Mankhwala Siofor 1000, malangizo ogwiritsira ntchito omwe ndiofunika kwambiri kuti mankhwalawa agwire bwino ntchito, ali m'gulu la Biguanides. Matenda a shuga ndi matenda oopsa omwe nthawi zambiri samachiritsidwa.
Kuti awonetsetse momwe mankhwalawo alili, wodwalayo ayenera kusintha kwambiri moyo wake. Koma ndi matenda a shuga II amtundu (osadalira insulin), kusintha kokha pakudya ndi masewera olimbitsa thupi sikokwanira. Kuti muchepetse vutoli, mankhwala apadera amaperekedwa kwa wodwala, omwe ndi Siofor 1000.
Mankhwalawa amalembedwa kwa onse akulu ndi ana azaka 10. Monga tawonera, mankhwalawa nthawi zambiri amaperekedwa kwa odwala omwe ali ndi kunenepa kwambiri, malinga ndi njira zomwe zimagwiritsidwa ntchito pakuchepetsa thupi ndizosakwanira (zakudya zoyenera, zolimbitsa thupi). Potere, mankhwalawa athandizira kwambiri kuchepetsa chiwopsezo cha matenda a shuga.
Zochizira odwala matenda ashuga akuluakulu, mankhwala a Siofor amawayikidwa limodzi ndi mankhwala ena omwe amatsitsa kuchepetsa misempha ya m'magazi. Mankhwalawa amaphatikizapo mankhwala aliwonse othandizira pakamwa, komanso jakisoni wa insulin. Kuphatikiza apo, Siofor imayikidwa popanda mankhwala ena. Kwa ana, Siofor yekha ndi amene amapatsidwa mankhwala owonjezera (pokhapokha ngati jakisoni wa insulini akufunika)
Pharmacodynamics ndi pharmacokinetics a mankhwalawa
Mankhwala a Siofor 1000 ndi a biguanides - gulu la mankhwala a hypoglycemic omwe amaperekedwa kwa odwala omwe samadalira shuga. The pharmacological zochita za Siofor cholinga chake kutsitsa kuchuluka kwa glucose m'magazi, ndiye kuti, ili ndi vuto la antiidiabetes.
Mankhwala amatha kusintha m'njira zosiyanasiyana. Choyamba, ntchito yopanga ndi kulowetsedwa kwa glucose kuchokera m'matumbo amachepetsa. Nthawi yomweyo, kukana insulini (kukana insulini) kumachepa.
Kuphatikiza apo, motsogozedwa ndi Siofor 1000, kugwiritsa ntchito shuga kumatheka, lipid metabolism imathandizira. Chifukwa cha izi, sikuti ndizotheka kungosintha pang'ono thanzi la wodwalayo, komanso, ngati kuli kofunikira, kuthandizira kuchepetsa thupi. Kuphatikiza apo, mankhwalawa amatha kuchepetsa kudya, omwe amathandizanso pochiza kunenepa kwambiri.
Mosasamala za kuchuluka kwa shuga m'magazi, mankhwalawo amathandizira kutsitsa kuchuluka kwa triglycerides, cholesterol - yonse yotsika komanso yotsika kachulukidwe.
Mankhwala amapezeka mwa mawonekedwe a mapiritsi, koma kusiyanasiyana kwake ndi kotheka:
- mapiritsi okhazikika
- mapiritsi otulutsidwa
- filimu yokutidwa
- ndi zokutira enteric.
Mapiritsi onse ali ndi notch yolekanitsa, komanso yopumira.
Gawo lalikulu la Siofor ndi metformin hydrochloride. Kuphatikizikako kumaphatikizanso titanium dioxide, magnesium stearate, povidone K-25, etc. Piritsi limodzi lili ndi 1000 mg ya yogwira ntchito.
Phukusili limatha kukhala ndi mapiritsi 10, 30, 60, 90 kapena 120, koma si mankhwala aliwonse omwe amagula zosankha zonse za mankhwalawa, chifukwa chake mapaketi okhala ndi chiwerengero choyenera cha mapiritsi sangakhalepo.
