ana 1000
Palibe chidziwitso pakugwiritsa ntchito mankhwalawa pochita ana.
Panthawi yamankhwala, mwana wakhanda ayenera kusinthidwa kuti akhale njira yodyetsera.
Gwiritsani ntchito mu ukalamba
Ndikofunikira kuchepetsa mlingo wa mankhwalawa chifukwa cha kusintha kwa kagayidwe kake.
The ntchito aimpso kuwonongeka
Pa magawo a kukanika kwa impso, mankhwalawa amaletsedwa, chifukwa ambiri amakhala ndi mkodzo. Pachimake ndi matenda pathologies amafuna mlingo malire kupewa kuledzera.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwalawa ndiosavomerezeka kwa anthu omwe ali ndi vuto lalikulu la chiwindi.
Bongo
Lactic acidosis imayamba. Nthawi yomweyo isanayambike lactic acidosis, pali aura. Imadziwonekera mu phokoso komanso kupuma pafupipafupi.
Chiwopsezo chokhala ndi lactic acidosis chikuwonjezeka mwa anthu omwe ali ndi mitundu yosiyanasiyana ya kulephera kwa mtima.
Chiwopsezo chokhala ndi lactic acidosis chikuwonjezeka mwa anthu omwe ali ndi mitundu yosiyanasiyana ya mtima, impso komanso chiwindi. Ndi chitukuko cha kusowa kwamadzi, kufa ndi mpweya wa okosijeni, muyenera kusiya mankhwalawo mwachangu.
Mankhwala osokoneza bongo amathandizidwa ndi hemodialysis.
Kuchita ndi mankhwala ena
Mankhwala otsatirawa amachepetsa mphamvu ya mankhwalawa:
- diuretic thiazide;
- mahomoni a chithokomiro;
- kulera kwamlomo;
- sympathomimetic;
- Isoniazid.
Kuyenderana ndi mowa
Zakumwa zoledzeretsa zimawonjezera zotsatira za metformin komanso kuwonongeka kwa lactic acid. Ngakhale mlingo waukulu wa mowa umakulitsa chiopsezo cha lactic acidosis.
Analogi
Mankhwala othandizira omwe ali ndi katundu wofanana ndi awa:
- Avandamet;
- Vokanamet;
- Glibomet;
- Glucovans;
- Gentadueto;
- Dianorm;
- Dibizide;
- Yanumet Long;
- Sinjardi.
Zinthu za tchuthi Yanumeta 1000 kuchokera ku pharmacy
Ikhoza kugulidwa pokhapokha ngati mukumvera mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Kupatula.
Mtengo wa Yanumet 1000
Mapiritsi a 56 - ma ruble pafupifupi 2200.
Zosungidwa zamankhwala
Sungani pamalo amdima kutali ndi ana.
Tsiku lotha ntchito
Osaposa zaka 2.
Wopanga Yanumet 1000
"Pateon wa Puerto Rico, Inc.", Puerto Rico.
Ndemanga za madokotala za Yanumet 1000
Irina, wazaka 55, endocrinologist, Nizhny Novgorod: "Mankhwalawa amachepetsa glucose wamagazi mwa anthu omwe ali ndi matenda a mtundu wa 2. Sindinazindikire zotsatira zoyipa zilizonse panthawi ya chithandizo, chifukwa odwala onse amamwa mapiritsi okhawo omwe amapereka Yanumet. glycemia wabwino kwambiri ndikuletsa kukula kwa zovuta za matenda ashuga. "
Oksana, wazaka 34, wodwala matenda ashuga, ku Moscow: "Izi ndi njira zabwino zothandizira kugwiritsa ntchito mankhwala a hypoglycemic omwe ali ndi sulfonylurea. Mankhwalawa amawongolera bwino matenda ashuga komanso amalepheretsa zochitika zomwe zitha kukhala pachiwopsezo cha moyo.
Ndemanga za Odwala
Alexander, wazaka 55, ku Moscow: "Mothandizidwa ndi Yanumet, ndimatha kusunga kuchuluka kwa shuga kwa nthawi yayitali. Mosiyana ndi mankhwala ena, sindinakhale ndi vuto la kuthamanga kwa magazi. Thupi langa ndilabwino, ndinali ndi mphamvu, ndakhala ndikusamva njala nthawi zonse."
Olga, wazaka 49, ku St. Petersburg: "Mankhwalawa adandithandiza kukhala wathanzi, ndimapweteka kwambiri, ndimayamba kupita kuchimbudzi nthawi zambiri usiku. Tsopano ndazindikira kuti maso anga amasintha pang'ono pambuyo pa Yanumet. Mwazi wanga wamagazi uli paliponse. palibe kudumpha mosiyanasiyana, kunalibe hypoglycemia atayamba kulandira chithandizo. "
Oleg, wazaka 60, Stavropol: "Ndikamwa mankhwalawa, ndikuwonetsetsa kuti ndili ndi thanzi labwino. Ndinatsala pang'ono kusiya kupita kuchimbudzi usiku, potency yanga inayamba bwino. Ndimalandila chithandizo changa chamankhwala ndipo ndayiwaliratu za kulumpha kwa shuga m'magazi. Ndimayang'anira kutsatira zochitika zolimbitsa thupi. "
