Zotsatira za Matenda a Pentoxifylline

Pazovuta za matenda omwe amaphatikizana ndi zovuta m'mitsempha yamagazi, kugwiritsa ntchito vasodilators kukuwonekera, kuphatikizapo Pentoxifylline.

Mukamagwiritsa ntchito mankhwalawa, malangizo omwe aphatikizidwa akuyenera kuwonedwa mosamala.

ATX

C04AD03.

Kukonzekera kwa Pentoxifylline kumavomerezeka kuti agwiritsidwe ntchito pochiza zilonda zam'mimba, zilonda zam'mimba, angiopathy komanso kupatuka kwazowoneka m'ndondomeko ya odwala omwe ali ndi matenda ashuga.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapangidwa mu mawonekedwe a mapiritsi, dragees ndi yankho la intravenous infusions (ma dontho), jakisoni ndi mu mnofu makonzedwe.

Mosasamala mtundu wa kumasulidwa, mankhwalawa amakhala ndi chofunikira chachikulu chogwiritsira ntchito - pentoxifylline (mu Chilatini - Pentoxyphyllinum).

Pankhaniyi, Mlingo wa gawo yogwira ntchito ukhoza kukhala wosiyana.

Mapiritsi

Mapiritsi okhala ndi interic okhala ndi 100 mg ya pentoxifylline.

Mankhwalawa ndi a gulu la vasodilators (vasodilators).

Njira Zothetsera

Njira yothetsera jakisoni ili ndi 20 mg yogwira pophika 1 ml. Mankhwalawa amagulitsidwa mu ampoules a 1, 2, 5 ml.

Nyemba zonona

Ma Dragees (retard) ndi makapisozi omwe ali ndi nembira yama pinki. Piritsi limodzi muli 400 mg yogwira ntchito.

Njira yamachitidwe

Mankhwalawa ndi a gulu la vasodilators (vasodilators).

Pharmacological zotsatira za mankhwala umalimbana kusintha magazi ndi kusintha magazi.

Mankhwalawa ali ndi zotsatirazi mthupi la wodwalayo:

• amachepetsa magazi m'magazi, amachepetsa mwayi wamagazi;
• amachepetsa mitsempha yamagazi (pang'ono), amachotsa mavuto ndi kuchepa kwa magazi;
• amalimbikitsa machulukitsidwe a minofu ndi mpweya, kuletsa kukula kwa hypoxia (chifukwa cha kukulira kwa ziwiya zam'mapapo mwanga ndi mtima);
• kumawonjezera mamvekedwe a diaphragm, minofu yopuma;
• zopindulitsa pa ntchito ya mantha;
• Zimathandizira kuthetsa kukokana komanso kupweteka m'misempha ya ng'ombe yokhudzana ndi kuzungulira kwa miyendo.

Mankhwala amachepetsa kukhuthala kwa magazi, amachepetsa mwayi wamagazi.

Pharmacokinetics

Zinthu zomwe zimagwiritsidwa ntchito popanga mankhwalawa zimatengedwa bwino m'magazi kuti zizigaya bwino ndipo zimapangidwa pang'ono m'chiwindi. Zida za mankhwala zimachotsedwa m'thupi masana kudzera mu impso (mkodzo) komanso matumbo (okhala ndi ndowe).

Zomwe zimathandiza

Mankhwala ntchito mankhwalawa zotsatirazi pathologies:

• kuphwanya magazi owonjezera kumanja ndi kumapazi (matenda a Raynaud);
• kuwonongeka kwa minofu chifukwa cha kuwonongeka kwam'magazi m'mitsempha ndi mitsempha (zilonda zamkati zam'matumbo, posthlebotic syndrome, gangrene);
• kuwonongeka kwa mawonekedwe ndi kumva komwe kumayenderana ndi kusayenda kwa magazi;
• ubongo ischemia waubongo;
• Matenda a Buerger (thromboangiitis obliterans);
• kusabala kochititsidwa ndi magazi osakwanira ku ziwalo zoberekera;
• matenda atherosulinosis;
• matenda oopsa;
• angiopathy odwala matenda a shuga;
• matenda a mtima;
• vegetovascular dystonia;
• encephalopathy yamitundu yosiyanasiyana.

