Mankhwala Movogleken: malangizo ogwiritsira ntchito

Movoglechen ndi mtundu wa 2 womb sulfonylurea womwe umakhala ndi mphamvu pa thupi. Limagwirira ntchito zachokera kukulitsa chidwi cha minyewa kupita insulin ndi kukulitsa chinsinsi cha mahomoni a maselo a beta apamba. Muzochita zamankhwala, mankhwala a hypoglycemic amapatsidwa mtundu wa matenda a shuga a 2. Ndi zoletsedwa kugwiritsa ntchito matenda osokoneza bongo a insulin.

Dzinalo Losayenerana

Glipizide. Mu Chilatini - Glipizide.

Mankhwala a Movoglecen ali ndi dzina lodziwika bwino padziko lonse lotchedwa Glipizide.

ATX

A10BB07.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa mwanjira ya mapiritsi oyera. Kumbali yakumaso kwa chipangizocho, pamakhala chiwopsezo, pomwe zolemba za "U" zili mozungulira zikuwonekera kuchokera kumbuyo. 1 piritsi ili ndi 5 mg ya yogwira pawiri - glipizide. Kuonjezera kuchuluka kwa mayamwidwe ndi bioavailability, piritsi ili ndi zina zowonjezera:

• wowuma pregelatinized;
• hypromellose;
• shuga mkaka;
• stearic acid;
• microcrystalline mapadi.

Mapiritsiwo amakhala ndi mawonekedwe ozungulira, amakutidwa pamapeto omaliza ndi filimu ya enteric. Chotsirizachi chimakhala ndi talc, titanium dioxide, macrogol. Mankhwala amapaka matuza a zidutswa 24. Mu bokosi la katoni amaikapo miyala 48.

Zotsatira za pharmacological

Mankhwala amkamwa a hypoglycemic ndi zotumphukira za sulfonylurea.

Movoglechen ya mankhwala imakhudza ntchito ya kapamba ndipo nthawi yomweyo imakhala ndi mphamvu yowonjezera pancreatic.

Zomwe zimapangidwira ndi za m'badwo wachiwiri. Kupanga kwa gawo logwira ntchito kumakhudza ntchito ya kapamba ndipo nthawi yomweyo imakhala ndi mphamvu yowonjezera pancreatic. Glipizide imayendetsa njira ya insulin yopanga ndi maselo a pancreatic beta panthawi ya kukhumudwa kwa minyewa ndi glucose, imathandizira chiwopsezo cha minofu ku hypoglycemic mphamvu ya mahomoni.

Pokwaniritsa njira yothandizira achire, phula lomwe limagwira limapangitsa kuti insulin ikulunjike kumaselo, imakulitsa kumasulidwa kwa mahomoni a pancreatic. Zotsatira zake, kuchuluka kwa insulin pamamolekyu a glucose kumalimbikitsidwa, ndipo kuchuluka kwa kuyamwa kwa shuga ndi minofu ya mafupa ndi hepatocytes kumakulitsidwa. Pali kuchepa kwa gluconeogenesis m'chiwindi ndi kupindika kwa lipid mu minofu ya adipose.

Kukula kwa achire kumatengera kuchuluka kwa ma cell a beta ochita kupangika.

Mankhwalawo amakhala ndi fibrinolytic, diuretic ndi lipid-kutsitsa, amalepheretsa kuphatikiza kwa maselo, kenako nkupanga kwa magazi.

Movoglechen imalepheretsa kuphatikiza kwa mapulatele, motsatiridwa ndi kupangidwa kwa thrombus.

Pharmacokinetics

Mukatha kugwiritsa ntchito, wothandizira wa hypoglycemic wothandizirana amakhala pafupi kulowa mkati mwa khoma la matumbo a proximal kuthamanga kwambiri.

Kudya kwakanthawi imodzi sikumabweretsa kusintha kwa magawo a pharmacokinetic. Poterepa, nthawi ya mayamwidwe imawonjezeka ndi mphindi 45. Mankhwala akaphatikizidwa ndikuyenderera kozungulira, kuchuluka kwambiri kwa plasma kumatha kukhazikitsidwa mkati mwa maola 1-3 mutatha kugwiritsa ntchito piritsi limodzi.

