Insulin Lantus Solostar: ndemanga ndi mtengo, malangizo ogwiritsira ntchito

Insulin Lantus SoloStar ndi analogue ya mahomoni omwe amakhala ndi nthawi yayitali, omwe cholinga chake ndi chithandizo cha matenda a shuga a mtundu 1 komanso a 2. Chithandizo chogwira mankhwalawa ndi insulin glargine, chinthu ichi chimapezeka ku Escherichiacoli DNA pogwiritsa ntchito njira yobwerezeranso.

Glargin amatha kumangiriza ma insulin zolandilira ngati insulin yaumunthu, chifukwa chake mankhwalawo ali ndi zonse zofunika pobadwa mu mahomoni.

Kamodzi mu subcutaneous mafuta, insulin glargine imalimbikitsa kupangika kwa microprecipitate, chifukwa chomwe kuchuluka kwa mahomoni kumatha kulowa m'mitsempha ya wodwala matenda ashuga. Njira imeneyi imapereka mbiri yabwino kwambiri ya glycemic.

Zolemba za mankhwala

Opanga mankhwalawa ndi kampani yaku Germany ya Sanofi-Aventis Deutschland GmbH. Chofunikira chachikulu cha mankhwalawa ndi insulin glargine, kapangidwe kake kamaphatikizanso othandizira mu mawonekedwe a metacresol, zinc chloride, glycerol, sodium hydroxide, hydrochloric acid, madzi a jakisoni.

Lantus ndi madzi owoneka bwino, opanda khungu kapena pafupifupi khungu. Kuzungulira kwa yankho la subcutaneous makonzedwe ndi 100 U / ml.

Kathumba kalikonse kamakhala ndi 3 ml ya mankhwala; cartridge iyi imayikidwa mu cholembera cha syloge SoloStar. Ma cholembera asanu a insulini amagulitsidwa pabokosi la makatoni, setiyi imaphatikizapo buku la malangizo a chipangizocho.

• Mankhwala omwe ali ndi ndemanga zabwino kuchokera kwa madotolo ndi odwala angagulidwe ku pharmacy kokha ndi mankhwala othandizira.
• Insulin Lantus akuwonetsedwa chifukwa cha matenda a shuga omwe amadalira odwala ndi ana opitirira zaka zisanu ndi chimodzi.
• Fomu yapadera ya SoloStar imalola kuti ana azitha zaka zopitilira ziwiri azilandira.
• Mtengo wa phukusi la zolembera zisanu ndi mankhwala a 100 IU / ml ndi ma ruble 3,500.

Malangizo ogwiritsira ntchito mankhwalawa

Musanagwiritse ntchito mankhwalawa, muyenera kufunsa dokotala, endocrinologist angakuthandizeni kusankha mlingo woyenera ndikupereka nthawi yeniyeni ya jekeseni. Insulin imalowetsedwa kamodzi kamodzi patsiku, pomwe jakisoni imachitidwa mosamalitsa panthawi inayake.

Mankhwala amalowetsedwa mu mafuta ochepa a ntchafu, phewa kapena pamimba. Nthawi iliyonse mukasinthana ndi tsamba la jakisoni kuti mkwiyo usatuluke pakhungu. Mankhwalawa amatha kugwiritsidwa ntchito ngati mankhwala odziimira pawokha, kapena kuphatikiza ndi mankhwala ena ochepetsa shuga.

Musanagwiritse ntchito Lantus SoloStar insulini mu cholembera kuti mupeze chithandizo, muyenera kudziwa momwe mungagwiritsire ntchito jakisoni. Ngati m'mbuyomu, mankhwala a insulini adachitika ndi thandizo la insulin yochita masewera olimbitsa thupi kapena yapakati, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kusinthidwa.

