Mankhwala Combilipen akuimira gulu la mankhwala ophatikiza, omwe amakulitsa kukula kwake. Ili ndi zigawo zingapo zogwira ntchito, chifukwa zomwe zizindikiro zosiyanasiyana zimachotsedwa nthawi yomweyo. Mankhwala amamulembera matenda amitsempha. Amapezeka mumitundu yosiyanasiyana. Mtengo wa mankhwalawo ndi wocheperako.
ATX
A11DB (kuphatikiza mavitamini B1, B6 ndi / kapena B12).
Mankhwala Combilipen ndi gulu la mankhwala ophatikiza pamodzi.
N07XX (mankhwala ochizira matenda amanjenje).
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa mwa njira yothetsera jakisoni. Phukusi limatha kukhala ndi ma 5 kapena 10 ampoules (2 ml iliyonse). Njira ina ndi mankhwala a piritsi. Samasiyana pakapangidwe. Phukusi la Combilipen TABS limakhala ndi miyala 30 kapena 60. Zophatikizira zazikulu pazomwe zimapangidwira:
- thiamine hydrochloride (kuchuluka kwa 100 mg);
- pyridoxine hydrochloride - 100 mg;
- cyanocobalamin - 1 mg;
- lidocaine wa - 20 mg.
Zida zazing'ono: sodium tripolyphosphate, potaziyamu hexacyanoferrate, mowa wa benzyl, madzi oyeretsedwa, sodium hydroxide.
Mankhwalawa amapangidwa mwa njira yothetsera jakisoni ndi mapiritsi.
Njira yamachitidwe
Izi ndi zovuta multivitamin, muli mavitamini a gulu B la chikhalidwe cha neurotropic. Chifukwa cha Kombilipen, kukula kwa zotupa, njira zoyipa zomwe zimakhudza mitsempha ndi minyewa ya mafupa zimayimitsidwa. Mankhwala amakhudzidwa ndi mankhwalawa amatchulidwa ndi machitidwe a gulu la mavitamini.
Mankhwalawa amakhudza njira zosiyanasiyana zamankhwala osiyanasiyana. Mwachitsanzo, vitamini B1 amalimbikitsa kupendekeka kwa minyewa yam'mitsempha kumakokedwe omwe amaperekedwa ku thupi la khungu. Zotsatira zake, magwiridwe antchito omwe akhudzidwa abwezeretsedwa, zizindikirizo zimachotsedwa mwachangu. Pogwira vitamini B6, njira ya metabolic (mapuloteni, mafuta, chakudya) imakhala yofanana. Chifukwa cha gawo ili, ntchito ya hematopoiesis, dongosolo lamanjenje lamkati ndi zotumphukira zimathandizidwa.
Kuphatikiza apo, vitamini B6 imalepheretsa dongosolo lamkati lamanjenje: kayendedwe kazinthu zomwe zimakhala m'maselo a mitsempha. Ichi chimakhudzidwa ndi kapangidwe ka ketocholamines.
Vitamini B12 ndi gawo lofunikira mu hematopoiesis. Popanda iyo, mapangidwe a ma nucleotide amasokonezeka. Vitamini iyi imapangitsa kukula kwachilengedwe kwa maselo a epithelial. Ndi chithandizo chake, zinthu zingapo zimayamwa bwino.
Lidocaine ndiwothandiza kuthetsa zizindikiro zosasangalatsa. Zimathandizira kuchepetsa kukula kwa ululu, ndi mankhwala oletsa kupweteka. Mothandizidwa ndi lidocaine, zinthu zopindulitsa zimamwa bwino. Mukamaliza jakisoni wa Kombilipen, njira yopangira zolakwika m'mapeto amitsempha imatsekedwa ndipo ululuwo umaleka.
Pharmacokinetics
Zinthu zosiyanasiyana zomwe zimapangidwa zimapangidwira pamitengo yosiyanasiyana. Mwachitsanzo, thiamine kuchokera ku minofu yofewa imalowa m'magazi 15 patadutsa jakisoni. Mlingo wa kuchotserera umatengera gawo la kagayidwe. Gawo lomaliza, zimatenga pafupifupi masiku awiri. Kwa thiamine, placenta sichinthu chotchinga chachikulu, chinthucho chimadutsa mosavuta, chimadutsa mkaka wa m'mawere. Mukuchita izi, ma metabolites angapo akuluakulu amasulidwa.
Kuyamwa kwa Pyridoxine kumathamanga kwambiri. Thupi limagwirizanitsa ndi mapuloteni amwazi. Vitamini amagawika thupi lonse. Imadziunjikira m'chiwindi, komwe makutidwe ndi okosijeni ake amapezeka. Katunduyo amachotseredwa patatha maola angapo atayamwa. Kwa pyridoxine, placenta sichingalepheretse, chinthucho chimagonjetsa chotchinga mosavuta. Pulogalamuyi imadutsanso mkaka wa m'mawere.
