Mankhwala Simbalta amagwiritsidwa ntchito mwachangu pantchito yawo ndi ma neuropathologists ambiri ndi amisala. Zimathandizira kukonza mkhalidwe wa odwala omwe ali ndi nkhawa, kuwonetsa kwa matenda ashuga a m'mimba komanso mavuto ena.
Dzinalo Losayenerana
Duloxetine
ATX
N06AX21.
Simbalta imathandiza kukonza mkhalidwe wa odwala omwe ali ndi nkhawa, kuwonetsa kwa matenda ashuga a m'mimba komanso mavuto ena.
Kutulutsa mafomu ndi kapangidwe kake
Chogulitsacho chimapezeka m'mavilidwe ang'onoang'ono. Kapisozi 1 imakhala ndi 30 kapena 60 mg yogwira ntchito ya duloxetine hydrochloride. Zosakaniza zina:
- hypromellose acetate chikuku;
- shuga wonenepa ndi sucrose;
- talc;
- hypromellose;
- utoto oyera, triethal citrate;
- titanium dioxide;
- indigo carmine;
- TekPrint inks zobiriwira ndi zoyera;
- sodium lauryl sulfate;
- gelatin.
Chogulitsacho chimapezeka m'mavilidwe ang'onoang'ono.
Zotsatira za pharmacological
Duloxetine ndi wothandizira. Thupi silikugwirizana ndi cholinergic, adrenergic, dopaminergic ndi histaminergic receptors. Mfundo zoyeserera zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimatengera kukakamiza kobwerera kwa norepinephrine, serotonin, ndi kugwidwa kwa dopamine. Zotsatira zake, odwala omwe ali ndi vuto lakukhumudwa amayenda bwino
Thupi limaletsa ululu. Ndi kupweteka kwa neuropathic, zotsatira zofananazi zimawonetsedwa ndi kuwonjezeka kwa malire a kupwetekeka kwa kupweteka.
Pharmacokinetics
Thupi limalowetsedwa m'mimba m'mimba pambuyo pokhazikitsa. Kuchuluka kwa duloxetine mu plasma kumawonekera patatha maola 6. Zakudya sizikhudzana ndi mayendedwe a mayamwidwe, koma nthawi yofika ndende ya plasma ya zinthuyo imachulukitsidwa mpaka maola 10.
Thupi limalowetsedwa m'mimba m'mimba pambuyo pokhazikitsa.
Duloxetine metabolites amuchotsa makamaka ndi impso. Kutha kwa theka-moyo kuli mpaka maola 12.
Ndi kulephera kwa chiwindi, chopinga wa cleavage ndi kuwononga kwa yogwira pophika kuonedwa.
Zizindikiro zogwiritsidwa ntchito
- mavuto ambiri limodzi ndi nkhawa;
- mayiko okhumudwitsa (kukhumudwa);
- aakulu ululu kutikita m'malo osiyanasiyana musculoskeletal dongosolo;
- kupweteka kwa matenda ashuga a m'mimba (zotumphukira);
- Matenda a Stevens.
Contraindication
- kutsekedwa kwa khungu
- matenda oopsa (osasamala);
- hepatic matenda;
- kulephera kwambiri kwaimpso (ndi CC mpaka 30 ml / miniti);
- zaka zosakwana 18;
- kuphatikiza ndi fluvoxamine, ciprofloxacin ndi enoxacin;
- kusalolera payekha.
Ndi chisamaliro
Mankhwalawa amagwiritsidwa ntchito mosamala mu zotsatirazi:
- kupsinjika kwa mitsempha ndi mania;
- kuyesa kudzipha ndi malingaliro okhudzana;
- chiopsezo cha matenda oopsa (intraocular) ndi glaucoma;
- kukokana
- hepatic cirrhosis;
- chiwindi ndi kulephera kwa impso.
Kutenga Simbalta?
Fomu ya kapisozi ya mankhwalawa imapangidwa kuti izigwiritsidwa ntchito pakamwa, ngakhale nthawi yakudya. Sikoyenera kutafuna makapisozi, apo ayi, ntchito zawo zamankhwala zimakhala zochepa. Mlingo waukulu:
- Zolemba zowonjezera: kukonzanso ndi koyamba Mlingo - 60 mg / tsiku. Zotsatira zabwino zimawonekera mkati mwa masiku 14-28 a mankhwalawa.
- Matenda omwe amakumana ndi nkhawa: mlingo woyambirira ndi 30 mg / tsiku. Palibe mphamvu zopatsa mphamvu, mulingo ungathe kuchuluka mpaka 60 mg / tsiku. Kutalika kwa mankhwalawa kumachitika kuyambira pa 8 mpaka 12 milungu.
