Mankhwala a Vasotenz nthawi zambiri amaperekedwa kwa anthu odwala matenda oopsa. Chifukwa cha kuphatikiza komwe, mankhwalawa samangothandiza kuti magazi azikhala mwamphamvu, komanso amathandizira kulimbitsa thupi panthawi yochita masewera olimbitsa thupi komanso amachepetsa chiopsezo cha matenda ambiri a mtima. Chida ichi chikuyenera kugwiritsidwa ntchito motsogozedwa ndi dokotala muyezo wosaposa womwe umaonetsedwa mu malangizo omwe aperekedwa pa mankhwalawa.
Dzinalo Losayenerana
INN yamankhwala ndi losartan.
Mankhwala a Vasotenz nthawi zambiri amaperekedwa kwa anthu odwala matenda oopsa.
ATX
Mu gulu la padziko lonse la ATX, mankhwalawa ali ndi code C09CA01.
Kutulutsa mafomu ndi kapangidwe kake
Chofunikira chachikulu mu Vazotens ndi potaziyamu losartan. Zina mwa mankhwalawa zimaphatikizira croscarmellose sodium, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, etc. Kapangidwe ka Vazotenza N, kuwonjezera pa losartan, kumaphatikiza hydrochlorothiazide.
Vasotens amapezeka mu mawonekedwe a mapiritsi okhala ndi Mlingo wa 25, 50 ndi 100 mg. Mapiritsiwa amawazunguliza. Amakutidwa ndi chipolopolo choyera ndipo amatchedwa "2L", "3L" kapena "4L" kutengera mlingo. Zadzaza matuza 7 kapena 10 ma PC. Mu bokosi la makatoni pamakhala matuza 1, 2, 3 kapena 4 ndi pepala lophunzitsira lomwe lili ndi chidziwitso cha mankhwalawa.
Vasotens amapezeka mu mawonekedwe a mapiritsi okhala ndi Mlingo wa 25, 50 ndi 100 mg.
Zotsatira za pharmacological
Mankhwala omwe amapezeka pamankhwala amapezeka chifukwa cha ntchito yotchedwa Vazotenz, yomwe ndi yofunika kwambiri yomwe ndi mtundu 2 angiotensin receptor antagonist. Pochita mankhwala a vasotenz, mankhwala omwe amagwiritsidwa ntchito ndi mankhwalawa amathandiza kuchepetsa OPSS. Mankhwala amachepetsa kuchuluka kwa aldosterone ndi adrenaline m'madzi a m'magazi. Mankhwalawa ali ndi mphamvu yophatikiza, amathandizira pakuthamanga kwa kukakamizika kwa kufalikira kwa mapapu ndi kufalikira kwa m'mapapo.
Kuphatikiza apo, magwiritsidwe ake a mankhwalawa amachepetsa kulemera kwa mtima ndipo amakhala ndi tanthauzo la diuretic. Chifukwa cha zovuta zake, kulandira mankhwala a vasotens kumachepetsa chiopsezo cha myocardial hypertrophy. Mankhwalawa amathandizira kukulitsa kulolera kwa odwala omwe ali ndi zizindikiro zazikulu zakulephera kwa mtima.
Mankhwalawa saletsa kuphatikizira kwa mtundu 2 kinase. Enzyme iyi imatha kuwononga bradykinin. Mukamamwa mankhwalawa, kuchepa kwa magazi kumawonedwa pambuyo pa maola 6. M'tsogolomu, ntchito ya mankhwala omwe amapezeka pang'onopang'ono amachepera maola 24. Ndi kugwiritsa ntchito mwadongosolo, mphamvu yake yayikulu imawonedwa pambuyo pa masabata 3-6. Chifukwa chake, mankhwalawa amafunika kugwiritsa ntchito nthawi yayitali.
Pharmacokinetics
Changu cha vasotenza chimatengedwa mwachangu m'makoma a m'mimba. Poterepa, bioavailability wa wothandizira amafika pafupifupi 35%. Kuchuluka kwa gawo logwira ntchito m'magazi kumachitika pambuyo pa ola limodzi. Kagayidwe ka mankhwala kumachitika mu chiwindi. Mtsogolomo, pafupifupi 40% ya mankhwalawa amachotsedwa mu mkodzo ndi pafupifupi 60% mu ndowe.
Zizindikiro zogwiritsidwa ntchito
Kugwiritsidwa ntchito kwa vasotenz kumasonyezedwa pochiza matenda oopsa. Chida ichi chimagwiritsidwa ntchito popewa matenda oopsa kwambiri komanso matenda oopsa kwambiri. Mwa zina, mankhwalawa nthawi zambiri amatchulidwa pochiza matenda a mtima. Ndi matenda a mtima dongosolo, mankhwalawa amagwiritsidwa ntchito ngati gawo limodzi la mankhwala. Kuphatikiza apo, kugwiritsa ntchito vazotens ndikoyenera kwa odwala omwe ali ndi tsankho la ACE.