Zinthu zabwino kwambiri zomwe zimapezeka m'thupi zimakwaniritsidwa maola 2,5 mutamwa mapiritsi. Bioavailability (kwa munthu wathanzi) - mpaka 60%. Kuchita bwino kwa mankhwalawa kumatsimikiziridwa makamaka ndi nthawi ya chakudya chomaliza: chifukwa chake, ngati mumwa mankhwalawo ndi chakudya, mphamvu yake imawonongeka kwambiri.
Metformin hydrochloride sitingathe kumanga mapuloteni amwazi. Pakutupa kwa chinthu kuchokera mthupi, chizolowezi chimakhala maola 5 ndi ntchito yachibadwa ya impso.
Ngati ntchito yawo imalephera, chindapusa cha metformin m'magazi chimakwera, popeza nthawi yochotsa imachulukitsidwa.
Contraindication
Ngakhale kuti mankhwalawa amavomerezedwa bwino ndi odwala ambiri, pali zotsutsana chifukwa chotenga mapiritsi a Siofor 1000. Chowopsa chachikulu ndi matenda a shuga a I.
Mankhwalawa sanatchulidwe ngati mukumwa mankhwala omwe amagwiritsidwa ntchito ndi mankhwala - metformin hydrochloride - kapena mankhwala ena aliwonse.
Mavuto aliwonse omwe amayamba chifukwa cha matenda a shuga omwe amadalira insulin atha kukhala osokoneza. Izi zimaphatikizapo, mwachitsanzo, ndizochulukirapo kuposa zamagulu am'magazi zomwe zimayang'ana m'madzi a m'magazi, oxidation yamagazi chifukwa chazomwe zimakhala ndi zinthu zowola (matupi a ketone) chifukwa cha zotupa ndi zina zina. Vutoli limatha kutsimikizika ndi kupweteka kwambiri m'mimba, kununkhira kwa zipatso kuchokera mkamwa, kugona, komanso kupuma movutikira.
Malangizo a boma omwe amamwa mankhwalawa akuwonetsanso zochitika zina ndi matenda omwe osavomerezeka kuti atenge Siofor 1000:
- Ndi kukula kwa pachimake chikhalidwe, chifukwa cha zomwe kuphwanya kugwira ntchito kwa impso kuwonekera, pamaso pa matenda, ndi kutaya madzi ambiri chifukwa kusanza, kutsegula m'mimba, kusokonezeka kwa magazi,
- Kumayambiriro kwa kuphunzira kwa kusiyanasiyana kochokera ku ayodini. Zinthu ngati izi zimagwiritsidwa ntchito, mwachitsanzo, pakafukufuku wa X-ray.
- Matenda ndi mikhalidwe yomwe idayambitsa kuperewera kwa oxygen - kusokonezeka kwa mtima, kudwala mtima kwakanthawi mankhwala atalembedwa, kuwonongeka kwa magazi, matenda a impso, impso, chiwindi,
- Kuledzera / kuledzera.
Komanso contraindication imaphatikizapo:
- kudwala matenda ashuga (kapena vuto lakelo);
- ketoacidosis;
- chakudya cham'mimba (zosakwana 1000 kcal / tsiku);
- zaka za ana (mpaka zaka 10);
- opaleshoni yaposachedwa kapena kuvulala;
- kusala kwachiritsi ndi mtundu 2 shuga;
- Kuchotsa kwachilengedwe kupanga insulin.
Zina mwa zinthuzi zikachitika, muyenera kufunsa dokotala kuti akupatseni mankhwala ena.
Kuphwanya mosamalitsa kwa kumwa mankhwalawa ndi nthawi yokhala ndi pakati komanso mkaka wa m'mawere.
Zochizira pankhaniyi, mankhwala osiyanasiyana okhala ndi insulin amagwiritsidwa ntchito.
Malangizo ogwiritsira ntchito mankhwalawa
Kuti mukwaniritse zomwe mukufuna, ndikofunikira munthawi ya chithandizo ndi Siofor 1000, malangizo ogwiritsira ntchito kuti atsatire molondola momwe mungathere.
