Accupro ndi mankhwala ogwiritsidwa ntchito pochotsa kuchepa kwa mtima komanso kutsitsa magazi. Imakhala ndi metabolic, Cardio- ndi nephroprotective zotsatira, zomwe zimathandiza pamtima. Mankhwalawa amalepheretsa kutembenuka kwa mankhwala omwe ali ndi zinthu za vasoconstrictor. Zotsatira zake zimafalikira ku plasma ndi michere yama minofu, ndikupatsa chidwi chambiri.
Dzinalo Losayenerana
Dzina lachi Latin la mankhwala: Accupro. INN: Quinapril.
ATX
Mankhwala a antihypertensive, ACE inhibitor. Code ya ATX: C09A A06.
Accupro ndi mankhwala ogwiritsidwa ntchito pochotsa kuchepa kwa mtima komanso kutsitsa magazi.
Kutulutsa mafomu ndi kapangidwe kake
Amapezeka mwanjira yozungulira, yama makulidwe atatu kapena chowulungika, mapiritsi okhala ndi mafilimu oyera kapena ofiira. Piritsi 1 ili ndi 5, 10, 20 kapena 40 mg yogwira ntchito - quinapril mu mawonekedwe a hydrochloride, komanso ma exipients. Phukusi la makatoni mumakhala matuza 3 kapena 5, lililonse lili ndi mapiritsi 6 kapena 10.
Zotsatira za pharmacological
Mankhwala ochita kupanikizika omwe amachepetsa ntchito ya eniotensin-kutembenuza, ndi kutenga nawo mbali komwe angiotensin I adasinthidwa kukhala angiotensin II. Yotsirizirayi ndiyo gawo logwira ntchito kwambiri lomwe limakulitsa kuthamanga kwa magazi. Kuchepa kwa katulutsidwe kameneka kumapangitsa kuti sodium ichoke komanso kuchedwa kwa potaziyamu m'thupi, komwe kumachepetsa kukana kwa zotumphukira ndi kutsitsa magazi. Ndi kugwiritsa ntchito pafupipafupi, kumachepetsa kukula kwa minofu ya mtima ndi mitsempha yamagazi, yomwe imayamba motsutsana ndi maziko a matenda oopsa.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, kuchuluka kwa quinapril mu seramu kumatheka mkati mwa mphindi 60-90. Osachepera 55% ya mankhwalawa imamwetsa.
Mothandizidwa ndi michere ya chiwindi, chinthu chogwiritsidwa ntchito chimapangidwira quinaprilat, yomwe ndi ACE inhibitor yamphamvu. Dongosolo lake la bioavailability ndi 35%.
Chithandizo chogwira ndi ma metabolites ake sichilowera mu chotchinga cha magazi ndipo chimatsitsidwa ndi zotupa kudzera mu impso. Odwala ndi mkhutu aimpso ntchito, kuwonongedwa theka moyo kumawonjezeka ndi kuchepa kwa creatinine chilolezo.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa ndi mankhwala ochizira matenda oopsa komanso kulephera kwa mtima.
Mankhwala ndi mankhwala ochizira matenda oopsa.
Contraindication
Kugwiritsa ntchito mankhwalawa kumapangidwa pamaso pa matenda ndi zinthu zotsatirazi:
- Hypersensitivity kwa chigawo chilichonse;
- mbiri ya angioedema chifukwa cha chithandizo cham'mbuyomu ndi mankhwala a antihypertensive kapena cholowa ndi / kapena matenda osokoneza;
- lactose tsankho, shuga-galactose malabsorption.
Ndi chisamaliro
Amagwiritsidwa ntchito mosamala pamaso pa matenda ndi zochitika zina:
- Symbstatic ochepa ochepa hypotension, makamaka mwa odwala omwe kale amamwa mankhwala osokoneza bongo ndikutsatira zakudya zopanda mchere;
- pachimake matenda chifukwa kuwonongeka kwa mtima minofu;
- matenda a shuga;
- kulephera kwa impso kapena chiwindi;
- autoimmune connective minofu matenda;
- kuperewera kwa coronary;
- Hyperkalemia
- kuchepa kwa magazi mozungulira magazi.
