Moflaxia 400 - mapiritsi okhala ndi antibacterial kanthu, okhala ndi 400 mg ya moxifloxacin. Pulogalamu yogwira amagwira ntchito motsutsana ndi gram-negative ndi gram-aerobes yabwino. Akatswiri azachipatala amapereka mankhwala othandizira kuti apangitse matenda opatsirana, limodzi ndi kutupa kwambiri. Munthawi yamankhwala, ndikofunikira kutsatira malangizo a dokotala ndi malangizo kuti agwiritse ntchito.
Dzinalo Losayenerana
Moxifloxacin.
Moflaxia 400 - mapiritsi okhala ndi antibacterial kanthu, okhala ndi 400 mg ya moxifloxacin.
ATX
J01MA14.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi 400 mg a yogwira mankhwala - moxifloxacin hydrochloride. Kupititsa kuyamwa, chinthu chogwira ntchito chimaphatikizidwa ndi zina zowonjezera:
- magnesium wakuba;
- ma cellcose a microcrystalline;
- croscarmellose sodium.
Utoto wa mawonekedwe a mankhwalawo ndi pinki yakuda, chifukwa cha zomwe utoto wofiira umapezeka. Mapiritsiwa amaphatikizidwa ndi titanium dioxide, macrogol ndi hypromellose. Magawo a mankhwalawa ali m'matulu a makatoni a 5, 10, 15 m'matumba.
Mphamvu ya bactericidal imachitika chifukwa cha kuletsa kwa michere ya enzymatic ya mankhwala osakanikirana omwe amaphatikizidwa ndi kubwereza ndi kusindikiza kwa majini.
Zotsatira za pharmacological
The bactericidal limagwirira zake chifukwa cha ziletso za topoisomerase II ndi IV, mapuloteni kagayidwe kachakudya ndi kulepheretsa kwa enzymatic ntchito za intracellular mankhwala omwe akukhudzidwa ndi kubwereza ndi kulemba kwa majini. Zotsatira zakwaniritsa zochizira, kulimba kwa khoma la maselo kumachepa. Vuto la pathogenic limafa chifukwa chophwanya kukoka kwa osmotic.
Pharmacokinetics
Akamtenga, wothandizira pakamwa amayamba kulowa mkati mwa khoma lamatumbo, kuchokera pomwe limasiyanirana ndi magazi. Ndi gawo limodzi lokha la 400 mg, pazofunikira kwambiri za seramu imakhazikika mkati mwa mphindi 30-240 mutatha kugwiritsa ntchito. Bioavailability ndi 91%. M'magazi, kulumikizana ndi mapuloteni a plasma kumafika pa 45%.
Mankhwala osakanikirana ndi albumin amayamba kufalikira kudzera mu minofu ndi zamadzimadzi. A kuchuluka kwa moxifloxacin amawona mu alveoli wamapapu, bronchi, cutaneous epithelium, m'dera la kutupa. Mukamadutsa hepatocytes, gulu logwira limakhala ndi biotransfform ndikupanga glucuronides ndi sulfates omwe alibe antimicrobial.
Kuchotsa theka moyo kumatenga maola 12. Mankhwala a antibacterial amuchotseredwa mu mawonekedwe oyamba a moxifloxacin ndi mkodzo ndi 15%, wokhala ndi ndowe mu mawonekedwe a metabolites ndi 25%.
Akamtenga, wothandizira pakamwa amayamba kulowa mkati mwa khoma lamatumbo, kuchokera pomwe limasiyanirana ndi magazi.
Zizindikiro zogwiritsidwa ntchito
Akatswiri azachipatala amatha kutsegula Moflaxia pamaso pa njira zopatsirana zomwe zimayambitsidwa ndi tizilombo tating'onoting'ono tokhala ndi moxifloxacin:
- pachimake kutupa kwa sinuses;
- bakiteriya matenda;
- chibayo chopezeka pagulu;
- kuwonongeka kwakakhungu pakhungu ndi minofu yofewa, zovuta kapena zovuta zovuta zachiwiri (matenda ashuga);
- matenda otupa a chiwalo cha wamkazi;
- matenda amkati pamimba;
- stomatitis, prostatitis, pachimake cystitis;
- yotupa ndi yotupa njira mu pelvic patsekeke, osatsagana ndi kukula kwa zovuta.
Contraindication
Muzochitika zamankhwala, Moflaxia sanalembedwe kuti:
- kukhalapo kwa pathological process of tendons yomwe yayamba chifukwa cha mankhwala a quinolones;
- kukulitsa nthawi pakati pa mano a Q-T pa mtima;
- zosokoneza pamiyeso yamagetsi yamagetsi;
- anena ndi chidwi cha thupi ku ma fluoroquinolones maantibayotiki kapena zinthu zina za Moflaxia;
- kwambiri mtima pathologies;
- kuchuluka kwa hepatic aminotransferases.
