Victoza ndi analogue wa glucagon-peptide. Izi zimafanana ndi GLP yaumunthu. Mankhwalawa amakhumudwitsa kaphatikizidwe ka insulin ndi ma cell apadera ngati ma glucose ayamba kupitirira muyeso wamba. Mankhwalawa amagwiritsidwa ntchito ndi anthu odwala matenda ashuga komanso odwala omwe akufuna kuchotsa mapaundi owonjezera.
Dzinalo Losayenerana
Liraglutide
ATX
A10BX07
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka mu mawonekedwe a yankho, omwe amawapangira pakhungu ndikuyikidwa syringe yapadera ya 3 ml.
1 cholembera cha syringe chili ndi 18 mg yogwira mankhwala (liraglutide).
Zowonjezera:
- sodium hydrogen phosphate dihydrate;
- hydrochloric acid;
- phenol;
- digoxin;
- propylene glycol;
- madzi a jakisoni.
Mankhwala Viktoza amapezeka mu mawonekedwe a yankho lomwe limayikidwa mu syringe ya metered.
Zotsatira za pharmacological
Chithandizo chophatikizika cha mankhwalawa chimayambitsa kapangidwe ka insulin ndi kapamba. Kuphatikiza apo, amachepetsa kupanga glucagon. Izi zimakuthandizani kuti muchepetse shuga yanu popewa hypoglycemia. Mankhwalawa amathandizira kuchepetsa kulakalaka, amachepetsa kusintha kwa zakudya zomwe zatha m'matumbo kuchokera m'mimba.
Kuyesedwa kwa zamankhwala kwatsimikizira kutha kwa mankhwalawa pakuchepetsa thupi. Ichi ndichifukwa choletsa kwamatumbo kutulutsa.
Mankhwala a Victoza amatha kuchepetsa shuga m'magazi.
Pharmacokinetics
The pazipita kuchuluka kwa yogwira plasma zimatheka maola 8-12 pambuyo ntchito mankhwala. Lysinopril imapukusidwa pambuyo pake.
Izi zimachitika pang'onopang'ono, motero mankhwalawa amadziwika ndi kuwonekera kwa nthawi yayitali.
Zizindikiro zogwiritsidwa ntchito
Nthawi zambiri, mankhwalawa amaperekedwa kwa odwala omwe ali ndi mtundu II matenda a shuga. Zochita zake ndizothandiza kwambiri kuphatikiza masewera olimbitsa thupi komanso kudya kwapadera. Pali malo atatu omwe makhazikitsidwe omwe mankhwalawa amalembedwa:
- Monotherapy. Mankhwalawa ndi okhawo omwe amagwiritsidwa ntchito kuti apititse patsogolo odwala omwe ali ndi mtundu wachiwiri wa shuga komanso kuti azitha kulimbitsa thupi ngati atalephera kudya kagayidwe kazakudya chifukwa chamadya.
- Mankhwala osakanikirana ndi othandizira a hypoglycemic (urea sulfinyl derivatives ndi metformin). Njira yochiritsira iyi ndi othandiza pakanachitika mankhwala omwe amakhalanso amtundu wa mankhwalawa sizinachitike.
- Kuphatikiza chithandizo ndi basal insulin mwa odwala omwe sanathandize mitundu yina yamankhwala.
Victoza amadziwika kwambiri ndi matenda ashuga amtundu II.
Contraindication
Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa zoletsa izi:
- kuwonongeka koyipa kwa chithokomiro;
- mtundu 1 matenda a shuga;
- munthu tsankho kwa mankhwala zikuchokera mankhwala;
- kwambiri / pachimake hepatic / aimpso kulephera;
- kulephera kwa mtima.
Ndi chisamaliro
Mankhwala amalembedwa mosamala:
- ndi mkaka wa m'mawere ndi pakati;
- ndi matenda a chithokomiro;
- Pamaso pa pancreatitis pachimake;
- ndi kutupa kwa mucosa wam'mimba;
- ndi matenda a shuga a gastroparesis;
- ali aang'ono;
- ndi matenda ashuga ketoacidosis.
Mankhwala Victoza ndi mankhwala mosamala pamaso pa kutupa kwa mucous m'mimba.
Momwe mungatenge Victoza
Mankhwalawa amapaka pakhungu pakhungu pamapewa, phewa kapena ntchafu pogwiritsa ntchito cholembera chapadera. Jekeseni wa mankhwalawa samamangidwa pakudya ndipo amapangidwa nthawi 1 patsiku nthawi yomweyo. Komabe, akatswiri amalimbikitsa kuchita izi pamankhwala opanda kanthu. Pankhaniyi, singano zapadera za Novo-Twist kapena NovoFayn zimagwiritsidwa ntchito, zomwe zimayenera kutayidwa ukatha kugwiritsa ntchito.
