Chiwerengero cha odwala omwe ali ndi matenda ashuga ku Russia aposa 6 miliyoni, theka la iwo ali ndi matendawa m'magawo omwe awola. Kupititsa patsogolo moyo wabwino wa anthu odwala matenda ashuga, kukulitsa ma insulin komwe akupitiliza.
Chimodzi mwazinthu zatsopano zamankhwala zolembedwa m'zaka zaposachedwa ndi Toujeo. Ichi ndiye insulin yatsopano ya basofi insulin, yomwe imaperekedwa kamodzi patsiku ndipo imakupatsani mwayi wowongolera glycemic poyerekeza ndi omwe adalipo, Lantus. Malinga ndi kafukufuku, Tujeo ndiotetezeka kwa odwala, popeza chiopsezo cha hypoglycemia chogwiritsidwa ntchito ndizochepa.
Malangizo achidule
Tujeo SoloStar ndi chimodzi mwa atsogoleri mdziko lapansi popanga insulin, nkhawa yaku Europe Sanofi. Ku Russia, malonda a kampani adayimiriridwa kwazaka makumi anayi. Tujeo adalandira satifiketi yoylembetsa ku Russia posachedwa kwambiri, mu 2016. Mu 2018, insulin iyi idayamba kupangidwa ku nthambi ya Sanofi-Aventis Vostok, yomwe ili mdera la Oryol.
Wopangayo amalimbikitsa kuti asinthe kupita ku Tujeo insulin ngati sizingatheke kulipirira chindapusa cha matenda ashuga kapena kuti achotse pafupipafupi hypoglycemia. Ambiri odwala matenda ashuga ayenera kugwiritsa ntchito Tujeo mosasamala kanthu za zomwe akufuna, chifukwa zigawo za Russia zidagula insulin m'malo mwa Lantus.
| Kutulutsa Fomu | Toujeo ali ndi ndende katatu kuposa momwe amapangira insulin - U300. Njira yothetsera vutoli ndi yowonekera, sikutanthauza kusakanikirana musanayende. Insulin imayikidwa m'magalota am'magalasi a 1.5 ml, omwe amasindikizidwa ndi zolembera za SoloStar ndi gawo limodzi la 1 ml. M'malo mwa cartridgeges simuperekedwa mwa iwo, atagwiritsidwa ntchito atataya. Mu phukusi 3 kapena 5 syringe pensulo. |
| Malangizo apadera | Anthu ena omwe amadwala matenda ashuga amatulutsa makatoni kuchokera ku zolembera zotayika kuti ziwayikirane ndi mankhwalawa. Mukamagwiritsa ntchito Tujeo ndi zoletsedwa kotheratu, popeza zolembera zonse za syringe, kupatula SoloStar yoyambirira, adapangira insulin U100. Kusintha chida chothandizira kungayambitse katatu mankhwala. |
| Kupanga | Monga ku Lantus, chinthu chogwira ntchito ndi glargine, kotero malingaliro azomwe amachita insulini ziwiri ndizofanana. Mndandanda wazinthu zothandizira zimagwirizana mokwanira: m-cresol, glycerin, chloride ya zinc, madzi, zinthu zakonzanso acidity. Chifukwa cha kapangidwe kofananako, chiwopsezo cha zotsatira zoyipa nthawi yonse pakusintha kuchoka ku insulin kupita ku chimzake chimachepetsedwa kukhala zero. Kukhalapo kwa mankhwala awiri osungidwa mu yankho kumathandizira kuti mankhwalawa asungidwe kwa nthawi yayitali, kutumikiridwa popanda mankhwala owonjezera a antiseptic pakhungu, komanso amachepetsa chiopsezo chotupa pamalo opaka jekeseni. |
