Jekeseni wa insulin Glulisin amagulidwa ndi odwala matenda a shuga. Mankhwalawa amafunikira kuti muchepetse shuga wamagazi, komanso mankhwalawa. Uku ndi kufupikitsa insulini. Ndi gawo limodzi la mankhwala ena a odwala matenda ashuga. Glulisin ali ndi tanthauzo la hypoglycemic.
Kuchita bwino ndi limagwirira ntchito
Ichi ndi analogue a insulin yamunthu, yomwe ili ndi zofanana. Nthawi yomweyo, wothandizirayo amachita zinthu mwachangu mthupi (pakadutsa mphindi 10-20 pambuyo pa kuperekera), koma amakhala ndi nthawi yochepa.
Ntchito yayikulu ya mankhwalawa ndikuchepetsa kuchuluka kwa glucose, omwe amapezeka chifukwa cha kukondoweza kwa mayamwidwe ndi minofu yake yapafupipafupi.
Minofu ya mafupa ndi adipose minofu imatenga glucose wabwino koposa zonse, osapanga nkhokwe yake m'chiwindi. Kuchita bwino kwa mankhwalawa sikudalira mtundu kapena mtundu wa wodwalayo.
Pharmacokinetic katundu
Kuyamwa kwa mankhwalawa m'thupi la munthu kumachitika mwachangu kwambiri (pafupifupi kawiri). Kafukufuku wotere adachitika kwa odwala omwe amadwala matenda amtundu wa 2 komanso matenda a shuga.
Ngati tilingalira za makonzedwe a subcutaneous, nthawi yozunzika kwa odwala omwe ali ndi vuto la 1 ndi mphindi 55, koma nthawi yomweyo, mahomoni abwinobwino amunthu amakhala akufalikira kwa pafupifupi mphindi 62.
Pambuyo pa kafukufuku wambiri, zidapezeka kuti mankhwalawa amagwira bwino ntchito kwambiri pakabayidwa m'njira yolowera khoma lamkati, ndipo zotsatira zazing'ono zimatha kupezeka m'chiuno.
Odwala omwe ali ndi vuto la impso amamva kugwiranso ntchito kofanana ndi mitundu ina ya odwala, koma ena mwa iwo amachepetsa kufunika kwa insulini. Kuchuluka kwa msambo komanso kutalika kwa mankhwalawa akaperekedwa kwa mwana kapena mwana azikhala wofanana ndi munthu wamkulu.
Mayina amalonda
Insulin Glulisin ali ndi mayina ena 2 ogulitsa: Apidra ndi Apidra SoloStar. Njira yoyamba imagwiritsidwa ntchito pochiza matenda osokoneza bongo kwa ana kuyambira zaka 6, ndipo imagwiritsidwanso ntchito kwa achikulire omwe amafuna insulin. Apidra ili ndi 3.49 mg ya chinthu chachikulu (insulin glulisin). Izi zimatha kufaniziridwa ndi 100 IU ya mahomoni amunthu.
Mankhwalawa amagulitsidwa mu botolo la 10 ml kapena ma cartridge atatu apadera a 3 ml. Njira yoyamba imanyamula mu bokosi la cathodic, ndipo chachiwiri - mumakhala chodzaza ndi maselo. Mwa mtundu waposachedwa, pali ma cartridge atatu otere omwe amalembetsa cholembera (syringe) "OptiPen" kapena "OptiSet" (cholembera zotayika).
Wopangitsanso amapanga dongosolo lina la cartridge "OptiKlik". Zotengera zonse zimakhala ndi madzi amtundu wowoneka bwino.
Chowonjezera china cha mankhwalawa ndi Apidra SoloStar. Zomwe zimagwiritsidwa ntchito momwe ziliri chimodzimodzi monga momwe zimakhalira m'mbuyomu.
Zizindikiro ndi Kugwiritsa Ntchito
Mankhwalawa ali pafupifupi ofanana ndi anthu kupatula nthawi yowonekera, yomwe ndiyifupi. Ndikokwanira kupatsa wodwala jakisoni imodzi ya mankhwalawa, ndipo pakatha mphindi 15 amva bwino.
Njira zoyendetsera zitha kukhala zosiyanasiyana: mosazindikira munjira yina ya thupi komanso ndi pampu ya insulin. Kusankha komaliza kumachitika ndi kulowetsedwa (popanda kupuma) m'matumbo amafuta pansi pa khungu.
Njirayi iyenera kuchitika musanadye, kapena itatha, koma yomweyo. Kubaya jakisoni kumachitika bwino kwambiri pamimba, komanso amathanso kukhala phewa, ntchafu. Koma kulowetsedwa ndikololedwa kokha pamimba.
Ndi dokotala wokhawo amene angakupatseni mankhwala othandizira. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito ngati pakufunika kupatsa insulin kwa wodwala nthawi yayitali kapena yapakati.
Ndizovomerezeka kuphatikiza kukhazikitsidwa kwa mankhwala ndi mapiritsi (mankhwala a hypoglycemic). Mlingo komanso kusankha kwa mankhwalawo kumatsimikiziridwa ndi adotolo, popeza wodwalayo alibe ufulu wosankha yekha. Izi zili ndi zovuta zoyipa.
Mwa malangizo apadera omwe mungagwiritsire ntchito, mutha kupezanso chidziwitso cha malo omwe mankhwalawo amakuperekera. Chifukwa chake, ndikofunikira kupewa mitsempha yamagazi.
Kuphatikiza apo, ndizoletsedwa kutikita minofu komwe adapangira jakisoni.