Kumayambiriro kwa mankhwalawa, mankhwalawa amalimbikitsidwa kuti agwiritsidwe ntchito pokhapokha pakuwonetsa zizindikiro za kuthamanga kwa magazi.
Momwe mungatengere Avupro
Kutalika kwa maphunzirowa ndi kaundulidwe kamadongosolo kumayesedwa ndi katswiri, makamaka pozindikira momwe wodwalayo alili. Mankhwala amatengedwa pakamwa, ngakhale kudya zakudya, 0,01 ga 1-2 pa tsiku. Pakufunika kwa achire kwenikweni, mlingo umodzi ukhoza kuwonjezeka ndi 2, koma osapitilira muyeso wa 0,88 g patsiku. Ndi chololedwa kumwa tsiku lililonse kamodzi, osagawikana pakulipira zingapo. Mlingo utha kuwonjezeredwa pokhapokha akutsimikiziridwa ndi adokotala ndipo osapitirira masabata anayi kuchokera poyambira chithandizo.
Ndi matenda ashuga
Mankhwalawa amagwiritsidwa ntchito ngati gawo limodzi la mankhwala a antihypertensive, kuyang'anira kusamala kwambiri kwa glycemic ndi njira yolimbikitsira.
Zotsatira zoyipa
Mankhwalawa kwenikweni sayambitsa kukonzekera kosafunikira. Nthawi zambiri, amawonedwa motsutsana ndi maziko a kuchepekera kwa ziwalo zake kapena ngati mulingo wosavomerezeka unawonedwa. Therapy ayenera kuikidwa ndi katswiri atazindikira, mukuyang'ana ndi ma concomitant pathologies.
Matumbo
Kuuma kwa mucous nembanemba mkamwa kapena kummero, kusokonezeka kwa dyspeptic, nseru, kupweteka pamimba, kuchepa kwa chakudya, komanso kuphwanya kuzindikira.
Pakati mantha dongosolo
Kutengera komwe kumamwa mankhwalawa, kusintha kwa machitidwe, vertigo, kusokonezeka kwamatenda, kuchuluka kwa kutopa kapena kukwiya, vuto lakumverera kwa khungu lomwe limadziwika ndi dzanzi ndi kumva kuwawa ndizotheka.
Kuchokera kwamikodzo
Nthawi zina, matenda amkodzo amadziwika.
Kuchokera ku kupuma
Nthawi zambiri pamakhala chifuwa chosalekeza, chosabereka chomwe chimadutsa kutha kwa mankhwala, kumverera kosowa kwa mpweya, kutupa kwakapweteka kwa pharyngeal mucosa, kupweteka pachifuwa.
Pa khungu
Momwe khungu limakhudzidwira komanso minyewa yolumikizira, monga kutuluka thukuta, erythema ndi desquamation, zotupa, kuyabwa, kuchepa kwa tsitsi, pemphigus, zochitika zapakhomo kapena zamachitidwe.
Kuchokera ku genitourinary system
Nthawi zina, kuchepa kwa potency, kuchepetsedwa pokodza kumatha.
Kuchokera pamtima
Kutheka kwa ziwalo za hematopoietic, monga kuchepa kwa maselo ofiira amwazi m'magazi, kuchepa kwa kuchuluka kwa hemoglobin, agranulocytosis, kuchepa kwamapulogalamu am'magazi, komanso kuchepa kwamitundu yonse yam'magazi.
Mbali ya mtima, kupweteka kwamtunduwu monga kuchepa kwa magazi, kusakhazikika m'chifuwa, kukhumudwa kwa mtima, kugunda kwa mtima, tachycardia, ndi kuwonjezeka kwa lumen m'mitsempha yamagazi.
Kuchokera minofu ndi mafupa
Nthawi zambiri pamakhala kupweteka kumbuyo. Nthawi zina, motsutsana ndi momwe ntchito mankhwalawa imagwiritsidwira ntchito, matendawa amatha.
Kuchokera ku chitetezo chamthupi
Anaphylactoid zimachitika, angioedema ndizotheka.