Mankhwalawa amaletsedwa kuti azigwiritsidwa ntchito ndi amayi omwe ali ndi pakati komanso oyembekezera.
Ndi chisamaliro
Ndikofunika kumwa mankhwalawa moyang'aniridwa ndi achipatala pamaso pa zinthu zotsatirazi:
- matenda a chapakati mantha dongosolo, amene angayambitse kukula minofu kukokana;
- kusokonezeka kwa malingaliro, kuchuluka kwa mkwiyo, mantha;
- matenda am'mimba am'mimba;
- kusokonezeka kwa mtima;
- matenda a mtima;
- kuchepa kwamafuta kapena matenda ena a chiwindi;
- kusowa kwa shuga-6-phosphate dehydrogenase;
- myasthenia gravis.
Iwo ali osavomerezeka kuti amwe mankhwalawo limodzi ndi mankhwala omwe amachepetsa ndende ya potaziyamu mu plasma.
Momwe mungatenge Moflaxia 400
Maantibayotiki adapangira pakamwa. Mlingo watsiku ndi tsiku womwe ungagwiritsidwe ntchito kamodzi ndi 400 mg, osasamala nthawi yakudya. Kutalika kwa mankhwala antimicrobial kumatsimikiziridwa ndi adokotala omwe amapita, motsogozedwa ndi kuwonongeka kwa mabakiteriya, malo ake ndi zambiri zazachipatala za wodwalayo:
- Kutalika konse kwa mankhwalawa omwe amapezeka ndi chibayo cha m'magazi omwe amagwiritsidwa ntchito ndi intravenous mankhwala akutsatiridwa ndi Moflaxia 400 ndi masabata 1-2;
- mu pachimake sinusitis - 1 sabata;
- chotupa chopatsirana pakhungu, pakapita popanda zovuta, chimafuna chithandizo mkati mwa masiku 7;
- kutupa kwa khungu ndi zofewa zimakhala amathandizira masitepe othandizira masiku 7-21;
- matenda mabakiteriya mu pachimake gawo amathandizira masiku 5-10;
- matenda a m'mimba ziwalo ayenera kuchitira kwa masiku 5-14 pamaso pa zovuta;
- mankhwalawa zimatha 2 milungu.
Kutalika kwambiri kwa mankhwala a antimicrobial ndi masiku 21. Sitikulimbikitsidwa kupitilira njira yovomerezeka ya chithandizo. Ndikofunika kukumbukira kuti tizilombo tating'onoting'ono tomwe timayambitsa matenda timatha kukokana ndi fluoroquinolone, chifukwa chomwe achire sichidzakhalakonso.
Kumwa mankhwala a shuga
Mankhwala a antibacterial samakhudzanso glycemic bwino m'thupi komanso zotsatira za mankhwala a hypoglycemic. Nthawi yomweyo, moxifloxacin saphwanya zochitika za mahomoni a ma pancreatic beta cell, chifukwa chake, kusintha kowonjezera kwa anthu omwe ali ndi matenda amtundu wa 1 kapena 2 sikofunikira.
Zotsatira zoyipa za Moflaxia 400
Zotsatira zoyipa zimayamba ndi kugwiritsa ntchito mankhwala osokoneza bongo kapena kuchitiridwa nkhanza.
Matumbo
Mavuto am'mimbamo am'mimba amatha kutsatiridwa ndi kupweteka, nseru, dysphagia, kutsekula m'mimba komanso vuto la kukomoka, kukula kwa pseudomembranous colitis. Wotsirizayo akuwonekera motsutsana ndi maziko a kutsegula m'mimba kwa nthawi yayitali ndi zovuta za magazi. Mukatsimikizira kuti mukudwala, muyenera kusiya kumwa mankhwalawo.
Chifukwa cha kuletsa kwa ziwalo zopanga magazi, kuchuluka kwa maselo ofiira am'magazi, maselo oyera am'magazi ndi ma cell am'magazi mu seramu yamagazi amachepa.
Hematopoietic ziwalo
Chifukwa cha kuletsa kwa ziwalo zopanga magazi, kuchuluka kwa maselo ofiira am'magazi, maselo oyera am'magazi ndi ma cell am'magazi mu seramu yamagazi amachepa.
Pakati mantha dongosolo
Kuphwanya kwamanjenje kumawonekera monga:
- kusokonezeka kwa tulo (kusowa tulo);
- kugwedezeka
- zovuta zamagalimoto;
- dziko lokhumudwa;
- chisokonezo ndi kutayika kwa chikumbumtima;
- minofu kukokana;
- Chizungulire
- kulemera m'malo otsika;
- kutaya mtima.
