Mankhwala a insulin odwala omwe ali ndi matenda ashuga, mankhwalawa omwe amasiyana pakapita nthawi amagwiritsidwa ntchito.
Izi zimachitika chifukwa chakuti insulini yolowa m'malo mwa insulini iyenera kupereka insulin ndikulowanso magazi kulowa mukatha kudya.
Kusunga insulini yokhazikika monga analogue ya basal secretion, ma insulin aatali amagwiritsidwa ntchito. Chimodzi mwa mankhwala atsopano m'gululi ndi insulin degludec pansi pa dzina la malonda la Tresiba FlexTouch. Ichi ndi insulin yayitali kwambiri ya anthu pochiza matenda amtundu 1 komanso matenda a shuga.
Kapangidwe ndi mawonekedwe a kumasulidwa kwa Tresib
The yogwira pophika mankhwala Tresib ndi recombinant anthu insulin degludec. Insulin imapezeka monga njira yopanda utoto yoyendetsera khungu. Mitundu iwiri yomasulidwa alembedwa:
- Mlingo wa 100 PIECES / ml: insulin degludec 3.66 mg, cholembera cha syringe ndi 3 ml ya yankho. Mumakulolani kuti muyike mpaka magawo 80 pazowonjezera za 1 unit. Mu phukusi 5 zolembera FlexTouch.
- Mlingo wa 200 PESCES pa 1 ml: insulin degludec 7.32 mg, 3 ml syringe cholembera, mutha kulowa mu PIECES mu 160 mu 2 PIECES. Mu phukusi pali zolembera 3 FlexTouch.
Cholembera pakuyambitsa insulin ndiyotaya, pakubayira mobwerezabwereza mankhwala.
Tresiba Insulin Properties
Watsopano insulin yokhala ndi nthawi yayitali wokhala ndi mphamvu yopanga depot mu minofu yaying'ono yokhala ngati mashegi angapo osungunuka. Pang'onopang'ono gululi limatulutsa insulini kulowa m'magazi. Chifukwa cha kukhalapo kosalekeza m'magazi, kuchuluka kwa glucose m'magazi kumatsimikiziridwa.
Ubwino wawukulu wa Tresib ndi mbiri komanso yosabisa ya zochita za hypoglycemic. Mankhwalawa m'masiku ochepa amafika paphiri la glucose ndikuwusunga nthawi yonse yogwiritsira ntchito, ngati wodwalayo sakuphwanya malamulo othandizira ndikutsatira kuchuluka kwa insulin ndikutsatira malamulo a zakudya.
Kuchita kwa Tresib pamlingo wa glu m'magazi kumawonekera chifukwa chogwiritsa ntchito shuga ndi minofu ndi minyewa ya adipose monga gwero lamphamvu mkati mwa khungu. Tciousba, wolumikizana ndi ma insulin receptors, amathandiza glucose kudutsa membrane wa cell. Kuphatikiza apo, imathandizira kupanga kwa glycogen kupanga chiwindi ndi minofu minofu.
Mphamvu ya Tresib pa metabolism imawonekera chifukwa chakuti:
- Palibe mamolekyu atsopano a shuga omwe amapangidwa m'chiwindi.
- Kuwonongeka kwa glycogen kuchokera m'matumbo mumaselo a chiwindi kumachepetsedwa.
- Mafuta acids amapangidwa, ndipo kusweka kwamafuta kumayima.
- Mlingo wa lipoproteins m'magazi ukuwonjezeka.
- Minofu kukula.
- Kupanga kwa mapuloteni kumathandizidwa ndipo mawonekedwe ake amatsika nthawi yomweyo.
Tresiba FlexTouch insulin imateteza ku ma spikes a shuga masana pambuyo pa kukhazikitsa. Kutalika konse kwa kuchitapo kwake kupitirira maola 42. Kuphatikizika kosalekeza kumatheka mkati mwa masiku awiri kapena atatu pambuyo pa jekeseni woyamba.