Matupi omaliza
Ngati pali laryngeal whistle kapena kutukusira kwa kachulukidwe kake ka nkhope, lilime kapena makutu am'kamwa, mankhwala omwe ali ndi mankhwalawa ayenera kuyimitsidwa nthawi yomweyo. Ngati kutupa kwa lilime kapena larynx kukuopseza kusokoneza mpweya m'mapapo, chithandizo chokwanira chokwanira ndikuwunikira musanabwezeretse zizindikiro za ziwengo ndizofunikira.
Zokhudza mphamvu pakuwongolera njira
Mukamamwa mankhwalawa, muyenera kusamala pakuwongolera njira ndikugwirira ntchito yowonjezera chidwi, makamaka kumayambiriro kwa chithandizo, chifukwa cha chiwopsezo cha chizungulire komanso hypotension.
Malangizo apadera
Kugwiritsa ntchito nthawi yomweyo sikumakhudza kuchuluka kwa mankhwalawa, koma kumawonjezera nthawi kuti afike pazomwe zimagwira.
Mukamamwa mankhwala, tikulimbikitsidwa kupatula zakudya zamafuta m'zakudya.
Nthawi zina, kulandira chithandizo cha angiotensin-converting enzyme kumayendera limodzi ndi kukula kwa hypoglycemia kwa odwala omwe ali ndi matenda osokoneza bongo, kumwa mankhwala a hypoglycemic kapena kulandira insulin. Yogwira pophika mankhwala kumawonjezera zochita insulin ndi antidiabetes.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Contraindified mu mimba ndi mkaka wa m`mawere.
Kusankhidwa Akkupro kwa ana
Mankhwalawa sagwiritsidwa ntchito machitidwe a ana chifukwa chosowa deta pa chitetezo chake komanso kugwira ntchito kwawo.
Gwiritsani ntchito mu ukalamba
Imavomerezedwa kuti igwiritsidwe ntchito pakakhala kuti pali ma contraindication. Mlingo woyambirira wa mankhwalawa ndi 10 mg kamodzi patsiku. Moyang'aniridwa ndi adotolo, amatha kuwonjezereka kuti akwaniritse zochizira zomwe mukufuna.
The ntchito aimpso kuwonongeka
Odwala omwe ali ndi vuto la kufooka kwa thupi, kuwonjezereka kwa theka la moyo wogwira ntchito kumadziwika, motero, ndikofunikira kusintha muyezo, mukuganizira zizindikiro za clearinine clearance. Mlingo woyambira waukulu kwambiri umachokera ku 2.5 mpaka 10 mg patsiku. Kuchulukitsa mlingo wa mankhwalawa kumatheka pokhapokha pakuwongolera ziwalo. Kulephera kutsatira malangizo azachipatala kungayambitse kusokonekera kwa ziwalo, kuphatikizapo chiopsezo chakulephera kwa impso.
Bongo
Zizindikiro za mankhwala osokoneza bongo ndi kuphwanya kuchuluka kwa ma electrolyte, kupindika kwambiri, kuchepa kwa pafupipafupi mtima, komanso kuwonongeka kwa mawonekedwe. Chithandizo chikuchitika ndi mtsempha wa magazi kusintha kwa plasma njira kuti kuwonjezera kuchuluka kwa magazi. Kugwiritsa ntchito mankhwala a dialysis ali ndi gawo lonyansa pazinthu zomwe zimagwira. Pakakhala kuchepa kwa kuthamanga kwa magazi, chithandizo chothandizira ndi chofunikira ndikofunikira.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito pamodzi mankhwala a tetracycline ndi mankhwala a antihypertgency kumachepetsa kuyamwa kwa ma tetracyclines. Chithandizo cha mankhwala omwe ali ndi kukonzekera kwa lithiamu ndi zoletsa za ACE zimawonjezera zomwe zili seramu lifiyamu, ndikuwonjezera ngozi ya kuledzera. Kukonzekera kwa potaziyamu kumathandizira antihypertensive mphamvu yogwira mankhwala, kuonjezera gawo la zinthu mu magazi. Kuphatikiza mankhwala ndi mankhwala omwe amalepheretsa kugwira ntchito kwa mafupa kumawonjezera chiopsezo cha magazi a m'magazi, kuphatikizapo kuchepa kwa kuchuluka kwa ma granulocytes ndi neutrophils.
