Vipidia 25 ndi gawo la hypoglycemic lomwe limagwiritsidwa ntchito popanga matenda kuti matenda a shuga asamangodalira shuga. Mankhwala angagwiritsidwe ntchito ngati gawo la kuphatikiza mankhwalawa kuti achulukitse kuchuluka kwa shuga. Mankhwalawa amapezeka mwanjira yabwino ya mapiritsi. Mankhwala a hypoglycemic sayenera kumwa ndi ana ndi amayi apakati.
Dzinalo Losayenerana
Alogliptin.
Vipidia 25 ndi gawo la hypoglycemic lomwe limagwiritsidwa ntchito popanga matenda kuti matenda a shuga asamangodalira shuga.
ATX
A10BH04.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa piritsi la 25 mg la yogwira - alogliptin benzoate. Pakatikati mwa mapiritsiwo mumakhala mankhwala othandizira:
- ma cellcose a microcrystalline;
- magnesium wakuba;
- mannitol;
- croscarmellose sodium;
- hyprolose.
Pakatikati mwa mapiritsiwo amathandizidwa ndi cellcrystalline cellulose.
Pamwambapa mapiritsiwo pali mawonekedwe a filimu yopanga hypromellose, titanium dioxide, macrogol 8000, utoto wachikasu womwe umatengera iron oxide. Mapiritsi a 25 mg ndi ofiira.
Zotsatira za pharmacological
Mankhwala ndi a gulu la hypoglycemic wothandizira chifukwa cha kusankha kuponderezedwa kwa ntchito ya dipeptidyl peptidase-4. DPP-4 ndi puloteni yofunika yophatikizira kuchepa kwapang'onopang'ono kwa kuphatikiza kwa mahomoni a ma insretins - enteroglucagon ndi insulinotropic peptide, yomwe imadalira kuchuluka kwa glucose (HIP).
Mahomoni ochokera ku gulu la ma insretins amapangidwa m'matumbo. Kuphatikizika kwa mankhwala opangira mankhwala kumawonjezeka ndi chakudya. Glucagon-ngati peptide ndi GUI imakulitsa kaphatikizidwe ka insulini m'malo opezeka pancreatic a Langerhans. Enteroglucagon nthawi imodzi imalepheretsa kuphatikizika kwa glucagon ndipo imalepheretsa gluconeogeneis mu hepatocytes, yomwe imapangitsa plasma ndende ya insretins. Alogliptin imakulitsa katemera wa insulini, kutengera shuga.
Pharmacokinetics
Mukamamwa pakamwa, alogliptin imalowa mu khoma lamatumbo, pomwe imasiyanitsidwa ndi kama. The bioavailability wa mankhwala ukufika 100%. M'mitsempha yamagazi, chinthu chogwira ntchito chimafikira kuchuluka kwa plasma mkati mwa maola 1-2. Palibe kudzikundikira kwa alogliptin mu minofu.
Mukamamwa pakamwa, alogliptin imalowa mu khoma lamatumbo, pomwe imasiyanitsidwa ndi kama.
Pulogalamu yogwira imamangirako plasma albumin ndi 20-30%. Pankhaniyi, mankhwalawa sasintha ndikusintha kwa hepatocytes. Kuchokera pa 60% mpaka 70% ya mankhwalawa amachoka m'thupi momwe adapangidwira kudzera mu kwamikodzo, 13% ya alogliptin amawachotsa ndowe. Hafu ya moyo ndi maola 21.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amathandizidwa ndi odwala zochizira osagwirizana insulin 2 matenda a shuga ndi matenda a glycemic motsutsana kumbuyo kwa mphamvu yochepa ya kudya mankhwala ndi zolimbitsa thupi. Kwa odwala akuluakulu, mankhwalawa amatha kutumikiridwa onse monga monotherapy, komanso ngati gawo la chithandizo chovuta ndi Insulin kapena mankhwala ena a hypoglycemic.
Contraindication
Mankhwala contraindised otsatirawa milandu:
- pamaso pa minofu hypersensitivity kwa alogliptin ndi zina zowonjezera;
- ngati wodwala amakonda kuchita anaphylactoid zimachitika DPP-4 zoletsa;
- mtundu 1 matenda a shuga;
- ana ochepera zaka 18;
- odwala ndi mtima kulephera;
- kwambiri aimpso ndi chiwindi kukanika;
- azimayi oyembekezera komanso oyembekezera.
Mankhwalawa sanatchulidwe matenda a shuga a ketoacidosis.
Ndi chisamaliro
Ndi bwino kukhala osamala odwala ndi pachimake kapamba, odwala ndi zolimbitsa aimpso kulephera. Ndikofunikira kuyang'anira momwe ziwalo zimagwirira ntchito limodzi ndi mankhwala a sulfonylurea kapena chithandizo chovuta ndi glitazones, Metformin, Pioglitazone.