Kuchokera pakugwiritsa ntchito mankhwalawa, kusokonezeka kwa tulo (kusowa tulo) kumawonetsedwa.
Zotsatira zoyipa za mankhwalawa ndizosautsa mtima.
Popeza mankhwalawa atha kukhala osazindikira.
Kuchokera pakugwiritsa ntchito mankhwalawa, kusokonezeka kwamanjenje kumawonekera mu mawonekedwe amisempha.
Kuchokera kwamikodzo
Nthawi zina, kusungika kwamikodzo ndikotheka.
Kuchokera ku kupuma
Ndi masewera olimbitsa thupi, dyspnea imayamba.
Pa khungu ndi subcutaneous minofu
Maonekedwe a zoyipa pakhungu amadziwika ndi kukula kwa kuyabwa, kupezeka kwa zotupa, erythema.
Pa gawo la kagayidwe ndi zakudya
Mukudutsa mayeso a labotale, kuchepa kwa prothrombin nthawi ndi kuwonjezeka kwa zochitika za amylase ndizotheka.
Kuchokera pamtima
Nthawi zina, tachycardia imatenga nthawi yayitali.
Zotsatira zoyipa zogwiritsa ntchito Moflaxia 400 kuchokera mu mtima zimatha kukhala kupuma tachycardia.
Dongosolo la Endocrine
Kuthanso thukuta.
Kuchokera minofu ndi mafupa
Wodwalayo amamva kupweteka kumbuyo, mafupa, komanso minofu.
Matupi omaliza
Ngati pali vuto lotsogola, pamakhala mwayi wopanga anaphylactic mantha kapena khungu.
Zokhudza mphamvu pakuwongolera njira
Maantibayotiki samakhudza kuyendetsa galimoto kapena njira zovuta, chifukwa chake, panthawi yopangira mankhwala othandizira, kuyendetsa galimoto kapena kuchita zinthu zina zomwe zimafunikira chidwi chochulukirapo komanso kuloleza kwakukulu kuchokera kwa wodwala kuloledwa.
Malangizo apadera
M'pofunika kugwiritsa ntchito moxifloxacin mosamala odwala omwe ali ndi khunyu, kuchuluka kwa QT kokwanira pa electrocardiogram, ndi kulephera kwa chiwindi.
Pa mankhwala osokoneza bongo omwe ali ndi fluoroquinolones, pamakhala chiopsezo chotenga njira yotupa m'misempha yodziwika ndi kupasuka kwa zimakhala. Kuchepa kwa tenosynovitis kumawonjezeka mwa anthu azaka zopitilira 65 ndipo ndikuthandizanso chimodzimodzi ndi glucocorticosteroids. Zizindikiro zopweteka zoyambirira zikayamba kuwoneka, muyenera kusiya kumwa Moflaxia nthawi yomweyo. Ndikulimbikitsidwa kuchepetsa kuchita masewera olimbitsa thupi, makamaka katundu pa miyendo ndi njira yothandizira.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa sanalembedwe kwa amayi apakati, chifukwa chiopsezo cholowerera moxifloxacin kudzera mu chotchinga chachikulu. Chidacho chogwira ntchito chimatha kusokoneza chizindikiro chachikulu chazindikiritso pakukonzekera kukula kwa embryonic.
Panthawi ya chithandizo, ndikofunikira kusamutsa mwana ku zakudya zopanda ntchito.
Kulembera Moflaxia kwa ana 400
Asanakwanitse zaka 18, kumwa mankhwalawo ndizoletsedwa.
Gwiritsani ntchito mu ukalamba
Anthu achikulire amatha kupezeka ndi zotumphukira m'matumbo ndi m'mizimba, kenako ndikumapunduka.
The ntchito aimpso kuwonongeka
Odwala omwe ali ndi vuto lolakwika laimpso safunika kusintha mlingo.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Odwala omwe ali ndi vuto la chiwindi safunika kusintha njira.
Kuchulukitsa kwa Moflaxia 400
Pa maphunziro a preclinical, panalibe zizindikiro za kumwa mopitirira 1200 mg wa mankhwala kamodzi kapena 600 mg tsiku lililonse kwa masiku 10. Kutengera mawonekedwe a munthu payekha, kukulitsa zotsatira zoyipa kapena kufalikira kwawo ndizotheka.
Pakachitika chipatala, njira zochizira zidzalimbana ndikuwachotsera chithunzi cha bongo. Kaboni yokhazikitsidwa imalimbikitsidwa kuti iziteteza kuyamwa kwa antibacterial.
Kuti tichotse chithunzi chokhala ndi mankhwala osokoneza bongo, tikulimbikitsidwa kuti muthe makala o makala.