1. Pankhani ya kusintha kwa jakisoni wa insulin-isophan wa nthawi ziwiri kupita kwa jekeseni mmodzi wa Lantus mkati mwa milungu iwiri yoyambirira, mlingo wa tsiku ndi tsiku wa hormone ya basal uyenera kuchepetsedwa ndi 20-30 peresenti. Mlingo wochepetsedwa uyenera kulipidwa pochulukitsa kuchuluka kwa insulin yochepa.
2. Izi zimalepheretsa kukula kwa hypoglycemia usiku ndi m'mawa. Komanso, mukasinthira ku mankhwala atsopano, kuyankha kowonjezereka kwa jakisoni wa mahomoni kumawonedwa nthawi zambiri. Chifukwa chake, poyamba, muyenera kuyang'anira kuchuluka kwa shuga m'magazi pogwiritsa ntchito glucometer ndipo ngati kuli koyenera, sinthani mawonekedwe a insulini.
3. Ndi kusintha kwa kagayidwe kakang'ono, nthawi zina kumva kukhudzidwa kwa mankhwalawa kumatha kuwonjezeka, motere, ndikofunikira kusintha regimen. Kusintha kwa mankhwalawa kumafunikanso pakusintha moyo wa anthu odwala matenda ashuga, kuchulukitsa kapena kuchepa thupi, kusintha nthawi ya jakisoni ndi zinthu zina zomwe zimapangitsa kuti ma hypo- kapena hyperglycemia aziwoneka.
4. Mankhwala ndi oletsedwa kwa mtsempha wa magazi, izi zimapangitsa kuti matenda a hypoglycemia atukuke. Musanapange jakisoni, muyenera kuwonetsetsa kuti cholembera cha syringe ndi choyera komanso chosadetsa.

Monga lamulo, Lantus insulin imayendetsedwa usiku, mlingo woyambirira ungakhale magawo 8 kapena kupitilira. Mukasinthira ku mankhwala atsopano, kuyambitsa mtundu waukulu kumawopseza, motero kukonza kuyenera kuchitika pang'onopang'ono.

Glargin amayamba kugwira ntchito mwachangu ola limodzi pambuyo pa jekeseni, pafupifupi, amachita kwa maola 24. Komabe, ndikofunikira kulingalira kuti ndi mlingo waukulu, nthawi yomwe mankhwalawa angagwire maola 29.

Insulin Lantus sayenera kusakanikirana ndi mankhwala ena.

Zotsatira zoyipa

Mothandizidwa ndi kuchuluka kwa insulin, wodwala matenda ashuga amatha kukhala ndi vuto la hypoglycemia. Zizindikiro za matendawa nthawi zambiri zimayamba kuoneka mwadzidzidzi ndipo zimayenda limodzi ndi kumva kutopa, kufooka, kufooka, kuchepa kwa tulo, kugona, kusokonezeka kowoneka, kupweteka mutu, nseru, chisokonezo, ndi kupsinjika.

Mawonetsedwe awa nthawi zambiri amatsogozedwa ndi zizindikiritso zamtundu wa njala, kukwiya, kusangalala kapena kugwedezeka, kuda nkhawa, khungu lotuwa, mawonekedwe a thukuta lozizira, tachycardia, palpitations. Hypoglycemia yayikulu imatha kuwononga mphamvu yamanjenje, motero ndikofunikira kuthandiza odwala matenda ashuga panthawi yake.

Nthawi zina, wodwalayo amakhala ndi vuto chifukwa cha mankhwalawo, omwe amaphatikizidwa ndi mawonekedwe amtundu wapakhungu, angioedema, bronchospasm, ochepa hypertension, mantha, komanso oopsa kwa anthu.

Pambuyo jakisoni wa insulin, ma antibodies omwe amagwira ntchito amatha kupanga. Pankhaniyi, ndikofunikira kusintha mtundu wa mankhwalawa kuti muchepetse chiopsezo chokhala ndi hypo- kapena hyperglycemia. Osowa kwambiri, mwa odwala matenda ashuga, kukoma kumatha kusintha, nthawi zina, ntchito zowoneka zimasokonezeka kwakanthawi chifukwa cha kusintha kwa maginito amaso.

Nthawi zambiri, m'malo a jakisoni, odwala matenda ashuga amakhala ndi lipodystrophy, yomwe imachedwetsa kuyamwa kwa mankhwalawa. Kuti mupewe izi, muyenera kusinthasintha malo omwe jakisoni. Komanso, kufiyanso, kuwonda, kuwawa kumawoneka pakhungu, matendawa ndi osakhalitsa ndipo nthawi zambiri amatha pambuyo masiku angapo ochizira.