The pazipita kuchuluka kwa cyanocobalamin zimatheka 1 ora pambuyo jekeseni. The bioavailability wa thunthu ndi wapamwamba. Cyanocobalamin imamangiriza mapuloteni amwazi ochuluka kuchuluka kwa 90%. Kupanga ma metabolism kumachitika m'chiwindi. Kuchotsa chinthu kumaperekedwa kudzera mu impso ndi matumbo. Komanso, ndi kulephera kwa aimpso, m'matumbo mumagwira ntchito yayikulu.
Lidocaine amathanso kuthana ndi zotchinga, kulowa mkaka wa m'mawere.
Pambuyo pa jekeseni, lidocaine wa zinthu mwachangu. Pambuyo pa mphindi 5 mpaka 15, zotulukapo zikuwoneka: kupweteka kumacheperache, mkhalidwe wa wodwalayo ukupita bwino. Lidocaine amamangilira ku mapuloteni a plasma ambiri 60-80%. Izi zimathandizanso kuthana ndi zotchinga, kulowa mkaka wa m'mawere. Monga momwe zinalankhulidwapo m'mbuyomu, kagayidwe kazomwe kamachitika m'chiwindi. Ndi kusachita bwino kwa chiwalochi, kuchuluka kwa kusintha kwa lidocaine kumachepa.
Kodi limayikidwa kuti?
Mankhwala amapereka zotsatira zabwino zotsatirazi matenda:
- kuwonongeka kwamitsempha yama nkhope ndi nkhope;
- zinthu zopweteka (dorsalgia, makamaka, ndi osteochondrosis, hernia ya msana);
- lumbar ischialgia;
- kuchuluka;
- polyneuropathy;
- zotupa za mitsempha yotsalira ya etiology iliyonse: matenda a msana, neuralgia ya mkati, etc.
Contraindication
Pali zolephera zingapo:
- zochita za munthu pazogwira mankhwala;
- Kwa ana ochepera zaka 18, mankhwalawa amakwiriridwa chifukwa chosazindikira zambiri zakhudza thupi la odwala asanadutse;
- mkaka wa m`mawere ndi pakati, izi zimachitika chifukwa chakuti zigawo zikuluzikulu za mankhwalawa zimakhudza chitukuko cha mwana wosabadwayo;
- kulephera kwa mtima (mawonekedwe pachimake komanso chodwala).
Kutenga?
Mlingo umatengera momwe thupi limakhalira, mtundu wa matenda. Nthawi zambiri, kuchuluka kwa tsiku lililonse kwa 2 ml ndi komwe.
Amaloledwa kusintha mawonekedwe amomwe mankhwalawa amasulidwa.
Pa gawo loyamba, ndikofunikira kubaya mankhwalawa, ndiye kuti ndizololeka kumwa mapiritsi. Mlingo ukusungidwa. Mapiritsi tikulimbikitsidwa kumwa pambuyo chakudya.
Kangati?
Pa gawo loyamba, jakisoni amapangidwa tsiku lililonse. Patatha masiku 7 chiyambireni chithandizo, mankhwalawa amasinthidwa mpaka katatu pa sabata. Pafupipafupi kugwiritsa ntchito mankhwalawa imatsimikiziridwa payekhapayekha.
Masiku angati?
Malangizo ogwiritsira ntchito:
- pa siteji yoyamba, jakisoni amachitika masiku 5-7;
- kumapeto kwa nthawi yino, chiwembucho chimasinthidwa: m'masiku 14 otsatira, jakisoni amachitidwa pafupipafupi;
- Ngati wodwalayo alibe vuto lokwanira, mankhwalawa amatha kuduladula kwa masiku 7-10.
Zotsatira zoyipa
Zotsatira zoyipa zimachitika mosiyanasiyana. Zizindikiro zina zimachitika kawiri kawiri, zina nthawi zambiri, zonse zimatengera ngati mankhwala amulemekezedwa kapena kuchuluka kwa kuchuluka kwa mankhwala. Ganizirani zochita za wodwalayo ku chinthu chomwe chili ndi mankhwala.
Kuchokera m'mimba thirakiti
Kusintha kumachitika kawirikawiri.
Kusintha kumachitika kawirikawiri.
Kuchokera ku dongosolo lamanjenje
Chizungulire zitha kuwoneka. Odwala ena amasokonezeka.
Kuchokera ku CCC
Ndi mankhwala a Combilipen, pali mwayi wokhala ndi zovuta zamatenda monga tachycardia, arrhythmia, bradycardia.
