Langerin ndi imodzi mwazamankhwala ambiri omwe amagwiritsidwa ntchito pochiza matenda a matenda a shuga omwe samatengera insulin. Mankhwalawa ndi gawo la gulu la mankhwala a greatuanide, zomwe zimapangitsa kuti pakhale vuto lalikulu loti athandize kuti inshuwaransi ipangike.
Mtengo wa Langerin m'masitolo ogulitsa, kutengera mlingo womwe ungafunike, ukhoza kuchokera ku ruble zana limodzi mpaka mazana atatu.
Langerin ndi mankhwala apiritsi a pakamwa omwe amagwiritsidwa ntchito pochiritsira matenda a shuga. Gawo lake lalikulu ndi mankhwala a metformin. Mankhwalawa ndi amodzi mwa mankhwala ochepetsa shuga ndipo nthawi zambiri amagwiritsidwa ntchito kuti matenda ashuga azikhala ndi matenda ashuga.
Chimodzi mwazomwe mungafotokozere za mankhwalawa ndi kukhazikitsidwa kwake ngati mapiritsi omwe amagwiritsidwa ntchito kale kuchokera ku gulu la sulfonylurea. Kuphatikiza apo, kunenepa kwambiri ndi vuto lolumikizana kwa anthu onse omwe ali ndi matenda ashuga.
Chifukwa chake, Langerin samangoleketsa kuchuluka kwa shuga, komanso zimathandizira kuti wodwalayo achulukane.
Katundu wama mankhwala ndi zizindikiro zogwiritsira ntchito
Kupanga kwa gawo lalikulu la mankhwala kumalumikizidwa ndi mphamvu yake yoletsa njira za gluconeogeneis, komanso njira za kaphatikizidwe wamafuta acids amafuta ndi oxidation wamafuta. Oyimira kalasi ya biguanide sichikhudza kuchuluka kwa insulin yomwe imatulutsidwa m'magazi, koma amasintha ma pharmacodynamics awo mwa kuchepetsa kuchuluka kwa insulini kumasulidwa ndikuwonjezera kuchuluka kwa insulin kuti proinsulin.
Chofunikira pakuwoneka kwa mapiritsi oterewa ndi kukondoweza kwa glucose omwe amapezeka m'maselo a minofu.
Chizindikiro chachikulu chogwiritsira ntchito mankhwalawa ndikutukuka kwa matenda a shuga omwe amadalira insulin mwa munthu, makamaka ndi kusakwanira kwa zakudya zomwe amatsata.
Mankhwala enieni a Langerin ndi awa:
- amachepetsa kuchuluka kwa hemoglobinꓼ ya glycated
- zimalepheretsa insulin kukaniza maselo ku hormone insulinꓼ
- zimakhudza kutengera kwa mawonekedwe a lipid a plasmaꓼ
- amachepetsa cholesterolꓼ yoyipa
Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kumatha kulimbitsa thupi.
Malangizo ogwiritsira ntchito mapiritsi
Mankhwala Langerin amapezeka mu mawonekedwe a mapiritsi okhala ndi tulo.
Mapiritsiwo amadzaza ndi thumba la pulasitiki, lomwe limasindikizidwa ndi zojambulazo za aluminiyamu.
Mapaketi amaikidwa pabokosi la makatoni pamodzi ndi malangizo ogwiritsira ntchito mankhwalawa.
Kutengera mlingo womwe umagwiritsidwa ntchito ndi mankhwalawa, mankhwalawo atha kugulidwa ndi mlingo wa:
- Ma milligram 500.
- Ma milligram 850.
- Gramu imodzi yogwira ntchito.
Njira yothetsera mapiritsiwa imakhala pakumwa, panthawi yakudya kapena itatha. Dotoloyo akupereka mankhwala kwa wodwala aliyense payekha malinga ndi kuopsa kwa matendawa. Komanso, katswiri wazachipatala amazindikira kuchuluka kwa mankhwalawa tsiku lililonse masana.
Langerin-malangizo angagwiritsidwe ntchito amalimbikitsa kuyambitsa njira yochiritsira yochepetsera ndi osachepera 500 mg a yogwira ntchito. Kuchuluka kwa Mlingo wa mankhwalawa masana kungakhale kwa mmodzi kapena atatu. Pang'onopang'ono, mlingo ungathe kuwonjezeka mpaka 850 mg wa chinthu chogwira tsiku lonse (kamodzi kawiri pa tsiku). Dokotala wothandizirayo amawunikira wodwalayo ndipo osapitirira kamodzi pa sabata, amasintha mlingo wa mankhwalawo.
