Malangizo ogwiritsira ntchito mankhwala a Bayeta

Chimodzi mwa mankhwala a hypoglycemic omwe adapangidwa pochiza matenda a shuga 2 ndi Bayeta. Mankhwalawa amathandiza odwala omwe ali ndi matendawa kuti akwaniritse bwino mawonekedwe a glycemic.

Kufotokozera za mankhwalawa, mawonekedwe a mawonekedwe ndi mawonekedwe

Baeta imakhala ngati logoglucagon receptor agonist (glucagon-ngati peptide), yopangidwa poyankha chimbudzi ndi chakudya. Mankhwalawa amathandizira kuchepetsa shuga, amathandizanso kugwira ntchito kwa maselo a beta mu kapamba.

Ngakhale kufanana ndi insulin, Baeta imasiyana ndi mahomoni mumapangidwe ake amakanidwe ndi mankhwala, komanso mtengo wake.

Mankhwalawa amapezeka m'matenti a syringe, omwe ndi analogue a insulin omwe amagwiritsidwa ntchito ndi odwala ambiri. Palibe singano zama jakisoni mumkati, chifukwa chake ziyenera kugulidwa padera. Phukusili limangokhala ndi cholembera cha syringe chokha ndi bokosi lozunguliridwa lomwe limakhala ndi mankhwalawo mu Vol.

Kupanga (pa 1 ml):

1. Chofunikira kwambiri ndi Exenatide (250 mcg).
2. Acetic acid sodium mchere (1.59 mg) ndi chinthu chothandiza.
3. Chuma Metacresol mu kuchuluka kwa 2.2 mg.
4. Madzi ndi zotulutsa zina (zimakhala mpaka 1 ml).

Baeta ndi njira yopanda utoto, wowonekera, wopanda fungo.

Pharmacological zochita za mankhwala

Pambuyo pakukhazikitsa yankho mu magazi, mulingo wa shuga umasinthika chifukwa cha njira zotsatirazi:

1. Panthawi yowonjezera shuga, pamakhala kuchuluka kwa insulin ya mahomoni omwe amapezeka m'maselo a beta.
2. Shuga wamagazi akatsika, kutulutsa kwa mahomoni kumatha, komwe kumakupatsani mphamvu yokhazikika ya shuga, kupewa mkhalidwe wa hypoglycemia, womwe umakhala wowopsa mthupi.
3. Kuchepetsa kwambiri shuga, zigawo za mankhwalawa sizikhudza kuzungulira kwa glucagon, zomwe zimapangitsa kuti timadzi tambiri tambiri tiziwonjezeranso magazi.

Pambuyo jekeseni, njira zotsatirazi zimachitika m'thupi:

1. Kupanga kwa glucagon kwambiri kumapanikizidwa.
2. Kusunthika kwa m'mimba kumachepa, njira yopezera zonse zomwe zili mkati mwake imachepetsa.
3. Odwala ali ndi kuchepa kwakudya.

Kuphatikizika kwa zigawo za mankhwala a Bayet ndi Thiazolidinedione kapena Metformin kumathandizanso kuchepetsa shuga m'mawa ndi kufunika kwake mutatha kudya, komanso glycosylated hemoglobin.

Subcutaneous makonzedwe a mankhwala amalola kuti azitha kuyamwa, mpaka kufika pochita pambuyo maola 2. Hafu ya moyo wake imakhala pafupifupi maola 24 ndipo sizimatengera mlingo womwe wodwala amalandira.

Pharmacokinetics

Pambuyo jekeseni wa mankhwala kulowa mthupi, njira ya mayamwidwe, kulowa m'maselo onse, kugawa ndi kupukusa kumachitika motere:

1. Zogulitsa. Zosakaniza zomwe zimagwiritsidwa ntchito ndi mankhwalawa, mutatha kupanga jakisoni wambiri, kulowa mkatikati mwa magazi, chindapusa chachikulu chitha kufikira pambuyo pa mphindi 120 (211 pg / ml). Tsamba la jakisidwe silikhudza kuchuluka kwa mayamwidwe.
2. Kugawa. Kukula kwa Vd ndi 28.3 malita.
3. Kupenda. Zigawo zamankhwala zimagawidwa mu kapamba, maselo am'mimba (m'mimba), komanso kuthamanga kwa magazi.
4. Kuswana. Njirayi imatenga maola pafupifupi 10, ngakhale kuti ndi mlingo. Mankhwala amachotsedwa ndi impso, chifukwa chake, kuphwanya chiwindi sikukhudza kuchuluka kwa zotupa.