Mlingo wa mankhwalawa umayikidwa payekhapayekha kwa wodwala aliyense, kutengera kuchuluka kwa shuga, ndiye kuti umasintha.
Kumayambiriro kwa chithandizo, osapitirira 1 g ya Siofor (500 kapena 850) nthawi zambiri amakhazikitsidwa. Pambuyo pake, mlingo wa sabata umakulitsidwa sabata iliyonse mpaka 1.5 g, omwe amafanana ndi mapiritsi atatu a Siofor 500 kapena mapiritsi awiri a Siofor 850.
Kwa mankhwalawa Siofor, 1000 mg pafupifupi amamuganizira kuti ndi ochokera ku mapiritsi 2 g (i.e. 2), koma osapitilira 3 g (mapiritsi atatu) pafupifupi payezo ngati mankhwala abwinobwino.
Kuti mapiritsi azitha kugwira bwino ntchito, ndikofunikira kutsatira mosamalitsa malangizo omwe aperekedwa chifukwa cha mankhwalawa.
Ndikofunikira kutenga Siofor ndi chakudya. Mapiritsi sayenera kulumwa kapena kutafuna. M'malo mwake, imwani madzi ambiri.
Ngati mukufuna kutenga piritsi limodzi la Siofor patsiku, ndiye kuti ndikulimbikitsidwa kuti mugawire magawo awiri kapena atatu ofanana ndikutenga chakudya chilichonse. Mankhwala omwe mwasowa mwadzidzidzi sayenera kubwezeretsedwanso motere, kumwa mankhwalawa kawiri.
Kutalika kwa nthawi ya mankhwala pogwiritsa ntchito kukonzekera kwa Siofor kumatsimikiziridwa ndi dokotala.
Monga tanena kale, Siofor amadziwikiratu pakubala, mkaka wa m`mawere. Popeza palibe zambiri zolondola zamankhwala, mankhwalawa sanadziwitsidwe zochizira matenda a shuga omwe amadalira ana.
Kuphatikiza pa shuga, Siofor amakulolani kuti muchepetse thupi mofulumira. Koma posakhala ndi mtundu wa shuga I, ngati mankhwalawo akuyenera kugwiritsidwa ntchito kokha pakuchepetsa thupi, muyenera kukhala ndi lingaliro labwino momwe mungatenge Siofor pankhaniyi. Palibe chifukwa chomwe muyenera kupitirira muyeso osachepera 0,5 mapiritsi a Siofor 1000.
Panthawi yoonda, ndikofunikira kutsatira zakudya ndikuwonjezera zolimbitsa thupi. Zotsatira zoyipa zilizonse zikachitika, tikulimbikitsidwa kusiya kumwa mankhwalawa.
Pitilizani njira yotenga Siofor kuti muchepetse thupi siipitilira miyezi itatu.
Zotsatira zoyipa
Monga mankhwala ena aliwonse, nthawi zina, Siofor 1000 imatha kuyambitsa mavuto osiyanasiyana, ngakhale ndiyosowa komanso si kwa aliyense amene amamwa mankhwalawa.
Nthawi zambiri, zimachitika chifukwa chopitilira muyeso wovomerezeka wa mankhwalawa.
Mwa zina zomwe zimachitika pafupipafupi, zotsatirazi zimasiyanitsidwa - nseru, kuwonda kwambiri kapena kusowa chilala, kutsegula m'mimba, kusintha kwa zomverera.
Zotsatira zoyipa za Siofor nthawi zambiri zimachitika pokhapokha pakuyamba mankhwala. Nthawi zambiri amadutsa popanda chithandizo chapadera pakapita kanthawi. Popewa kuwonetsedwa kwa zizindikirozi, ndikofunikira kuyang'anira mosamala malangizo omwe akuperekedwa kwa mankhwalawo.
Kuchuluka kwa mankhwalawa kuyenera kugawidwa mu Mlingo wa 2-3. Ngati, mukutsatira zonse zofunikira, Zizindikiro sizitha, muyenera kufunsa dokotala.
