Melfor adziyambitsa yekha pamsika wama pharmacological chifukwa chothandiza pakuyenda bwino kwa magazi. Mofananamo, mankhwalawa amagwiritsidwa ntchito kuti athetse kufooka kwakutali komwe kumadza chifukwa cha kupsinjika kwakuthupi ndi kwamakhalidwe. Mankhwala amathandizira kuphatikiza magazi kupita ku ischemic m'dera la myocardium, ubongo, wokhala ndi dystrophic pathologies mu retina yamaumboni osiyanasiyana.
Dzinalo Losayenerana
Meldonium.
Melfor adziyambitsa yekha pamsika wama pharmacological chifukwa chothandiza pakuyenda bwino kwa magazi.
ATX
C01EB.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka m'mitundu ingapo:
- Njira yothandizira jekeseni.
- Manyuchi pakamwa.
- Makapisozi ogwiritsira ntchito pakamwa.
Njira Zothetsera
1 ml ya mawonekedwe a madzi amadzimadzi ali ndi 100 mg yogwira mankhwala - meldonium, kusungunuka m'madzi osalala a jakisoni. Njira yothetsera makonzedwe a parabulbarly, intramuscularly komanso kudzera mu mtsempha amagulitsidwa m'magalasi amiyeso ya 5 ml chidutswa chilichonse kapena 2, 20, 50, 100 pamagawo.
Makapisozi
Makapisozi oyera oyera okhala ndi chipolopolo cholimba cha gelatin chakunja chili ndi osakaniza a 250 mg meldonium. Mankhwala amaphatikizidwa ndi matuza a 10-30 zidutswa chilichonse.
Zotsatira za pharmacological
Mankhwalawa ndi opangidwa kuchokera ku gamma-butyrobetaine. Mankhwalawa cholinga chake ndi kukonza kagayidwe kake konse. Makina ochitapo kanthu adatengera kulepheretsa kwa enzyme gamma-butyrobetaine hydroxynase, chifukwa chomwe kupanga kwa carnitine komanso kulowa kwa ma lipid acid okhala ndi ma cell ochepa kumasokonekera. Mankhwalawa amalepheretsa kudziunjikira kwamitundu yogwira yamafuta acids (zotumphukira za acyl coenzyme A ndi acyl carnitine) zomwe sizinachitike mthupi la oxidative.
Mankhwalawa cholinga chake ndi kukonza kagayidwe kake konse.
Ndi kuchepa kwa plasma ndende ya carnitine, kaphatikizidwe ka gamma-butyrobetaine amayamba, komwe kumatha kupumula m'makoma a mtima. Nthawi yomweyo, chinthu chogwira ntchito chimathandizira:
- kuchuluka kwa ntchito;
- Kuchepetsa kutopa pamsana pamavuto amthupi;
- kukulitsa mtima;
- kukulitsa mayankho amanyazi komanso chitetezo cha mthupi.
Pamaso pa ischemia, meldonium imakhudzidwa pakubwezeretsa magazi kumadera omwe amapangidwira komanso njira zamagetsi. Minofu imapeza mpweya wambiri mwa kuyambitsa nthawi yomweyo glycolysis pansi pa anaerobic. Ngati matenda akhunyu a mtima apezeka, mankhwalawa amawononga malo a necrotic komanso amachepetsa nthawi yokonzanso. Ndi kukula kwa mtima kulephera, kutsutsana myocardial kuonjezera nkhawa, mwayi wa angina pectoris umachepa, komanso kugunda kwa mtima kumawonjezeka.
Mu mtundu wa pachimake kapena matenda a cerebrovascular ngozi atalandiridwa ndi Melfort, microcirculation imasinthidwa nthawi ya ischemic mtundu matenda. Magazi amayamba kugawa ndikuthandizira minyewa yomwe yakhudzidwa.
Meldonium imagwiritsidwa ntchito pochita zachipatala pochiza dystrophy ya optic nerve ndi ziwiya za fundus. Nthawi yomweyo, mankhwalawa amalimbikitsa machitidwe a chapakati chamanjenje ndikuwachotsa matenda amitsempha mwa odwala omwe ali ndi vuto lochotsa chidakwa ndi zakumwa zoledzeretsa.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, meldonium imayamba kugwira ntchito mwachangu ndi microvilli yaing'ono yamatumbo. The bioavailability pambuyo limodzi mlingo 78%.
Pambuyo pakukonzekera pakamwa, meldonium imayamba kugwira ntchito mwachangu ndi microvilli yaing'ono yamatumbo.