Kutenga Vipidia 25?
Mapiritsiwo adapangira pakamwa. Ndi bwino kugwiritsa ntchito mankhwalawa ndi Mlingo wa 25 mg kamodzi patsiku, mosasamala kanthu za kudya. Maumwini a mankhwalawa sangathe kutafunidwa, chifukwa kuwonongeka kwa makina kumachepetsa kuyamwa kwa alogliptin m'matumbo aang'ono. Osamwa pawiri. Piritsi yosowa pa chifukwa chilichonse iyenera kutengedwa ndi wodwala posachedwa.
Chithandizo cha matenda ashuga
Othandizira azaumoyo amalimbikitsa kuti mutenge mapiritsi a Vipidia mukatha kudya pamene magazi a shuga akukwera. Mukamapereka mankhwala ngati chida chowonjezera chothandizira ndi Metmorphine kapena Thiazolidinedione, palibe chifukwa chosinthira mtundu wa mankhwala omaliza.
Ndi kufanana kwa sulfonylurea zotumphukira, mlingo wawo umachepetsedwa kuti ateteze kukula kwa boma la hypoglycemic. Chifukwa cha chiwopsezo cha hypoglycemia, ndikofunikira kuthana ndi shuga panthawi ya mankhwala ndi Metformin, mahomoni am'mapapo ndi Thiazolidinedione palimodzi ndi Vipidia.
Chifukwa cha chiwopsezo cha hypoglycemia, ndikofunikira kuthana ndi shuga panthawi ya Metformin.
Zotsatira zoyipa za Vipidia 25
Zotsatira zoyipa zamagulu ndi minofu zimawonekera chifukwa cha regimen yosankhidwa bwino.
Matumbo
Mwina kukula kwa ululu mu epigastric dera ndi zilonda zam'mimbamo zam'mimba, duodenum. Nthawi zina, pancreatitis yachilendo imatha kuchitika.
Kuphwanya chiwindi ndi njira ziwiri
Mu hepatobiliary dongosolo, kuwoneka kwamisempha mu chiwindi ndi kukula kwa chiwindi kulephera ndikotheka.
Pakati mantha dongosolo
Nthawi zina, mutu umayamba.
Kusokonezeka Kwa Magazi
Potengera maziko ofooka chitetezo chokwanira, chotupa cha chapamwamba kupuma dongosolo ndi kukula kwa nasopharyngitis n`zotheka.
Pa khungu
Chifukwa cha kuchepa kwa minofu, zotupa pakhungu zimatha kuonekera. Mwachizolowezi, mawonekedwe a Stevens-Johnson syndrome, urticaria, matenda opatsirana pakhungu.
Matupi omaliza
Odwala omwe akuwoneka kuti akuwoneka kuti anaphylactoid zimachitika, urticaria, edema ya Quincke imawonedwa. Woopsa milandu, anaphylactic mantha.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa samakhudza kuyendetsa magalimoto ndi machitidwe, koma ndi kuphatikiza mankhwala ndi mankhwala ena, muyenera kusamala kwambiri.
Malangizo apadera
Odwala omwe ali ndi vuto lothana ndi vuto laimpso ayenera kukonza mankhwalawa tsiku lililonse ndipo munthawi yonse ya mankhwala othandizira amafunika kuwunika nthawi zonse chiwalo. Woopsa matenda a pathological, Vipidia ali osavomerezeka, monga odwala hemodialysis kapena odwala omwe ali ndi mawonekedwe amtundu waimpso.
Chifukwa cha kuchuluka kwa njira yotupa, ndikofunikira kudziwitsa odwala za kupezeka kwa kapamba.
Ma DPP-4 zoletsa amatha kupweteketsa ziphuphu zakumaso. Mukamawunika mayesero 13 azachipatala pomwe odzipereka adatenga 25 mg ya Vipidia patsiku, mwayi wokhala ndi kapamba amatsimikizika mwa odwala 3 mwa 1000. Chifukwa chakuwonjezeka kwa njira yotupa, ndikofunikira kudziwitsa odwala za kupezeka kwa kapamba, omwe amadziwika ndi zizindikiro zotsatirazi:
- kupweteka kwapafupipafupi m'chigawo cha epigastric ndi radiation kumbuyo;
- kumverera kolemetsa mu hypochondrium yamanzere.
Ngati wodwala akuwonetsa pancreatitis, mankhwalawa amayenera kuyimitsidwa mwachangu ndikuwunika kuti apange ziphuphu. Mukalandira zotsatira zabwino zoyeserera zasayansi, mankhwalawa samapangidwanso.