Zizindikiro zogwiritsidwa ntchito

Baeta imagwiritsidwa ntchito pochiza matenda ashuga amtundu wa 2.

Njira ziwiri za mankhwala:

1. Monotherapy. Mankhwalawa amagwira ntchito ngati mankhwala oyenera kukhalanso ndi shuga. Kuphatikiza apo, ndikulimbikitsidwa kutsatira zakudya zina ndi zolimbitsa thupi.
2. Kuphatikiza mankhwala. Baeta imakhala ngati chithandizo chowonjezera cha mankhwala monga Metformin, sulfonylurea derivatives kapena Thiazolidinedione, kuphatikiza kwawo. Ngati ndi kotheka, Byeta ikhoza kutumikiridwa molumikizana ndi kukhazikitsidwa kwa insulin insulin ndi Metformin kuti muwongolere mbiri ya glycemic.

Mankhwalawa amawonongeka pazochitika zotsatirazi:

• mimba
• nthawi ya mkaka wa m`mawere;
• shuga mellitus (mtundu wodalira insulin 1);
• kukhalapo kwa zizindikiro za matenda ashuga ketoacidosis;
• kulephera kwaimpso;
• ana, komanso achinyamata osakwana zaka 18;
• matenda oopsa a m'mimba;
• tsankho kwa zigawo zikuluzikulu za mankhwala.

Malangizo ogwiritsira ntchito

Mankhwala amayenera kuperekedwa mosavuta.

Malo omwe jakisoni akhoza kukhala:

• dera la m'chiuno
• dera lotsogola;
• malo pamimba kuzungulira navel.

Mankhwalawa amayenera kuyamba ndi mankhwala osachepera 5 mg. Iyenera kuperekedwa kawiri pa tsiku, osapitirira ola limodzi musanadye. Zingwe siziyenera kuperekedwa pambuyo pa chakudya cham'mawa kapena chamadzulo. Kudumpha jakisoni, mosasamala kanthu komwe zimayambitsa, sikusintha nthawi yotsatiridwa ndi mankhwala pansi pa khungu. Kukula koyamba kwa mankhwalawa mpaka 10 mcg ndikotheka patatha mwezi umodzi chiyambireni chithandizo.

Kugwiritsa ntchito mankhwala a Bayeta pamodzi ndi zotumphukira za sulfonylurea nthawi zambiri kumabweretsa kuchepetsedwa kwa mlingo wawo kuti muchepetse chiopsezo cha hypoglycemia. Jekeseni wa mankhwalawa samakhudza mlingo wa mankhwala ena.

Malangizo ofunikira:

• mankhwalawa sayenera kuperekedwa pambuyo pa chakudya cham'mawa kapena chamadzulo;
• Kubayira mkati kapena mu mnofu wa Bayet koletsedwa;
• osagwiritsa ntchito zolembera zama syringe ndi yankho lamatope, komanso losintha mtundu;
• mankhwalawa amatha kuyambitsa zochitika monga kusanza, kupindika, kupindika kapena kutsegula m'mimba, matenda ammimba komanso amanjenje.

Odwala apadera

Anthu omwe ali ndi matenda ashuga nthawi zambiri amakhala ndi matenda ena okhalitsa. Pankhaniyi, muyenera kusamala makamaka pakugwiritsa ntchito mankhwala a Bayeta.

Gulu la odwala omwe amafunikira chisamaliro chapadera limaphatikizapo:

1. Kukhala ndi kuphwanya ntchito ya impso. Odwala omwe akuwonetsa kuchepa kwa impso mwina sayenera kusintha mlingo wa Bayet.
2. Kuphwanya chiwindi. Ngakhale izi sizikhudza kusintha kwa kuchuluka kwa magazi m'magazi, kufunsa dokotala wofunikira ndikofunikira.
3. Ana. Zotsatira za mankhwalawa kwa chamoyo chambiri mpaka zaka 12 sizinaphunzire. Mu achinyamata zaka 12-16 zitakhazikitsidwa yankho (5 μg), magawo a pharmacokinetic anali ofanana ndi deta yomwe idapezeka mu kafukufuku wa odwala akuluakulu.
4. Amimba Chifukwa cha zovuta zomwe zingachitike ngati mankhwalawa amakula mwana wosabadwayo, amatengedwa kuti agwiritsidwe ntchito ndi amayi oyembekezera.