Kugwiritsidwa ntchito kwa vasotenz kumasonyezedwa pochiza matenda oopsa.
Contraindication
Simungagwiritse ntchito mankhwalawa ngati wodwala ali ndi vuto lakelo. Mankhwala a Vasotens osavomerezeka ngati wodwala ali ndi vuto la kutsika kwa magazi. Mankhwalawa sangathe kugwiritsidwa ntchito pamaso pa hyperkalemia, chifukwa izi zimatha kukulitsa mkhalidwe wa wodwalayo. Kuphatikiza apo, mankhwalawa sayenera kugwiritsidwa ntchito ngati pali zizindikiro za kuchepa thupi.
Ndi chisamaliro
Ngati wodwala ali ndi vuto la chiwindi ndi impso, chithandizo ndi Vazotens chimafuna kuthandizidwa ndi dokotala. Kuphatikiza apo, chisamaliro chapadera chimafuna kugwiritsa ntchito vazotens pochiza anthu omwe akudwala matenda a Shenlein Genoch. Pankhaniyi, kusinthasintha kwa mankhwalawa kwa mankhwalawa kumafunikira kuti muchepetse chiopsezo chokhala ndi zovuta zazikulu.
Kodi kumwa vasotens?
Mankhwalawa amapangidwira pakamwa. Kuti mukwaniritse zochizira, wodwalayo ayenera kumwa 1 nthawi ya m'mawa. Kudya sizikhudzana ndi mayamwa. Kuti akhazikitse kuthamanga kwa magazi ndikuisunga bwino, odwala amawonetsedwa kumwa Vazotenza pa mlingo wa 50 mg patsiku. Ngati ndi kotheka, mlingo utha kuwonjezeka mpaka 100 mg patsiku.
Ngati wodwala ali ndi vuto la mtima kulephera, pang'onopang'ono kuchuluka kwa vasotenz ndikofunikira. Choyamba, wodwalayo amapatsidwa mankhwala pa mlingo wa 12,5 mg wa patsiku. Pakupita pafupifupi sabata limodzi, mlingo umawonjezeka mpaka 25 mg. Pambuyo masiku ena 7 a kumwa mankhwalawa, mlingo wake umakwera mpaka 50 mg patsiku.
Ngati wodwala ali ndi vuto la kukanika kwa chiwindi, kulandira chithandizo ndi Vazotens kumafuna chidwi ndi dokotala.
Ndi matenda ashuga
Chida chitha kugwiritsidwa ntchito pothandiza odwala omwe ali ndi matenda a shuga a 2 omwe alibe zizindikiro za matendawa. Ndi matendawa, mankhwalawa nthawi zambiri amaperekedwa pa mlingo wa 50 mg patsiku.
Zotsatira zoyipa za vasotenza
Gawo logwira ntchito la Vazotens limalekeredwa bwino, chifukwa chake, zovuta zoyambira ndizosowa kwambiri.
Matumbo
Pochita ndi Vasotens, wodwalayo amatha kukumana ndi mseru komanso kupweteka kwam'mimba. Matenda a Stool, pakamwa pouma, potsegula, anorexia samachitika chifukwa chotenga vasotenz.
Kuchokera ku minculoskeletal system
Pochiza ndi vasotens, arthralgia ndi myalgia zimatha kuchitika. Odwala samakonda kumva ululu m'miyendo, pachifuwa, m'mapewa ndi mawondo.
Pakati mantha dongosolo
Pafupifupi 1% ya odwala omwe ali ndi vuto la vasotens ali ndi zizindikiro za asthenia, kupweteka mutu, komanso chizungulire. Kusokonezeka kwa tulo, kugona tulo, kutopa mtima, zizindikiro za ataxia ndi zotumphukira neuropathy nthawi zina kumatha kuchitika pakumwa ndi vazotens. Kuyola kuphwanya kukoma ndi kuwonongeka kwa mawonekedwe. Kuphatikiza apo, pamakhala chiwopsezo cha kusamva bwino kwa miyendo.
Kuchokera ku kupuma
Zotsatira zoyipa za kupuma ndizosowa kwambiri. Kutsokomola komanso kutsokomola m'mphuno ndizotheka. Kugwiritsa ntchito vasotenza kungapangitse kuti pakhale matenda apamwamba am'mapapo. Kawirikawiri, matenda a rhinitis, bronchitis ndi dysapnea amawonetsedwa ndi mankhwala ndi mankhwalawa.