Nthawi yotsatsa itatha, milandu ya chiwindi chokhala ndi vuto lotsatira inalemba. Kulumikizana ndi kugwiritsa ntchito Vipidia panthawi ya maphunziro sikunayambike, koma munthawi ya chithandizo ndi mankhwalawa, tikulimbikitsidwa kuti odwala omwe ali ndi chiwopsezo chofufuzira amafufuza nthawi zonse kuti ayang'anire ntchito ya chiwindi. Ngati, chifukwa cha kafukufuku, kupatuka pantchito ya chiwalo chokhala ndi etiology yosadziwika kwapezeka, ndikofunikira kusiya kumwa mankhwalawo poyambiranso.
Mankhwalawa akamagwiritsa ntchito mankhwala omwe amayamba kukhudzana ndi chiwindi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Kafukufuku wokhudzana ndi zamankhwala pokhudzana ndi mankhwalawa pa thupi la azimayi panthawi yoyembekezera sanachitike. M'nthawi yoyesera nyama, panalibe zotsatirapo zoipa za mankhwalawa pakubala kwamayi, embryotoxicity, kapena teratogenicity ya Vipidia. Nthawi yomweyo, pazifukwa zotetezeka, mankhwalawa sanalembedwe kwa azimayi panthawi yoyembekezera (chifukwa cha chiwopsezo chophwanya kuyika kwa ziwalo ndi machitidwe pakukonzekera kwa embryonic).
Alogliptin imatha kupukusidwa kudzera m'magazi a mammary, motero tikulimbikitsidwa kusiya mkaka wa m'nthawi yamankhwala.
Kulembera Vipidia kwa ana 25
Chifukwa cha kusowa kwa chidziwitso pazinthu zomwe zikugwira pakulidwe ndi kutukuka kwa thupi laumunthu muubwana ndi unyamata, mankhwalawa amatsutsana ndikugwiritsa ntchito mpaka zaka 18.
Gwiritsani ntchito mu ukalamba
Odwala a zaka zopitilira 60 safuna kusinthidwa kwa Mlingo wowonjezera.
The ntchito aimpso kuwonongeka
Pamaso pa kufooka pang'ono kwa impso pakati pa creatinine chilolezo (Cl) kuchokera pa 50 mpaka 70 ml / mphindi, zosintha zina zamankhwala sizimapangidwa. Ndi Cl kuchokera pa 29 mpaka 49 ml / min, ndikofunikira kuti muchepetse kuchuluka kwa tsiku lililonse mpaka 12,5 mg wa mlingo umodzi.
Pamaso pa kufooka pang'ono kwa impso pakati pa creatinine chilolezo (Cl) kuchokera pa 50 mpaka 70 ml / mphindi, zosintha zina zamankhwala sizimapangidwa.
Ndi kukanika kwambiri kwa aimpso (Cl imafikira zosakwana 29 ml / min), mankhwalawo ndi oletsedwa.
Overdose wa Vipidia 25
Panthawi ya mayeso azachipatala, mulingo woyenera wokhazikika unakhazikitsidwa - 800 mg patsiku mwa odwala athanzi, ndi 400 mg patsiku kwa odwala omwe samadalira insulin akamadwala mankhwala kwa masiku 14. Izi zimaposa kuchuluka kwa nthawi 32 ndi 16, motsatana. Maonekedwe a chipatala cha bongo wosokoneza bongo sanalembedwe.
Ndi kugwiritsa ntchito mankhwala osokoneza bongo, ndizotheka kuwonjezera kuchuluka kwa kukula kapena kukulitsa mavuto. Ndi zovuta zoyipa, phokoso lam'mimba ndilofunika. Pokhala m'malo, mawonekedwe a chithandizo amachitika. Pakupita maola atatu hemodialysis, 7% yokha ya mankhwala omwe atengedwe ndi omwe angatengedwe, motero makonzedwe ake satha.
Kuchita ndi mankhwala ena
Mankhwalawa analibe kuyenderana ndi ma pharmacological ndi nthawi imodzi yoperekera Vipidia ndi mankhwala ena. Mankhwalawa sanaletse ntchito ya cytochrome isoenzymes P450, monoo oxygenase 2C9. Simalumikizana ndi magawo a p-glycoprotein. Alogliptin pakapita maphunziro a zamankhwala sizinakhudze kusintha kwam'magazi a caffeine, warfarin, dextromethorphan, kulera kwapakamwa mu plasma.
Mankhwalawa samakhudza kusintha pamlingo wa Dextromethorphan m'thupi.