Mankhwalawa amagwiritsidwa ntchito pochiza matenda a Raynaud.

Mankhwalawa ndi othandizira matenda a ischemia.

Pentoxifylline imagwiritsidwa ntchito posabala mphamvu chifukwa cha magazi osakwanira ziwalo zoberekera.

Chida chimagwiritsidwa ntchito pochiza matenda oopsa.

Pentoxifylline amagwiritsidwa ntchito pochiza angiopathy mwa odwala matenda a shuga.

Pentoxifylline amalembera vegetovascular dystonia.

Chidachi chimagwiritsidwanso ntchito pochiza matenda a osteochondrosis ngati vasodilator wothandiza.

Contraindication

Mndandanda wa contraindication kugwiritsa ntchito mankhwalawa umaphatikizapo:

• matenda a porphyrin;
• pachimake myocardial infarction;
• hemorrhege
• magazi akulu.

Njira yothetsera vutoli siigwiritsidwa ntchito ku atherosulinosis ya mitsempha ya muubongo ndi mtima komanso mwamphamvu kwambiri.

Kugwiritsa ntchito Pentoxifylline sikumaperekedwa kwa odwala omwe ali ndi hypersensitivity kwa yogwira mankhwala, othandizira omwe amaphatikizidwa, kapenanso mankhwala ena a gulu la xanthine.

Ndi atherosulinosis ya mitsempha ya ubongo ndi mtima, musagwiritse ntchito mankhwalawa ngati njira yankho.

Momwe angatenge

Mankhwala, omwe amapezeka mu mawonekedwe a dragees ndi mapiritsi, adapangira pakamwa. Gwiritsani ntchito mankhwalawa mukatha kudya. Simungathe kutafuna makapisozi. Ayenera kutsukidwa ndi madzi ochepa.

Dokotalayo ndi amene amawona muyezo wa mankhwalawo payekhapayekha kwa wodwala aliyense, poganizira za momwe thupi lake limakhalira ndikuzindikira za chithunzi cha matenda. Mlingo wofanana muyezo ndi 600 mg tsiku lililonse (200 mg katatu patsiku). Pambuyo pa masabata 1-2, pamene zizindikiro za matendazo zimachepa, mlingo wa tsiku ndi tsiku umatsitsidwa mpaka 300 mg (100 mg katatu patsiku). Osamwa zochuluka kuposa kuchuluka kwa mankhwalawa tsiku lililonse (1200 mg).

Kutalika kwa mankhwalawa ndi pentoxifylline pamapiritsi ndi 4-12 milungu.

Njira yothetsera vutoli imatha kuperekedwa kudzera mu intramuscularly, kudzera m'mitsempha yamagazi. Mlingo umatsimikiziridwa payekhapayekha, poganizira kuopsa kwa matenda a mtima. Malangizo ogwiritsira ntchito mankhwalawa akuti muyenera kugwiritsa ntchito yankho motere:

1. Mwanjira ya ma dropper - 0,5 g ya mankhwala osakanikirana ndi 250-500 ml ya saline kapena 5% shuga. Ndikofunikira kupatsa mankhwala pang'onopang'ono, mkati mwa maola 1.5-3.
2. Jekeseni (mtsempha wa magazi) - pa gawo loyambirira la mankhwalawa, 0,5 ga mankhwalawa amalembedwa (kuchepetsedwa mu 20-50 ml ya sodium chloride), ndiye kuti mlingo umakulitsidwa kuti 0,2-0.3 g (wothira 30-50 ml ya zosungunulira). Mankhwalawa amayenera kuperekedwa pang'onopang'ono (0,1 g kwa mphindi 10).
3. Intramuscularly, mankhwalawa amaperekedwa pa mlingo wa 200-300 mg katatu patsiku.

Mlingo wofanana muyezo ndi 600 mg tsiku lililonse (200 mg katatu patsiku).

Kugwiritsa ntchito yankho kungaphatikizidwe ndi kukonzekera pakamwa pa piritsi lamankhwala.

