Amoxiclav ndi mankhwala ophatikiza ndi gulu la penicillin otetezedwa. Mbali yake ndi kukana beta-lactamase (enzyme) yama virus, yomwe imatsimikizira kukana kwa mabakiteriya osokoneza bongo. Kupanga mankhwalawa kumachitika ndi kampani yaku Britain yopanga mankhwala ku Glaxosmithklein Trading.
Dzinalo
Dzina lachi Russia la mankhwalawa ndi Amoxiclav, Latin - Amoksiklav.
Ath
Khodi yamankhwala mu gulu la ATX (anatomical-Therapeutic-chemical) ndi J01CR02.
Amoxiclav ndi mankhwala ophatikiza ndi gulu la penicillin otetezedwa.
Kutulutsa mafomu ndi kapangidwe kake
Amoxiclav 400 mg amagulitsidwa mu mawonekedwe a ufa, omwe amawumitsidwa kuti apeze kuyimitsidwa. The ufa ndi loyera kapena pang'ono chikasu. The yogwira mankhwala (amoxicillin) lilipo mu mawonekedwe a trihydrate. Kuchuluka kwa potaziyamu beta-lactamase inhibitor ndi 57 mg. Pamodzi ndi antibacterial wothandizila, kapangidwe kake ka ufa kamaphatikizira chingamu, sodium benzoate, citric acid, mannitol, flavorings, silicon dioxide ndi zinthu zina. Ufa umayikidwa m'mabotolo (ndi pipette) ndi mapaketi a makatoni.
Zotsatira za pharmacological
Kuphatikiza kwa clavulanic acid ndi amoxicillin kumapezeka m'mankhwala ochepa okha. Izi zimapereka mawonekedwe osiyanasiyana a antibacterial. Mankhwala ali ndi bacteriostatic (amalepheretsa kukula ndi kubereka kwa mabakiteriya achilengedwe) ndi bactericidal (yowononga ma virus). Amoxicillin, yomwe ndi gawo la mankhwalawa, amasokoneza kapangidwe ka khoma la bakiteriya.
Mankhwalawa amawononga matumbo komanso hemophilic bacilli.
Maantibayotiki amasokoneza staphylococci, streptococci, listeria, enterococci, campylobacter, matumbo ndi hemophilic bacilli, gardnerell, Helicobacter pylori, Proteus, cholera vibrio, Salmonella, Shigella ndi mabakiteriya ena. Clostridia, fusobacteria ndi bacteroids nawonso amamvera mankhwala.
Pharmacokinetics
Zigawo zikuluzikulu za ufa zimatengedwa mwachangu m'mimba. Zambiri zomwe zili m'magazi zimawonedwa ola limodzi mutatha kumwa mankhwalawa. The achire zotsatira za mankhwala popanda payokha chakudya. Wogulitsa mankhwalawa amagawidwa m'matumbo ambiri (chiwindi, ziwalo zamkati, m'mapapu, minofu, chikhodzodzo, ndulu) komanso zamadzimadzi zam'madzi (articular, pleural, intraperitoneal, komanso malovu).
Amoxicillin ndi clavulanate satengedwa kupita ku ubongo, koma kulowa mkatikati mwa chotchinga cha hematoplacental, komwe ndikofunikira pakukonzekera kwa amayi apakati.
Mbali ina ya mankhwalawa ndi mwayi wolowera mkaka wa m'mawere. Amoxicillin kagayidwe amapezeka mbali, pomwe clavulanic acid amawola kwathunthu. Mankhwalawa amachotseredwa ndi impso limodzi ndi mkodzo pokonzanso magazi.
Zizindikiro zogwiritsidwa ntchito
Amoxiclav 400 adalembedwa zotsatirazi matenda:
- Matenda a ziwalo za ENT ndi kupuma kwapadera (otitis media, kuwonongeka kwa ma sinuses, pharyngeal abscess, kutupa kwa tulu, larynx ndi pharynx).
- Kutupa kwa mapapu ndi bronchi.
- Matenda opatsirana a genitourinary ziwalo (urethritis, cystitis, kutupa kwa impso, endometritis, kuwonongeka kwa ziwalo za uterine, vulvovaginitis).
- Matenda a mafupa (osteomyelitis) ndi minofu yolumikizana.
- Kutupa kwa ndulu ndi ndulu zikuluzikulu.
- Kulumwa nyama.
- Matenda a pakhungu (pyoderma).
- Matenda a Odontogenic kumbuyo kwa kuwonongeka kwa mano.