Kuyenderana ndi mowa
Pa mankhwala ndi mankhwalawa, ndizoletsedwa kumwa mowa. Ethanol yomwe ili ndi zakumwa zoledzeretsa zimatha kuyambitsa mafuta ku chiwindi chifukwa cha zovuta za hepatocytes. Mukatenga Vipidia, poizoni wotsutsana ndi hepatobiliary system imakulitsidwa. Mowa wa Ethyl umayambitsa kuperewera kwa dongosolo lamkati lamanjenje, umasokoneza magazi ndipo umapangitsa kuti pakhale diuretic. Chifukwa cha kuchuluka kwa mowa mthupi, zochizira zamankhwala zimachepa.
Analogi
Magawo a mankhwala omwe ali ndi mankhwala omwewo ndi kapangidwe ka mankhwala pazomwe zimagwira:
- Galvus;
- Trazenta;
- Januvius;
- Onglisa;
- Xelevia.
Mankhwala omwe amafananizidwa amasankhidwa ndi adotolo kutengera ndi zomwe zimapangitsa kuti wodwala azikhala ndi shuga komanso momwe wodwalayo alili. Kusintha kumachitika pokhapokha ngati pakuchiritsa kapena pang'onopang'ono pomwe pakuyipa.
Kupita kwina mankhwala
Mankhwalawa sagulitsidwa popanda mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mlingo wolakwika wa mankhwalawa ungayambitse hypoglycemia kapena hyperglycemia. Kukula kwa chikumbumtima cha hypoglycemic ndikotheka, chifukwa chake, kugulitsa kwaulere kwa chitetezo cha odwala ndizochepa.
Mtengo wa Vipidia 25
Mtengo wapakati wamapiritsi ndi ma ruble 1100.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kuti Vipidia isungidwe pamatenthedwe mpaka + 25 ° C m'malo mwake ndi chinyezi chochepa, chomwe chili kutali ndi dzuwa.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Takeda Island Limited, Ireland.
Analogue ya mankhwalawa ndi Onglisa.
Ndemanga pa Vipidia 25
Pama intaneti pali ndemanga zabwino zochokera kwa azachipatala komanso malingaliro pa kugwiritsa ntchito mankhwalawa.
Madokotala
Anastasia Sivorova, endocrinologist, Astrakhan.
Chida chothandiza polimbana ndi matenda amtundu wa 2 shuga. Olekerera bwino ndi odwala. Muzochita zamankhwala, samakumana ndi hypoglycemia. Mapiritsi ayenera kumwedwa nthawi imodzi popanda kuwerengera mosamala. Wothandizila hypoglycemic kuchokera m'badwo watsopano, chifukwa chake, sizimathandizira kuti thupi lizikula. Ntchito yogwira maselo a pancreatic beta imasungidwa.
Alexey Barredo, endocrinologist, Arkhangelsk.
Ndinkakonda kuti kugwiritsa ntchito mankhwalawa kwakanthawi, mawonekedwe osalimbikitsa samakhala. Mankhwala othandizira amakhala ndi vuto lochepa kwambiri koma samawoneka nthawi yomweyo. Ndi yabwino kutenga - 1 nthawi patsiku. Mtengo wabwino wa ndalama. Sichimayambitsa zovuta kwa odwala.
Analogue ya mankhwalawa ndi Januvia.
Odwala
Gabriel Krasilnikov, wazaka 34, Ryazan.
Ndikutenga Vipidia pa 25 mg ya zaka 2 molumikizana ndi 500 mg ya Metformin m'mawa mutatha kudya. Poyamba, adagwiritsa ntchito Insulin malinga ndi dongosolo 10 + 10 + 8. Sizinathandize kuchepetsa bwino shuga. Zochita za mapiritsiwo ndizitali.Pambuyo pa miyezi itatu, shuga adayamba kutsika, koma patatha miyezi isanu ndi umodzi, shuga kuchokera 12 adagwa mpaka 4.5-5,5. Imapitilira kukhala mkati mwa 5.5. Ndinkakonda kuti kulemera kumachepa: kuyambira 114 mpaka 98 makilogalamu ndikukula kwa masentimita 180. Koma muyenera kutsatira malangizo onse kuchokera pamalangizo.
Ekaterina Gorshkova, wazaka 25, Krasnodar.
Amayi ali ndi matenda ashuga a 2. Dotolo adalamulira Maninil, koma sanakwanitse. Shuga sanachepe ndipo thanzi linali likuchepa chifukwa cha mavuto amtima. Kusinthidwa ndi mapiritsi a Vipidia. Ndi yabwino kutenga - 1 nthawi patsiku. Shuga sanachepetsedwa kwambiri, koma pang'onopang'ono, koma chinthu chachikulu ndikuti mayi akumva bwino. Chojambula chokha ndichakuti chimawononga chiwindi.
