Angiocardyl ndi module wa kagayidwe. Imakhala ndi phindu pamntchito ya mtima, imawonjezera kupirira, imateteza ku kupsinjika, koma imafanizidwa mosiyanasiyana ndi mankhwala osokoneza bongo. Amagwiritsidwa ntchito mu zovuta za mankhwala a mtima, mu ophthalmology ndi kuthandizira ndi zizindikiro zochoka.
Dzinalo Losayenerana
Malinga ndi malamulo omwe akhazikitsidwa ndi WHO, INN imaperekedwa pazomwe zimagwira. Chifukwa chake, dzina ladziko lonse la mankhwalawo ndi Meldonium.
Angiocardyl imakhala ndi phindu pantchito zamtima, imawonjezera kupirira, imateteza ku kupsinjika, koma imafanizidwa mosasamala ndi mankhwala osokoneza bongo.
ATX
Mankhwalawa ndi a gulu la metabolac of metabolites ndipo ali ndi code ya ATX ya C01EB.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa mwanjira yothetsera jakisoni wothandizidwa ndi chinthu cha 100 mg / ml. 5 ml ma CD. Ma ampoules agalasi amaikidwa m'makatoni ama 10 pcs. pamodzi ndi mpeni wokwanira / zopepuka ndi kapepala ka malangizo. Gawo lalikulu la angiocardyl ndi meldonium dihydrate. The solvent ndi madzi oyeretsedwa omwe amakonzekera njira za jakisoni.
Mankhwala amapangidwanso mawonekedwe a 500 mg makapisozi mu chipolopolo cholimba cha gelatin. Amadzazidwa ndi ufa wosakanizidwa woyera wokhala ndi fungo labwino. Zothandiza monga: kukhuthala, calcium yochepa, mawonekedwe a silloon dioxide. Makapisozi 10 ma PC. kuyikidwa matuza ndi okhazikika ndi zojambulazo. Matumba a 2 kapena 6 ma PC. atayikidwa mu makatoni ojambula. Malangizowo akuphatikizidwa.
Mankhwala amapangidwanso mawonekedwe a 500 mg makapisozi mu chipolopolo cholimba cha gelatin.
Palinso piritsi la angiocardyl. Gawo lalikulu limaperekedwa mwanjira ya phosphate, ndipo mawonekedwe ena amaphatikizanso mannitol, wowuma wa mbatata, magnesium stearate, microcrystalline cellulose ndi silicon dioxide. Mapiritsi a 500 mg amaikidwa m'matumba a 10 ma PC.
Mutha kupezanso mankhwalawa ngati mawonekedwe a madzi a pakamwa.
Zotsatira za pharmacological
Chithandizo chogwira ntchito cha Angiocardyl ndi meldonium. M'mapangidwe ake, imafanana ndi gamma-butyrobetaine (GBB), yomwe imapangidwa mkati mwa thupi pamavuto azovuta, kuphatikiza ndi kuperewera kwa mpweya.
Mwa kuletsa enzyme ya gamma-butyrobetaine hydroxynase, meldonium imalepheretsa kaphatikizidwe ka carnitine, yemwe amayang'anira kayendedwe kazinthu zamafuta m'maselo a mtima. Kupsinjika kwa kayendedwe ndikofunikira pakuchepa kwa oksijeni, chifukwa mu vutoli, makutidwe ndi okosijeni amafuta amawonedwa ndikupanga ma metabolites apakati omwe amakhudza mtima. Mwachitsanzo, amatchinga kulowa mamolekyulu a ATP m'maselo.
Kutsika kwa carnitine ndende kumathandizira kuphatikizika kwa GBB, komwe kumawonetsa katundu wa vasodilating, ndi kusokonezeka pakupereka mafuta achilengedwe chifukwa cha kuchepa kwa carnitine kumabweretsa kuti mphamvu imapangidwa m'njira yopulumutsa mpweya. Kafukufuku akuwonetsa kuti chifukwa cha izi, meldonium imawonjezera kugwira ntchito ndi kupirira, imathandizira kuchira pambuyo pakuchita masewera olimbitsa thupi, imayendetsa bwino masewera, imalimbikitsa zochitika zapakati zamanjenje, ndipo imakhala ndi mtima.
Ndi ischemic stroke, mankhwalawa amalimbikitsa kutseguka kwa kufalikira kwa minyewa, kumachepetsa dera la necrotic kuwonongeka kwa minyewa yaubongo.
Mu ischemic stroke, mankhwalawa amalimbikitsa kutseguka kwa kufalikira kwa minyewa, kumachepetsa gawo la kuwonongeka kwa minofu yaubongo komanso kumachepetsa nthawi yodwalanso. Imatha kuchepetsa pafupipafupi kuukira kwa angina, kuonjezera gawo lovomerezeka lazolimbitsa thupi pakulakwitsa kwa mtima, muyezo wazizindikiro za kusiya. Chida ichi chikugwiritsidwa ntchito mu ophthalmology. Apa amagwiritsidwa ntchito kuti athetse ma cell ena a mtima.
