Gensulin imalembedwa kwa odwala omwe ali ndi matenda ashuga, oyenera kuphatikiza ndi mitundu ina ya insulin. Mosamala, ziyenera kuphatikizidwa ndi mankhwala omwe amatha kukweza kapena kutsitsa mphamvu ya hypoglycemic.
Dzinalo Losayenerana
Mumtundu wa insulin waumunthu wophatikizika.
Gensulin imalembedwa kwa odwala omwe ali ndi matenda ashuga, oyenera kuphatikiza ndi mitundu ina ya insulin.
ATX
A10AB01.
Kutulutsa mafomu ndi kapangidwe kake
Yankho lomveka bwino, kuyimitsidwa koyera, kuyendetsedwa mosagwirizana. Mtengo ungawonekere kuti umasungunuka mosavuta ukagwedezeka. Mankhwalawa amamuikidwa m'mabotolo 10 ml kapena makilogalamu atatu a 3 ml.
Mu 1 ml ya mankhwalawa, chigawo chogwira ntchito chilipo mu mawonekedwe a recombinant human insulin 100 IU. Zowonjezera zake ndi glycerol, sodium hydroxide kapena hydrochloric acid, metacresol, madzi a jekeseni.
Mu 1 ml ya mankhwalawa, chigawo chogwira ntchito chilipo mu mawonekedwe a recombinant human insulin 100 IU.
Zotsatira za pharmacological
Amatanthauzanso ma insulin osakhalitsa. Pogwira ntchito ndi ma receptor apadera pa nembanemba ya cell, imalimbikitsa kupangika kwa insulin-receptor tata, yomwe imayendetsa ntchito mkati mwa cell ndi kapangidwe kazinthu zina za enzyme.
Mlingo wa shuga m'magazi ndiwowonjezereka pakuwongolera mayendedwe ake m'maselo, kuchuluka kwa ziwalo zonse za thupi, kuchepetsa kupanga shuga ndi chiwindi, komanso kulimbikitsa glycogenogeneis.
Kutalika kwa mankhwalawa zotsatira za mankhwalawa zimatengera:
- mayamwa gawo la yogwira;
- zone ndi njira yoyendetsera thupi;
- Mlingo.
Pharmacokinetics
Jakisoni wopulumutswayo atayamba kuchita theka la ola, ndiye kuti zochuluka kwambiri zimachitika kuyambira maola 2 mpaka 8 ndipo zimatha kwa maola 10.
Kugawidwa kopanda tanthauzo kumachitika mu minofu, ziwalo zomwe sizigwira ntchito sizidutsa mkaka wa m'mawere, musadutse placenta, i.e. Osakhudza mwana wosabadwa. Hafu ya moyo imatenga mphindi 5-10, yowonetsedwa ndi impso wokwanira 80%.
Magawo omwe amagwiritsidwa ntchito ndi mankhwalawa samadutsa placenta, i.e. Osakhudza mwana wosabadwa.
Zizindikiro zogwiritsidwa ntchito
Amasonyezedwa pochiza milandu yotsatirayi:
- Mtundu woyamba wa shuga.
- Matenda a Type II (pothana ndi mankhwala a hypoglycemic).
- Matenda apakati.
Contraindication
Sizoletsedwa:
- Aliyense tsankho kwa zigawo zikuluzikulu za mankhwala.
- Hypoglycemia.
Momwe mungatenge Gensulin?
Mankhwala chikuyendetsedwera m'njira zingapo - mu mnofu, subcutaneous, mtsempha wa magazi. Mlingo ndi gawo la jakisoni amasankhidwa ndi dokotala wopezeka kwa wodwala aliyense. Mlingo wokhazikika umasiyanasiyana kuyambira 0,5 mpaka 1 IU / kg ya kulemera kwa munthu, poganizira kuchuluka kwa shuga.
Insulin iyenera kuperekedwa kwa theka la ola musanadye chakudya kapena kuwunikira pang'ono pamatumbo. Njira yothetsera vutoli amakonzedwa kale kutentha kwa chipinda. Monotherapy imakhudzana ndi jakisoni wofikira katatu pa tsiku (mwapadera, kuchulukitsa kumachulukitsa mpaka 6).