Pa khungu
Mwina kuwoneka kwa thukuta kowonjezereka kapena khungu louma. Nthawi zina, kukula kwa erythema ndi chidwi chowala chikuwonekera. Mukamagwiritsa ntchito vasotenz, alopecia ndiyotheka.
Kuchokera ku genitourinary system
Kutenga vasotenza kungapangitse kuti pakhale matenda opatsirana kwamkodzo. Nthawi zina, odwala amadandaula kukodza pafupipafupi komanso kuwonongeka kwa impso. Mwa amuna, omwe ali ndi vasotenz mankhwala, kuchepa kwa libido ndi kukula kwa kusabereka kungawonedwe.
Mwina kuoneka ngati khungu louma.
Kuchokera pamtima
Ndi yaitali vasotenz mankhwala, wodwalayo akhoza kuyamba orthostatic hypotension. Angina ndi tachycardia kuukira ndikotheka. Nthawi zina, kumwa mankhwalawa kumayambitsa magazi m'thupi.
Matupi omaliza
Nthawi zambiri, kugwiritsidwa ntchito kwa vasotenz kumayambitsa zovuta zomwe zimakhudzana ndi kuyabwa, urticaria, kapena zotupa pakhungu. Kawirikawiri sanawone kukula kwa angioedema.
Zokhudza mphamvu pakuwongolera njira
Mankhwala amatha kubweretsa kugona komanso kuchepa kwa chidwi, chifukwa chake, pochiza ndi Vazotens, chisamaliro chimayenera kuthandizidwa pakuwongolera njira zovuta.
Malangizo apadera
Musanayambe mankhwala a vasotenz, kukonza madzi mthupi kuyenera kuchitidwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Kuchita bwino ndi chitetezo cha kugwiritsa ntchito vasotenza pa nthawi ya pakati sikunaphunzire konse. Komanso, pali umboni wa zotsatira zoyipa za yogwira mankhwala pa mwana wosabadwayo mu 2nd ndi 3 nyengo ya mimba. Izi zimawonjezera chiopsezo cha mwana kukulira zovuta zina ndi kufa kwa intrauterine. Ngati chithandizo chikufunika, kuyamwitsa kungalimbikitsidwe.
Ndi yaitali vasotenz mankhwala, wodwalayo akhoza kuyamba orthostatic hypotension.
Kupangira vasotenza kwa ana
Mankhwalawa sanatchulidwe kwa ana ndi achinyamata ochepera zaka 18.
Gwiritsani ntchito mu ukalamba
Pochiritsira okalamba, pamafunika kuwongolera kuchuluka kwa potaziyamu m'magazi. Muyenera kuyamba kumwa mankhwalawa ndi mlingo wocheperako wowonjezera.
The ntchito aimpso kuwonongeka
Chida chingagwiritsidwe ntchito mankhwalawa odwala omwe ali ndi vuto laimpso, koma pamenepa, kuchuluka kwa uric acid m'magazi ndikotheka. Kuphatikiza apo, kuyang'anira kuchuluka kwa potaziyamu m'magazi a odwala otere amafunika.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi pathologies limodzi ndi mkhutu chiwindi ntchito, kuphatikizapo matenda enaake, odwala amamutsitsa mlingo wa vasotenza, popeza matenda amtunduwu amachititsa kuchuluka kwa mankhwala omwe ali m'magazi.
Overdose wa vasotenza
Ngati mulingo woyenera wa mankhwalawa ukadutsa, odwala amatha kudwala tachycardia. Mwina kuchepa kwamphamvu kwa kuthamanga kwa magazi. Zizindikiro za mankhwala osokoneza bongo zikawoneka, chithandizo chamankhwala ndi kukakamizidwa kukakamizidwa chimayikidwa, chifukwa hemodialysis pamenepa sichitha.
Mankhwalawa sanatchulidwe kwa ana ndi achinyamata ochepera zaka 18.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito vazotens kuphatikiza ndi mankhwala ena a antihypertensive ndikuloledwa. Odwala omwe ali ndi diuretic mankhwala, kuchepa kwambiri kwa magazi kumatheka. Kulandila Vazotenza kumathandizira kuti azitha kukhala achifundo komanso a beta-blockers. Ndi kugwiritsidwa ntchito kwa vasotenza ndi kukonzekera kwa potaziyamu, chiopsezo chokhala ndi hyperkalemia chikuwonjezeka.
Kuyenderana ndi mowa
Pa mankhwala ndi vasotenz, osavomerezeka kumwa zakumwa zoledzeretsa.