• Insulin Lantus sayenera kugwiritsidwa ntchito ndi hypersensitivity kwa yogwira mankhwala glargine kapena zinthu zina zothandiza za mankhwalawa. Mankhwala ndi oletsedwa kugwiritsidwa ntchito mwa ana osakwana zaka zisanu ndi chimodzi, komabe, adokotala angakupatseni mtundu wina wa mankhwalawa SoloStar, wopangidwira mwana.
• Chenjezo liyenera kuchitidwa panthawi ya insulin. Ndikofunika tsiku lililonse kuyeza shuga wamagazi ndikuwongolera matendawa. Pambuyo pobereka, ndikofunikira kusintha mlingo wa mankhwalawa, chifukwa kufunika kwa insulin panthawiyi kumachepetsedwa kwambiri.

Nthawi zambiri, madokotala amalimbikitsa pakapita nthawi yokhala ndi matenda ashuga kuti agwiritse ntchito njira ina ya insulin - mankhwala Levemir.

Ngati bongo wapamwamba kwambiri, hypoglycemia imayimitsidwa ndikutenga zinthu zomwe zikuphatikiza chakudya cham'mimba chambiri. Kuphatikiza apo, mitundu ya mankhwalawa imasintha, zakudya zoyenera ndi zochitika zolimbitsa thupi zimasankhidwa.

Mu hypoglycemia yayikulu, glucagon imayendetsedwa kudzera m'mitsempha kapena pang'onopang'ono, ndipo jakisoni wofunsira wa njira yowonjezera shuga imaperekedwanso.

Kuphatikiza ndi adotolo angakulangireni kudya kwakutali kwa chakudya chambiri.

Momwe mungapangire jakisoni wa insulin

Musanapange jakisoni, muyenera kuwunika momwe bokosi lamatumba limayikidwa mu cholembera. Njira yothetsera vutoli iyenera kukhala yowoneka bwino, yopanda maonekedwe, osakhala ndi phokoso kapena tinthu tina tachilendo, mawonekedwe ofanana ndi madzi.

Khola la syringe ndi chida chotayikira, chifukwa pambuyo poti jekeseni wataya, kugwiritsanso ntchito kungayambitse matenda. Kubayira kulikonse kuyenera kuchitidwa ndi singano yatsopano yosabala, chifukwa singano yapaderayi imagwiritsidwa ntchito, yokonzedwa ndi zolembera za syringe kuchokera kwa wopanga uyu.

Zipangizo zowonongeka ziyeneranso kutayidwa; ndikungokayikira pang'ono pakulakwitsa, jakisoni sangapange ndi cholembera ichi. Pachifukwa ichi, odwala matenda ashuga nthawi zonse ayenera kukhala ndi cholembera chowonjezerapo kuti chilowe m'malo mwake.

1. Chovala chotchinga chimachotsedwa pachidacho, pambuyo pake chizindikiritso cha insulin chingafufuzidwe kuti zitsimikizire kuti kukonzekera koyenera kulipo. Maonekedwe a yankho limawunikiranso, pakakhala matope, zigawo zakunja zakunja kapena kusasinthasintha kwa insulin, insulini iyenera kulowedwa ndi ina.
2. Chotchinga chitachotsedwa, singano yosalala imasungidwa bwino komanso molimba. Nthawi iliyonse muyenera kuyang'ana chipangacho musanapange jakisoni. Ndikofunikira kuwonetsetsa kuti cholembedwayo poyamba chinali pa nambala 8, izi zikuwonetsa kuti syringe sigwiritsidwepo kale.
3. Kuti muyike mlingo womwe umafunikira, batani loyambira limatulutsidwa kwathunthu, ndipo pomwepo chosankha sangathe kuzungulira. Chovala chakunja ndi chamkati chikuyenera kuchotsedwa, chikuyenera kusungidwa mpaka njirayi itamalizidwa, kuti pambuyo pa jakisoni, chotsani singano yogwiritsidwa ntchito.
4. Cholembera cha syringe chimagwira ndi singano, ndiye muyenera kupukusa zala zanu zosungira insulini kuti mlengalenga mu thovu mutseguke kudutsa singano. Kenako, batani loyambira limakanikizidwa njira yonse. Ngati chipangizocho chili chokonzeka kugwiritsidwa ntchito, dontho laling'ono liyenera kuwonekera pamwamba pa singano. Pakapanda dontho, cholembera chimodzicho chimabwezedwanso.