Kugwiritsidwa ntchito mosiyanasiyana kwa mankhwala okhala ndi hinapril ndi Allopurinol, Novocainamide, cytostatic agents kapena ma immunosuppressants kumawonjezera mwayi wokhala ndi leukopenia. Mankhwala a antihypertensive, anesthetics, ndi opioid analgesics amalimbikitsa mphamvu yopatsitsa mphamvu ya quinapril, pomwe mankhwala omwe si a antiidal anti-yotupa amachepetsa mphamvu chifukwa chosungidwa ndi madzi mthupi.
Kuyenderana ndi mowa
Ethanol imathandizira antihypertensive mphamvu ya mankhwala.
Analogi
Mankhwala ali ndi mitundu ingapo ya gulu limodzi la mankhwala. Zina mwa izo ndi:
- Hinapril-C3;
- Prestarium
- Yotsatira.
Zomwe zimagwiritsidwa ntchito ndi mankhwala zimatha kusinthana, motero, kusintha kwa mankhwalawa kuyenera kuvomerezana ndi dokotala.
Mawu opuma Acupro kuchokera ku mankhwala
Kugula mankhwala a antihypertensive, kuikidwa kwa dokotala ndikofunikira.
Kodi ndingagule popanda kulandira mankhwala?
Yoperekedwa ndi mankhwala.
Mtengo wa Acupro
Mtengo wapakati wa mankhwala ndi ma ruble 535-640.
Zosungidwa zamankhwala
Sungani kutentha kwa chipinda cholamulidwa (osati chapamwamba kuposa + 20 ° C). Khala kutali ndi dzuwa. Chepetsani mwayi wa ana kulandira mankhwala.
Tsiku lotha ntchito
Patatha miyezi 36 kuchokera pomwe ntchito yake ndi yosavomerezeka kugwiritsa ntchito mankhwalawa.
Wopanga Akkupro
Pfizer Kupanga Deutschland (Germany).
Ndemanga za Akkupro
Musanagwiritse ntchito mankhwala a antihypertensive, tikulimbikitsidwa kuti muwerenge ndemanga za akatswiri azachipatala ndi odwala.
Sungani kutentha kwa chipinda cholamulidwa (osati chapamwamba kuposa + 20 ° C). Khala kutali ndi dzuwa.
Madokotala
Alevtina Ivanova (wamtima), wazaka 39, Ivanovo
Mankhwala othandizira opangidwa makamaka kuti muchepetse kuthamanga kwa magazi ndikuwongolera mtima. Kugwiritsira ntchito nthawi yayitali kumathandizira kulimbitsa makoma a mtima, kusintha kaso. Mankhwala amaperekedwa malinga ndi mankhwala, chifukwa chake, mankhwalawa ayenera kuyikidwa ndi katswiri kuti asatulukire zolakwika zomwe zingachitike ndikuchepetsa mwayi wokhala ndi zovuta zina.
Odwala omwe amamwa mankhwalawa
Alina, wazaka 43, Krasnoyarsk
Anatenga miyezi yambiri. Kugwiritsa ntchito bwino kwa mankhwalawa ndikokwera, kupanikizika kumabwereranso kwina pambuyo pa maola 1-2 mutatha kuperekera. Komabe, adakakamizidwa kusiya mankhwalawa chifukwa chotsatira chosasangalatsa - kuukira kwa chifuwa chosakhalitsa.
Anna, wazaka 28, Perm
Amayi kwa nthawi yayitali adayesetsa kuthana ndi kuthamanga kwa magazi pawokha, koma njira zakugwirira ntchito zimagwiritsidwa ntchito masiku ano. Ndimayenera kumuwona dokotala. Amayi adayikidwa mankhwalawa chifukwa adazindikira kulephera kwa mtima. Pambuyo pa chithandizo, zisonyezo zimapanikizika kukhala zabwinobwino, zizindikiro za matenda oopsa zidatha. Panalibe zovuta zoyipa, sikofunikira kuti musinthane ndi mitengo yamtengo wapatali yokhala ndi zovuta zingapo.