| Zotsatira za pharmacological | Kuzindikira kwa zochita za insulin zopangidwa mwa munthu wathanzi. Ngakhale pali kusiyana pang'ono pakapangidwe ka molekyu ya glargine ndi insulin ya insulin, Tujeo amathanso kumangiriza ma insulin cell receptors, chifukwa chomwe glucose kuchokera m'magazi imalowa m'matumba. Nthawi yomweyo, imathandizira kusungidwa kwa glycogen mu minofu ndi chiwindi (glycogenogeneis), ikuletsa kupangidwe kwa shuga ndi chiwindi (gluconeogenesis), kutsutsana ndi kuwonongeka kwa mafuta, ndikuthandizira mapangidwe a mapuloteni. |
| Zizindikiro | Kubwezeretsanso kwa kuchepa kwa insulin mwa akulu omwe ali ndi matenda ashuga. Insulin ya Tujeo imavomerezedwa kwa odwala omwe ali ndi matenda ashuga, kulephera kwaimpso, komanso matenda a chiwindi. Monga lamulo, mlingo wake mu izi umakhala wotsika. |
| Mlingo | Malangizo ogwiritsira ntchito alibe mulingo woyenera wa Tujeo, popeza kuchuluka koyenera kwa insulin kuyenera kusankhidwa payekha malinga ndi zotsatira za shuga. Mukawerengera insulin, amatsogozedwa makamaka ndi data ya nocturnal glycemia. Wopanga amalimbikitsa kubayira Tujeo kamodzi patsiku. Ngati jakisoni imodzi sangalole kukwaniritsa shuga wosalala pamimba yopanda, mlingo wa tsiku ndi tsiku ungagawidwe pawiri. Jakisoni woyamba amaperekedwa asanagone, wachiwiri - m'mawa kwambiri. |
| Bongo | Ngati kuchuluka kwa Tujeo wothandizidwa ndi wodwala kuposa zomwe insulin imafunikira, hypoglycemia imatheka. Pa siteji yoyamba, nthawi zambiri imayendera limodzi ndi zizindikiro zowoneka bwino - kunjenjemera, kunjenjemera, mtima. Onse omwe ali ndi matenda ashuga komanso abale ake ayenera kudziwa malamulo a ambulansi a hypoglycemia, nthawi zonse amakhala ndi chakudya champhamvu kwambiri komanso magawo a chithandizo choyamba ndi glucagon. |
| Mphamvu ya zinthu zakunja | Insulin ndi mahomoni omwe zochita zawo zimatha kufooketsedwa ndi mahomoni ena omwe amapangidwa m'thupi la munthu, omwe amadziwika kuti amatsutsana nawo. Mphamvu ya minofu kumankhwala itha kuchepa kwakanthawi. Kusintha kotereku ndi mikhalidwe yomwe imatsatana ndi zovuta za endocrine, kutentha thupi, kusanza, kutsegula m'mimba, kutupa kwambiri, ndi kupsinjika. Mwa anthu athanzi, munthawi zotere, kupanga insulin kumawonjezeka, odwala matenda ashuga ayenera kuwonjezera kuchuluka kwa Tujeo. |
| Contraindication | M'malo mankhwalawa ndikofunikira kuti pakhale zovuta zina zomwe zimayanjana ndi glargine kapena zigawo zina zothandizira. Tujeo, monga insulin iliyonse yayitali, singagwiritsidwe ntchito kukonza mwadzidzidzi shuga ya magazi. Ntchito yake ndikusunga glycemia pamlingo womwewo. Pakakhala maphunziro otsimikizira chitetezo cha ana, insulin Tujeo Chololedwa kwa odwala matenda ashuga okha. |
| Kuchita ndi mankhwala ena | Hormonal, hypotensive, psychotropic, mankhwala ochepetsa mphamvu ya antibacterial komanso anti-yotupa amatha kusokoneza zotsatira za hypoglycemic. Mankhwala onse omwe amagwiritsidwa ntchito pa matenda ashuga ayenera kuvomerezedwa ndi dokotala. |
| Zotsatira zoyipa | Malinga ndi malangizo, anthu odwala matenda ashuga akhoza kudziwa:
