Bagomet - mankhwala omwe amachepetsa shuga la magazi. Malangizo ogwiritsira ntchito

Bagomet ndi mankhwala omwe ali ndi mphamvu ya hypoglycemic, yomwe imagwiritsidwa ntchito kulipiritsa osagwirizana ndi insulin-basedabetes mellitus (DM), ngati chithandizo cha sulfonylurea sichigwira ntchito mokwanira.

Zotsatira zamtundu wa Bagomet

Bagomet ndi mankhwala a hypoglycemic omwe amachepetsa shuga komanso kuthamanga kwake pakudya. Mankhwala sasokoneza kapangidwe ka insulin. Zina mwazotsatira zoyipa za hypoglycemia sizinakhazikike. Kuthekera kwa mankhwalawa kumawonekera pambuyo poyimitsa glycogenolysis ndi gluconeogeneis, zomwe zimapangitsa kuti glycogen chiwindi chiwindi.

Bagomet imawonjezera mphamvu ya enzyme yomwe imathandizira kaphatikizidwe ka glycogen, imawonjezera kuthekera kwa transporter ya membrane glucose. Mankhwalawa amakongoletsa kagayidwe ka lipid - ndi mtundu wachiwiri wa shuga pali mwayi wonenepa.

Bagomet ikufananiridwa bwino ndi omwe amagwirizana nawo pankhani ya kuthamanga kwambiri komanso kotheratu.

Mukamwetsa, mankhwalawo amatengedwa nthawi yomweyo kuchokera m'mimba, chimbudzi chambiri chimafika patatha maola awiri ndi theka. Imachepetsa mwayi womwe ungakhale nawo pakudya. Zizindikiro za Bagomet za bioavailability ndizokwera 60% ya kuchuluka kwa mankhwala omwe amaperekedwa ku ziwalo.

Malinga ndi zotsatira za kafukufuku wa pharmacokinetic, titha kunena kuti mankhwalawa amasunthira minofu mosavuta, ndikudziwikiratu ndi plasma. Zigawo za mankhwala sizigwirizana ndi mapuloteni, zimatha kulowa m'magazi ofiira, koma m'magazi ndizochepa kwambiri poyerekeza ndi plasma.

Kuyesaku kunatsimikizira kuti mankhwalawa m'thupi samapangidwira - impso zimakongoletsa momwe zidakhalira. Poterepa, theka-moyo ndi maola sikisi ndi theka. Kutuluka kwa Bagomet kumamukwiyitsa chifukwa cha kusefera komwe kumachitika chifukwa cha kusefukira kwa khungu ndi impso, chifukwa chake, odwala onse omwe ali ndi aimpso a pathologies ali pachiwopsezo.

Hafu ya moyo imachulukitsidwa, zomwe zikutanthauza kuti pamakhala chiopsezo cha kuchuluka kwa mankhwala.

Zizindikiro ndi njira yogwiritsira ntchito

Bagomet imapangidwira zochizira odwala matenda ashuga omwe ali ndi mtundu wodziyimira pawokha wa matenda komanso kunenepa kwambiri (pakalibe ketoacidosis komanso yankho losakwanira lithandizo la sulfonylureas).

Mankhwalawa adapangira kuti azigwiritsidwa ntchito mkati. Finyani piritsi lonse ndi madzi. Izi zimachitika kawirikawiri ndi chakudya kapena zitatha. Mlingo woyambirira ndi 500-100 mg / tsiku, kutengera mlingo wa glycemia. Mutha kusintha mankhwalawa pokhapokha masabata awiri atatha kudya ndikuwunika mawonetsedwe a glycemic.

Ngati dokotala sanapange chisankho payekha pokhudzana ndi wodwalayo, ndiye kuti muyezo wowerengeka wothandizidwa ndi 1500 mpaka 2000 mg. Ndikosatheka kupitilira muyeso wokwanira. Ngati mankhwalawa akukhumudwitsa chopondacho, mutha kuthana ndi chizolowezi chatsiku ndi katatu.

Ndi zovuta mankhwala "Bagomet kuphatikiza insulin kukonzekera", muyezo Mlingo ndi 1500 mg / tsiku. Mapiritsi okhala ndi mphamvu yayitali, mulingo woyenera tsiku ndi tsiku ndi 850 mg -1000 mg. Ndi kulekerera kwabwinobwino, amayima pamlingo wokonza 1700 mg / tsiku, ndipo malire - 2550 mg / tsiku. Mankhwala osokoneza bongo ndi mankhwala ena ochepetsa shuga, piritsi limodzi (850 mg kapena 100 mg) limayikidwa.