Mankhwala osokoneza bongo komanso kuyanjana ndi mankhwala ena

Kuwoneka kwa zizindikiro monga kusanza kwambiri, nseru yayikulu, kapena kuchepa m'magazi m'magazi kungasonyeze kuchuluka kwa mankhwalawa (kupitirira kuchuluka kovomerezeka kwa mavutowo ka 10).

Chithandizo cha mankhwalawa chikuyenera kukhala chochepetsa zizindikiro. Ndi chiwonetsero chofooka cha hypoglycemia, ndikokwanira kudya chakudya chamthupi, ndipo ngati pali zizindikiro zazikulu, angafunike kukhazikika kwa dextrose.

Pochita mankhwala ndi Bayeta jakisoni, limodzi ndi mankhwala ena, mfundo zofunika kuziganizira ndi monga:

1. Mankhwala omwe amafunika kunyowetsedwa mwachangu m'matumbo am'mimba amayenera kumwa 1 ola limodzi asanayambitsidwe ndi Byet kapena mu chakudya chotere ngati jakisoni safunika.
2. Kuchita bwino kwa Digoxin kumachepa ndi kuyendetsa munthawi yomweyo ku Byet, ndipo nthawi yake yakuwonjezeka imawonjezeka ndi maola 2,5.
3. Ngati kuli kofunika kuchepetsa kuthamanga kwa magazi ndi mankhwala a Lisinopril, ndikofunikira kuyang'anira nthawi yayitali pakati pa kumwa mapiritsi ndi jekeseni wa Bayet.
4. Mukatenga Lovastatin, theka la moyo wake limakulitsidwa ndi maola 4.
5. Nthawi yodzipatula ya warfarin kuchokera mthupi imawonjezeka ndi 2 maola.

Malingaliro okhudzana ndi mankhwalawa

Kuchokera pakuwunika kwa odwala, zitha kutsimikiziridwa za kuthandizira kwa Byeta ndi kusintha magwiridwe ntchito atagwiritsidwa ntchito, ngakhale ambiri amawona mtengo wokwera wa mankhwalawo.

Matenda a shuga adawulula zaka 2 zapitazo. Munthawi imeneyi, kuyesera kuchepetsa shuga pogwiritsa ntchito mankhwala osiyanasiyana sikuyenda bwino. Mwezi watha, dotolo yemwe adandipatsa adandiuza kuti ndilandire mankhwala a Bayet mosadukiza. Ndinawerenga ndemanga pa intaneti ndikuganiza zamankhwala. Zotsatira zake zinali zodabwitsa. M'masiku 9 okhazikitsidwa, shuga anachepa kuyambira 18 mmol / L mpaka 7 mmol / L. Kuphatikiza apo, ndinatha kutaya owonjezera a 9 kg. Tsopano sindikumva kukoma mkamwa mwanga. Chowonongeka chokha cha mankhwalawo ndi mtengo wokwera.

Elena Petrovna

Kwa mwezi umodzi anapha Baeta. Zotsatira zake, ndinatha kuchepetsa shuga m'magawo angapo ndikuchepetsa thupi ndi 4 kg. Ndine wokondwa kuti chisangalalo chachepa. Dotolo adalimbikitsa kupitiliza kuperekera mankhwalawa kwa mwezi wina, koma pakadali pano ndaganiza zokhala ndizotsatira zamankhwala ndikubwerera ku mapiritsi akale. Mtengo wake ndi wokwera kwa ine, chifukwa sindingathe kuugula mwezi uliwonse.

Ksenia

Vidiyo pazogwiritsa ntchito cholembera cha syringe ndi mankhwala:

Kodi nditha kusintha mankhwalawo?

Palibe fanizo la yankho la kayendetsedwe ka Bayet pamsika wamafuta. Pali "Baeta Long" wokha - ufa wokonzekera kuyimitsidwa komwe kumagwiritsidwa ntchito jakisoni.

Mankhwala otsatirawa ali ndi zochizira zofananira, monga Baeta:

1. Victoza. Chidacho chapangidwa kuti chikhale chopondaponda ndipo chimapezeka ngati malembera. Kugwiritsidwa ntchito kwake ndi odwala omwe ali ndi matenda a shuga a 2 amatha kuchepetsa shuga ndikuchepetsa.
2. Januvia - likupezeka piritsi. Ndi njira imodzi yotsika mtengo yomwe imakhudzanso thupi.

Mankhwala a Baeta amagawidwa m'mafakisoni ndi mankhwala. Mtengo wake umasinthasintha mozungulira ma ruble 5200.