Plevilox ndi mankhwala osokoneza bongo a antibacteric antimicrobial omwe ali ndi mawonekedwe osiyanasiyana ochitika kuchokera ku gulu la fluoroquinolones a m'badwo wachinayi.
Dzinalo Losayenerana
Moxifloxacin (Moxifloxacin).
Plevilox ndi mankhwala osokoneza bongo a antibacteric antimicrobial omwe ali ndi mawonekedwe osiyanasiyana ochitika kuchokera ku gulu la fluoroquinolones a m'badwo wachinayi.
ATX
Khodi ya ATX ndi J01MA14, zomwe zikutanthauza kuti mankhwalawo ndi a gulu la antibacterial mankhwala ochokera ku quinolone.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka mu mawonekedwe a mapiritsi, okhala ndi filimu. Mapiritsiwo amakhala ndi matuza omwe amaikidwa m'mabhokisi a makatoni.
The yogwira Plevilox ndi moxifloxacin hydrochloride mu Mlingo wa 400 mg. Microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, magnesium stearate, Copovidone, polydextrose, polyethylene glycol, capste ndi capric acid triglycerides, titanium dioxide, chikasu cha quinoline varnish ndi iron iron oxide amagwiritsidwa ntchito ngati zinthu zothandizira.
Zotsatira za pharmacological
Mankhwala amatha kuletsa topoisomerase IV ndi DNA gyrase - ma enzyme omwe ali ndi vuto lotulutsira, kutulutsa, kukonza ndi kubwezeretsanso bakiteriya wa DNA. Ili ndi bactericidal kwambiri chifukwa cha kuthekera kwa moxifloxacin kusokoneza kaphatikizidwe ka DNA ka maselo okhala ndi micros.
Mankhwalawa amapezeka mu mawonekedwe a mapiritsi, okhala ndi filimu.
Yogwira ntchito motsutsana ndi gramu-gram komanso gram-hasi tizilombo tating'onoting'ono, komanso mabakiteriya a anaerobic, acid osagwira komanso mitundu ya atypical, monga Legionella spp., Chlamydia spp. ndi Mycoplasma spp. Kugwiritsa ntchito polimbana ndi mabakiteriya okhala ndi beta-lactams ndi macrolides. Yogwira polimbana ndi tizilombo tating'onoting'ono tambiri: gram-Staphylococcus aureus (kuphatikizapo osaganizira a methicillin), Streptococcus pneumoniae (kuphatikizapo kugonjetsedwa ndi penicillin ndi macrolides), Streptococcus pyogene A-magulu.
Pharmacokinetics
Mankhwala amadziwika ndi kuyamwa kwambiri, mosasamala nthawi yakudya, tanthauzo lake lonse la bioavailability lili pafupifupi 90-91%.
A pakamwa kamodzi pa moxifloxacin amakulolani kukwaniritsa Cmax m'magazi a 3.1 mg / l, pakatha mphindi 30 - maola 4.
Pharmacokinetics imakhala yofanana ndi Mlingo umodzi wa 50-1200 mg ndi mankhwala a masiku 10 ndi mlingo wa 600 mg / tsiku.
Malo omwe amakhala ndende kwambiri ya mankhwalawa ndi mapapu, ma alveolar macrophages, mucous membranes a sinuses ndi bronchi.
Mankhwala atha kuwachotsa ngati mankhwala osagwira mu kagayidwe kake ndi mawonekedwe ake amkodzo ndi ndowe.
Jenda ndi zaka sizimakhudza magawo a pharmacokinetic (zoyesa sizinachitike mwa ana), komanso sizikhudza kusokonezeka kwa impso.
Zizindikiro zogwiritsidwa ntchito
Mankhwala wolembedwa pa matenda a matenda okhudza chapamwamba ndi chapansi kupuma thirakiti: pachimake bakiteriya sinusitis, chibayo anapeza chibayo ndi kufalikira kwa chifuwa. Komanso, mankhwalawa amawonetsa kukhathamiritsa kochizira matenda a pakhungu ndi minofu yofewa.
