Metformin hydrochloride ndi chinthu chogwira ntchito chomwe chimatchedwa kutsitsa shuga. Mankhwala nthawi zambiri amawagwiritsa ntchito ngati gawo limodzi la zovuta za matenda a shuga a mtundu wachiwiri.
Pali ndemanga zabwino za kugwiritsidwa ntchito kwa mapiritsi a endocrine mtundu 1 pathology monga chowonjezera cha jakisoni wa insulin.
Mlingo woyenera komanso pafupipafupi wa Metformin wa matenda a shuga kwa wodwala wina amatsimikiza ndi endocrinologist, poganizira zinthu zingapo.
Gulu la mankhwala
Metformin ndi mankhwala opangidwa ndi hypoglycemic effect. Oral antidiabetesic wothandizira imagwiritsidwa ntchito mochizira mtundu wa endocrine pathology, kawirikawiri - kuwonjezera pa insulin. Mtundu waukulu wa mawonekedwe ndi kuchepa kwa shuga m'magazi.
Zotsatira zochizira Metformin
Zovuta zakuthambo zomwe zimakhala ndi shuga ndi mtundu wina wa matenda osokoneza bongo ndi chimodzi mwazabwino za mankhwala ogwira mtima. Yogwira pophika imagwira shuga wamagazi, komanso imasintha kagayidwe ka lipid. Mankhwala amachepetsa mphamvu ya kapamba (akuwonetsa zotumphukira zake m'magazi), kuchepa kwambiri kwa ndende ya glucose sikutha.
Mutatenga Metformin, thupi limakhudzana ndi zigawo za wothandizila wodwala matenda ashuga:
- kuchuluka kwa mapangidwe a shuga kuchokera ku lipids ndi mapuloteni amachepetsedwa;
- minofu kumverera kwa insulin kumawonjezera;
- glycogen ochokera ku maselo a chiwindi amatulutsidwa pang'onopang'ono, shuga m'magazi amabwerera mwakale;
- ulusi wa minofu umatha glucose mwachangu;
- excretion wa cholesterol yoyipa imatheka, mafuta kagayidwe imakonzedwa;
- kuyamwa kwa shuga m'matumbo sikugwira ntchito;
- m'mimba mumakhala kusintha kwamphamvu kwa glucose.
Oposa 50% ya odwala omwe ali ndi insulin kukana komanso osakwanira kupanga insulin amalandila mphamvu ya hypoglycemic.
Zisonyezero zakudikirira
Mankhwala Metformin ndi ofunikira pakuchiza matenda osokoneza bongo omwe amadalira matenda a shuga (mtundu 2 matenda).
Mankhwala okhala ngati Metformin hydrochloride amagwiritsidwanso ntchito ngati mtundu 1 endocrine matenda kuwongolera kuchuluka kwa glucose, kuphatikiza jakisoni wa insulin.
Zizindikiro zina:
- zovuta mankhwala a kunenepa pa maziko a insulin kukana;
- polycystic ovary syndrome;
- ndi shuga wambiri pamimba yopanda kanthu;
- mu zamankhwala zamasewera;
- ndi kuchepa kwa kulolera kwa shuga.
Mlingo
Makampani opanga zamankhwala amapereka mitundu iwiri ya Metformin:
- yayitali;
- wamba.
Mapiritsi ali ndi mlingo wosiyana - kuchokera 500 mpaka 1000 mg. Mitundu yambiri yophatikiza matenda okhudzana ndi shuga imakhalanso ndi chophatikizira, koma yaying'ono.
Endocrinologist amasankha mulingo woyenera kwambiri woganizira kuchuluka kwa shuga m'magazi ndi mtundu wa matenda ashuga. Chofunikira chochepa chatsiku ndi tsiku kuti mukwaniritse kuchepetsa shuga ndi 500 mg. Ndi chiopsezo chachikulu cha hyperglycemia, monga adokotala adalembera, mutha kuwonjezera kuchuluka kwa metformin hydrochloride mpaka 2 g.
Type 2 shuga
Metformin ndi hypoglycemic yayikulu. Mlingo wamba watsiku ndi tsiku ndi 0.5 kapena 0,85 g, kuchuluka kwake ndi piritsi 1.
Ndi matenda a kutsekula m'mimba kapena mseru, gwiritsani ntchito mankhwalawa ndi chakudya, mutatha kudya, kumwa ndi madzi.
Ndi mphamvu yofooka, mogwirizana ndi adotolo, mutha kuwonjezera kuchuluka kwa tsiku lililonse mpaka 2 g.
Carbohydrate metabolism imabweranso masiku awiri kapena atatu. Ndi kuchepa kwa kuchuluka kwa hyperglycemia, mlingo umachepetsedwa. Kuwongolera kuchuluka kwa mapiritsi ndi chilolezo cha tsiku ndi tsiku kumaloledwa malinga ndi endocrinologist.
Zofunikira zofunikira:
- ndi metabolic syndrome yolimbana ndi matenda a shuga, mutha kupeza mapiritsi a metformin hydrochloride kuti achulukitse kagayidwe, muchepetse triglycerides, muchepetse hyperglycemia mutatha kudya;
- kuphatikiza ndi sulfonylurea kukonzekera bwino kagayidwe mu 60% ya odwala. Mlingo wa glycemia amachepetsa - shuga yamasamba amagwa ndi 20-40%. Popita nthawi, thupi limazolowera mankhwala osokoneza bongo ndi sulfonylurea. Matenda a Metformin amakhala ndi kagayidwe ka lipid kagayidwe kake komanso shuga wokwanira wamagazi.