Ubwino wachiwiri wosakayikira wa mankhwalawa ndikutukuka kosowa kwa hypoglycemia, kuphatikiza usiku, poyerekeza kukonzekera kwina kwa insulin. Mu phunziroli, njira yotereyi idadziwika mu onse achinyamata ndi okalamba odwala.
Ndemanga za odwala omwe amagwiritsa ntchito mankhwalawa zimatsimikizira chitetezo chake chogwiritsidwa ntchito pokhudzana ndi kuchepa kwambiri kwa shuga ndi matenda a hypoglycemia. Maphunziro oyerekeza a Lantus ndi Tresib awonetsa kuyeserera kwawo kofanana pakukonda kuzungulira kwa insulin.
Koma kugwiritsa ntchito mankhwalawa kuli ndi zabwino zake, chifukwa n`zotheka kuchepetsa kuchuluka kwa insulini pakapita nthawi 20-30% ndikuchepetsa kwambiri kuchuluka kwa odwala usiku.
Tresiba imathandizira pamlingo wa hemoglobin wa glycated, zomwe zikutanthauza kuti zimachepetsa chiopsezo cha zovuta za shuga.
Kodi Treshiba akuwonetsedwa kwa ndani?
Chizindikiro chachikulu cha mankhwala a Treshib insulin, omwe amatha kukhalabe ndi gawo la glycemia, ndi matenda a shuga.
Contraindication yogwiritsira ntchito mankhwalawa ndikumvetsetsa kwamunthu payekha pazigawo za yankho kapena chinthu chogwira ntchito. Komanso, chifukwa cha kusadziwa za mankhwalawa, samalembera ana ochepera zaka 18, amayi oyamwitsa ndi amayi apakati.
Ngakhale kuti nthawi ya insulin excretion ndi yayitali kuposa masiku 1.5, tikulimbikitsidwa kuti mulowetsedwe kamodzi patsiku, makamaka nthawi imodzi. Wodwala matenda a shuga omwe ali ndi mtundu wachiwiri wa matenda amatha kulandira Treshiba kapena kuphatikiza ndi mankhwala ochepetsa shuga m'mapiritsi. Malinga ndi zomwe zikuwonetsa mtundu wachiwiri wa matenda ashuga, ma insulin omwe amagwira ntchito mwachidule amalembedwera limodzi ndi mankhwalawo.
Ndi mtundu woyamba wa matenda a shuga, Trecib FlexTouch nthawi zonse amalembedwa ndi insulin yochepa kapena yochepa kwambiri kuti athe kufunika kwa mayamwidwe azakudya.
Mlingo wa insulin umatsimikiziridwa ndi chithunzi cha matenda osokoneza bongo ndipo umasinthidwa malinga ndi kuchuluka kwa shuga m'magazi.
Kukhazikitsidwa kwa mtundu watsopano wa Tresib kumachitika:
- Mukamasintha zolimbitsa thupi.
- Mukasinthana ndi chakudya china.
- Ndi matenda opatsirana.
- Kuphwanya ntchito ya endocrine dongosolo - matenda a chithokomiro England, pituitary gland kapena adrenal gland.
Tresiba imatha kuperekedwa kwa odwala okalamba omwe ali ndi vuto la impso kapena hepatic, malinga ngati kuchuluka kwa shuga wamagazi kumayang'aniridwa mosamala.
Kwa odwala omwe ali ndi matenda a shuga a mtundu wachiwiri, amayamba ndi mlingo wa 10 PESCES, posankha munthu payekha. Odwala omwe ali ndi mtundu woyamba wamatenda, mukasinthira ku Treshiba ndi ma insulin ena omwe atenga nthawi yayitali, gwiritsani ntchito mfundo ya "kusintha unit ndi unit."
Ngati wodwala alandira jakisoni wa basal insulin kawiri, ndiye kuti mankhwalawa amasankhidwa potengera mbiri ya glycemic payekha. Tresiba imalola kupatuka munjira yoyendetsera, koma nthawiyo imalimbikitsidwa kwa maola osachepera 8.