Kuchokera ku chitetezo chamthupi
Zizindikiro za gululi zimawonekera kwambiri kuposa zina. Pali edema ya Quincke, kukayika kwa anaphylactic, kuzimiririka pazithunzi zakunja.
Thupi lawo siligwirizana
Kuyabwa, moto woyaka, urticaria.
Kuyabwa, moto woyaka, urticaria.
Malangizo apadera
Popeza mankhwalawo ali ndi mowa, sungagwiritsidwe ntchito pochiritsa ana. Kuyimitsidwa kumaperekedwa kokha mu intramuscularly. Osavomerezeka kuti agwiritse ntchito mankhwalawa kwa nthawi yopitilira miyezi isanu ndi umodzi, chifukwa pankhaniyi, mwayi wokhala ndi zotumphukira monga neuropathy ukuwonjezeka.
Palibe malingaliro aliwonse okhudza kuletsa kuyendetsa galimoto mukamalandira chithandizo. Komabe, popeza kuti mankhwalawo omwe amafunsidwa angayambitse chizungulire, kusokonekera kwa CCC, kumathandizira kuti mawonekedwe a pathological azikhala ngati chisokonezo, ndibwino kukana kuyendetsa galimoto nthawi yayitali. Ngati izi sizingatheke, kusamala kuyenera kugwiritsidwa ntchito panjira.
Ndi bwino kupewa kuyendetsa galimoto nthawi yayitali.
Palibe choletsa mwachindunji kugwiritsa ntchito kumwa nthawi yomweyo ndi kumwa mankhwalawa. Komabe, ziyenera kukumbukiridwa kuti zinthu zokhala ndi zakumwa zoledzeretsa zimasokoneza dongosolo lamanjenje, ndipo ntchito yayikulu ya Combibipen ndikuwonekeratu kuti ichira. Pazifukwa izi, phindu la kuchitira mankhwala panjira pomwe wodwala nthawi yomweyo amamwa mowa.
Bongo
Ngati mulingo wa mankhwalawa umaposedwa pafupipafupi, mavuto aliwonse angayambidwe. Nthawi zambiri ndi bongo, bradycardia, arrhythmia, tachycardia, chizungulire, chisokonezo, ndi kusanza kumachitika. Pankhaniyi, siyani njira yothandizira. Chithandizo chitha kuperekedwa kuti zithetse zizindikirozi.
Kuchita ndi mankhwala ena
Chidacho chimataya mphamvu mu mayankho okhala ndi sulfite. Kuphatikiza apo, zinthu monga iodide, chloride ya zebulone ndi zina zimapweteketsa mankhwala. Thiamine imataya mphamvu pamene pH idatha (kupitirira 3). Copper imakhalanso ndi zovulaza.
Lidocaine wa kapangidwe ka Combibipen sagwirizana ndi Epinephrine ndi Norepinephrine, pomwe katundu pamtima ukuwonjezeka: kukakamizidwa kumawonjezeka, arrhythmia imachitika.
Ngati mumagwiritsa ntchito mankhwalawa kuthandiza thupi, mphamvu ya mankhwala ena othandizira omwe amayamba chifukwa cha pyridoxine imatsika (munthawi yomweyo). Kusagwirizana kwa vitamini B12 ndi ascorbic acid, mchere wazitsulo zolemetsa umadziwika. Lidocaine wa kapangidwe ka Combibipen sagwirizana ndi Epinephrine ndi Norepinephrine, pomwe katundu pamtima ukuwonjezeka: kukakamizidwa kumawonjezeka, arrhythmia imachitika.
Analogi
M'malo mwake mankhwalawo ungakhale chida chomwe chili ndi zinthu zomwezi kapena zofanana. Poterepa, samalani ndi mankhwala. Ngati analogue ikupereka zotsatira zomwezo kapena zabwinobwino, itha kugwiritsidwa ntchito pochiza matenda omwe akuphatikizidwa ndi kuphwanya kwamitsempha yamagazi yamkati.
Analogue wamba ya Combibipen ndi Milgamm.
Analogue wamba ndi Milgamm. Mankhwalawa amapangidwa mwa njira yothetsera jakisoni. Ichi ndi chida chodula kwambiri. Mtengo wake wapakati ndi ma ruble 300-500. Zophatikiza zazikulu: thiamine, cyanocobalamin, pyridoxine. Mankhwala amapereka kubwezeretsa, koma sikuchotsa ululu, chifukwa lidocaine wa mafuta sakuphatikizidwa. Amawerengera matenda omwe amayamba chifukwa cha matenda a minyewa. Zotsatira zoyipa za munthu, kupweteka kwambiri komanso kudwala mtima.