Zotsatira zoyipa kwambiri ndizosowa:
- Khungu, zotupa, kuyabwa.
- Kutengera komwe kumamwa mankhwalawa, kuperewera kwa vitamini B12 kumatha kukhala chifukwa cha kuchepa kwa magazi m'thupi (megelblastic anemia).
- Mavuto osiyanasiyana a metabolic, mwachitsanzo, lactate acidosis - makutidwe ndi okosijeni a magazi mothandizidwa ndi lactic acid. Zizindikiro za lactic acidosis ndi ofanana ndi zovuta zina zoyambira (kutsegula m'mimba, kusanza, kupweteka pamimba). Koma patatha maola ochepa, zizindikiritso zambiri za matendawa zimayamba (kupuma mwachangu, kupweteka kwa minofu ndi kukokana, kusiya kudziwa, mwinanso kukomoka).
Osowa kwambiri, kusintha kwa chiwindi kumawonedwa: zotsatira zachilendo za kuyesa kwa chiwindi, hepatitis, limodzi ndi jaundice (kapena popanda iyo). Nthawi zambiri, pakutha kwa Siofor, mavuto onse amawonongeka munthawi yochepa.
Pali zochitika zochepa zoyipa zomwe zimachitika pakumwa ana mu mankhwalawa, kotero ziwerengero pamilandu iyi sizolondola. Mawonetsero onse ndi kuuma kwawo ali ofanana mu akulu. Mwana akakhala ndi zovuta atamwa Siofor zomwe sizikufotokozeredwa malangizo a mankhwalawa, ndikofunikira kudziwitsa dokotala kapena wafizikisi za iwo.
Kuchuluka kwa Siofor mu shuga sikumayambitsa hypoglycemia (kuchepa kwakukulu kwa shuga). Koma chiwopsezo chili pachiwopsezo chachikulu chokhala ndi lactic acidosis ndi mawonekedwe onse. Chifukwa chake, ndikofunikira kudziwitsa dokotala.
Popeza bongo wambiri umakhala ndi vuto lalikulu thanzi, wodwala amathandizidwa kuchipatala.
Mitengo ndi kuwunika kwa mankhwala
Mutha kugula mankhwalawo ku pharmacy iliyonse. Nthawi yomweyo, mtengo wa Siofor ku Russia m'malo osiyanasiyana umasinthasintha pafupifupi ma ruble 450 pachilichonse cha mankhwalawo.
Ma fanizo odziwika bwino a mankhwalawo ndi Fetmetin, Glucofage, Metformin 850.
Mukamavu mutha kupeza ndemanga zambiri zamankhwala, kuchokera kwa madokotala komanso kwa iwo omwe adalandira chithandizo cha matenda a shuga. Akatswiri amasiyira ndemanga za Siofor zabwino, monga zimadziwika kuti mankhwalawa amakulolani kusintha matenda a shuga m'magazi ndikuchepetsa pang'ono, zomwe ndizofunikira kwa odwala ambiri omwe ali ndi matenda ashuga. Koma, malinga ndi madotolo, ndikofunika kumwa mankhwalawo pokhapokha ngati muli ndi matenda a shuga a II.
Mwa odwala omwe ali ndi matenda ashuga, mankhwalawa adalandiridwa bwino, chifukwa Siofor amathandizira kuwongolera shuga komanso mwanjira ina amachepetsa moyo wa matenda ashuga II.
Omwe adatenga Siofor kuti achepetse thupi amati mankhwalawo amaperekanso mphamvu yofunikira, amathandiza kuchepetsa kulakalaka, ndipo pambali pake amagulitsidwa pamtengo wovomerezeka. Komabe, kutha kwa kudya, kulemera kwake kumabwereranso. Kuphatikiza apo, zovuta zoyipa monga kuwonongeka kwa chakudya cham'mimba nthawi zambiri zimawonekera. Kanemayo munkhaniyi akupitiliza mutu wa Siofor wa matenda ashuga.