Mlingo womwe wasowa ungathe kulowetsedwa nthawi iliyonse, tsiku lotsatira mutha kubwerera ku chiwembu chapitacho.
Malamulo ogwiritsira ntchito Treshiba FlexTouch
Tresib imayendetsedwa kokha pakhungu. Mtsempha wamkati wamitsempha umapangidwa chifukwa cha kukula kwambiri kwa hypoglycemia. Sizikulimbikitsidwa kuti ziperekedwe intramuscularly ndi mapampu a insulin.
Malo omwe insulin amayendetsedwera ndi kutsogolo kwa ntchafu, phewa, kapena khoma lamkati lakumbuyo. Mutha kugwiritsa ntchito gawo limodzi labwino kwambiri, koma nthawi iliyonse kumayambitsa malo atsopano kupewa lipodystrophy.
Kupereka insulin pogwiritsa ntchito cholembera cha FlexTouch, muyenera kutsatira njira zotsatirazi:
- Onani cholembera
- Onetsetsani kuwonekera kwa yankho la insulin
- Ikani singano mwamphamvu pachikuto
- Yembekezani mpaka dontho la insulini lithe kuyika pa singano
- Khazikitsani mlingo potembenitsira mtundu wosankha
- Ikani singano pansi pa khungu kuti mankhwala otsutsana nawo awoneke.
- Dinani batani loyambira.
- Lowetsani insulin.
Pambuyo pa jakisoni, singano iyenera kukhala pansi pakhungu kwa masekondi ena 6 kutulutsa kwathunthu kwa insulin. Kenako chogwiriziracho chimayenera kukwezedwa. Ngati magazi awoneka pakhungu, ndiye kuti amayimitsidwa ndi thonje. Musamasewetse malo a jakisoni.
Majakisoni amayenera kugwiritsidwa ntchito pokhapokha zolembera pazokha. Kuti izi zitheke, khungu ndi manja asana jekeseni ziyenera kuthandizidwa ndimayankho a antiseptics.
Cholembera cha FlexTouch sichiyenera kusungidwa pamtunda wambiri kapena wotsika kwambiri. Asanatsegule, mankhwalawa amasungidwa mufiriji pakashelefu apakati pamtunda wa madigiri 2 mpaka 8. Osakuyimitsani yankho. Pambuyo pakugwiritsira ntchito koyamba, cholembera chimasungidwa kutentha kwa chipinda kwa milungu yopitilira 8.
Osasamba kapena kudzoza mafuta chogwirizira. Iyenera kutetezedwa kuti isavunditsidwe ndikutsukidwa ndi nsalu yonyowa. Kugwa ndi maampu sikuyenera kuloledwa. Mukatha kugwiritsa ntchito kwathunthu, cholembera sichidzazidzanso. Simungathe kukonza kapena kudzipatula nokha.
Pofuna kupewa kutsata molakwika, muyenera kusunga ma insulini osiyanasiyana payokha, ndikuyang'anitsitsa cholembera musanachigwiritse ntchito kuti musapange jakisoni wina mwangozi. Muyeneranso kuwona bwino manambala pa kotsutsa. Ndi mawonekedwe opuwala, muyenera kugwiritsa ntchito thandizo la anthu omwe ali ndi maso abwino komanso ophunzitsidwa poyambitsa Tresib FlexTouch.
Zotsatira zoyipa Treshiba
Degludek, monga ma insulin ena, nthawi zambiri amayambitsa hypoglycemia ndi mlingo wosankhidwa bwino. Zizindikiro zadzidzidzi shuga atachepetsedwa ngati thukuta lozizira, khungu lotuwa, kufooka kwambiri ndi manjenjenje, komanso njala ndi manja akunjenjemera, sizingatheke kuzindikiridwa ndi odwala onse panthawi.