- Kupweteka kwapakati ndi kupweteka kwa minofu ndi neuropathic etiology syndrome: chithandizo chimayamba ndi Mlingo wa 30 mg / tsiku kwa masiku 7. Pambuyo Mlingo wa 60 mg / tsiku zotchulidwa. Kutalika kwa mankhwalawa kumachitika kuyambira pa 8 mpaka 12 milungu.
Fomu ya kapisozi ya mankhwalawa imapangidwa kuti izigwiritsidwa ntchito pakamwa, ngakhale nthawi yakudya.
Ndikofunika kusiya mankhwalawa ndi mapiritsi a-enteric-sungunuka pang'onopang'ono, apo ayi mutha kukumana ndi matenda achire.
Kumwa mankhwala a shuga
Kwa odwala matenda ashuga, Mlingo wa mankhwalawa umasankhidwa payekha, kutengera mtundu wa matenda. Pankhaniyi, wodwala amapatsidwa kuwongolera kwa glucose, komanso kusankha kwa mulingo woyenera wa insulin.
Zotsatira zoyipa za Simbalt
Matumbo
- chisangalalo;
- zizindikiro za dyspeptic;
- kupweteka kwa peritoneum;
- kusanza ndi mseru;
- dysphagia;
- hematochesia;
- halitosis ndi pakamwa lowuma;
- gastritis;
- magazi.
Pakati mantha dongosolo
- kupweteka mutu komanso kudwala;
- kumverera kwa kugona ndi kuwopa;
- kukwiya kwamanjenje;
- kufinya;
- mavuto a extrapyramidal;
- kugwedezeka kwamiyendo;
- malingaliro odzipha;
- Kuda nkhawa
- kukwiya ndi mania;
- dyskinesia;
- kukulira kwa ma psychomotor zochita.
Kuchokera kwamikodzo
- kukodza pafupipafupi;
- kusintha kwa kununkhira komanso kusasinthika kwa mkodzo;
- polyuria;
- kuchedwa ndi kuvuta kukodza;
- nocturia;
- kupweteka pokodza.
Kuchokera ku minculoskeletal system
- minofu kukokana;
- kupweteka kwa minofu ndi kupweteka kwa mafupa;
- kuuma kwa mayendedwe;
- trismus (nthawi zina).
Kuchokera ku genitourinary system
- kuphwanya ejaculation;
- kusabala
- kusamba kwa msambo;
- galactorrhea;
- Zizindikiro za kusamba;
- hyperprolactinemia;
- kupweteka ndi kusapeza bwino mu ma testicles.
Kuchokera pamtima
- kudumpha mu kuthamanga kwa magazi;
- orthostatic mawonekedwe a hypotension;
- kukomoka;
- matenda oopsa;
- kuzizira mmiyendo ndi miyendo;
- mafunde.
Matupi omaliza
- zotupa pakhungu;
- kuyabwa
- Edema wa Quincke.
Zokhudza mphamvu pakuwongolera njira
Munthawi ya kugwiritsa ntchito mankhwala osokoneza bongo, kukhala maso kwambiri kuyenera kuyendetsedwa ndikuwongolera njira zamagalimoto ndi mayendedwe amisewu, komanso kugwira nawo ntchito yolimbikitsa chidwi cha anthu ambiri.
Munthawi ya kugwiritsa ntchito mankhwala osokoneza bongo, kukhala maso kwambiri kuyenera kuchitidwa poyendetsa magalimoto.
Malangizo apadera
Chifukwa chakuti mankhwalawa amakhudza dongosolo lamanjenje lamkati, limayikidwa mosamala mu odwala omwe ali ndi khunyu komanso ma epicode a manic.
Chifukwa chakuganiza kwa kudzipha mukamagwiritsa ntchito mankhwalawa, wodwalayo ayenera kuyang'aniridwa ndi ogwira ntchito kuchipatala komanso okondedwa.
Ndikofunikira kuphatikizira odwala pakulankhulana, kukhala ndi chidwi ndi malingaliro omwe amawasokoneza. Tiyenera kukumbukira kuti kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumatha kukhala mavuto osokoneza bongo komanso ogaya.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Munthawi ya bere, mankhwalawa angagwiritsidwe ntchito kokha pazolinga zake ndikuyang'aniridwa ndi dokotala. Ndi mkaka wa m`mawere, mankhwalawa sagwiritsidwa ntchito. Izi zimatsimikiziridwa ndi malangizo ogwiritsa ntchito malonda.
Munthawi ya bere, mankhwalawa angagwiritsidwe ntchito kokha pazolinga zake ndikuyang'aniridwa ndi dokotala.