Mtundu woyamba wa shuga
Mankhwalawa nthawi zambiri amalembera mtundu wa 2 matenda, koma madokotala ambiri amawonjezera jakisoni wa insulin ndi Metformin.
Zovuta zake zimakhazikitsa mkhalidwe wodwala.
Kuwonjezeka kwamankhwala a insulin pambuyo pa jekeseni, kuphatikiza ndi kuchepa kwa shuga wamagazi, kumachepetsa chiopsezo cha zovuta zamtundu wodalira insulin.
Kugwiritsa ntchito antidiabetesic (majekeseni a insulin ndi metformin hydrochloride) kumachepetsa kufunikira kwa kusunga mahomoni 20% kapena kupitirira. Mayeso nthawi zambiri amawonetsa kusintha kwa kagayidwe kazachilengedwe.
Kodi Metformin ikhoza kugwiritsidwa ntchito poteteza matenda ashuga?
Madokotala aku America chakumapeto kwa zaka za zana la 20 adachita kafukufuku wambiri kuti adziwe zotsatira za wothandizira wa hypoglycemic wokhala ndi zotumphukira.
Odwala omwe ali pachiwopsezo adayitanidwa: ndi kulolerana kwa shuga ndikutsimikizira prediabetes.
Ambiri anali ndi vuto la kunenepa kwambiri, adadandaula za kuthamanga kwa magazi, mavuto amtima, mayeso adawonetsa mlingo woyipa wa triglycerides ndi "oyipa" cholesterol.
Miyeso yapadera ndi zoyeserera zinachitidwa ku malo 27. Odwala amalandira Metformin kawiri patsiku pa 850 g kwa zaka zitatu. Kafukufuku akuwonetsa: chithandizo cha mankhwala osokoneza bongo, kuphatikiza kukonza moyo ndi zakudya, zimachepetsa kufa kwa mtima.
Mankhwala othandizira odwala matenda ashuga adawonetsa kukhathamiritsa kwakukulu ndikuwonetsa kukhazikika kwa shuga mumagazi ndikudziwikiratu kwa matenda ashuga mwa anthu omwe ali ndi kunenepa kwambiri. Ngakhale ndi moyo wamba, mwayi wopanga matenda a shuga omwe amadzimvera pawokha amatsika ndi 30%. Zotsatira za mankhwalawa mukudya, kuwonjezeka kwa zochitika zamagalimoto, ndi kuchepa kwamlingo wopsinjika kunakulirakulira: mu 58% ya anthu omwe ali pachiwopsezo, glucose amakhala okhazikika.
Contraindication
Mosiyana ndi mitundu ina ya mankhwala othandizira odwala matenda ashuga, Metformin ndi zotanthauzira zina zili ndi zoletsa zochepa:
- zaka za mwana mpaka zaka 10;
- anavulala kwambiri komanso maopareshoni ambiri;
- mbiri ya lactic acidosis;
- nthawi ya mkaka wa m`mawere;
- kudya calorie pansipa 1000 kcal patsiku: chiopsezo cha metabolic acidosis;
- kulephera kwaimpso;
- kuvulala kwambiri kwa chiwindi;
- mtima matenda;
- mimba
- zinthu zomwe kukula kwa lactic acidosis ndikotheka.
Malangizo apadera
Pochiza ndi Metformin, ndikofunikira kudziwa: kuchuluka kwa zinthu zomwe sizikugwira kumayambitsa hypoglycemia, koma ndi mankhwala osokoneza bongo, oopsa, lactic acidosis ingayamb. Odwala odwala matenda ashuga komanso achibale ayenera kudziwa chizindikiro cha kusintha kwa mankhwalawo kuti afotokozere mwachangu ambulansi kuti amugulitse.
Chithunzi cha chipatala ndi kukula kwa lactic acidosis:- kupuma msanga;
- kutsegula m'mimba
- hypothermia;
- nseru
- kupweteka kwam'mimba;
- kusanza
- kupweteka kwa minofu;
- kulephera kudziwa.
Analogi
Metformin hydrochloride ndi gawo la mankhwala ambiri. Makampani opanga zamankhwala amapereka mankhwala okhala ndi zosakaniza zogwira ntchito pansi pa mayina osiyanasiyana kupita ku malo ogulitsa mankhwala. Kusiyana kwazinthu zothandizira kwenikweni sikukhudza kayendedwe ka thupi.
Mayina ogwira mtima potengera metformin hydrochloride:
- Fomu.
- Glucophage.
- Metospanin.
- Glycomet.
- Siofor.
- Glyminfor.
- Novoformin.
- Vero-Metformin.
- Bagomet.
- Dianormet ndi ena.
Kawunikidwe ka Metformin ndi ma fanizo ake zimatsimikizira kukhazikika kwa mtundu wa shuga.
Zotsatira zabwino za mankhwala omwe ali ndi mawonekedwe a insulin omwe amadalira matenda amawonetsedwanso. Kutengera ndi chizolowezi cha tsiku ndi tsiku, zovuta zoyipa zimachitika mwa ochepa odwala. Mtengo wovomerezeka (kuchokera ku ma ruble 110 mpaka 190, ma CD a No. 30 ndi No. 60) ndi mwayi wosakayikira wokhala ndi chithandizo chambiri.
