Amoxiclav 312 mg imaphatikiza 250 mg ya semisynthetic amooticillin ndi 62 mg ya beta-lactamase inhibitor. Kuphatikiza kwa clavulanic acid ku amoxicillin kuloledwa kukulitsa mawonekedwe a antibacterial. Wothandizira antimicrobial amagwiritsidwa ntchito pamaso pa matenda opatsirana, limodzi ndi kutupa. Mankhwala amathandizira kuthetsa microflora ya bakiteriya ndi zinthu zake zama metabolic.
ATX
J01CR02.
Amoxiclav 312 mg imaphatikiza 250 mg ya semisynthetic amooticillin ndi 62 mg ya beta-lactamase inhibitor.
Kutulutsa mafomu ndi kapangidwe kake
Mlingo wa mankhwalawa mwanjira yowoneka ndi ufa woyera womwe umapangidwira kukonzekera kuyimitsidwa. Kuphatikizidwa kwa 250 mg ya amoxicillin trihydrate (kapena 500 mg) ndi 62 mg ya clavulanic acid mu mawonekedwe a mchere wa potaziyamu (125 mg) amagwiritsidwa ntchito ngati mankhwala ena. Kupititsa patsogolo kuthandizira komanso kupititsa patsogolo phindu la bioavailability, zinthu zomwe zimagwiritsidwa ntchito zimaphatikizidwa ndi izi:
- colloidal dehydrate silika;
- Kukongola kwa Cherry
- benzoate, carboxycellulose ndi sodium saccharin;
- ma cellcose a microcrystalline;
- xanthan chingamu;
- mannitol.
Wothandizira antimicrobial amagwiritsidwa ntchito pamaso pa matenda opatsirana.
Mankhwalawa amapezeka m'mbale zamagalasi. Mukapaka ufa ndi madzi owiritsa, kuyimitsidwa kumaliziridwa kumapezeka, komwe kumakhala kusakanikirana kophatikizika ndi tint yoyera kapena yachikasu.
Zotsatira za pharmacological
Maantibayotiki amagwira mabakiteriya, kupha tizilombo toyambitsa matenda. Limagwirira ntchito amatengera mphamvu antimicrobial wa amoxicillin, chopangidwa pawiri kuchokera gulu penicillin. Beta-lactam wothandizila linalake ndipo tikulephera ndi michere ntchito ya zinthu zomwe zimayambitsa kapangidwe ka peptidoglycan. Kapangidwe kake ndikofunikira kuti kulumikizane kwachilengedwe ndikulimbikitsa nembanemba ya pathogen yopatsirana. Ikawonongeka, chipolopolo chakunja chimafinya, ndipo bakiteriya amafa mothandizidwa ndi zosmotic.
Nthawi yomweyo, amoxicillin satha kugwira ntchito polimbana ndi tizilombo tosiyanasiyana tomwe timapanga beta-lactamases. Ma Enzymes amawononga anti-synthetic antiotic, kotero mchere wa potaziyamu wa clavulanic acid unawonjezeredwa ku mankhwala kuti atetezeke. Imalepheretsa zochitika za beta-lactamases, pomwe amoxicillin amayambitsa kufa kwa mabakiteriya. Chifukwa cha kuphatikiza uku, antibacterial agent ali ndi chiwonetsero chokwanira.
Pharmacokinetics
Mukamagwiritsa ntchito kuyimitsidwa pakamwa, ziwalo zonse zogwira ntchito zimamasulidwa mothandizidwa ndi esterases m'matumbo ndipo zimayikiridwa kukhoma la matumbo ochepa. Akalowa m'magazi, semisynthetic penicillin ndi beta-lactam amafika pazofunikira kwambiri za seramu mkati mwa ola limodzi. Zinthu zonsezi sizigwirizana ndi mapuloteni a plasma. Ndi albin, mitundu yovuta imangokhala 18-20% ya zinthu zomwe zimagwira.