Ndi matenda ashuga

Kukonzekera kwa Pentoxifylline kumavomerezeka kuti agwiritsidwe ntchito pochiza zilonda zam'mimba, zilonda zam'mimba, angiopathy komanso kupatuka kwazowoneka m'ndondomeko ya odwala omwe ali ndi matenda ashuga. Komabe, mutha kumwa mankhwalawo pokhapokha ngati adokotala adanenanso, yemwe amamwetsa payekha payekha ndipo akuwonetsetsa kuti wodwalayo atamwa mankhwala a hypoglycemic. Kudzipatsa nokha mankhwala a pentoxifylline pamenepa sikuvomerezeka, chifukwa mankhwalawa osankhidwa molakwika angayambitse zotsatira zoyipa (kuphatikizapo hypoglycemic coma).

Pentoxifylline pomanga thupi

Kugwiritsidwa ntchito kwa Pentoxifylline kungakhale kothandiza osati kokha pochiza matenda ozungulira, komanso pamasewera, popeza mankhwalawa amatha kuwonjezera mphamvu ya kuphunzitsa, kuwonjezera kupirira, ndikuthamangitsa kukwaniritsa zotsatira zomwe mukufuna chifukwa cha zotsatira zopindulitsa thupi.

Pentoxifylline imatha kuwonjezera luso la maphunziro, kuwonjezera kupirira, imathandizira kukwaniritsa zotsatira zomwe mukufuna.

Ochita masewera komanso omanga olimbitsa thupi amalangizidwa kuti amwe mankhwalawa motere:

1. Ndikofunikira kuyamba ndi mlingo wochepa - 200 mg 2 kawiri pa tsiku. Imwani mapiritsi mutatha kudya.
2. Pokhapokha ngati pali zovuta komanso kulekerera bwino kwa mankhwalawa, mutha kuwonjezera kuchuluka kwa tsiku lililonse mpaka 1200 mg (400 mg katatu pa tsiku).
3. Kuti mukwaniritse bwino, ndikulimbikitsidwa kuti mumwe mankhwalawo m'mphindi 30 musanayambe ntchito ndipo maola ochepa atamaliza.
4. Kutalika kwa kugwiritsa ntchito mankhwalawa ndi milungu 3-4. Pambuyo pa maphunzirowa, muyenera kupuma kwa miyezi iwiri.

Zotsatira zoyipa

Mukamamwa mankhwalawa, kumachitika ziwopsezo zamkati mwa ziwalo zamkati ndi machitidwe ofunikira samatsutsidwa.

Matumbo

Mankhwalawa angayambitse kutupa kwa chiwindi, limodzi ndi zovuta mu kutuluka kwa mapapo a bile, kuchulukitsa kwa matenda otupa a ndulu, kukulira kwamatumbo, kuchepa kwamtima, komanso kumva kutiuma pakamwa. Nthawi zina, magazi amatuluka.

Chidacho chimatha kuyambitsa chiwindi, limodzi ndi zovuta mu kutuluka kwa mapapo a bile.

Hematopoietic ziwalo

Zotsatira zotsatirazi zochokera m'madongosolo oyendetsera magazi ndizotheka:

• kutsika kwamapazi a m'magazi;
• dontho la kuthamanga kwa magazi;
• kupweteka mtima
• kutentha kwa mtima.

Pakati mantha dongosolo

Kusokonezeka, kupweteka mutu, chizungulire, komanso kugona pang'ono kumachitika.

Wodwala yemwe amamwa mankhwalawo nthawi zambiri amakhala wosakwiya ndipo amakhala ndi nkhawa kwambiri.

Matupi omaliza

Mukamagwiritsa ntchito mankhwalawa, zimachitika khungu (kuyabwa, urticaria) ndi anaphylactic mantha.

Zina

Pakhoza kukhala kuwonongeka pamalingaliro a tsitsi, misomali, kutupa, kufiyira kwa khungu ("mabulangete" a magazi kumaso ndi chifuwa).

Mukamagwiritsa ntchito mankhwalawa, khungu limayamba kusokonekera komanso kuwonongeka kwa anaphylactic.