Kusankhidwa kwa Simbalta kwa ana
Chidachi sichikugwiritsidwa ntchito pochiza odwala ang'onoang'ono.
Gwiritsani ntchito mu ukalamba
Mu gulu ili la odwala, mankhwalawa amatchulidwa muyezo wochepetsetsa. Komanso, odwala otere amafunika kuwunika mwapadera ndi ogwira ntchito kuchipatala.
The ntchito aimpso kuwonongeka
Chithandizo cha mankhwala ndi contraindicated mu pachimake kulephera kwa chiwindi.
Chithandizo cha mankhwala ndi contraindicated mu pachimake kulephera kwa chiwindi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwala osokoneza bongo amaletsedwa kwambiri pakulephera kwa chiwindi.
Mankhwala ochulukirapo a Simbalta
Pali milandu yovuta mpaka kufa kwa omwe amamwa 3 g ya duloxetine 1 nthawi. Mankhwala osokoneza bongo osakanikirana ndi omwe amakhala okha nthawi zambiri amachititsa izi:
- kukokana
- chikomokere
- mydriasis;
- kugona kwambiri;
- kusanza ndi kusanza;
- kugwedezeka
- ataxia
- kuwonongeka kwa chapakati mantha dongosolo ndi kugaya chakudya dongosolo.
Chithandizo cha zinthu zotere zimachitika pakumatenga kuyamwa, kutsekeka kwa m'matumbo ndikuwonetsetsa kutuluka kwa mpweya. Kuphatikiza apo, wozunzidwayo amapatsidwa mphamvu zakulamulira mtima komanso zizindikiro zazikulu zamankhwala. Chithandizo chotsatira chimayenera kukhala chizindikiro.
Kuchita ndi mankhwala ena
Kuphatikiza kwa mankhwala ndi mankhwala ena, izi zimachitika.
- histamine receptor antacid ndi antagonists: sizikuwakhudza mayamwidwe;
- Fluoxetine, Paroxetine, Venlafaxine, Quinidine, Tramadol, Tryptophan, wort wa St. John: pali chiopsezo cha serotonin syndrome.
Kuphatikiza apo, ngati mumwa mankhwalawo nthawi yomweyo ngati Mao inhibitors, ndiye kuti chiwopsezo cha serotonin syndrome chikuwonekera.
Kuyenderana ndi mowa
Chifukwa cha chiopsezo chambiri chamtopola, muyenera kupewa kumwa makapisozi ndi mowa nthawi yomweyo.
Muyenera kupewa kumwa makapisozi ndi mowa nthawi yomweyo.
Analogi
Mitundu yotsika mtengo kwambiri komanso yothandiza yamankhwala:
- Duloxetine;
- Duloxent;
- Duloxetine Canon.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Mankhwalawa sangagulidwe popanda kulandira mankhwala.
Mtengo wamtengo
Mtengo wa mankhwalawa umachokera ku ma ruble 1600-1800 pachilichonse cha makapisozi 28.
Mankhwalawa sangagulidwe popanda kulandira mankhwala.
Zosungidwa zamankhwala
Zomwe zimasungidwa zimasungidwa m'malo osavomerezeka ndi ana, kutentha kwa + 15 ... + 30 ° C.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Eli Lilly & Company (USA) ndi Lilly S.A. (Spain).
Ndemanga za Simbalt
Tamara Kupriyanova (neuropathologist), wazaka 40, Voronezh.
Mankhwala amatha kuthana ndi matenda opweteka am'malo osiyanasiyana. Kuphatikiza apo, nthawi zambiri amagwiritsidwa ntchito pochiza fibromyalgia. Mphamvu ya mankhwalawa imafotokozedwa ndi mfundo yothetsanso serotonin. Chifukwa cha izi, osati kupweteka kokha kumachotsedwa, komanso mawonekedwe amakhudzidwe amakonzedwa, omwe ndi othandiza pakukhumudwitsa kwawoko. Mtengo wa mankhwalawo ulibe malire.
Fedor Arkanov (wothandizira), wazaka 37, Tver.
Duloxetine ndiwothandiza kwambiri ku United States. Komabe, m'dziko lathu likupeza kutchuka. Zothandiza, koma pakadali pano ndizokwera mtengo, ndipo ma analogu omwe amapezeka ndi osowa kwambiri pamsika waulere.
Lyudmila Guseva, wazaka 45, mzinda wa Voskresensk.
Ndidasinthira mankhwalawa kuchokera ku Stimulon, popeza kuyambira pamenepo ndidayamba kumva zovuta. Tsopano ndikumva bwino, monga momwe zikuwonekeranso ndi zotsatira za mayeso omwe ndidadutsa posachedwa ku chipatala cha komweko.