Chimodzi mwazomwe mungagwiritse ntchito Victoza ndi kuyambitsa syringe pansi pa khungu pamimba.
Ndi matenda ashuga
Therapy iyenera kuyamba ndi mlingo wa 0,6 mg. Iyenera kukula mpaka 1.8 mg patsiku. Izi zimachitika mkati mwa masabata 1-2.
Kugwiritsa ntchito mankhwalawa sikukutanthauza kuti kuthetseratu kwa mankhwala ochepetsa shuga.
Kuchepetsa thupi
Kuchepetsa thupi, mankhwalawa amagwiritsidwa ntchito pafupifupi mulingo womwewo. Pokhapokha pakuchitika zinthu zabwino, mlingo umasinthidwa kupita kumwamba ndi dokotala.
Zotsatira zoyipa
Mukamagwiritsa ntchito mankhwalawa, zotsatira zoyipa zitha kuonedwa. Zikaonekera, muyenera kufunsa dokotala.
Matumbo
Zowonekera:
- kutsegula m'mimba
- nseru
- gastritis;
- kuchuluka kwa mpweya;
- kusanza
- malamba;
- kutentha kwa mtima.
Kutentha kwa mtima ndi chimodzi mwazotsatira za mankhwala a Victoza.
Hematopoietic ziwalo
Zowonekera:
- leukocytopenia;
- kuchepa magazi
- thrombocytopenia;
- hemolytic mawonekedwe a magazi m'thupi.
Pakati mantha dongosolo
Odwala amatha kudandaula:
- pamutu;
- pa chizungulire (kawirikawiri).
Kupweteka m'mutu kumatha chifukwa cha mankhwala a Viktoza ochokera ku ubongo wamkati.
Kuchokera kwamikodzo
Otsatirawa akuti:
- impso zolakwika;
- kuchuluka kwa aimpso kulephera.
Pa khungu
Zitha kuchitika:
- Khungu;
- zotupa.
Kuchokera ku genitourinary system
Kuwonekera:
- utachepa libido;
- kusabala.
Kuchokera pamtima
Otsatirawa akuti:
- tachycardia (kawirikawiri);
- kugunda kwa mtima.
Tachycardia ndi zovuta zina zomwe zimachitika mukamagwiritsa ntchito mankhwala a Victoza.
Dongosolo la Endocrine
Zowonekera:
- kuchuluka kwa calcitonin;
- Goiter;
- matenda a chithokomiro.
Pa mbali ya chiwindi ndi biliary thirakiti
Kuchulukitsa kwa chiwindi kulephera kungakhale kovuta.
Matupi omaliza
Zotsatira zoyipa zimachitika:
- Edema ya Quincke (kawirikawiri);
- Kutupa pa malo a jakisoni;
- kuvutika kupuma.
Kupuma movutikira ndi njira imodzi yomwe singagwiritsire ntchito mankhwala a Viktoza.
Malangizo apadera
Pamaso pa vuto la mtima (kalasi yoyamba kapena II), ntchito yolimbitsa thupi yaimpso komanso ukalamba, gwiritsani ntchito mankhwalawa mosamala momwe mungathere.
Ndi zizindikiro za kapamba, mankhwalawa ayenera kusiyidwa.
Kuyenderana ndi mowa
Ngakhale kuti kulibe malangizo aliwonse a mankhwalawa okhudzana ndi kumwa kwake, simuyenera kumwa mowa. Ethanol imawonjezera mwayi wokhala ndi kapamba ndi hypoglycemia.
Zokhudza mphamvu pakuwongolera njira
Odwala omwe amagwiritsa ntchito mankhwalawa ayenera kuchenjezedwa za hypoglycemia. Chifukwa chake, mukamagwira ntchito ndi zovuta kupanga ndi kuyendetsa, muyenera kuyang'anira momwe mulili.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Ndi mkaka wa m'mawere ndi kugwiritsa ntchito mankhwalawa, kuyamwitsa kuyenera kuyimitsidwa. Pa nthawi yoyembekezera, mankhwalawa amaletsedwa kugwiritsa ntchito.
Kusankhidwa kwa Victoza kwa ana
Ndi zoletsedwa kugwiritsa ntchito mankhwalawa kwa ana osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Odwala opitirira zaka 75 azigwiritsa ntchito mankhwala mosamala kwambiri komanso moyang'aniridwa ndi dokotala.