Akalowa m'magazi, semisynthetic penicillin ndi beta-lactam amafika pazofunikira kwambiri za seramu mkati mwa ola limodzi.
Amoxicillin amakumana ndi biotransformation mu hepatocytes pamlingo wocheperapo kuposa clavulanic acid. Zinthu zofunikirazi zimachotseredwa kudzera mu impso kudzera mu kusefera kwa mawonekedwe ake oyambirira. Chiwonetsero china cha clavulanate chimachoka m'thupi momwe amapangira michere yokhala ndi ndowe. Hafu ya moyo ili pafupifupi mphindi 60-90.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amagwiritsidwa ntchito ngati matenda a bakiteriya omwe amayambitsidwa ndi kukula kosalamulirika kwa tizilombo toyambitsa matenda:
- matenda a kumtunda kwa kupuma thirakiti ndi ziwalo ENT: pharyngeal abscess, kutupa kwa paranasal ndi paranasal sinuses, otitis media, tonsillitis, sinusitis;
- matenda a m'mapapo ndi bronchi (chibayo, bronchitis);
- matenda a mabala otseguka, kuwonongeka kwa minofu ya mafupa (osteomyelitis), matenda a minofu yofewa;
- matenda a mano (alveolitis);
- kuwonongeka kwa biliary thirakiti ndi ndulu ya ndulu;
- matenda amiseche komanso matenda opatsirana pogonana (chinzonono ndi chlamydia).
Mankhwala amaloledwa kugwiritsidwa ntchito poletsa zovuta za postoperative, zodziwika ndi kukhalapo kwa matenda, kapena zochizira ziphuphu zomwe zimayambitsidwa ndi kukula kwa staphylococcus.
Contraindication
Mankhwala othandizira amaletsedwa kwa anthu omwe ali ndi vuto la cephalosporins, beta-lactams ndi gulu la penicillin. Simungathe kupereka mankhwalawa kwa anthu omwe ali ndi cholestatic jaundice komanso matenda a chiwindi omwe amakwiya chifukwa chotenga amoxicillin ndi clavulanate. Mankhwala ali contraindicated kwa lymphocytic leukemia kapena mononucleosis wachibadwa.
Ndi chisamaliro
M'pofunika kuwunika momwe alili pamaso pa chiwindi kulephera kapena aimpso ntchito. Ngati pali chopondapo chopanda magazi ndi zosafunikira zamagazi, ndikofunikira kukayezetsa kuti mudziwe chomwe chimayambitsa magazi. Ngati kutsegula m'mimba kumalumikizidwa ndi pseudomembranous enterocolitis, mankhwala a antimicrobial ayenera kuyimitsidwa nthawi yomweyo.
Momwe mungatenge Amoxiclav 312
Kukonzekera kuyimitsidwa, ndikofunikira kupukuta ufa m'madzi owiritsa firiji. Ndi bwino kumwa mankhwalawa pakudya kapena mukamadya. Kutalika kwa mankhwalawa sikuyenera kupitilira masabata awiri, chifukwa pali chiopsezo chotukuka cha microflora cha Amoxiclav.
M'pofunika kuwunika momwe zinthu zilili pakakhala vuto la chiwindi.
Akuluakulu
Kwa odwala akuluakulu, Mlingo wa tsiku ndi tsiku ndi 5 ml kapena 312 mg wa mankhwalawa, wokhala ndi 250 mg ya semisynthetic amooticillin ndi 62 mg ya clavulanic acid. Kuyimitsidwa kulikonse kumabwera ndi supuni ya 5 ml kapena pipette. Mankhwalawa amatengedwa kamodzi patsiku.