Kugwa kwamphamvu kwa shuga pambuyo poyambira insulini kungayambitse kuchepa kwa kanthawi kochepa kwa m'mitsempha, myalgia, masinthidwe, kutupa. Zotsatira zoyipa izi zidzazimiririka thupi likamalizidwa. Kuti mupewe izi, odwala omwe ali ndi matenda a shuga ophatikizika amathandizira kuchuluka kwa Tujo SoloStar bwino, kukwaniritsa kuchepa kwapang'onopang'ono kwa glycemia. |
| Mimba | Insulin ya Tujeo siyimayambitsa kusokonezeka kwa fetus; ngati kuli kotheka, ingagwiritsidwenso ntchito pathupi. Sichowona mkaka, chifukwa chake amayi amaloledwa kuyamwitsa mankhwala a insulin. |
| Gwiritsani ntchito ana | Pakadali pano, malangizo a Tujeo amaletsa kugwiritsa ntchito insulin iyi mwa ana omwe ali ndi matenda ashuga. Zikuyembekezeredwa kuti zotsatira za kafukufuku zikawoneka, izi zichotsedwa. |
| Tsiku lotha ntchito | Zaka 2.5 kuyambira tsiku lotulutsa, masabata 4 atatsegula cartridge, ngati malo osungirako akwaniritsidwa. |
| Zinthu zosungirako ndi zoyendera | Thukuta Tujeo SoloStar limasungidwa 2-8 ° C mufiriji, cholembera chogwiritsidwa ntchito chimakhala chamkati m'nyumba ngati kutentha mkati mwake sikupitirira 30 ° C. Insulin imataya katundu wake ukamayatsidwa ndi ma radiation a ultraviolet, kuzizira, kutentha kwambiri, motero imatetezedwa ndi zofukizira zapadera zamafuta pamayendedwe. |
| Mtengo | Phukusi lokhala ndi zolembera 3 za syringe (yonse 1350 mayunitsi) imakhala pafupifupi ma ruble 3200. Mtengo wa bokosi lomwe lili ndi maipi 5 (mayunitsi 2250) ndi ma ruble 5200. |
Zambiri zothandiza za Tujeo
Toujeo ndiye insulin yayitali kwambiri m'gulu lake. Pakadali pano, ndi apamwamba kuposa mankhwala a Tresib, okhudzana ndi ma insulin owonjezera. Tujeo pang'onopang'ono imalowetsa ziwiya kuchokera ku minofu yaying'ono ndipo mkati mwa maola 24 imapereka glycemia, pambuyo pake zotsatira zake zimayamba kufooka. Nthawi yogwira ntchito pafupifupi maola 36.
Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale
- Matenda a shuga -95%
- Kuthetsa kwa mitsempha thrombosis - 70%
- Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
- Kuthana ndi kuthamanga kwa magazi - 92%
- Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%
Monga ma inshuwiti ena, Tujeo sangathe kusintha kwathunthu kupanga kwachilengedwe kwa mahomoni. Komabe, mphamvu zake zimakhala pafupi kwambiri ndi zosowa za thupi. Mankhwala ali pafupifupi pang'onopang'ono pochita masana, omwe amathandizira kusankha kwamankhwala, amachepetsa kuchuluka ndi kuvutikira kwa hypoglycemia, ndipo amakwaniritsa bwino matenda osokoneza bongo okalamba.
Tujeo insulin imalimbikitsidwa makamaka kwa odwala omwe ali ndi Mlingo wambiri wa mankhwalawa. Kuchulukitsa kwa yankho komwe kumayambitsidwa ndi cholembera kumachepera pafupifupi katatu, chifukwa chake, kuwonongeka kwa minofu yam'mimba kumachepetsedwa, majekeseni amaloledwa mosavuta.
Kusiyana kwa Lantus
Wopanga adavumbulutsa zabwino zingapo za Tujeo SoloStar pa Lantus, chifukwa chake, popanda chiphuphu chokwanira cha matenda ashuga, adalimbikitsa kuti asinthane ndi mankhwala atsopano.