Mukukula, Bagomet imatenga zosaposa 1000 mg / tsiku. Mutha kupereka mankhwala kwaana azaka zopitilira 10. Ana, komanso achikulire, ayenera kuyambiranso chithandizo cha 500-850 mg / tsiku. Muubwana, pazipita tsiku lililonse ndi 2000 mg.

Zotsatira zoyipa

Mwambiri, mankhwalawa amaloledwa ndi odwala ambiri, koma, monga ndi mankhwala aliwonse, pamakhala zovuta zina.

Kuyang'ana kwapadera kunawonetsa kuti Bagomet sikupangitsa mutagenicity, carcinogenicity ndi teratogenicity. Zake zosagwirizana ndi ntchito yobereka zimatsimikiziridwa.

Contraindication

Sitikulimbikitsidwa kutenga botomet ndi matenda otsatirawa:

• Matenda a matenda ashuga ketoacidosis, chikomokere shuga ndi mikhalidwe ya makolo;
• Mavuto opatsirana;
• Matenda a mtima, makamaka pamtima;
• Cerebral flow flow;
• Lactic acidosis;
• Kuledzera, kusowa kwamadzi;
• Kulephera kwamlomo;
• Kutengeka kwakukulu kwa zosakaniza za formula ya Bagomet;
• Ntchito zofunika mapiritsi ndi insulin jakisoni;
• Kulephera kwa chiwindi;
• Mimba ndi yoyamwitsa;
• X-ray yogwiritsa ntchito ayodini monga mosiyanitsa (kuletsa - kwa masiku awiri isanachitike komanso pambuyo pa kuyesedwa);
• Zakudya za Hypogalogy;
• Okhwima (atatha zaka 60), makamaka ndi katundu wolemera wa minyewa yolimbikitsa lactic acidosis;
• Ana (mpaka azaka 10).

Malangizo pathupi

Kuyesa kwa zamankhwala sikunatsimikizire za mutagenic ndi teratogenic katundu wa Bagomet, koma sanakhazikitsidwe kwa amayi oyembekezera. Mankhwala amatha kulowa mkaka wa m'mawere, ngati palibe njira ina ya Bagomet, mwana amayenera kusinthidwa kuti adyetsedwe.

Zotsatira Zogwiritsa Ntchito Mankhwala

Kugwiritsa ntchito kwa hypoglycemic kwa Bagomet kumathandizidwa ndi sulfonamides, insulin, acarbose, mankhwala osapweteka a antiidal, ACE ndi mao inhibitors, oxytetracycline, β-blockers.

Glucocorticosteroids, GOK, epinephrine, glucagon, mahomoni a chithokomiro, ma sympathomimetics, thiazide ndi "loop" diuretics, zotumphukira za phenothiazine ndi nicotinic acid zimalepheretsa ntchito yake.

Kuchotsa kwa Bagomet ku ziwalo kumaletsedwa ndi cimetidine. Kuthekera kwa kutulutsidwa kwa Coumarin kwa zotumphukira zathu kumalepheretsa Bagomet.

Kumwa moledzeretsa kamodzi kumakwiyitsa lactic acidosis. Mawonetseredwe ake ndi kutsika kwa kutentha kwa thupi, myalgia, kusapeza bwino pamimba, kusokonezeka kwa dyspeptic, kufupika, kuperewera kwa tulo, kukomoka. Pokayikira koyamba kwa wozunzidwayo, amagonekedwa m'chipatala ndipo matendawa amafotokozedwa pofufuza kuchuluka kwa lactate mu ziwalo ndi minofu.

Zizindikiro zosokoneza bongo

Ngati Mlingo wa Bagomet uli pamtunda wovomerezeka, lactic acidosis yokhala ndi zotsatirapo zoyipa kwambiri ngakhale kufa. Zofanana zimachitika chifukwa cha kuchuluka kwa mankhwalawa m'thupi ndi mavuto ndi impso. Mavuto amakula patangotha ​​maola ochepa ndipo amayenda ndi zomwe ali nazo:

• Matenda a Dyspeptic;
• Hypothermia;
• Kuphwanya miyambo yamatumbo;
• Ululu pamimba;
• Myalgia;
• Kuwonongeka kwa mgwirizano;
• Kukomoka ndi matenda ashuga.