Ngati mlingo wa tsiku ndi tsiku umaposa 0,6 IU / kg, umagawidwa pazidutswa zingapo, jakisoni amaikidwa m'malo osiyanasiyana a thupi - minyewa ya brachial yakuda, khomo lakumbuyo lakumaso. Pofuna kuti musakhale ndi lipodystrophy, malo omwe jakisoni amasinthasintha. Singano yatsopano imagwiritsidwa ntchito jekeseni iliyonse. Zokhudza kayendetsedwe ka IM ndi IV, zimachitika kokha kuchipatala komwe ogwira ntchito azaumoyo amachita.
Zotsatira zoyipa za Gensulin
Ndi kuphwanya mlingo wa jekeseni ndi regimen, zotsatira zoyipa zimapangika monga:
- kugwedezeka
- mutu;
- kutsekeka kwa khungu;
- paresthesia pamimba;
- kumverera kwanjala yokhazikika;
- thukuta kwambiri;
- tachycardia.
Ndi hypoglycemia yayikulu, kumayambira kwa hypoglycemic coma ndikotheka.
Zotsatira zoyipa zonse, edema ya Quincke, totupa pakhungu, mantha anaphylactic nthawi zambiri amawonekera. Machitidwe am'deralo akuwonetsedwa ndi kuyabwa ndi kutupa, kawirikawiri kwambiri lipodystrophy, hyperemia. Kumayambiriro kwa zamankhwala, odwala ena amakumana ndi zolakwitsa zina zomwe zimachitika popanda thandizo ladzidzidzi.
Zokhudza mphamvu pakuwongolera njira
Kuyamba kwa kugwiritsa ntchito insulin kapena kusintha kwa mtundu wina kungapangitse kuwonongeka m'moyo wabwino, kukhazikika kwa zoyipa. Munthawi imeneyi, munthu safunika kuyendetsa magalimoto, magwiridwe antchito. Ndikofunika kusiya ntchito yomwe ingakhale yoopsa.
Malangizo apadera
Kukhazikitsa kwa mankhwalawa sikovomerezeka ngati kuli kwamtambo, mapangidwe olimba a tinthu tating'onoting'ono, okhathamira mitundu ina. Nthawi yonse ya chithandizo, wodwalayo ayenera kuyang'anitsitsa mayendedwe a shuga. Hypoglycemia imachitika pamene:
- bongo;
- kuchuluka zolimbitsa thupi;
- m'malo mwa insulin;
- kusanza ndi m'mimba;
- kudumpha chakudya;
- ntchito yotsika kwambiri ya impso kapena chiwindi, chithokomiro cha chithokomiro, adrenal cortex;
- malo atsopano a jakisoni;
- kuphatikiza ndi mankhwala ena.
Mlingo wokhazikitsidwa bwino, kusowa kwa mankhwalawa, makamaka mtundu wa matenda ashuga 1, umayambitsa matenda a hyperglycemia. Zizindikiro zimawonjezeka pang'onopang'ono ndikuwonetsa kukoka kukodzerera, ludzu losatha, kuyanika ndi khungu, kutsekemera kwa nthawi, kupezeka kwa acetone mu mpweya wotuluka. Ngati palibe chithandizo cha panthawi yake komanso cholondola, matenda ashuga a ketoacidosis, chikomokere mu ubongo chitha kuyamba.
Kuwongolera kwa mankhwalawa kumachitika ndi hypopituitarism, matenda a Addison, zosokoneza mu chithokomiro cha chithokomiro, impso kapena chiwindi, mu ukalamba (kuyambira zaka 65). Nthawi zambiri, kuchuluka kwa mankhwalawa kwa odwala omwe amathandizidwa kwambiri, amasintha kwambiri chakudya. Ngati munthu ayamba kumwa mtundu wina wa mankhwala, shuga amawongolera momveka bwino.
Insulin imakonda kukondana, chifukwa chake mapampu a insulin sayenera kugwiritsidwa ntchito.
Gwiritsani ntchito mu ukalamba
Pambuyo pazaka 65, kusinthidwa kwa mlingo ndi shuga pafupipafupi kumafunikira.
Kupatsa ana
Palibe zinachitikira kugwiritsa ntchito Gensulin mwa ana.
Palibe zinachitikira kugwiritsa ntchito Gensulin mwa ana.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Odwala omwe apezeka ndi matenda a shuga panthawi ya kukonzekera, mimbulu yotsatira iyenera kuwunika kuchuluka kwa shuga m'magazi, chifukwa angafunike kusintha kwa mankhwala.