Zotheka kukhala ndi mavuto
Ngati Insulin Glulizin yasankhidwa, malangizo omwe angagwiritsidwe ntchito ayenera kuchenjeza ogwiritsa ntchito za zotsatira zoyipa zingapo. Ngati munthu wapatsidwa mankhwala osokoneza bongo, koma osafuna izi, wodwalayo atha kukhala ndi hypoglycemia. Izi ndi zotsatira zoyipa kwambiri chifukwa chogwiritsa ntchito mankhwalawa.
Pamaso pazotsatira zoyipa zoterezi ndikulowetsedwa kwa mankhwalawa, wodwalayo nthawi zambiri amakhala ndi zizindikiro za matendawo nthawi yomweyo. Amaponyedwa thukuta lozizira, munthu amakhala wotopa, watopa, komanso wasokonezeka. Nthawi yomweyo amakhala ndi miyendo komanso chikondwerero champhamvu.
Zizindikiro zowonjezera: nseru, palpitations, ndi kutupa kwa mitsempha. Zizindikiro za pathology iyi zimakula, ngati sangayimitsidwe, munthu akhoza kulephera kudziwa. Wodwala amapezeka kuti wakomoka, kugwira ntchito kwa ubongo kumadodometsa, ndipo vuto lalikulu kwambiri, limamupangitsa kuti afe.
Pafupipafupi, odwala amawona kusokonezeka komwe kumagwira ntchito kwa matupi awo. Mwachitsanzo, nthawi zina wodwala amatha kuyamba kuyabwa, ming'oma, kapena khungu. Zizindikirozi zimatha kukhala limodzi komanso kumva kukomoka pachifuwa kapena kukomoka. Zotsatira zoyipa zamtunduwu zikamayamba, ngati zotsatira zake zimakhala zosagwirizana, mantha a anaphylactic, izi zimatha kupha.
Nthawi zina pamalo opaka jekeseni pakhungu, zotsatira za hypersensitivity zimadziwika. Itha kufotokozedwa ngati dera lokongola lomwe limayamwa. Popita nthawi, vutoli limafanana lokha, ndipo njira zingapo zikadzatheratu. Odwala ena amatha kudwala lipodystrophy.
Gwiritsani ntchito pobereka komanso podyetsa ana
Ngati Glulisin adalembedwa kwa mkazi nthawi yosangalala iyi, koma nthawi yovuta, malangizowo akufotokozera zomwe zimagwiritsidwa ntchito pa mankhwalawa ngati chinthu chosiyana. Malowa sanaphunziridwe bwino, choncho palibe zambiri zokwanira.
Mankhwalawa anayesedwa pazinyama. Phunziroli silinawonetse kusiyana pakukhazikitsidwa kwa chida ichi ndi kusiyanasiyana kwaumunthu pa nthawi yapakati. Pambuyo pa kuyambitsa, panalibe chosintha pakukula kwa mwana wosabadwayo panthawi ya kubereka komanso panthawi yomwe itachitika.
Koma nthawi yomweyo, odwala otere ayenera kukhala osamala popereka mankhwala. Njirayi iyenera kuchitika moyang'aniridwa ndi shuga. Pankhani ya matenda ashuga, mkazi ayenera kuyang'anira kagayidwe kake ka mankhwala.
Nthawi zambiri, madokotala amachenjeza odwala kuti asinthe ma dosages panthawi zosiyanasiyana zamisala. Chifukwa chake, amatha kuchepetsa mankhwalawa mu trimester yoyamba, ndikuchulukana panthawi yazitsulo ziwiri zotsatila. Mayiyo akadzabereka, adzapeza kuchepa kwa zofunika za insulin.
Thupi silimalowa mkaka wa m'mawere ndipo silimayamwa mkaka wa m'mawere. Koma dotolo yemwe akupezekapo amatha kusintha mankhwalawa panthawiyi ndikupereka zakudya zapadera kwa mzimayi.
Kuchita ndi mankhwala ena
Insulin Glulisin akaphatikizidwa ndi guanethidine angayambitse kukula kwa hypoglycemia, zomwe sizidzawala kwambiri.
Magulu otsatirawa a mankhwala amatha kukhala othandizira pakukula kwa zoyipa:
- Disopyramids;
- Mao kapena PAF zoletsa;
- Sulfonamides;
- Fizates;
- Salicylates;
- Propoxyphene.
Kutsika kwa zizindikiro za hypoglycemic kumawonedwa ndi kuphatikiza kwa mankhwala ndi othandizira:
- Zowonjezera;
- Danazole;
- Protease inhibitors;
- Diazoxide;
- Mankhwala a antipsychotic;
- Epinephrine et al.
Magulu otsatirawa a mankhwala amachepetsa mphamvu za insulin:
- Clonidine;
- Mchere wa Lithium;
- Ethanoli;
- Beta blockers.
Simungathe kuletsa, mwachangu kapena kuwonjezera kuchuluka kwa mankhwalawo, komanso kuphatikiza ndi mankhwala ena. Kusintha kwa mtundu wina wa insulin kumachitika kokha ndi adokotala, ndipo izi zimachitika moyang'aniridwa ndi achipatala.
Pakadali pano, kusintha kwapakanthawi kwa mlingo kungakhale kofunikira. Ngati simutsatira malangizowa kapena musanalowe mosayenera mankhwala, mutha kuyambitsa chidwi cha hypoglycemia, komanso chinthu china choopsa.
Kuphatikiza apo, adotolo amatha kusintha mlingo ngati wodwalayo asintha mu zakudya, komanso momwe zinthu zolimbitsa thupi zimasinthira. Mukangodya, wodwalayo amaletsedwa kuyenda mwachangu, chifukwa izi zimapangitsa kuyamba kwa hypoglycemia.
