Ultrashort insulin Glulizin - mawonekedwe ndi mawonekedwe a ntchito

Mtundu wa matenda ashupi amtundu woyamba, wodwala amatha kugwiritsa ntchito insulin yofulumira (yofulumira), yochepa, yapakatikati, yayitali komanso yosakanikirana ndi insulin.

Yemwe angafotokozere za mtundu wokwanira wa mankhwala zimadalira munthu payekha. Ngati insulin yochepa kwambiri ndiyofunikira, Glulisin amagwiritsidwa ntchito.

Mwachidule za insulin Glulizin

Molecule wa insulin

Insulin Glulisine ndi analogue ya insulin ya anthu, yofanana ndi iyi timadzi. Koma mwachilengedwe, limagwira mwachangu komanso limakhala lalifupi.

Glulisin imaperekedwa ngati yankho la subcutaneous makonzedwe. Chimawoneka ngati madzi owonekera popanda zosayera.

Mayina amalonda a mankhwala okhala ndi iye: Apidra, Epidera, Apidra Solostar. Cholinga chachikulu cha mankhwalawa ndikukhazikitsa kagayidwe ka glucose.

Malinga ndi zomwe zikuchitika, zabwino ndi zovuta zotsatirazi zingathe kusiyanitsidwa:

• imachita mofulumira kuposa mahomoni amunthu (+);
• imakwaniritsa kufunika kwa chakudya mu insulin (+);
• kuthekera kosayembekezereka kwa zotsatira za mankhwalawa pamagulu a shuga (-);
• mphamvu yayikulu - gawo limachepetsa shuga kuposa ma insulin ena (+).

Pharmacology ndi pharmacokinetics

Pambuyo pa subcutaneous makonzedwe, pali kuchepa kwa glucose chifukwa cha kukoka kwake kwa kugwiritsidwa ntchito kwake mu minofu komanso kupsinjika kwa njirazi mu chiwindi. Kuchitikaku kumayambira mphindi 10 jekeseni.

Ndi kukhazikitsidwa kwa Glulisin ndi insulin yokhazikika mphindi zingapo asanadye, wakale amakhala ndi mphamvu yolamulira pakatha kudya. The bioavailability wa chinthu pafupifupi 70%.

Kulumikizana ndi mapuloteni a plasma ndikosatheka. Amachotseredwa mwachangu pang'ono kuposa momwe amapangira jakisoni wa anthu. Hafu ya moyo wa mphindi 13.5.

Malangizo ogwiritsira ntchito

Mankhwalawa amaperekedwa nthawi yomweyo musanadye (kwa mphindi 10-15) kapena mukangomaliza kudya, poganizira mankhwala omwe mumalandira ndi ma insulin ena (munthawi ya chochitika kapena kuyambira). Njira zoyendetsera: mozungulira mwendo, phewa. Popewa kuvulala, tsamba la jakisoni limatsitsidwa. Mankhwalawa amaperekedwa m'malo osiyanasiyana, koma m'malo omwewo.

Glulisin amaphatikizidwa ndi ma insulin ndi othandizira otsatirawa:

• ndi analog ya basal hormone;
• ndi pafupifupi;
• ndi yayitali;
• Mankhwala okhala ndi hypoglycemic.

Mphamvu ya glycemia ndi kuwonjezera kwa insulin Glulizin kuchiritsa ndi basal insulin

Ngati njira yothetsera vutoli ikuyenera kuperekedwa pogwiritsa ntchito zolembera, ma jakisoni amachitidwa mogwirizana ndi malangizo a umakanichi. Mlingo wa mankhwalawa umasankhidwa payekha, poganizira momwe wodwalayo alili komanso kuchuluka kwa chiphuphu.

Musanagwiritse ntchito Glulizin, yodzazidwa mu cartridge, kuyendera kumachitika - njira yamatope yokhala ndi inclusions sioyenera kugwiritsidwa ntchito.

Malangizo a kanema ogwiritsa ntchito cholembera:

Zizindikiro, mavuto, bongo

Mankhwala amalembedwa motere:

• Mtundu woyamba wa shuga;
• Mtundu 2 shuga;
• Matenda a shuga kwa ana kuyambira zaka 6.

Contraindging poika mankhwala ali motere:

• hypoglycemia;
• Hypersensitivity kuti glulisin;
• Hypersensitivity pamavuto othandizira a mankhwalawo.

Munthawi ya mankhwala ndi mankhwala, zimachitika zovuta.

Pafupipafupi zochitika zolakwika pamanambala, pomwe zina 4 ndizofala kwambiri, 3 nthawi zambiri, 2 ndizosowa, 1 ndizosowa kwambiri:

Pa bongo wambiri, hypoglycemia ya zovuta zosiyanasiyana imawonedwa. Itha kuchitika nthawi yomweyo kapena kukula pang'onopang'ono.

Kutengera mphamvu ya insulin mankhwala, nthawi yayitali komanso kuuma kwa matendawa, zizindikiro za hypoglycemia zitha kusokonekera kwambiri. Wodwala ayenera kulingalira izi kuti ateteze vutolo munthawi yake. Kuti muchite izi, muyenera kukhala ndi shuga (maswiti, chokoleti, ma cubes opanda shuga) nanu.