Mlingo Amoxiclav 312 wa ana
Ana obadwa kumene mpaka masiku 90 amalangizidwa kuti awerengere mankhwalawa kutengera kulemera kwa thupi: 30 mg pa 1 kg ya kulemera kwa thupi patsiku. Kuyimitsidwa amatengedwa ndi imeneyi maola 12 kawiri pa tsiku. Makanda achikulire amalangizidwa kuti atenge 20 kapena 40 mg pa kilogalamu ya thupi. Pankhaniyi, gawo pakati pakati Mlingo amachepetsa mpaka maola 8.
Kwa mwana wolemera zosakwana 40 kg, mlingo woyenera wololedwa tsiku lililonse ndi 2.4 mg wa amoxicillin ndi 0,6 g wa clavulanate. Mlingo wokhazikika umasiyana kuchokera ku 20 + 5 mg / kg kulemera kwa thupi (amoxicillin + clavulanic acid) mpaka 60 + 15 mg pa kilogalamu imodzi ya thupi. Ana opitilira 40 kg amalangizidwa kuti apereke mlingo woyenera wa akulu.
Kumwa mankhwala a shuga
Odwala omwe ali ndi matenda ashuga safunika kuwonjezera kusintha kwa mankhwalawa. Ichi ndichifukwa chosowa mankhwala oletsa kugwira ntchito kwa ma cell a pancreatic beta, komanso kuchuluka kwa insulin kapena glucose m'madzi am'magazi.
Odwala omwe ali ndi matenda ashuga safunika kuwonjezera kusintha kwa mankhwalawa.
Zotsatira zoyipa
Kuwoneka kwa zotsatira zoyipa kumachitika chifukwa cha regimen yosayenera kapena kupezeka kwa hypersensitivity kwa zinthu za Amoxiclav. Zomwe zimachitika kawirikawiri zimaphatikizanso kupezeka kwa superinfection kapena fungus matenda. Mwapadera, pali chiopsezo chokhala ndi alopecia, kuti muchepetse kuwoneka kwa komwe kusamalidwa kwa tsitsi ndi malamulo aukhondo ndikofunikira pakhungu.
Matumbo
Zotsatira zoyipa m'mimbidwe yakudya zimadziwika ndi mawonekedwe a zotsatirazi:
- ululu wamkati;
- zosokoneza mu chiwindi;
- ntchito yothandizira ya enzymatic ya AST ndi ALT - hepatic aminotransferases;
- kutupa kwa chiwindi;
- anti-anti-colitis;
- kusanza, mseru, m'mimba;
- kuchepa kwamtima.
Mwapadera, pali chiopsezo cha cholestatic jaundice chifukwa cha kuchuluka kwa bilirubin.
Hematopoietic ziwalo
Ndi kuwonongeka kwa mapfupa a hematopoiesis, kusintha kwa zotupa zamitsempha ndi kuchuluka kwa zinthu zomwe zimapangidwa ndimagazi kumatha kuchitika:
- kuchepa kwamapulatifomu, maselo ofiira, maselo oyera ndi neutrophils;
- eosinophilia;
- pancytopenia;
- agraulocytosis obweza.
Kuchepetsa kuchuluka kwa maselo ofiira am'magazi kungayambitse kukula kwa hemolytic anemia.
Kuchepetsa kuchuluka kwa maselo ofiira am'magazi kungayambitse kukula kwa hemolytic anemia.
Pakati mantha dongosolo
Zotsatira zoyipa zamagetsi zimayendera limodzi ndi mawonekedwe a:
- Chizungulire
- minofu kukokana;
- kuwonjezera kuchepa kwa mitsempha;
- kumverera kwa nkhawa, kuda nkhawa, kukhumudwa;
- kuchepa kwa kugona kapena kugona;
- mutu.
Odwala omwe ali ndi vuto laimpso amakhala ndi chiopsezo chogwidwa ntchito pogwiritsa ntchito mankhwala akulu.
Kuchokera kwamikodzo
Zovuta zamkati mwa kwamikodzo zimatha kuwonetsedwa mu mawonekedwe a crystalluria ndi interstitial nephritis.