Kuchita ndi mankhwala ena
Pali kusagwirizana kwa mankhwala ndi kufanana kwa moxifloxacin ndi mankhwala otsatirawa:
- antiarrhythmic mankhwala IA ndi III kalasi;
- antihistamines;
- Maantibayotiki, erythromycin yankho la mtsempha wa magazi, antimalarials, Sparfloxacin;
- Vincomycin;
- antipsychotic mankhwala;
- Kusiyana;
- antidepressants;
- Cisapride.
Maantacid okhala, othandizira pakudya ndi multivitamin ndi mchere, kukonzekera kwa magnesium ndi chitsulo, mankhwala ochepetsa mphamvu ya kachilomboka angathandize kuyamwa kwa moxifloxacin. Pankhaniyi, antibacterial zotsatira zimafooka. Kuthira kwachilendo kwa moxifloxacin, ndikofunikira kumwa mankhwalawa patatha maola 4 kapena maola 4 mutatha kugwiritsa ntchito maantibayotiki.
Warfarin ndi mankhwala ena osokoneza bongo omwe amasintha kuchuluka kwa magazi samasintha magawo a pharmacokinetic a moxifloxacin.
Ndi kugwiritsidwa ntchito komweko kwa anticoagulants, milandu yowonjezera ya anticoagulant ya mankhwala yalembedwa. Chiwopsezo chowonjezeka cha zochita za anticoagulant chimawonjezeka pamaso pa ndondomeko yotupa kwambiri, wodwalayo sanathere. Okalamba amakhala ndi chizolowezi chomakula. Chifukwa chake, ndi munthawi yomweyo makonzedwe a moxifloxacin okhala ndi anticoagulants osafunikira, ndikofunikira kusintha njira yotsirizira.
Moxifloxacin amatha kuwonjezera kuchuluka kwa plasma ndende ya digoxin ndi 30%. Komabe, ichi sichizindikiro chodwala, chifukwa kuchuluka kwa zomwe zimagwira sikukhudza mkhalidwe wa wodwalayo.
Yogwiritsa kaboni imalepheretsa kuyamwa kwa yogwira phula Moflaxia ndi 80-90%, potero kuchepetsa kuchepa kwa antibacterial mankhwala.
Kuyenderana ndi mowa
Munthawi yamankhwala, ndizoletsedwa kumwa zakumwa zoledzeretsa chifukwa cha kuchuluka kwa chiwindi. Ethanol imafooketsa masinthidwe othandizira pa microflora ya bakiteriya, imakulitsa mkhalidwe wamkati wamanjenje komanso wamagazi.
Kugulitsa kwaulere kwa mankhwala kumakhala kochepa chifukwa cha chiwopsezo cha dysbiosis yamatumbo ndikugwiritsa ntchito molakwika mankhwalawa.
Analogi
Moflaxia m'malo mwake ndi imodzi mwamankhwala otsatirawa:
- Alvelon;
- Moxifloxacin Canon;
- Megaflox;
- Maxiflox;
- Rotomox.
Kupita kwina mankhwala
Mankhwalawo amagulitsidwa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Kugulitsa kwaulere kwa mankhwala kumakhala kochepa chifukwa cha chiwopsezo cha dysbiosis yamatumbo ndikugwiritsa ntchito molakwika mankhwalawa.
Mtengo wa Moflaxia 400
Mtengo wapakati wa antibayotiki ndi ma ruble 350.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kuti muteteze mapiritsi kuti angayikidwe ndi cheza cha ultraviolet. Mukasungidwa, ndikofunikira kuyang'anira kutentha kwa kutentha + 8 ... + 25 ° C.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
JSC "Krka, dd, Novo mesto", Slovenia.
Ndemanga za Moflaxia 400
Valentin Kalashnikov, wazaka 39, Moscow
Anazindikira chibayo cham'magazi ndipo anagonekedwa m'chipatala. Panali sabata m'chipatalamo, pomwe a Moflaxia adawonetsedwa ndi mankhwala ena a Doxycycline. Ngakhale mndandanda wa zotsutsana ndi zoyipa, thupi limalekerera bwino mankhwalawo. Ndinaona zotukuka tsiku loyamba: kutentha, komwe kunali kokhazikika pa + 38 ° C, kudatsika pang'ono.
Galina Antonova, wazaka 27, Arkhangelsk
Ndinayenera kumwa maantibayotiki osiyanasiyana, ena omwe matupi awo sagwirizana. Anapeza Moflaxia pazotsatira za otolaryngologist wokayikira. Koma sinusitis amayenera kuchitiridwa. Mantha sanawonekere, chifukwa kunalibe ziwopsezo kapena zovuta zina. Patsiku lachiwiri la mankhwala, mankhwalawa adayamba kuyenda bwino. Zinayamba kupumira, kutupa kunayamba kutha. Ndinkamwa piritsi limodzi patsiku.