Contraindication
Ndi zoletsedwa kugwiritsa ntchito ana ndi achinyamata ochepera zaka 18, kuphatikiza, pa nthawi yomwe ali ndi pakati, mkaka wa m`mawere ndi hypersensitivity kuti moxifloxacin ndi aliyense wofuna kupezeka Plevilox.
Ndi chisamaliro
Kuwonetsetsa makamaka poika Plevilox kumafunikira mbiri ya kupweteketsa mtima, kulephera kwa chiwindi, kutalika kwa nthawi ya QT, bradycardia, myocardial ischemia, kutsegula m'mimba ndi pseudomembranous colitis.
Mankhwala saloledwa kugwiritsidwa ntchito mwa ana ndi achinyamata ochepera zaka 18.
Chifukwa chosakwanira ndi kugwiritsa ntchito komanso maphunziro aposachedwa, kusamala kumafuna kupereka mankhwala kwa odwala omwe ali ndi hemodialysis. Mothandizanso ndi mankhwala a glucocorticosteroids ndi mankhwala omwe amachepetsa kuyendetsa bwino kwa minofu ya mtima (antiarrhythmics, antidepressants, antipsychotic), kuyang'anira akatswiri ndikofunikira.
Momwe mungatenge Plevilox
Tengani pakamwa 1 nthawi patsiku pa 400 mg. Kutalika kwa chithandizo kumatengera matendawa:
- mu gawo la kufalikira kwa bronchitis - masiku 5;
- ndi chibayo chopezeka m'deralo - masiku 10;
- ndi sinusitis pachimake, matenda a pakhungu ndi zimakhala zofewa - masiku 7.
Ndi matenda ashuga
Kafukufuku awonetsa kuti chithandizo cha fluoroquinolone chimawonjezera chiopsezo cha zotsatira zoyipa mu matenda a shuga, makamaka kukula kwa dyslexemia. Kukhazikitsidwa kwa maantibayotiki m'makalasi ena ndikulimbikitsidwa: beta-lactams ndi macrolides.
Komabe, nthawi zina (mwachitsanzo, ndimatenda osokonezeka a phazi amtundu wa odwala omwe ali ndi matenda ashuga), kugwiritsa ntchito mankhwalawa ndikoyenera. Pochita opaleshoni, ma pathologies oterewa ndi omwe amachititsa kuti azidulidwa popanda vuto lililonse, momwe amalipira chidwi kwambiri ndi maantibayotiki okwanira (kuphatikizapo mankhwala okhala ndi moxifloxacin).
Mankhwala a Plevilox amawonjezera chiopsezo cha zotsatira zoyipa za shuga.
Zotsatira zoyipa za Pleviloksa
Kuchokera minofu ndi mafupa
Mwina kuwoneka kwa ululu kumbuyo, kakulidwe ka arthralgia ndi myalgia.
Matumbo
Zotsatira zoyipa zam'mimba zimakhudzidwa ndi kupweteka kwam'mimba, nseru, kutsegula m'mimba, kusanza, dyspepsia, flatulence, kudzimbidwa, kuwonjezeka kwa chiwindi transaminases, kusokoneza kwa zomverera.
Hematopoietic ziwalo
Pali mwayi wopanga leukopenia, eosinophilia, thrombocytosis, thrombocytopenia ndi magazi m'thupi.
Pakati mantha dongosolo
Zotsatira zoyipa zochokera ku dongosolo lamkati lamanjenje zimawonekera mwa mawonekedwe a chizungulire, kusokonezeka kwa kugona, mantha, kuchuluka kwa nkhawa, asthenia, kupweteka mutu, kugwedezeka, paresthesia, kupweteka kwa mwendo, kukokana, kusokonezeka komanso mkhalidwe wopsinjika.