The ntchito aimpso kuwonongeka
Sizoletsedwa kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi vuto lalikulu laimpso.
Ndi zoletsedwa kugwiritsa ntchito mankhwala a Victoza mu kulephera kwambiri kwaimpso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi kulephera kwa chiwindi (zolimbitsa), mphamvu ya mankhwalawa imachepetsedwa ndi 15-30%. Muzovuta kwambiri, kugwiritsa ntchito koletsedwa.
Bongo
Nkhani imodzi yokha ya mankhwala osokoneza bongo omwe adalembedwa. Kuchuluka kwake kunali kochulukirapo maulendo 40 kuposa zomwe zinali zovomerezeka. Zotsatira zake, wodwalayo anali kusanza ndi mseru.
Ngati zizindikiro zotere zikuwoneka, ndikofunikira kugwiritsa ntchito mankhwala othandizira ndikutsatira malangizo a dokotala.
Kuchita ndi mankhwala ena
Pa mayesero azachipatala, zidapezeka kuti zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimatha kuthana ndi mankhwala ena.
Kuphatikiza kophatikizidwa
Sizoletsedwa kuphatikiza jakisoni wa mankhwalawa ndi zinthu zomwe zingapangitse kuwonongeka kwa gawo lake.
Osavomerezeka kuphatikiza
Popeza kusowa kwa chidziwitso chachipatala pakugwirizana kwa mankhwalawa ndi Insulin ndi mankhwala omwe ali ndi zotumphukira za coumarin, ayenera kuphatikizidwa mosamala kwambiri.
Palibe zambiri zachipatala pazomwe zimagwirizana ndi mankhwala Victoza ndi Insulin.
Kuphatikiza komwe kumafunikira kusamala
Akaphatikizidwa ndi warfarin ndi zotumphukira za sulfonylurea, wodwala amafunikira kuyang'anira kwa INR. Kuphatikiza apo, mankhwalawa amayenera kuphatikizidwa mosamala ndi Griseofulvin, Atorvastin, Paracetamol ndi insulin.
Analogi
Maphatikizidwe a mankhwala opezeka:
- Jardins (mapiritsi);
- Atorvastatin (makapisozi);
- Thiazolidinedione (makapisozi);
- Attokana (mapiritsi);
- Baeta (yankho la jakisoni);
- Digoxin (yankho la jakisoni);
- Trulicity (jakisoni njira), ndi zina.
Kupita kwina mankhwala
Mankhwala amangotulutsidwa ndi mankhwala okha.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala sangathe kugulidwa popanda kulandira mankhwala.
Ndalama zingati Viktoza
Mtengo wa mankhwala umayambira ku rubles 8,8,000 kwa paketi imodzi ya zolembera ziwiri za syringe.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kusunga mankhwalawo mufiriji pa kutentha kwa + 2 ... + 8 ° C.
Tsiku lotha ntchito
Moyo wa alumali wa cholembera wotseguka sapitirira mwezi umodzi.
Wopanga
Kampani yamankhwala "NOVO NORDISK A / S" (Denmark).
Ndemanga za Victoza
Za mankhwalawa, nthawi zambiri amayankha bwino. Ndemanga zoyipa zimagwirizanitsidwa ndi mtengo wokwera wa mankhwalawo komanso kugwiritsa ntchito kosayenera.
Madokotala
Albert Gorbunkov (endocrinologist), wazaka 50, Mines
Mankhwala abwino omwe amasintha msanga shuga. Ndimakonda njira yosavuta kugwiritsa ntchito. Ndikokwanira kuti wodwalayo awonetse kamodzi, pambuyo pake amadzibaya.
Victoria Shlykova (wochiritsa), wazaka 45, Novorossiysk
Ndikulemba mankhwala a shuga komanso kuwonda. Chida chabwino kwambiri, chimatsimikizira kufunika kwake.
Odwala
Albina Alpatova, wazaka 47, Moscow
Matenda a shuga anali mavuto ambiri. Komabe, adotolo atamulembera mankhwalawa, zonse zidasintha. Kuchokera "zovuta" zomwe ndimakumana nazo ndimutu wokha.
Semen Boshkov, wazaka 50, St. Petersburg
Ndili ndi shuga. Kuti athetse vutoli, adotolo adalimbikitsa kugwiritsa ntchito jakisoni wa Victoza. Ndinkakonda mankhwala aku Danish, ndidazindikira zabwino nthawi yomweyo, mankhwalawo adathetsa vutoli. Zimangovutitsa kuti sizotsika mtengo kwambiri, koma mtengo wokwera ndi wolungamitsidwa.