Ngati zina mwazizindikiro zomwe zatchulidwa zachitika, Bagomet iyenera kuchotsedwa mwachangu, ndipo wolakwiridwayo ayenera kuchipatala.

Kutulutsa mawonekedwe, kapangidwe kake, malo osungira

Mapiritsi amatha kukhala ndi mawonekedwe ndi mitundu yosiyanasiyana, kutengera mulingo: yoyera, yozungulira komanso yopukutira - 500 mg aliyense, mwanjira ya makapisozi - 850 mg wa buluu wamtundu ndi 1000 mg mu yoyera. Omalizirawo akhala ndi katundu wautali. Gawo la mafomu kumasulidwa ndi mzere wogawa ndi logo ya wopanga, womangidwa pamapiritsi onse.

Piritsi limodzi lili ndi 500 mpaka 100 mg ya yogwira pophika metformin hydrochloride kuphatikiza mawonekedwe a croscarmellose sodium, povidone, stearic acid, chimanga wowuma, lactose monohydrate.

Zipangizo zothandizira zoyambira ndi mankhwala ziyenera kuyikidwa pamalo osavomerezeka ndi ana, pamtunda wofika mpaka 25 ° C. Sungani Bagomet zosaposa zaka ziwiri.

Zizindikiro ndi fanizo la mankhwalawa

Mgwirizano wofanizira wa Bagomet umaphatikizapo mankhwala omwe gululi (mankhwala amkati mwa antidiabetic) ndi zigawo zomwe zimagwira (metformin) zimagwirizana.

1. Methamine;
2. NovoFormin;
3. Fomu;
4. Fomu.

Ma analogi a Bagomet ndi mankhwala omwe matenda kapena vuto limodzi limangofanana mu umboni, mwanjira iyi mtundu wachiwiri wa matenda ashuga.

1. Avandia
2. Apidra
3. Baeta;
4. Glemaz;
5. Glidiab;
6. Glucobay;
7. Glurenorm;
8. Lymphomyozot;
9. Levemir Penfill;
10. Levemir Flekspen;
11. Multisorb;
12. Methamine;
13. NovoFormin;
14. Piroglar;
15. Fomu;
16. Fomu.

Ndi chithandizo chovuta ndi mankhwala ena omwe ali ndi vuto lofananalo, ndikofunikira kulingalira za hypoglycemia. Mankhwalawa amatha kusokoneza mgwirizano ndikuchepetsa kuyendetsa kwa psychomotor, chifukwa chake mukamagwiritsa ntchito njira zoyenera kapena mukuyendetsa, ndibwino kukana kumwa mankhwalawo. Kugwiritsa ntchito kwa Bagomet kumafuna kutsatira mosamalitsa chakudya chamagulu ochepa omwe amawongolera kudya kwamphamvu m'magazi.

Ndemanga za Bagomet

Za mankhwala a Bagomet, ndemanga za madokotala zimakhala zabwino. Malinga ndi akatswiri, kumwa mankhwala otchuka kotere kumapangitsa kuti magazi azitha kwa maola 12. Mwayi wotere umamutsimikizira zabwino zake: mutha kuchepetsa pafupipafupi kumwa mankhwalawo, kusintha kayendedwe ka metabolic. Nthawi yomweyo, kuyamwa kwa zinthu zogwira ntchito m'mimba kumakonzedwa ndipo chiwopsezo chokhala ndi zovuta zimachepa.

Kufotokozera kwa mankhwalawa sikungakhale chitsogozo chogwiritsidwa ntchito. Musanagule, muyenera kufunsa wa endocrinologist, ndipo musanamwe mankhwala a Bagomet, werengani malangizo omwe angagwiritsidwe ntchito ndi wopanga. Zambiri zokhudzana ndi Bagomet zimaperekedwa kuti zidziwidwe bwino ndi kuthekera kwake ndipo sikuti ndizitsogozo zodzipulumutsira nokha. Njira yeniyeni yochiritsira, poganizira kuopsa kwa matenda ashuga, matenda ofanana ndi kuchuluka kwa odwala matenda ashuga, amatha kupangidwa ndi katswiri.