Kuchulukitsa kwa hypoglycemia kumawonetsedwa ndi kuphwanya chidwi cha malo ndi kuwongolera m'mlengalenga, kugona kugona kumachitika, kuwona kumalephera, pamakhala mutu ndi matenda a shuga komanso nseru. Pakhoza kukhala kulumikizana kosangalatsa kwamtima. Ngati palibe zomwe zikuchitika pakadali pano, ndiye kuti chikumbumtima chasokonekera, kukomoka kumawonekera, wodwalayo amatha kugwa. Ngakhale zotsatira zakupha ndizotheka.
Panthawi ya hypoglycemia, kuchuluka kwa momwe angagwiritsire ntchito komanso kuthekera kuyankha molondola, komanso chidwi ndi chidwi chitha kuchepa, zomwe zitha kukhala zowopsa pamoyo poyendetsa kapena kugwiritsa ntchito njira zina kuntchito.
Chifukwa chake, musanayendetse, muyenera kuwonetsetsa kuti shuga ndiwabwinobwino ndikukhala ndi shuga kapena zinthu zofananira nanu. Ngati wodwala yemwe ali ndi matenda ashuga samva kuthekera kwa hypoglycemia kapena atakhala ndi zoterezi, ndiye kuti ndi bwino kusiya kuyendetsa.
Njira yachiwiri yomwe imakhala yovuta kwambiri kugwiritsa ntchito Tresib ndi lipodystrophy pamalo opangira jekeseni. Pofuna kupewa, muyenera kuyika mankhwalawa nthawi iliyonse m'malo atsopano. Pakhoza kukhalanso kupweteka, kuphwanya, kufiyanso, kapena kuyambitsa malo a jekeseni. Khungu limatha kusintha mtundu, kutupa, kuyabwa. Pa malo a jakisoni, timinofu ta minye yolumikizirana imapangidwa nthawi zina.
Zocheperako ndizovuta izi kuchokera ku Tresib:
- Thupi lawo siligwirizana ndi mankhwalawo.
- Kutupa.
- Kuchepetsa mseru
- Kulimbikitsa retinopathy.
Kuti athane ndi hypoglycemia m'njira yokhutiritsa yodwala, ayenera kumwa mankhwala okhala ndi shuga kapena ufa. Popanda chikumbumtima, glucose amatumizidwa kudzera m'mitsempha yamagazi pansi pa khungu. Pofuna kupewa zotsatirazi, mutabwezeretsa chikumbumtima, muyenera kudya chakudya chopatsa mphamvu.
Tresiba siyingasakanikirane ndi mankhwala ena. Mankhwala siwowonjezera kulowetsedwa njira. Ndi kusankha kwa Tresib ndi Aktos kapena Avandia, panali zochitika za kukhazikika kwa mtima. Pamaso pa matenda amitima ya mtima komanso chiopsezo cha kuwonongeka kwa mtima wa Tresib, mankhwalawa sanaphatikizidwe.
Ndi kudziyimira pawokha pobwera kapena kumwa mankhwala osakwanira, hyperglycemia ndi matenda a shuga a ketoacidosis amakula. Izi zimathandizidwa ndi tizilombo kapena matenda a bakiteriya, matenda a ziwalo za endocrine, komanso kayendedwe ka mankhwala a glucocorticosteroid, estrogens, njira zakulera zamkamwa, diuretics, mahomoni okula kapena Danazole.
Zizindikiro za hyperglycemia zimawonjezeka pang'onopang'ono ndipo zimawonetsedwa ndi nseru, ludzu, kutuluka kwamkodzo, kugona, kuwoneka pakhungu, pakamwa pouma. Pakakhala fungo la acetone, chiopsezo cha ketoacidosis ndi chikomokere zimachuluka. Odwala amawonetsedwa kuchipatala mwachangu. Ultrashort insulin imagwiritsidwa ntchito pochiza.
Kumwa zakumwa zoledzeretsa kungakhudze kulimbikitsa ndi kufooka kwa zochita za insulin.
Mankhwala omwe amapanga insulin Treshiba adzafotokozera vidiyo iyi.