Zotsatira zoyipa za Plevilox kuchokera ku dongosolo lamanjenje lamkati zimawonekera mu mawonekedwe a chizungulire.
Pa khungu
Kugundika pakhungu, m'malo osowa kwambiri, kutentha thupi kwa nettle ndikotheka.
Kuchokera ku genitourinary system
Pali chiopsezo cha candidiasis ndi vaginitis.
Kuchokera pamtima
Kuwonjezeka kwa kuthamanga kwa magazi, kupezeka kwa tachycardia, zotumphukira edema, palpitations ndi kupweteka m'chifuwa.
Matupi omaliza
Thupi lawo siligwirizana chifukwa cha kuyabwa komanso kuzimiririka, milandu yodabwitsayo inali yosowa kwambiri. Ndi kulowetsedwa, zimachitika zakumudzi zimatha kuchitika: kupweteka pamalo a jekeseni, kutupa ndi kutupa.
Zokhudza mphamvu pakuwongolera njira
Mukamamwa mankhwalawa, kusokonezeka ndi kuwonongeka kwakanthawi kungamveke, pazinthu izi, kayendetsedwe ka kayendedwe kamavomerezeka.
Mukamamwa mankhwalawa, kusokonezeka ndi kuwonongeka kwakanthawi kungamveke, pazinthu izi, kayendetsedwe ka kayendedwe kamavomerezeka.
Malangizo apadera
Gwiritsani ntchito mu ukalamba
Pambuyo pa zaka 60, chiopsezo cha tendonitis ndi kupindika kwa tendon chimawonjezeka (Achilles tendon, knuffs yokhudza kupindika kwa mapewa, tendons yamanja, biceps, zithupsa, etc.). Zizindikiro zoyambirira za kukanika ngati izi zikuwonekera, wodwalayo ayenera kupuma kwathunthu ndipo mitundu ina ya mankhwala ogwiritsa ntchito mankhwala omwe si a quinolone iyenera kukambirana.
Kupatsa ana
Chifukwa cha chitetezo chosasinthika ndikuyenda bwino kwa mankhwalawa sikufotokozedwa muubwana, unyamata ndi unyamata (mpaka zaka 18). Tiyenera kukumbukira kuti maphunzirowa adawonetsa kudalira kwachidziwikire komwe kumachitika chifukwa cha kupezeka kwa arthropathy pa mankhwalawa okhala ndi mankhwala a moxifloxacin.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala a Plevilox ndi otheka mwa amayi apakati, ngati kuthekera kwake ndikokwezeka kuposa chiwopsezo cha mwana wosabadwayo, popeza kuti kuphunzira koyenera komanso kokhwima mosamalitsa sikunachitike.
Panthawi yoyamwa, makonzedwe a Plevilox sayenera kuphatikizidwa.
Pa mkaka wa m`mawere, Plevilox sayenera kuyikidwa kunja, chifukwa zatsimikiziridwa kuti zimatha kulowa mkaka wa m'mawere ndikusokoneza ana pambuyo pake.
The ntchito aimpso kuwonongeka
Ndi kulephera kwa aimpso, gwiritsani ntchito mosamala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kulephera kwa chiwindi ndi ma transaminase okwera kwambiri ndi ma contraindication popereka moxifloxacin chifukwa chochepa pazachipatala.
Mankhwala osokoneza bongo a Plevilox
Palibe kulimbikira komwe kumachitika mosagwirizana ndi mankhwala komwe kumapezeka ndi limodzi mankhwala omwe ali ndi 2.8 g.
Acid bongo wambiri amathandizidwa ndi chapamimba cha m'mimba ndikugwiritsanso ntchito makala ake. Pankhani ya bongo mopitirira muyeso, kuwunikira kwa ECG ndikulimbikitsidwa, popeza kutalika kwa nthawi ya QT ndikotheka. Dokotala atha kukulemberani mankhwala othandizira.