Ngati mukufuna mankhwala otsika mtengo, mutha kulabadira Compligam B. Amapangidwa m'njira yothetsera jakisoni, mankhwalawa amaperekedwa ma ampoules. Mtengo wapakati: kuchokera ku ma ruble 140 mpaka 280. Kupangidwe kwa chida ichi ndi chofanana ndi Combilipen: ili ndi zinthu zomwezi, koma Mlingo wawo ndi wosiyana. Zizindikiro zogwiritsidwa ntchito ndizovuta za CNS. Mankhwala ndi oletsedwa kugwiritsa ntchito milandu:
- zaka mpaka 18;
- tsankho limodzi pazinthu zazikulu;
- kukomoka kwa mtima.
Neuromultivitis ndi mankhwala osiyanasiyana, ndi analogue ina ya Kimbilipen.
Neuromultivitis ndi mankhwala osiyanasiyana, ndi analogue ina ya Kimbilipen. Zophatikiza zazikulu: thiamine, pyridoxine, cyanocobalamin. Lidocaine kulibe, zomwe zikutanthauza kuti mankhwalawa sangakhudze ululu. Chifukwa cha mankhwalawa, ntchito yachilendo yamkati wamanjenje imasungidwa. Amaperekedwa mu mawonekedwe a mapiritsi. Zotsutsana ndi zaka 12, hypersensitivity kwa zinthu zazikulu zomwe zimapangidwa.
Analogs amatha kugawidwa m'magulu awiri. Otsika kwambiri ndi diclofenac. Mankhwala a gulu la pakatikati: Mexicoidol, Arthrosan, Amelotex. Movalis ndiokwera mtengo.
Kusungidwa kwa mankhwala Combilipen
Kutentha kotsimikizika: + 2 ... + 8 ° ะก. Komanso, ndikofunikira kuti mankhwalawa atetezedwe ku dzuwa.
Tsiku lotha ntchito
Chogulacho chimataya katundu wake patatha zaka ziwiri kuchokera pa tsiku lomwe adapanga.
Kupita kwina mankhwala
Mutha kugula mankhwala omwe mumalandira.
Combilipen ndi zingati?
Mtengo wapakati umasiyana kuchokera ku ma ruble 150 mpaka 230. Mtengo umasiyanasiyana madera.
Mtengo wapakati umasiyana kuchokera ku ma ruble 150 mpaka 230.
Ndemanga pa Combilipen
Kuwunika kwa ogula kumakhala ndi gawo lalikulu pakusankhidwa kwa mankhwala. Iyenera kuganiziridwa limodzi ndi zida zazikulu za mankhwalawo. Ganizirani malingaliro a akatswiri.
Madokotala
A. N. Nikolaev, wamisala
Chiwerengero chabwino cha mtengo ndi mtundu wa mankhwalawo amadziwika. Amawerengera ma pathologies osiyanasiyana, limodzi ndi kuphwanya kwamanjenje. Komanso, jakisoni ndi mitundu ya mankhwalawa imathandizanso chimodzimodzi. Muyenera kumvetsera thupi, chifukwa cha mankhwala, zizindikiro za ziwengo zimakonda kuonekera.
Izi ndi zovuta multivitamin, muli mavitamini a gulu B la chikhalidwe cha neurotropic.
Odwala
Anatoly, wazaka 39, Svobodny
Anadwala jakisoni wamitsempha yam'mimba. Ndinganene kuti kuyambira pamenepo mkhalidwe wa msana sunadetse, ndipo ukukondweretsa. Zingwe zopweteka ndizopweteka kwambiri, koma chitani zinthu mwachangu. Ululu umadutsa ndipo sabwerera kwa nthawi yayitali. Ndibwereza maphunzirowa posachedwa.
Anastasia, wazaka 37, Oryol
Anayamba kugwiritsa ntchito mankhwalawa pambuyo pangozi kuntchito - adamuvulaza msana wake atagwa kuchokera kumtunda wawung'ono. Zikuwoneka kuti palibe chomwe chimawonongeka (mafupa ndi minofu yolimba), koma ululu womwe umazunzidwa kwanthawi yayitali. Ma analgesics sanathandize, ndipo sanafune kumwa mankhwala amphamvu - ndikuopa zotsatira zoyipa. Dokotala adalimbikitsa jakisoni wa combibipen. Pambuyo pa chithandizo, ululu unadutsa mwachangu ndipo sunabwererenso. Ndikupangira izi kwa iwo omwe akhala akuvutika kwakanthawi m'miyendo kapena kumbuyo: omasuka kupaka jekeseni, koma pokhapokha mukaonana ndi dokotala.