Ngati ilowa pabedi lamitsempha, magazi ambiri omwe amapezeka m'madzi am'magazi amayikika pambuyo pa maola 1-2. Meldonium imasinthidwa mu hepatocytes ndikupanga 2 yogwira metabolic zopangidwa kudzera mu impso. Kutha kwa theka-moyo mwachindunji kumatengera mlingo wolandiridwa - ndi muyezo wa 250 mg wa meldonium ndi maola 3-6.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amatengedwa pakamwa ndikuilowetsa mu mtsempha kuti alandire milandu iyi:
- kuthamanga kwa minofu kusinthika pambuyo opaleshoni;
- kusiya zachikhalidwe zakumwa kwambiri;
- zovuta mankhwala a mtima Kulephera, mtima matenda, limodzi ndi pachimake myocardial infarction ndi angina pectoris;
- kulephera kwa mahomoni ndi mtima;
- Kuchepetsa magwiridwe;
- kuphatikiza mankhwala a ubongo;
- kupewa mikwingwirima, cerebrovascular insufficiency;
- kupsinjika kwakuthupi, makamaka pakati pa othamanga.
Jakisoni wa parabulbar amagwiritsidwa ntchito pamaso pa zovuta zamtundu wa retina, thrombosis, hemorrhage wa magwero osiyanasiyana, retinopathy, hemophthalmus.
Contraindication
Mankhwalawa amaletsedwa kugwiritsidwa ntchito ndi odwala omwe ali ndi vuto lochulukirapo la intracranial motsutsana ndi zovuta za chotupa cha venous outflow ndi intracranial chotupa, chokhala ndi minofu hypersensitivity kuti meldonium.
Ndi chisamaliro
Ndikulimbikitsidwa kusamala ndi chithandizo cha nthawi yayitali kwa odwala omwe ali ndi matenda a chiwindi ndi impso.
Momwe mungatenge Melfort
Makapisozi amakulimbikitsidwa kuti azimwedwa pakamwa musanadye m'mawa chifukwa chosangalatsa.
Makapisozi amakulimbikitsidwa kuti azimwedwa pakamwa musanadye m'mawa chifukwa chosangalatsa.
| Matendawa | Chithandizo cha mankhwala | |
| Yankho la jakisoni | Makapisozi | |
| Zolimbitsa thupi | Limodzi mlingo - mtsempha wa magazi 5 ml. Kutalika kwa mankhwalawa ndi masiku 10-14. Ngati ndi kotheka, maphunzirowa atha kubwerezedwa pambuyo pa masabata awiri. | 250 mg 4 pa tsiku kwa masiku 10-14. Mankhwalawa amabwerezedwa pambuyo pa masabata awiri ndi atatu ngati kuli kotheka. Ochita masewera amalimbikitsidwa kumwa mankhwalawa 0,5-1 g pa tsiku musanayambe kuchita masewera olimbitsa thupi. Pokonzekera mpikisano, njira yamankhwala imatenga masiku 14 mpaka 14, masiku ena - nthawi yayitali. |
| Monga gawo la mankhwala a mtima | Mu / mu 5-10 ml kwa masabata awiri. |
|
| The pachimake gawo la ischemic cerebrovascular ngozi | Zilonda zimaperekedwa pokhapokha. Kumapeto kwa jakisoni, pakamwa pakamwa paperekedwa mankhwala; kukhazikitsidwa kwa iv 5 ml tsiku lililonse kwa masiku 7-10. Ngati matenda a cerebrovascular akuperewera, ndikofunikira kupaka jekeseni wa mankhwalawa kwa masiku 10-14. | Chithandizo cha mankhwalawa chimatha milungu 6, pamene muyenera kumwa 500 mg ya mankhwala patsiku. |
| Kuletsa mowa | 5 ml amalowetsedwa mu mtsempha katatu patsiku. Njira ya chithandizo ndi masiku 7-10. | 500 mg 4 pa tsiku kwa masiku 7-10. |
| Zowonongeka za m'matumbo a fundus | Jekeseni wa 0,5 ml ya retrobulbar kapena m'dera pansi pa conjunctiva kwa masiku 10. | Makapisozi sangapereke achire zotsatira. |
Ndi matenda ashuga
Mankhwalawa sasokoneza chinsinsi cha ma cell a pancreatic beta ndi shuga wamagazi, motero, kuwongolera kowonjezera kwa odwala matenda a shuga sikofunikira.
Mankhwalawa sasokoneza chinsinsi cha ma cell a pancreatic beta ndi shuga wamagazi.