Kuphwanya kwamawonedwe owonekera ndi kukula kwa ma scotomas amaso sikumachotsedwa.

Malangizo apadera

Mankhwala a Pentoxifylline amachitika mosamala kwambiri anthu omwe ali ndi vuto la zilonda zam'mimba komanso duodenum, pathologies a impso ndi chiwindi, kulephera kwa mtima, ndipo amakonda kuthamanga magazi. Kwa magulu awa a odwala, kusintha kwakakamizidwe kake komanso kuwongolera mosamalitsa kuchipatala pakufunika.

Kuyenderana ndi mowa

Madokotala amalimbikitsa mwamphamvu kuti odwala omwe amamwa mankhwala a Pentoxifylline asamamwe kumwa mowa asanathe.

Ndikulimbikitsidwa kuti mowa uchotsedwe mankhwala osagwirizana ndi Pentoxifylline.

Mowa wa Ethyl umatha kumangika ku mamolekyulu a mankhwala, kuwapangitsa kuti asagwiritsidwe ntchito, zomwe zingayambitse kuchepa kwa mankhwalawa kapena kuyambitsa zovuta.

Zokhudza mphamvu pakuwongolera njira

Mankhwalawa sakukhudza mwachindunji mphamvu yakuwongolera machitidwe ophatikizika, kuphatikiza magalimoto, komabe, ngati zotsatira zoyipa (chizungulire, kusokonezeka kwa kugona, ndi zina) zimachitika, chidwi cha wodwalayo chitha kuwonongeka. Izi zitha kuchepetsa kuyendetsa bwino komanso magalimoto ena.

Pa mimba ndi mkaka wa m`mawere

Mukamayamwitsa komanso panthawi yomwe muli ndi pakati, kugwiritsa ntchito mankhwalawa kumaletsedwa. Ngati mayi woyamwitsa sangapewe kumwa mankhwalawa, ayenera kusiya kuyamwitsa asanathe chithandizo.

Zomwe zimaperekedwa kwa ana

Kuchita bwino ndi chitetezo cha mankhwalawa muubwana sichinaphunzire, chifukwa chake opanga Pentoxifylline samalimbikitsa kupereka mankhwala kwa odwala omwe sanakwanitse zaka 18.

Pentoxifylline sichilimbikitsidwa kwa odwala osakwana zaka 18.

Komabe, pochita, ngati kuli kofunikira, madokotala amatha kupereka mankhwala kwa mwana wazaka zopitilira 12. Nthawi zambiri izi zimachitika chifukwa cha zovuta kuzungulira kwa magazi komanso kusagwira bwino ntchito kwa njira zina.

Mlingo wokalamba

Mukakalamba, mankhwalawa amachepetsa, motero amalimbikitsidwa kugwiritsa ntchito mankhwalawa.

Bongo

Kugwiritsa ntchito mankhwala kwa nthawi yayitali.

• kusanza, kusanza kwa "malo a khofi" (akuwonetsa kukula kwa magazi m'mimba);
• Chizungulire
• kufooka
• kukokana.

Woopsa milandu bongo, kukomoka, kupuma, anaphylaxis zimawonedwa.

Milandu yowonjezereka, kukomoka, kupuma, ma anaphylaxis amawonedwa.

Kuchita ndi mankhwala ena

Mankhwala atha kuwonjezera zotsatira za mankhwala otsatirawa:

• anticoagulants;
• thrombolytics;
• mankhwala omwe amachepetsa kuthamanga kwa magazi;
• maantibayotiki
• mankhwala a insulin okhala ndi hypoglycemic;
• kukonzekera kwa valproic acid.

Kugwiritsa ntchito pamodzi kwa Pentoxifylline ndi mankhwala okhala ndi cimetidine kumawonjezera chiopsezo cha mavuto. Kukonzekera kochokera ku ketorolac ndi Mexico sikugwirizana ndi Pentoxifylline, chifukwa akamagwiritsira ntchito mankhwala, amawonjezera mwayi wokhala ndi magazi mkati.

Mutha kugula zokhazo ngati muli ndi malangizo oyenerera omwe dokotala wakupatsani.