Mankhwalawa adapangidwanso kuti athandize odwala matendawa osaposa zaka khumi. Monotherapy iyenera kuyamba ndi mlingo wa 500 mg yogwira ntchito kamodzi kapena kawiri pa tsiku. Pakapita kanthawi, kuwonjezeka kwapang'onopang'ono kwa mlingo wa mankhwalawa amaloledwa, koma osaposa magalamu awiri patsiku, omwe amagawidwa pawiri kapena katatu.
Nthawi zambiri, kusintha kwa muyezo wa mankhwalawa kumachitika pakatha masiku khumi mpaka khumi ndi asanu potengera zotsatira za kuyezetsa magazi pamlingo wama glucose.
Nthawi zina, kuphika piritsi ndi gawo limodzi la mankhwala ophatikiza ndi jakisoni wa insulin.
Tisaiwale kuti kuphatikiza kwa munthawi yomweyo kwa Langerin ndi insulin, zotumphukira za sulfonylurea, acarbose, kapena ACE inhibitors kumawonjezera kuchuluka kwa mankhwalawa.
Nthawi zina, dokotala yemwe amapezekapo akhoza kusintha kugwiritsa ntchito Langerin ndi mapiritsi ofanana. Masiku ano, pali mitundu yambiri ya mankhwala, omwe amagwiritsidwa ntchito kwambiri ndi metformin.
Mtengo wa mankhwala a analog ukhoza kusiyana kwambiri, kutengera kampani yopanga mankhwala.
Kodi zotsutsana ndizogwiritsa ntchito chiyani?
Mlingo wosankhidwa molakwika kapena kusatsatira malangizo a dokotala kungakupangitseni kuoneka ngati musanamwe mankhwala.
Kuphatikiza apo, pali zochitika zina komwe kugwiritsa ntchito mankhwala ozungulira metformin ndikoletsedwa.
Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa mndandanda wazotsatira zazikulu.
Milandu yayikulu pakugwiritsa ntchito mapiritsi a Langerin ndi awa:
- kuwonongeka kwakukulu kwa chiwindi kapena impso, kusakwanira kwawo
- uchidakwa, kuphatikiza pamakhalidwe oyipaꓼ
- mtima kapena kupuma kwamphamvuꓼ
- pachimake myocardial infarctionꓼ
- Mkhalidwe wodwala matenda ashuga kapena kholo
- chitukuko cha matenda ashuga phaziꓼ
- pamaso pa tsankho la munthu ndi metformin komanso kusintha kwa zinthu zina zosagwirizana ndi gawoꓼ
- kukhalapo kwa matenda opatsirana infectious
- kusala ndi matenda ashuga kapena kutsatira zakudya zomwe zakudya zake za tsiku ndi tsiku siziposa kilocalories chikwi
- Opaleshoni isanachitike komanso itachitika
- ndimavulala azambiri recent
- isanachitike komanso itatha diagnostic omwe amagwiritsa ntchito radioot isotropes ya iodineꓼ
- ketoacidosis ndi lactic acidosis.
Kuphatikiza apo, azimayi sayenera kumwa mankhwalawa panthawi yoyembekezera komanso mkaka wa m'mawere.
Kupezeka kwa zoyipa kumatha kudziwonekera mwa mbali zosiyanasiyana za thupi ndi machitidwe a thupi - matumbo am'mimba, kagayidwe kazinthu, mtima dongosolo, khungu. Zoyipa zazikulu zomwe zimachitika chifukwa chomwa mankhwalawa ndi:
- Kukweza mwachangu. Nthawi zina mseru umapezeka mu mtundu 2 shuga. Khansa ya m'magazi ikhoza kulowa m'malo mwa kusanza.
- Mtundu wopweteka wam'mimba.
- Maonekedwe akununkhira wachitsulo pamkamwa wamkamwa.
- Hematopoiesis ndi heestasis.
- Megaloblastic anemia.
- Kutsitsa shuga m'magazi pansi pazovomerezeka - hypoglycemia.
- Maonekedwe ofooka m'thupi.
- Kugona.
- Hypotension.
- Matenda opatsirana.
- Maonekedwe a dermatitis kapena totupa pakhungu.
Chenjezo liyenera kumwedwa mukamamwa Langerin ndi mankhwala ena. Kugwiritsa ntchito pamodzi mapiritsi ndi cymeditine kumawonjezera chiopsezo cha lactic acidosis. Kuphatikizika kwa Langerin ndi ma loopture otentha kumatha kukhala ndi zotsatira zomwezo. Pankhaniyi, kuwonjezera pakuwonetsedwa kwa lactic acidosis, chiwonetsero cha kulephera kwa impso chitha kuonedwa.
Kugwiritsa ntchito mankhwalawa, ndikofunikira kuyang'anira momwe impso zimayendera ndikuwona kuchuluka kwa lactate mu plasma osachepera kawiri pachaka.
Zambiri zokhudzana ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga zimaperekedwa mu kanema munkhaniyi.