Matupi omaliza
Odwala omwe ali ndi chidwi chotsogola thupi lawo siligwirizana, kukula kwa:
- urticaria;
- erythema, kuphatikizapo matenda a Stevens-Johnson kapena matenda a Lyell;
- anaphylactic mantha;
- kutupa kwa mphuno, pharynx, lilime;
- angioedema wamatumbo;
- chibayo;
- kuyabwa pakhungu ndi zotupa.
Malangizo apadera
Ndi kuwonjezeka kwa seramu ndende ya amoxicillin pakudutsa mkodzo pakuwunikira kokwanira, ndikofunikira kukumbukira mawonekedwe osabereka omwe amapezeka pakhungu la mkodzo. Potere, kuwunika kwa enzymatic kumalimbikitsidwa ngati njira yolondola yozindikira.
Pofuna kupewa matenda a pakhungu ndi minofu yofewa pamaso pa ziphuphu, ndikofunikira kuwonjezera pazinthu zaukhondo.
Kuyenderana ndi mowa
Pa mankhwala a antibacterial, musamwe mowa. Ethanol imatha kuchepetsa mphamvu ya antimicrobial ya Amoxiclav, imabweretsa zotsatira zoyipa m'maselo a chiwindi.
Zokhudza mphamvu pakuwongolera njira
Mankhwala a antibacterial samakhudza kuthekera kwazomwe zimachitika, zokhudzana ndi kuzindikira komanso kuthamanga kwa kusintha kwa thupi. Chifukwa chake, munthawi yogwiritsira ntchito mankhwala osokoneza bongo, palibe chifukwa chochepetsera nthawi yogwira ntchito ndi zida kapena kuyendetsa galimoto. Pakabuka mavuto kuchokera ku dongosolo lamanjenje, njira zotetezera ziyenera kuonedwa.
Pa nthawi yoyembekezera, mankhwalawa sagwiritsidwa ntchito, chifukwa pali chiopsezo chachikulu cha zotupa za intrauterine pakukula kwa mluza.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pa nthawi yoyembekezera, mankhwalawa sagwiritsidwa ntchito, chifukwa pali chiopsezo chachikulu cha zotupa za intrauterine pakukula kwa mluza. Kuyamwitsa kumaloledwa ngakhale pakalibe matenda oyamba ndi fungus komanso photosensitivity mwa mwana. Pamaso pa candidiasis kapena hypersensitivity zimachitika, ndikofunikira kusamutsa mwana ku yokumba zakudya.
Bongo
Munthawi ya mayeso oyeserera komanso kuchita malonda atangotsatsa, padalibe milandu yotsatila komanso kupezeka koyipa komwe kumadzetsa chiwopsezo pamoyo wa wodwalayo. Mankhwala akamagwiritsa ntchito mankhwala opha tizilombo, zingachitike zotsatirazi:
- chimbudzi;
- kupweteka pamimba;
- vuto la kugona;
- Chizungulire
- minofu kukokana;
- kutaya mtima;
- kusanza
Chithunzithunzi cha bongo chikawoneka, kulandira kuchipatala ndi chithandizo chamankhwala ndikofunikira.
Kuchita ndi mankhwala ena
Mukamagwiritsa ntchito Amoxiclav ndi aminoglycosides, mankhwala ofewetsa thukuta, ma phenenecid ndi maantacid, kuchuluka kwa mankhwalawo kumachepa, pomwe vitamini C imathandizira kuyamwa.
Mankhwala osokoneza bongo okhathamiritsa komanso osapweteka a antiidal, Allopurinol ndi mankhwala omwe amachepetsa kubisala kwamkodzo mu impso. Zotsatira zake, mankhwalawa amachotsa mankhwalawa amachepetsa, chifukwa chomwe plasma ndende ya semisynthetic penicillin imachulukanso. Allopurinol imawonjezeranso mwayi wa exanthema.
Kuphatikiza ndi rifampicin, kufooka kwa zochizira kumawonedwa.