Zotsatira zoyipa Melfora
Zotsatira zoyipa kuchokera ku ziwalo ndi machitidwe osiyanasiyana zitha kuwoneka chifukwa cha njira zosayenera za dosing komanso kunyalanyaza malangizo azachipatala.
Matumbo
Nthawi zina, zizindikiro za dyspeptic, nseru, kupweteka kwam'mimba, kutsegula m'mimba, kusefukira kwamadzi, komanso kudzimbidwa kumatha kuchitika.
Hematopoietic ziwalo
Ndi makonzedwe amkamwa, pali chiopsezo cha kuchepa kwa kuchuluka kwa zinthu zopangidwa m'magazi. Ngati zimachitika zoipa mu magazi, tachycardia, kuchuluka magazi, kapena ochepa hypotension.
Pakati mantha dongosolo
Mwina kukula kwa psychomotor mukubwadamuka.
Matupi omaliza
Mwambiri, kukula kwa anaphylactic kugwedeza komanso edema ya Quincke sikufika. Odwala amatha kumva totupa pakhungu, kuyabwa, komanso mafinya.
Zokhudza mphamvu pakuwongolera njira
Munthawi ya kugwiritsa ntchito mankhwala osokoneza bongo, kuyendetsa galimoto, masewera owopsa, kugwira ntchito ndi zida zovuta komanso zochitika zina zomwe zimafunikira chidwi ndi kukulitsa luso lagalimoto zimaloledwa.
Malangizo apadera
Mu maphunziro azachipatala komanso luso logwiritsira ntchito mankhwalawa ndi akatswiri a zamankhwala muzochitika zamankhwala, zidapezeka kuti meldonium sangabwezeretse kwathunthu zochitika za thupi mu kusowa bwino kwa coronary.
Gwiritsani ntchito mu ukalamba
Anthu opitilira zaka zopitilira 60 sayenera kusintha njira zina zochizira.
Kupatsa ana
Makapisozi ndi yankho silikulimbikitsidwa kuti mugwiritse ntchito kufikira zaka 18 chifukwa cha kusowa kwa kafukufuku wokwanira komanso chidziwitso cha zotsatira za meldonium pa kukula ndi kukula kwa mwana muubwana, unyamata. Syrup sagwiritsidwa ntchito mpaka zaka 12.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pali chiopsezo cholowa cha meldonium kudzera mu chotchinga cham'mimba, chifukwa chomwe kuyikika kwakukulu kwa minofu ndi ziwalo panthawi ya embryonic kumatha kusokonezeka. Mankhwalawa amalembera azimayi oyembekezera pokhapokha ngati pali ngozi kwa moyo wa wodwalayo yomwe imaposa chiopsezo cha intrauterine pathologies ya mwana wosabadwayo.
Munthawi ya chithandizo, ndikofunikira kusiya kuyamwitsa.
The ntchito aimpso kuwonongeka
Chisamaliro chiyenera kuthandizidwa pakumwa mankhwalawo kumbuyo kwa vuto lolakwika la impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwalawa saloledwa kwa anthu omwe ali ndi vuto lalikulu la chiwindi.
Overfose Melfora
Ndi gawo limodzi lokha la mlingo waukulu, pali chiopsezo cha kutsika kwa magazi, chizungulire, ochepa tachycardia, kufooka kwa minofu, ndi mutu. Chithandizo cha chiberekero chimachitika kuti athetse vuto la matenda osokoneza bongo. Mukamamwa pakamwa (makapisozi, manyumwa), ndikofunikira kuti wodwalayo apatsidwe makala kuti achepetse kuyamwa kwamatumbo ang'onoang'ono.
Kuchita ndi mankhwala ena
Ndi othandizira a Melfora ndi mankhwala ena, zotsatirazi zimawonedwa:
- The achire zotsatira za antianginal mankhwala, mtima glycosides, hypoglycemic wothandizidwa umatheka.
- Pali chiopsezo chotenga tachycardia ndi hypotension mukamamwa Nifedipine, vasodilators, antihypertensive mankhwala, alpha-adrenergic blockers, Nitroglycerin.
Pali chiopsezo chokhala ndi tachycardia ndi hypotension pogwiritsa ntchito Nifedipine.
Potsirizira pake, chisamaliro chiyenera kuchitidwa.
Kuyenderana ndi mowa
Munthawi yamankhwala osokoneza bongo, sikulimbikitsidwa kumwa zakumwa zoledzeretsa. Ethanol linalake ndipo tikulephera kugwira ntchito kwa chapakati mantha dongosolo, ali ndi hepatotoxic zotsatira ndi kumawonjezera mwayi wosiyanasiyana. Mowa wa Ethyl umayambitsa kufa kwa maselo a chiwindi, omwe amachepetsa mphamvu ya Melfor, ndikuwonjezera mwayi wokhala ndi mafuta osalimba a chiwalo.