The bioavailability wa glipizide ukufika 90%. M'magazi, gawo lomwe limagwira limamangiriridwa ku albumin ndi 98-99%. Pamene glipizide ikudutsa hepatocytes, chinthu chogwiritsidwa ntchito chimapakidwa mu zinthu za metabolic zomwe sizikuwonetsa ntchito za hypoglycemic. Kuchotsa theka moyo kumapangitsa maola 2-4. Mankhwalawa amachotseredwa 90% mu mawonekedwe a metabolites kudzera mu impso, 10% momwe adapangidwira kale.

Zizindikiro zogwiritsidwa ntchito

Mapiritsi a Movoglechen atha kuchepetsa kuchuluka kwa shuga m'magulu a 2 shuga ngati matenda osagwiritsa ntchito insulin samalandira chithandizo chamankhwala, masewera olimbitsa thupi komanso njira zina zochepetsera kunenepa kwambiri.

Contraindication

Kumwa mankhwala ndikuloledwa motere:

• kutanthauzira zamisempha yamapangidwe am'mimba kuti sulfonamides, glipizide, zigawo zowonjezera za Movogleken kapena zotumphukira za sulfonylurea;
• mtundu 1 matenda a shuga;
• cholowa chokhala ndi chibadwa chathu, shuga ndi galactose mayamwidwe, kusowa kwa lactase;
• kuwotcha komanso kuchitapo kanthu kwa opaleshoni kwa malo ambiri ochitapo kanthu, zochitika zowopsa pambuyo povulala ndi kuvulala, njira zopatsirana ndi kutupa;
• odwala matenda ashuga ndi hyperosmolar, dziko labwino;
• ketoacidosis;
• matenda akulu a chiwindi ndi impso.

Osatengera Movoglechen kwa anthu omwe ali ndi matenda ashuga 1.

Mankhwalawa amaletsedwa pamankhwala ochita opaleshoni okhala ndi malo ambiri ochitapo kanthu.

Komanso, Movoglecen sagwiritsidwa ntchito chifukwa cha matenda oopsa a chiwindi.

M'pofunika kupereka mankhwala mosamala kuona momwe vutoli limayambira, anthu omwe ali ndi vuto la adrenal, leukopenia, kutentha thupi komanso kuwonongeka kwa chithokomiro, limodzi ndi vuto lakelo.

Momwe mungatenge Movoglechen

Mlingowo umasinthidwa ndi katswiri wa zamankhwala malinga ndi kulemera kwa thupi ndi zaka za wodwalayo, komanso machitidwe a pathological process.

Dokotala amatha kusintha kusintha kwa dosing regimen ndikusintha kwamphamvu mumagulu a shuga a seramu.

Chifukwa chake, kuyang'anitsitsa ndende ya magazi ndikofunikira: Zizindikiro pamimba yopanda kanthu komanso mutatha maola awiri mutatha kudya.

Ndi matenda ashuga

Mapiritsi amafunikira pakamwa pakadutsa mphindi 30 asanadye. M'mawa musanadye chakudya cham'mawa, muyenera kumwa 5 mg ya mankhwalawa, pakalibe chithandizo chamankhwala, kuonjezera mlingo ndi 2,5-5 mg, kutengera kulolerana.

Mlingo wovomerezeka wa Movoglek wovomerezeka tsiku lililonse ndi 40 mg, Mlingo wogwiritsidwa ntchito kamodzi ndi 15 mg.

Mlingo wovomerezeka tsiku lililonse ndi 40 mg, mlingo woyenera kugwiritsa ntchito limodzi ndi 15 mg. Mapiritsi ayenera kuledzera 1 nthawi patsiku. Ndi chizolowezi cha tsiku ndi tsiku pamwambapa 15 mg, ndikofunikira kugawa muyezo Mlingo wa 2-4.

Zotsatira zoyipa za Movoglyken

Zokhudza mphamvu pakuwongolera njira

Mankhwala a hypoglycemic samasokoneza mitsempha yamagetsi komanso luso labwino lamagalimoto, chifukwa chake munthawi ya chithandizo sikuletsedwa kuyendetsa galimoto kapena kugwira ntchito ndi zida zovuta zomwe zimafuna kuyankha mwachangu komanso kuzunza kwambiri.

Munthawi ya chithandizo ndi Movogleken sizoletsedwa kuyendetsa galimoto.