Mankhwalawa amagwiritsidwa ntchito kwambiri mu obstetrics ndi gynecology.
Contraindication
Mankhwala sayenera kumwedwa ndi:
- Hypersensitivity (tsankho) mankhwala;
- kukhalapo kwa thupi lawo siligwirizana ndi mankhwala a beta-lactam;
- kuwonongeka kwa ziwalo za hemopoietic (lymphocytic leukemia);
- mononucleosis;
- kukanika kwa chiwindi;
- cholestatic mawonekedwe a jaundice.
Ndi chisamaliro
Chenjezo liyenera kugwiritsidwa ntchito pakugwiritsa ntchito Amoxiclav ngati pali colitis, vuto laimpso, komanso kulephera kwambiri kwa chiwindi. Mosamala, mankhwala opha mabakiteriya amapatsidwa kuti azimangira akazi.
Momwe mungatenge Amoxiclav 400
Mukamapereka mankhwala othandizira kuti alandire, mawonekedwe azaka za odwala ndi omwe ali ndi vutoli amatengedwa.
Akuluakulu
Mlingo wa akulu ndi 25-45 mg / kg. Mlingo wa mankhwalawa ukhoza kufika 2,085 mg. Phukusili lili ndi supuni yoyesera 5 ml kapena pipette yomaliza. Mlingo wambiri (wa amoxicillin) ndi 6 g. Mankhwalawa amatengedwa kawiri patsiku ndi zakudya.
Mlingo wa ana
Kwa ana kuyambira miyezi itatu mpaka chaka masekeli 5 mpaka 10, mankhwalawa ndi mankhwala a ¼ kapena ½ pipette, kutengera kuopsa kwa matendawa kawiri pa tsiku. Kwa ana a zaka zapakati pa 1-2 ndi thupi lolemera makilogalamu khumi, mulingo woyenera umachokera ku ½ mpaka ¾ ma papa. Ana omwe ali ndi zaka 2-3 ndi kulemera kwa 15-16 makilogalamu amawayikira kuchokera ku ¾ mpaka 1 unit. 2 pa tsiku. Chizindikiro chachikulu chowerengera si m'badwo, koma kulemera kwa mwana.
Chizindikiro chowerengedwa chachikulu cha kuchuluka kwa mankhwalawa si m'badwo, koma kulemera kwa mwana.
Kumwa mankhwala a shuga
Amoxiclav odwala matenda ashuga ayenera kumwa monga mapiritsi a 500 mg kawiri tsiku lililonse maola 12 aliwonse. The ufa suyenera kuchitira odwala omwe ali ndi matenda ashuga.
Zotsatira zoyipa
Zotsatira zoyipa ndizochepa, ndipo ndizofatsa.
Matumbo
Mukamamwa mankhwalawa, zizindikiro za kuwonongeka kwa kugaya kwam'mimba (mseru, kusowa kwa chakudya, mapando otayirira, kupweteka pamimba, kusanza) ndizotheka. M'mavuto akulu, pali:
- Jaundice Imachitika chifukwa cha kusayenda kwa ndulu.
- Hepatitis.
- Pseudomembranous colitis.
- Kuchuluka kwa chiwindi michere (ALT ndi AST).
Hematopoietic ziwalo
Mukamathandizidwa ndi Amoxiclav 400, kusintha koyezetsa magazi nthawi zina kumawonedwa (kuchepa kwa maselo ofiira amwazi, hemoglobin, maselo othandiza magazi kuundana ndi magazi. Mitundu yambiri ya eosinophils. Pancytopenia nthawi zina amapezeka (osakwanira kupanga maselo amwazi onse).
Pakati mantha dongosolo
Zotsatira zoyipa zaubongo zimaphatikizapo: kupweteka mutu, chizungulire, kukokana, kuda nkhawa, kugona tulo, ndikuwonjezera kukwiya.
Kuchokera kwamikodzo
Odwala ena amatenga nephritis (kutupa kwa impso). Mchere wambiri ungawonekere mkodzo.
Matupi omaliza
Mukamagwiritsa ntchito Amoxiclav, zimachitika zovuta zamkati (khungu redness, zotupa za papular zamtundu wa urticaria, pruritus, angioedema, dermatitis, kugwedezeka ndi matenda a Stevens-Johnson).
Mukamagwiritsa ntchito Amoxiclav, zimachitika zovuta zamkati (khungu redness, zotupa za papular zamtundu wa urticaria, kuyabwa, ndi zina).