Analogi
| Mutu | Mtengo, pakani. | Zochita ndi kusiyana kwa Melfora |
| Magnikor | 75 | Maziko a mankhwalawa amaphatikiza acetylsalicylic acid ndi magnesium hydrochloride. Ntchito mapiritsi zochizira pachimake ndi matenda a mtima ischemia. |
| Pumpan | 274-448 | Madontho ndi mapiritsi omwe ali m'gulu la mankhwala osakanikirana ndi matenda oopsa, arrhythmia ndi matenda ena a mtima. |
| Cordaflex | 76 | Amapezeka m'mapiritsi otsekemera. The yogwira mankhwala ndi nifedipine. Amathandizanso ndi cardiomyopathy, myocardial ischemia, kuthamanga kwa magazi ndi vuto la matenda oopsa osiyanasiyana. |
| Amlipin | 340 | Mphamvu ya zochita za mankhwalawa imachokera kuphatikizidwa kwa lisinopril ndi amlodipine, ogwiritsidwa ntchito pochiza komanso kupewa mtima wa mtima. |
| Corvitol | 250 | Yogwira pophika ndi metoprolol, yofunikira pochizira angina pectoris, hyperthyroidism, kugunda kwa mtima, kuchotsa malo a ischemic ndi matenda a mtima. |
| Kudesan | 330 | Madontho ndi mapiritsi, ma cellacological omwe amawonetseredwa chifukwa cha ubidecarenone. Amagwiritsidwa ntchito ngati arrhythmias, kuchira pambuyo pa vuto la mtima, pochiza matenda a mtima. |
| Bisoprolol | 95-115 | Chithandizo cha angina pectoris, matenda oopsa komanso kulephera kwa mtima. |
Kupita kwina mankhwala
Mankhwalawa amagulitsidwa m'mafakisoni mosiyanasiyana malinga ndi mankhwala.
Mtengo
Mtengo wapakati wa mankhwalawa umafika ku ruble 500-560.
Zosungidwa zamankhwala
Ndikofunikira kukhala ndi yankho ndi makapisozi a mankhwalawa pa kutentha kwa + 15 ... + 25 ° C m'malo osavomerezeka ndi chinyezi ndi dzuwa.
Tsiku lotha ntchito
Miyezi 24.
Wopanga
Ozone LLC, Russia.
Ndemanga
Marina Kutina, katswiri wamtima, Rostov-on-Don
Ndakhala ndikugwira ntchito ndi Melfor kwa zaka 6. Perekani kwa kugwiritsa ntchito mu mnofu, mtsempha wamkamwa komanso pakamwa. Odwala amafotokoza bwino masiku 10 atachira. Zotsatira zakuchiritsa ndikuwonjezera kupirira, kuwonjezereka kwa mphamvu ndi kusintha kwa dongosolo la mtima. Ndikupangira mlingo wa 500 mg. Zinthu zatsiku ndi tsiku zimachulukana pochiza matenda a mtima, a retinal dystrophy, fundus, post-infarction state, myocardial dystrophy.Sindikulimbikitsa kulandira ndi chidwi chochulukirapo.
Stepan Rogov, wazaka 34, Irkutsk
Dokotala adamupatsa mapiritsi a Melfor atatha kufananirana ndi Mildronate. Ndimamwa mankhwalawa kwa miyezi ingapo ndikubwereza maphunziro ataliatali okhudzana ndi ntchito yomwe ndikutembenukira kumpoto, komwe kumafuna kupirira kwambiri. Pali mavuto ena amtima komanso kutopa chifukwa chogwira ntchito mopitirira muyeso. Mukatenga makapisozi, kutopa kumachepa, kuukira kwa angina kumakhala kocheperako, kusinthasintha. Ndikusiyirani ndemanga yabwino.
Julia Gerasimova, wazaka 27, Lipetsk
Ndimagwira ntchito yosungiramo katundu kwa maola 12-14 patsiku, nchifukwa chake ndimakhala wotopa mwakuthupi komanso mwamalingaliro. Dokotala adalamulira makapisozi a Melfora. Chikuonetseratu - milungu iwiri iliyonse. Chida chothandiza chomwe chimakongoletsa kamvekedwe ka thupi, chimasintha mamvekedwe ndi kupsinjika. Zotsatira za mankhwalawa anamva patatha masiku awiri ndi atatu atapita. Makapisozi amatengedwa mosamalitsa malinga ndi malangizo kuti apewe mavuto.