Malangizo apadera

Mlingowo umasinthidwa pamaso pamikhalidwe yovuta yomwe imathandizira kuchepa kwa malingaliro am'maganizo, pazochitika zambiri zolimbitsa thupi, ndikusintha kwa zakudya.

Popereka mankhwala osokoneza bongo omwe amadalira insulin komanso mukamapereka opaleshoni, ndikofunikira kuti mufunsane ndi dokotala kuti muthandizenso ndi insulin.

Asanapereke mankhwala othandizira odwala matenda opatsirana, wodwala ayenera kudziwa kuti mwayi wokhala ndi vuto la shuga komanso matenda ashuga umawonjezeka ndi mowa, mankhwala osokoneza bongo, komanso kutopa kwa nthawi yayitali. Mukamamwa zakumwa zoledzeretsa, zimatha kukhala ngati zosakwaniritsidwa, zomwe zimadziwika ndi ululu wam'mimba, kusanza, ndi mseru.

Kuti muchepetse chiopsezo cha hypoglycemia chifukwa cha matenda opatsirana, zinthu zaukhondo ziyenera kugwiritsidwa ntchito kupewetsa izi.

Pogwiritsa ntchito kwa nthawi yayitali a Movoglecen, n`zotheka kukulitsa kukana kwa zomwe mankhwalawo akutsatira pambuyo pofooka. Pankhaniyi, tikulimbikitsidwa kuti muwonjezere Mlingo wa tsiku ndi tsiku wa mankhwalawo kapena m'malo mwa wothandizira wa hypoglycemic.

Mankhwalawa amaletsedwa kwa ana osakwana zaka 18.

Kupatsa ana

Mankhwalawa amaletsedwa kwa ana osaposa zaka 18 chifukwa chosadziwa zambiri zokhudza zotsatira za glipizide pa kukula ndi kukula kwa thupi la munthu muubwana ndi unyamata.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Sizikudziwika momwe mankhwala othandizira amatha kusinthira kukula kwa embryonic. Ndizotheka kungoloweka glipizide kudzera mu chotchinga cha hematoplacental ndikuphwanya buku lokhazikika la masculoskeletal system. Pokhudzana ndi izi, azimayi oyembekezera saloledwa kugwiritsa ntchito mankhwala a hypoglycemic pokonzekera pakamwa.

Ndikulimbikitsidwa kugwiritsa ntchito makatoni omwe ali ndi insulin ya anthu kuti muchepetse shuga.

Mankhwalawa ndi Movogleken, ndikofunikira kusamutsa mwana ku zakudya zamagetsi ndikuletsa kuyamwitsa.

Mankhwala ndi Movogleken, ndikofunikira kusamutsa mwana ku zakudya zopanda ntchito.

The ntchito aimpso kuwonongeka

Mu matenda owopsa a impso, kumwa mankhwalawa ndizoletsedwa, chifukwa mankhwalawa amamuchotsa mkodzo.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Ndikofunikira kuwongolera magwiridwe antchito a chiwindi ndi ma enzymes ake mofatsa pang'ono kuti akhale osakwanira. Pamaso pa njira yotchulidwa ya pathological, chithandizo chamankhwala chimaletsedwa.

Mankhwala osokoneza bongo a Movoglyken

Kugwiritsa ntchito mankhwala mopitilira muyeso kungayambitse hypoglycemia. Mkhalidwewo umatsatiridwa ndi:

• kumva kwamanjala yayikulu;
• kusinthasintha kwadzidzidzi kumayambitsa mkwiyo.
• thukuta;
• chodabwitsa cha mkhalidwe wopsinjika;
• kusowa tulo;
• hypoglycemic chikomokere;
• kuyankhula ndi kuwonera;
• kusokoneza chidwi;
• kulephera kudziwa.

Kugwiritsa ntchito mankhwala mopitilira muyeso kungayambitse thukuta kwambiri.

Ngati wodwala akudziwa, ndikofunikira kuti amupatse shuga. Pofuna kutaya chikumbumtima, 40% dextrose solution iyenera kuthandizidwa kudzera m'mitsempha kapena gawo la shuga. 1-2 mg ya glucagon imayendetsedwa mosavuta. Poteteza matenda abwinobwino ngati wodwala ayambanso kuzindikira, ayenera kudya chakudya chamagulu omwera. Izi ndizofunikira kupewa kukonzanso kwa hypoglycemia. Ndi ubongo edema, chithandizo ndi Dexamethasone kapena Mannitol ndi chofunikira.