Malangizo apadera
Mukamagwiritsa ntchito Amoxiclav 400, zotsatirazi ziyenera kutsatiridwa:
- sinthani mulingo wa kukanika kwa impso;
- kuwunika momwe chiwindi, impso ndi magazi amapanga ziwalo kudzera mwa mayeso a labotale;
- tengani kuyimitsidwa pokhapokha ndi zakudya kuti musawononge dongosolo la chimbudzi.
Kuyenderana ndi mowa
Kugwiritsa ntchito zakumwa zoledzeretsa pamankhwala a Amoxiclav kumatsutsana.
Zokhudza mphamvu pakuwongolera njira
Palibe chidziwitso chokhudza zovuta za mankhwalawa pakutha kuyendetsa galimoto ndikugwiritsa ntchito zida.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Munthawi ya kubereka ndi kudyetsa mwana, maantibayotiki amaikidwa mosamala komanso molingana ndi mawonekedwe okhwima.
Bongo
Zizindikiro za bongo za Amoxiclav 400 ndi:
- kupweteka kwam'mimba
- nseru
- kusanza
- kumverera kwa nkhawa;
- kukokana.
Choyambitsa kuledzera ndikuphwanya njira. Chithandizo chimaphatikizapo kupindika kwammimba (osadutsa maola 4 mutatha kumwa mankhwalawa), kugwiritsa ntchito sorbent (mpweya wodziyimira, kaboni wa smecta kapena Polysorb). Mankhwala othandizira amawonetsedwa (antiemetics, painkiller). Ngati ndi kotheka, magazi amayeretsedwa kuchokera ku mankhwalawa ndi hemodialysis.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito pamodzi kwa Amoxiclav 400 ndi ma antacid, glucosamine-based chondroprotectors, aminoglycosides, pakamwa kulera, methotrexate, allopurinol, disulfiram, anticoagulants, macrolides, mankhwala ochokera ku gulu la tetracycline ndi sulfonamides osavomerezeka. Imachepetsa ndende ya Amoxiclav Probenecid.
Kuwonjezeka kwa kuchuluka kwa amoxiclav m'magazi kumalimbikitsidwa ndi:
- okodzetsa;
- NSAIDs;
- Phenylbutazone
Analogi
Ma Amoxiclav 400 ma analogi ndi Amoxiclav Quiktab ndi Augmentin (yankho la jakisoni atha kukonzekera kuchokera pamenepo).
Analogue ya Amoxiclav 400 ndi Augmentin.
Kupita kwina mankhwala
Ngati zakudya zowonjezera zambiri komanso zodzikongoletsera zimaperekedwa momasuka ku mafakitala, ndiye kuti Amoxiclav amagulitsidwa kokha ndi mankhwala a dokotala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwalawa amaletsedwa kupita kukapikisana nawo. Kuphwanya malamulo kumabweretsa udindo kwa wogulitsa mankhwala.
Mtengo wa Amoxiclav 400
Mtengo wochepetsetsa wa mankhwala osokoneza bongo ndi ma ruble 111. Mtengo ukhoza kusiyana ndi omwe amapereka ndi opanga osiyanasiyana.
Zosungidwa zamankhwala
Amoxiclav iyenera kusungidwa pa kutentha osaposa 25ºC, komanso kutetezedwa ku chinyezi ndi ana.
Tsiku lotha ntchito
Ufa umasungidwa kwa zaka ziwiri kuyambira tsiku lakonzekera. Kuyimitsidwa kotere ndi koyenera kwa sabata ngati kwasungidwa mufiriji kutentha kwa + 2 ... + 8ºC mu botolo lotsekedwa.
Ndemanga za Amoxiclav 400
Ndemanga za akatswiri ndi anthu omwe adagwiritsa ntchito mankhwalawa ndizabwino kwambiri.
Madokotala
Yuri, wazaka 47, Kostroma: "Nthawi zambiri ndimapereka Amoxiclav kwa odwala anga omwe ali ndi matenda otupa a ziwalo zoberekera zachikazi. Chithandizo chake chimagwira kwambiri mukamatsatira malamulo a ukhondo wachikazi."
Valery, wazaka 32, Vorkuta: "Amoxiclav ndiyabwino ku matenda a ziwalo za ENT, kuphatikizapo khutu lapakati. Mankhwalawa ndiokwera mtengo ndipo samapereka zotsatira zoyipa."
Odwala
Alena, wazaka 28, ku Moscow: "Mwana wazaka 4 wapezeka posachedwapa ndi matenda opha ziwonetsero. Amathandizira 400 ndi Amoxiclav mu mawonekedwe a ufa. Njira yabwino kwambiri."