Sitikulimbikitsidwa kuphatikiza kugwiritsa ntchito mankhwalawa ndi kugwiritsidwa ntchito kwa ma xanthines ena, chifukwa izi zimatha kuyambitsa mantha ambiri.

Analogi

Mankhwalawa a pathologies omwe amayamba chifukwa cha kusokonezeka kwa magazi, ma analogu a Pentoxifylline otsatirawa amagwiritsidwa ntchito:

• Cavinton;
• Trental;
• Pentoxifylline-NAS;
• Piracetam
• Pentilin;
• Mexicoidol;
• Fluxital;
• Latren;
• nicotinic acid.

Kuti mudziwe kuti ndi iti mwa mankhwalawa omwe amagwiritsidwa ntchito bwino ndikulowerera kwina kwa magazi, muyenera kufunsa dokotala.

Wopanga

Mankhwala omwe amapangidwa ku Russia amapangidwa ndi makampani opanga mankhwala Organika (Novokuznetsk) ndi Akrikhin (Moscow). Mankhwala ofananawa amapangidwa ndi mafakitale aku Czech (Zentiva) ndi Israeli (Teva).

Kupita kwina mankhwala

Mutha kugula zokhazo ngati muli ndi malangizo oyenerera omwe dokotala wakupatsani.

Mtengo wa Pentoxifylline

Mankhwala opangidwa ku Russia ali ndi mtengo wotsika - kuchokera 40 mpaka ma ruble 40. Mankhwala ochokera kunja a Pentoxifylline amawononga ndalama zowirikiza kawiri.

Malo osungira

Kusunga m'malo otetezedwa kwa ana, pamtunda wofunda wosapitirira + 25 ° C.

Mankhwala opangidwa ku Russia ali ndi mtengo wotsika - kuchokera 40 mpaka ma ruble 40.

Pentoxifylline

Chidacho chitha kugwiritsidwa ntchito patatha zaka zitatu kuyambira tsiku lopangidwa.

Ndemanga za Pentoxifylline

Madokotala ndi odwala ambiri amayesetsa kugwiritsa ntchito Pentoxifylline.

Madokotala

E. G. Polyakov, neurosurgeon, Krasnoyarsk

Mankhwala ali ndi tanthauzo labwino mu matenda osiyanasiyana a chapakati ndi kufalikira kwa magazi. Chidachi ndichabwino kwambiri komanso mtengo wotsika, chifukwa chake chimapezeka m'magulu onse a odwala. Zoyipa za mankhwalawa zimaphatikizanso kufooka kwa angiopathies.

Odwala

Lily, wazaka 31, Astrakhan

M'mbuyomu, nthawi zambiri ndimadwala matenda ofooketsa zam'mimba omwe amachititsa kuti ndikhale ndi thanzi labwino. Tsopano ndikuthandizidwa ndi Pentoxifylline. Ndili ndi vuto lotsatira, ndiyamba kugwiritsa ntchito mankhwalawa kumapeto (pasanathe masiku 10). Kuthandizanso kumachitika m'masiku oyamba a chithandizo, ndipo pakatha masiku 10 zizindikilo zonse zimatha. Chisamaliro chapadera chimaperekedwa ku mtengo wa mankhwalawa: ndizotsika kwambiri kuti poyamba zimawopsa. Koma mtundu wa Russian Pentoxifylline siwolakwika kuposa wa analogues akunja, omwe amatenga 2, kapena ngakhale katatu mtengo wokwera.

Igor, wazaka 29, Volgograd

Kupititsa patsogolo kukwera kwa magazi mu impso, ma vasodilators amayenera kutengedwa.Curantil adalembedwa kale, koma mutu wake udayamba kupweteka kwambiri, chifukwa chake ndidasinthira ku Trental. Awa ndi mapiritsi abwino, koma okwera mtengo kwambiri, chifukwa chake ndidaganiza kuti ndikawasinthe ndi Pentoxifylline wopangidwa ndi Russia. Sindinazindikire kusiyana kulikonse (kupatula mtengo wake). Amachitanso, samayambitsa mavuto, amagwira ntchito yawo mwangwiro.