Mankhwala osokoneza bongo a Plevilox amathandizidwa ndikutsuka m'mimba ndikugwiritsa ntchito makala opaleshoni.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito pamodzi ndi ma antacid, mineral ndi multivitamini kumapangitsa mayamwidwe ndikuchepetsa kuchuluka kwa zinthu zomwe zimagwira m'madzi a m'magazi. Ndi mankhwala ophatikiza, zotsatirazi zikulimbikitsidwa:
- Maola 2 atatenga Pleviloksa;
- Maola 4 asanavomerezedwe.
Kugwiritsa ntchito palimodzi ndi mankhwala ena a kalasi ya fluoroquinolone kumalimbikitsa chitukuko cha zithunzi.
Kumwirira kwa moxifloxacin m'magazi kumachepetsedwa ndikumatenga Runitidine.
Kuyenderana ndi mowa
Ndi zoletsedwa kumwa mowa munthawi ya mankhwala ndi plevilox chifukwa cha kuchuluka kwa zovuta (makamaka kuchokera ku mtima wamkati). Kuphatikiza apo, ntchito yotsitsa ya ethanol siyikulola kufikira mphamvu ya yogwira yogwira ntchito m'magazi, yomwe imakhudza kuyipa kwa mankhwala.
Analogi
The fanizo la mankhwala ndi:
- Avelox;
- Aquamox;
- Megaflox;
- Moxispenser;
- Moxiflo;
- Moxifloxacin;
- Rotomox;
- Simoflox;
- Ultramox;
- Heinemox.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Palibe mankhwala omwe sanapatsidwe.
Mtengo
Mtengo wopaka mankhwala opangidwa ndi Russia (mapiritsi 5) umayamba pa ma ruble 500.
Zosungidwa zamankhwala
Sungani pamalo amdima, otetezedwa ku chinyontho, kutentha osapitirira + 25 ° C.
Tsiku lotha ntchito
Kwa zaka 2 ndikusungidwa koyenera.
Wopanga
Zogulitsa ndizopanga za opanga aku Russia ndi India: Farmasintez OJSC (Irkutsk) ndi Plethiko Pharmaceuticals Ltd (Indore).
Ndemanga
Sophia, wazaka 24, Krasnodar
Ndinatenga mankhwalawa ndi sinusitis yovuta, idathandiza mwachangu. Chida chokha chomwe chinakhala chothandiza, zisanachitike, ndi mankhwala ena onse munagwiritsa ntchito maantibayotiki ena.
Ivan, wazaka 46, Kazan
Panali zovuta zoyipa pamankhwala awa. Mutu, kusowa tulo, kusanza. Ndimaganiza kuti ndizolowera, zidatenga masiku atatu, koma sizinasinthe. Ndinapita kwa adotolo kuti ndikatenge china, ndipo nditachisinthitsa ndi ma analogue a Aquamox ngati kulowetsedwa, Zizindikiro zonse zidachoka.
Dmitry, wazaka 35, Lyantor
Ndinatha kuchiritsa matenda opha ziwonetsero kokha. Mumzinda wathu kudali kovuta kuzipeza, tidazilamula kuchokera ku Surgut, koma sizinadandaule, chifukwa zotsatira zake zimawoneka nthawi yomweyo.
Marina, wazaka 36, ​​Vladivostok
Dokotala adapereka mankhwala awa chifukwa cha sinusitis ya pachimake, adati ayenera kuwunika mosamala mawonetseredwe azotsatira zoyipa, popeza mankhwalawa adalembedwa panthawi yomwe ali ndi pakati. Ndili bwino kuti ndidakuchenjezani, chifukwa mseru udalimba, koma ndikuganiza kuti izi ndi mawonetseredwe a toxosis. Ndipo pomwepo m'malo mwanjira ya chithandizo, zonse zidayenda bwino.