>> Werengani zambiri za Lantus insulin - werengani apa
Ubwino wa insulin Tujeo:
- Kuchuluka kwa yankho kumacheperachepera, motero, malo omwe mankhwalawo amakhudzana ndi mitsempha ya magazi amachepetsedwa, timadzi timalo timalowa m'magazi pang'onopang'ono.
- Nthawi yochitikirayi imaposa maola 24, yomwe imakupatsani mwayi wosunthira pang'ono jakisoni popanda kuvulaza thanzi.
- Mukasinthira ku Toujeo kuchokera ku insulin ina yoyambira, kufupika kwa hypoglycemia kumachepa. Zotsatira zabwino zimawonedwa mwa okalamba omwe ali ndi matenda amtundu wa 2 shuga, madontho awo a shuga achepa ndi 33%.
- Kusintha kwa glucose masana kumachepetsedwa.
- Mtengo wa insulin wa Tujeo molingana ndi 1 unit ndiyotsika pang'ono kuposa Lantus.
Ambiri mwa ndemanga za odwala matenda ashuga ndi abwino, kusankha kwa mankhwalawa posintha insulin ndikosavuta, sizitengera sabata limodzi. Odwala omwe amagwiritsa ntchito Tujeo molingana ndi malangizo amalankhula za iye ngati mankhwala apamwamba, osavuta kugwiritsa ntchito. Tujeo sasangalala ndi anthu odwala matenda ashuga omwe amakonda kugwiritsa ntchito singano ya cholembera kangapo. Chifukwa cha kuchuluka kwa ndende, nthawi zambiri imakhala yotseka, motero, imatha kubowola bowo singano.
Zomwe thupi limachita Toujeo ndimunthu payekha, monga insulin iliyonse. Odwala ena akukumana ndi kulephera kotenga mankhwalawa, kudumphadumpha, kuwonjezeka kwa kufunikira kwa insulin yayifupi, ndi kuwonjezeka kwa thupi, chifukwa akubwerera kugwiritsa ntchito Lantus.
Kusintha kuchokera ku Lantus kupita ku Tujeo
Ngakhale pali zigawo zomwezi, insulin ya Tujeo siili yofanana ndi Lantus. Malangizo ogwiritsira ntchito akuwonetsa kuti sungangopereka mankhwala ena ndi ena. Ndikofunikira kusankha mlingo watsopano komanso nthawi zonse glycemic control nthawi imeneyi.
Momwe mungasinthire kuchokera ku Lantus kupita ku Tujeo odwala matenda ashuga:
- Timasiya mlingo woyambirira wosasinthika, malingana ngati pali magulu ambiri a Tujeo monga momwe panali Lantus. Kuchuluka kwa yankho kumakhala kocheperako katatu.
- Osasintha jakisoni nthawi.
- Timayang'anira glycemia kwa masiku atatu, pomwe nthawi yomwe insulin imayamba kugwira ntchito mwamphamvu.
- Timayeza shuga osati pamimba yopanda kanthu, komanso tikatha kudya. Lantus amatha kukonza zolakwika pang'onopang'ono powerengera zakudya zamagulu azakudya. Tujeo SoloStar sakhululuka zolakwitsa, chifukwa chake, ndizotheka kuwonjezera mlingo wa insulin yochepa.
- Kutengera ndi zomwe zapezeka, timasintha mlingo. Nthawi zambiri zimafunika kuchuluka pang'ono (mpaka 20%).
- Chilango chilichonse chamtsogolo chiyenera kuchitika masiku osachepera atatu kuchokera pa chomaliza.
- Mlingo umawoneka kuti ndi wolondola ngati glucose pogona, m'mawa komanso m'mimba yopanda kanthu, amasungidwa chimodzimodzi.
Kuti mukhale otsimikiza za mlingo woperekedwa, muyenera kutsatira njira ya jakisoni. Pamaso pa jekeseni, muyenera kumasula insulin kuti muwone momwe cholembera chilili komanso momwe singano ilili.