Kuyamwitsa kumaloledwa kuphatikiza ndi kugwiritsa ntchito insulin, ngati mkhalidwe wa mwana ukhala wokhutiritsa, palibe m'mimba wokhumudwa. Mlingo umasinthidwanso malinga ndi kuwerenga kwa shuga.
The ntchito aimpso kuwonongeka
Kuwonongeka kwa impso ndi chizindikiro chachindunji cha kusintha kuchuluka kwa mankhwala omwe amaperekedwa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Pezani mankhwala osintha mlingo.
Gensulin Overdose
Kugwiritsa ntchito insulini yambiri kumabweretsa hypoglycemia. Kuchepa pang'ono kwa matenda kumatha mwa kutenga shuga, kudya zakudya zamafuta ambiri. Ndikulimbikitsidwa kuti anthu nthawi zonse amakhala ndi chakudya chokoma ndi zakumwa ndi iwo.
Kuchepetsa kwambiri kungachititse kuti musamaganize bwino. Potere, yankho la dextrose iv limaperekedwa mwachangu kwa munthu. Kuphatikiza apo, glucagon imayendetsedwa iv kapena s / c. Munthu akabwera, ayenera kudya zakudya zokwanira zomanga thupi kuti asayambirenso kutero.
Kuchepetsa kwambiri kungachititse kuti musamaganize bwino.
Kuchita ndi mankhwala ena
Pali mndandanda wa mankhwala omwe angasinthe kufunikira kwa insulin. Mphamvu ya hypoglycemic imalimbikitsidwa ikagwiritsidwa ntchito limodzi:
- m`kamwa hypoglycemia;
- carbonic anhydrase inhibitors, monoamine oxidase inhibitors, angiotensin kutembenuza enzyme inhibitors;
- sulfonamides;
- Bromocriptine;
- osasankha beta-blockers;
- Clofibrate;
- theophylline;
- mankhwala a lithiamu;
- cyclophosphamide;
- zinthu zomwe Mowa alipo.
Mphamvu ya hypoglycemic imachepetsedwa ngati itengedwa:
- thiazide okodzetsa;
- mahomoni a chithokomiro;
- glucocorticosteroids;
- sympathomimetics;
- Danazole;
- calcium blockers;
- morphine;
- Phenytoin.
Ndi ma salicylates, mphamvu zonse za mankhwalawa zimawonjezeka ndikuchepera.
Kuyenderana ndi mowa
Kugwiritsira ntchito insulin nthawi yomweyo ndi zakumwa zoledzeretsa sizimavomerezeka.
Analogi
Zofananira za mankhwalawa zilipo: Insuman, Monodar, Farmasulin, Rinsulin, Humulin NPH, Protafan.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Sizingatheke. Makamaka kutengera chinsinsi.
Mtengo
Kuyambira 450 rub.
Zosungidwa zamankhwala
Potentha kutentha kuchokera + 2 ° С mpaka + 8 ° С.
Tsiku lotha ntchito
Zaka 2
Wopanga
BIOTON S.A. (BIOTON S.A.), Poland.
Insuman ndizowonetsera zamankhwala.
Ndemanga
Ekaterina amaze emyaka 46, Kaluga
Ndakhala ndikugwiritsa ntchito Gensulin R kwa zaka zingapo. Pamaso pake ndinayesa mankhwala ambiri omwe sanali oyenera. Ndipo izi zimakwanira komanso ndizolekeredwa. Ndimakonda kuti botolo lotseguka limasungidwa bwino, mankhwalawo sataya mphamvu. Zotsatira zake zimapitilira kwanthawi yayitali.
Sergey wazaka 32, Moscow
Mankhwalawa atalembedwa, ndimawopa kwambiri mavuto, koma sizinathandize. Ndimalowa, monga momwe malangizo akugwiritsira ntchito cholembera. Gensulin M30 koyambirira kwa chithandizo adayambitsa chizungulire, koma zonse zidatha patatha milungu ingapo. Ndikumva bwino, shuga akupitilira.
Inga wazaka 52, Saratov
Ndimayembekezera zotsatira zoyipa za mankhwalawo, koma zidakhala bwino. Zabwino kugwiritsa ntchito kawiri, kuphatikiza mankhwala. Zotsatira zoyipa sizinadziwonetse, ngakhale ambiri ali ndi totupa pakhungu poyambira kugwiritsa ntchito Gensulin N.