Ndi hypoglycemia yolimbitsa komanso yolimbitsa, zinthu zomwe zimakhala ndi shuga zimatengedwa. Woopsa, komanso limodzi ndi kuwonongeka kwa chikumbumtima, jakisoni adzafunika.

Kuyimitsidwa kwa hypoglycemia kumachitika mothandizidwa ndi glucagon (s / c kapena i / m), yankho la glucose (i / v). Pakupita masiku atatu, mkhalidwe wa wodwalayo umayang'aniridwa. Popewa kukula kwa hypoglycemia wobwereza, ndikofunikira kumwa chakudya pakapita kanthawi.

Kuyanjana kwa mankhwala osokoneza bongo

Kumayambiriro kwa mankhwala omwe ali ndi insulin ya ultrashort, kuyanjana kwake ndi mankhwala ena kumazingidwa.

Mankhwala ambiri amatha kuthana ndi kagayidwe ka glucose, kukulitsa kapena kuchepetsa zotsatira za insulin. Asanalandire chithandizo, wodwala ayenera kudziwitsidwa kuti apewe mavuto.

Mankhwala otsatirawa amalimbikitsa zotsatira za Glulisin: Fluoxetine, othandizira a hypoglycemic mapiritsi, makamaka, sulfonylureas, sulfonamides, salicylates, fibrate, ACE inhibitors, Disopyramide, MAO inhibitors, Pentoxifylline, Propoxifen.

Mankhwala otsatirawa amachepetsa mphamvu ya mankhwala a insulin: atypical antipsychotic, sympathomimetics, njira zakulera pakamwa, mahomoni a chithokomiro, glucagon, mahomoni achigololo achikazi, thiodiphenylamine, somatropin, diuretics, glucocorticosteroid mankhwala (GCS), proteinase inhibitors,

Pentamidine, beta-blockers, clonidine amatchulidwa kwa mankhwala omwe mosasamala angakhudze mphamvu ya mphamvu ya Glulisin ndi mulingo wa shuga (kuchepa ndi kuwonjezeka). Mowa ulinso ndi zomwezo.

Kusamala kwakukulu kumawonedwa popereka Pioglitazone kwa odwala omwe ali ndi mtima wamtima. Akaphatikizidwa, milandu ya kukhazikika kwa mtima idanenedwa mwa odwala omwe ali ndi chiyembekezo cha matendawa.

Ngati chithandizo cha pioglitazone sichitha kutha, ndikofunikira kuyang'anira momwe zinthu ziliri. Ngati zizindikiro zilizonse zamtima (kuwonda, kutupa) ziwoneka, kugwiritsa ntchito mankhwalawa kumachotsedwa.

Malangizo apadera

Wodwalayo ayenera kuganizira izi:

1. Ndi vuto la impso kapena kuphwanya ntchito yawo, kufunika kwa insulini kungachepe.
2. Ndi kukanika kwa chiwindi, kufunikira kumacheperanso.
3. Chifukwa cha kusowa kwa chidziwitso, mankhwalawa saikidwa kwa ana osakwana zaka 6.
4. Gwiritsani ntchito mosamala amayi apakati omwe ali ndi kuyang'anira pafupipafupi zizindikiro.
5. Pa mkaka wa m`mawere, kusintha kwa mlingo ndi zakudya zimafunika.
6. Mukasintha kupita ku Glulisin kuchokera ku hormone ina chifukwa cha hypersensitivity, kuyesedwa kwa ziwengo kuyenera kuchitidwa kupatula kusagwirizana.

Kusintha kwa Mlingo

Kusintha kwa Mlingo kumachitika pa kusintha kwa mtundu wina wa mahomoni obayira. Mukasamutsa kuchokera ku insulin ya nyama kupita ku Glulisin, mlingo umakonda kusintha m'njira yochepetsera chomaliza. Kufunika kwa mankhwalawa kumatha kusinthika ndikusokonezeka kwamalingaliro / kukhumudwa, munthawi ya matenda opatsirana.

Chiwembucho chimayendetsedwa mothandizidwa ndi mankhwala a mapiritsi a hypoglycemic. Ngati mutasintha gawo lililonse la pulogalamuyi, mungafunike kusintha mlingo wa Glulisin.

Nthawi zambiri za hyperglycemia / hypoglycemia, zinthu zotsatirazi zomwe zimadalira mlingo zimafotokozedwa musanayambe kuchuluka kwa mankhwalawa:

• njira ndi malo mankhwala;
• kutsatira kwambiri njira zochizira;
• kugwiritsa ntchito mankhwala ena;
• psycho-state state.

Zowonjezera

Zabwino - zaka 2

Alumali moyo mutatsegula - mwezi

Kusungirako - kuyambira pa +2 mpaka + 8ºC. Osamawuma!

Kupumula ndikumvera mankhwala.

Glulisin ndiwofanana ndi insulin ya anthu:

• Insuman Rapid;
• Humulin;
• Humodar;
• Gensulin P;
• Vosulin P;
• Khalid.

Glulisin ndi mahashoni a ultrashort wokhazikitsa kagayidwe ka glucose. Amawerengera limodzi ndi ma insulin ena, poganizira zosankha zomwe zidasankhidwa. Musanagwiritse ntchito, ndikofunikira kuphunzira malangizo ndi kulumikizana ndi mankhwala ena.