Analogi
Mankhwala omwe ali ndi vutoli ofanana ndi awa:
- Lozap.
- Cozaar.
- Presartan.
- Losocor.
- Lorista.
- Zisakar.
- Blocktran.
- Lozarel, etc.
Kupita kwina mankhwala
Mankhwala agulitsidwa.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwalawa atha kugulidwa popanda mankhwala.
Mtengo wa vasotens
Mtengo wa mankhwalawa m'mafakisoni umachokera ku ma ruble 115 mpaka 300, kutengera mlingo.
Zosungidwa zamankhwala
Zogulitsazo ziyenera kusungidwa pamalo amdima pamawonekedwe a kutentha mpaka + 30 ° C.
Tsiku lotha ntchito
Mutha kugwiritsa ntchito mankhwalawa kwa zaka zitatu kuyambira tsiku lomasulidwa.
Wopanga
Mankhwalawa amapangidwa ndi AKTAVIS JSC.
Ndemanga za Vasotense
Mankhwalawa amagwiritsidwa ntchito nthawi zambiri, motero amakhala ndi ndemanga zambiri kuchokera kwa madokotala komanso odwala.
Omvera zamtima
Grigory, wazaka 38, Moscow
Pazachipatala changa, nthawi zambiri ndimalemba ntchito za vazotens kwa odwala omwe ali ndi matenda oopsa. Chifukwa cha kuphatikiza kwa hypotensive ndi diuretic kwenikweni, mankhwalawa samangothandizira kuthamanga kwa magazi, komanso amathandizira kulolerana kwa masewera olimbitsa thupi ndikuchepetsa zovuta za edema. Mankhwalawa amaloledwa ngakhale ndi odwala okalamba. Kuphatikiza apo, ndioyenera kuphatikizidwa ndi zovuta zovuta kugwiritsa ntchito mankhwala owonjezera a antihypertensive.
Irina, wazaka 42, Rostov-on-Don.
Ndakhala ndikugwira ntchito ya mtima kwa zaka zopitilira 15, ndipo odwala omwe amalandila madandaulo a magazi pafupipafupi amapereka mankhwala a Vazotens. Zotsatira za mankhwalawa nthawi zambiri ndizokwanira kukhala ndi zovuta popanda kugwiritsa ntchito okodzetsa. Mankhwalawa amavomerezedwa bwino ndi odwala ndipo nthawi zambiri samayambitsa mavuto. Chifukwa cha izi, mutha kugwiritsa ntchito bwino m'maphunziro atali.
Igor, wazaka 45, Orenburg
Nthawi zambiri ndimalimbikitsa kugwiritsa ntchito vasotenza kwa odwala omwe ali ndi vuto la mtima. Mankhwala amakupatsani mwayi kufatsa matenda a magazi ndi kuchepetsa kuopsa kwa edema yam'munsi malekezero. Chidachi chimaphatikizidwa pamodzi ndi mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda amtunduwu. Pazaka zanga zambiri zoyeserera, sindinakumanepo ndi mawonekedwe a zovuta zina mwa odwala omwe amagwiritsa ntchito vazotens.
Mukamagwiritsa ntchito mankhwalawa, chisamaliro chimayenera kuthandizidwa kuti muthane ndi njira zovuta.
Odwala
Margarita, wa zaka 48, Kamensk-Shakhtinsky
Ndakhala ndikudziwa vuto la kuthamanga kwa magazi kwa zaka zoposa 15. Poyamba, madokotala ankalimbikitsa kuchepetsa kunenepa, kuyenda pafupipafupi ndi mpweya wabwino komanso kudya moyenera, koma pang'onopang'ono vutoli limakulirakulira. Kupanikizika kudayamba kukhazikika pa 170/110, madokotala adayamba kupereka mankhwala. Zaka 3 zapitazi ndidathandizidwa ndi vasotens Chidacho chimapereka zotsatira zabwino. Ndimatenga m'mawa. Kupanikizika kwakhazikika. Kutupa kwamiyendo kunazimiririka. Anayamba kumva bwino kwambiri. Ngakhale kukwera masitepe tsopano kumaperekedwa popanda kufupika.
Andrey, wazaka 52, Chelyabinsk
Anamwa mankhwala osiyanasiyana pokakamiza. Pafupifupi chaka chimodzi, katswiri wa mtima adamuwuza kugwiritsa ntchito vazotens. Chidacho chimapereka zotsatira zabwino. Muyenera kumwa kamodzi kokha patsiku. Kupanikizika kunabweranso kwawokha pakangotha milungu iwiri yokha. Tsopano ndimamwa mankhwalawa tsiku lililonse. Sindinawone zotsatira zoyipa.