Kuchita ndi mankhwala ena

Kuphatikizana kwa pharmacological ndi miconazole kumawonedwa.

Movoglecen amachepetsa achire zotsatira za furosemide.

Kugwiritsa ntchito pamodzi mankhwala a myelotoxic kumawonjezera chiopsezo cha agranulocytosis, kumatha kuyambitsa kuwonekera kwa thrombocytopenia.

Kuyenderana ndi mowa

Mowa wa Ethyl umakulitsa mphamvu ya hypoglycemic, umapangitsa hematopoietic dongosolo, ntchito ya chiwindi ndikuwonjezera mwayi wovala magazi chifukwa cha kuchuluka kwa maselo ofiira am'magazi ndi ma cell. Ethanol imakhudza dongosolo lamkati lamanjenje ndi trophism yamitsempha yamanjenje, chifukwa chake, ndikofunikira kusiya kumwa kwa nthawi yayitali ya chithandizo ndi Movogleken.

Analogi

Mutha kusintha mankhwalawo ndi imodzi mwamankhwala otsatirawa:

• Glenez;
• Glibenesis;
• Antidiab;
• Diabetes.

Kupita kwina mankhwala

Hypoglycemic mankhwala amagulitsidwa ndi mankhwala azachipatala.

Kodi ndingagule popanda kulandira mankhwala?

Chifukwa cha chiwopsezo chokhala ndi kukomoka kwa hypoglycemic, ndizoletsedwa kugwiritsa ntchito mankhwalawo popanda malangizo a kuchipatala.

Mtengo wa Movoglechen

Mtengo wapakati pamsika wamankhwala umafikira ma ruble 1,600.

Zosungidwa zamankhwala

Ndikulimbikitsidwa kuti asunge miyala ndi malo otalikirana ndi malowedwe a UV pa kutentha kwa + 8 ... + 25 ° C.

Tsiku lotha ntchito

Miyezi 42.

Analogue ya Movogleken - mankhwala a shuga. Amasungidwa m'malo osungidwa ndi UV kulowera.

Wopanga

Zhuhai United Laboratories Co, China.

Ndemanga za Movogleken

Kristina Doronina, wazaka 28, Vladivostok

Mwamuna wanga ali ndi shuga wambiri. Kwa zaka zingapo, samatha kupeza othandizira a glycemic, kuti asangochepetsa shuga, komanso kuti asunge mitengo yofananira. Pakukambirana kwotsatira, mapiritsi a Movoglecen adalembedwa. Pambuyo pa masiku 30 othandizira, shuga adabwezeretsa, mankhwalawa adayamba. Tsopano ili mkati mwa 8.2 mm, koma ndi bwino kuposa 13-15 mm, omwe anali m'mbuyomu.

Yaroslav Filatov, wazaka 39, Tomsk

Mankhwalawa sanathandizenso paciyambi. Pambuyo pothira 5 mg m'mawa, shuga amasungidwa mkati mwa 10-13 mm, chotupa cha khungu chinayamba. Ndi kuwonjezeka kwa mlingo mpaka 20 mg, shuga amayamba kuchepa m'milungu iwiri mpaka 6 mm. Zotsatira zoyipa zidadza mwa iwo okha. Koma chizindikiro ichi chimatengera zakudya ndi malingaliro m'mayendedwe. Mankhwala sangathe kutsika shuga ngati akudwala matenda osowa m'thupi.

Ulyana Guseeva, wa zaka 64, Krasnoyarsk

Ali ndi zaka 62, shuga wamwazi adakwera mpaka 16 mm. Zinayamba kasupe, atapuma pantchito. Anayamba kukhala moyo wongokhala chifukwa chosowa ntchito, zomwe zidapangitsa kuti glucose achepetse magazi. Kuphatikiza Gluconorm ndi Siofor sikunakhale koyenera.Analemba mapiritsi a Movoglek. Shuga amachepetsa 2 times. Pansi pa 8 mm sikuchepetsedwa. Sindinawone zotsatira zoyipa kwa zaka ziwiri. Pakadali pano, amakhalabe bwino, koma zikaipiraipira, ndibwino kusinthira ku mankhwala ena.