Wothandizira antimicrobial amawonetsa kusagwirizana kwa mankhwala ndi disulfiram. Sitikulimbikitsidwa kumwa mankhwalawa ndi methotrexate, chifukwa amoxicillin imachulukitsa kuopsa kwa chomaliza.
Nthawi zina, kuwonjezeka kwa prothrombin nthawi ndikotheka, chifukwa chake ndikofunikira kuyang'anira mosamala mukamagwiritsa ntchito anticoagulants pamlomo.
Kuphatikiza ndi Rifampicin, kufooka kwa njira yochiritsira kumawonedwa, monga kuphatikiza ndi antimicrobial mankhwala okhala ndi bacteriostatic kwenikweni kapena ndi sulfonamides.
Analogs of Amoxiclav 312
Amoxiclav yotsika-antibacterial mwina kapena kupanga zotsatira zoyipa akhoza m'malo mwa mankhwalawa:
- Augmentin;
- Panklav;
- Amoxiclav Quicktab;
- Flemoklav Solyutab.
Kupita kwina mankhwala
Mankhwala amaperekedwa mosiyanasiyana malinga ndi mankhwala omwe mwalandira.
Kodi ndingagule popanda kulandira mankhwala?
Ngati agwiritsidwa ntchito molakwika, maantibayotiki amatha kuyambitsa vuto la bakiteriya m'matumbo, chifukwa chomwe kuperewera kwa dysbiosis ndi vitamini K kumachitika nthawi zambiri.
Mtengo
Mtengo wapakati wa kuyimitsidwa uli pafupi ma ruble 150-200.
Zowongolera Amoxiclav 312
Ufa wokonzekera kuyimitsidwa uyenera kusungidwa kumalo osungidwa ndi kulowererapo kwa kuwala kwa dzuwa pa kutentha kwa + 8 ... + 30 ° C. Kuyimitsidwa kwamaliridwe kuyenera kusungidwa mufiriji pa + 2 ... + 8 ° C.
Tsiku lotha ntchito
Zaka zitatu
Ndemanga za Amoxiclav 312
Chifukwa cha ndemanga zabwino za akatswiri azamankhwala ndi odwala, maantibayotiki adatha kufalikira pamsika wamankhwala.
Madokotala
Roman Bariev, dokotala wamano, Irkutsk
Ndimakonda kupaka mankhwalawa m'mano kuchitira mano a alveoli, kuchotsa dzino lovuta, ndikuyika mayikidwe. Ndimawona zotsatira zabwino zokha.
Ivan Semendyaev, dotolo, St.
Wothandiza antibacterial wothandizila ine ntchito mankhwalawa matenda a pyelonephritis, matenda a cystitis. Zotsatira zoyeserera sizidziwika. Imagwira pang'onopang'ono ndi matenda a prostatitis. Nthawi zina, achire zotsatira zake sizinachitike.
Odwala
Vyachedlav Nikonov, wazaka 42, Vladivostok
Mankhwala abwino. Nthawi yozizira, ndidayamba kukhala ndi chifuwa chachikulu, kutentha kudakwera kwambiri. Dokotala adazindikira tracheitis ndipo adamupatsa Amoxiclav. Kuyimitsako kunathandizira kuthetseratu matendawa. Ndinkakonda kununkhira kwamatcheri ndi kukoma kwake. Mosiyana ndi mapiritsi, ndikosavuta kuyimitsa. Panalibe mavuto amimba. Anamwa mankhwalawo atangodya.
Galina Alexandrova, wazaka 34, Arkhangelsk
Ndimaona kuti mankhwalawo ndi mankhwala amphamvu, chifukwa amathandizira kuchotsa sinusitis yovuta nthawi yozizira. Matendawa ankatsagana ndi kupweteka kwambiri pamutu komanso kutentha thupi. Popewa mavuto m'matumbo, mavitamini ndi ma proiotic adayikidwa.