Wodwala matenda ashuga amatha kusankha kuchuluka kwa 2 mpaka 40 mayunitsi, gawo limodzi pankhani iyi ndi mayunitsi awiri. Ngati ndi kotheka, kuyambitsa kuchuluka kwa insulin, pangani jakisoni awiri.

Pa mulingo wotsalira wa insulin, mutha kuwona kuchuluka kwa mankhwalawo omwe atsala mu chipangizocho. Piston wakuda ali pachigawo choyambirira cha mzere wachikuda, mankhwalawo ndi 40 PISCES, ngati piston ayikidwa kumapeto, mlingo ndi 20 PISCES. Wosankha mlingo watembenuzidwa mpaka cholemba cholimira chikhale mlingo womwe mukufuna.

Kuti mudzaze cholembera, insani yoyamba imakokedwa mpaka kumapeto. Muyenera kuwonetsetsa kuti mankhwalawo amadziwika kuti ndiwofunikira. Batani loyambira limasinthidwa kukhala kuchuluka kwamahomoni omwe atsalira mu tank.

Pogwiritsa ntchito batani loyambira, wodwala matenda ashuga amatha kuwona kuchuluka kwa insulin. Panthawi yotsimikizira, batani limasungidwa mphamvu. Kuchuluka kwa mankhwalawa omwe atenga mankhwalawa kumatha kuweruzidwa ndi mzere wowoneka bwino womaliza.

• Wodwala ayenera kuphunzira kugwiritsa ntchito zolembera za insulin pasadakhale, njira yolumikizira insulin iyenera kuphunzitsidwa ndi ogwira ntchito kuchipatala. Singano imakhala imayikidwa nthawi zonse, kenako batani loyambira limakanikizidwa mpaka pamapeto. Ngati batani lipanikizidwa njira yonse, kuwonekera kumveka kumveka.
• Batani loyambira limasungidwa kwa masekondi 10, kenako singano imatha kutulutsidwa. Njira ya jekeseni iyi imakupatsani mwayi kuti mupeze mlingo wonse wa mankhwalawo. Jakisoni utapangidwa, singano imachotsedwa mu cholembera ndikuitaya; simungathe kuyigwiritsanso ntchito. Chotetezera chimayikidwa pa cholembera.
• Cholembera chilichonse cha insulini chimakhala ndi buku la malangizo, momwe mungadziwire momwe mungakhazikitsire cartridge, kulumikiza singano ndikupanga jakisoni. Musanayambe kuperekera insulin, katiriji amayenera kukhala osachepera maola awiri. Osamagwiritsanso ntchito makateleji opanda kanthu.

Lantus insulin ikhoza kusungidwa pansi pa kutentha kwa madigiri 2 mpaka 8 pamalo amdima, kutali ndi dzuwa. Mankhwalawa amayenera kuperekedwa kwa ana.

Moyo wa alumali wa insulin ndi zaka zitatu, pomwe yankho lake liyenera kutayidwa, silingagwiritsidwe ntchito pazolinga zake.

Mitu ya mankhwalawa

Mankhwala omwewo okhala ndi hypoglycemic effect akuphatikiza Levemir insulin, yomwe ili ndi ndemanga zabwino kwambiri. Mankhwala ndi oyambira sungunuka wa anthu omwe akhala akuchita insulin.

Timadzi timeneti timapangidwa kudzera mu michere ya DNA yomwe imapangidwanso mobwerezabwereza pogwiritsa ntchito Saccharomyces cerevisiae. Levemir imalowetsedwa m'thupi la odwala matenda ashuga kokha. Mlingo komanso kuchuluka kwa jakisoni ndi mankhwala kwa dokotala, potengera zomwe wodwalayo ali nazo.

Lantus amalankhula za insulin mwatsatanetsatane mu kanema munkhaniyi.