Pharmacokinetics
Kuchokera m'matumbo, mankhwalawa amalowetsedwa mkati mwa maola 1-2, kufikira plasma ndende ya pafupifupi 78%. Ikaperekedwa mwachindunji m'magazi, bioavailability ya meldonium ndi 100%. Kupanga kwa kuphatikizira kwa pawiri kumachitika m'chiwindi. Mankhwala amachotsedwa makamaka ndi impso kwa maola 6-12. Pa milingo yayitali, kuyeretsa kwathunthu kwa thupi kumatha miyezi yambiri, koma nthawi yomweyo, kupendekera kochepa kwambiri kotsalira kumatsalira.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa akuwonetsedwa kuti azigwiritsidwa ntchito pokhudzana ndi kutopa kwambiri, panthawi yolemetsa thupi, m'maganizo kapena m'maganizo, kuphatikiza pakuchita masewera. Tiyenera kudziwa kuti Anti-Doping Agency idaphatikizaponso mndandanda wazinthu zoletsedwa kuti zigwiritsidwe ntchito ndi osewera pamakonzedwe ndi machitidwe a mpikisano wamasewera. Lingaliro silinali lomveka konse, chifukwa meldonium simalola kuwonjezera kuwonjezera kapena kuwonjezera nthawi yophunzitsira, koma zimangoyambitsa kuchira msanga pambuyo pakuphunzitsidwa kolimba.
Mankhwalawa akuwonetsedwa kuti azigwiritsidwa ntchito pokhudzana ndi kutopa kwambiri, panthawi yolemetsa thupi, m'maganizo kapena m'maganizo, kuphatikiza pakuchita masewera.
Madokotala amaphatikiza mankhwalawa pakapangidwe kovuta ka matenda awa:
- matenda a mtima;
- angina pectoris;
- myocardial infarction;
- mawonekedwe owonekera a kulephera kwa mtima;
- dishormonal mtima;
- sitiroko;
- ngozi yamitsempha;
- achire syndrome.
Kuchita kwa ophthalmic, kugwiritsa ntchito Angiocardil kumathandiza pochiza:
- hemorrhege
- hemophthalmus;
- mitsempha ya retinal;
- mitundu yosiyanasiyana ya retinopathy;
- dystrophic pathologies a fundus.
Muzochita za ophthalmic, kugwiritsidwa ntchito kwa Angiocardil kumathandiza pochizira matenda am'mimba, hemophthalmus, retinal vein thrombosis, etc.
Contraindication
Kuchuluka kwa chiwopsezo cha meldonium kapena zigawo zothandizira za mankhwala ndikutsutsana mosagwiritsidwa ntchito ndi angiocardyl mwanjira iliyonse. Sangatengedwe pazochitika zina. Zoyipa:
- kuthamanga kwazinthu zamkati;
- zotupa za intracranial;
- kuphwanya kwa venous yotuluka mu ubongo;
- nthawi yobereka mwana;
- kuyamwitsa;
- wazaka 18.
Pamaso pa matenda a impso kapena kwa hepatic, mankhwalawa ayenera kuikidwa mosamala.
Momwe mungatengere angiocardil
Njira yomwe makonzedwe ake amathandizira pa mankhwala, kuchuluka kwake komanso nthawi ya maphunzirowa imatsimikiziridwa ndi dokotala payekhapayekha. Chifukwa cha kuthekera kosangalatsa kwa meldonium pakatikati wamanjenje, ndikulimbikitsidwa kusamutsa kugwiritsidwa ntchito kwa theka loyamba la tsiku. Pazigawo zogwiritsidwa ntchito, magawo omalizira sayenera kupitirira 1700.
Jekeseni wa mankhwala amalumikizidwa kudzera m'mitsempha kapena kudzera m'mitsempha yochepa. Pambuyo pake (ngati kuli kotheka) amasinthana ndikutenga mawonekedwe amkamwa a angiocardyl. Nthawi zina, mlingo umodzi wochepetsedwa ukhoza kutumikiridwa, kutsitsidwa ku 125-250 mg. Ngati ndi kotheka, chithandizo chimabwerezedwa pakatha milungu ingapo. Monga adanenera dokotala, maphunziro achire amatha kuchitika katatu pachaka.
Jekeseni wa mankhwala amalumikizidwa kudzera m'mitsempha kapena kudzera m'mitsempha yochepa.
Mu ophthalmology, mankhwalawa amagwiritsidwa ntchito kuphatikiza parabulbar. Mwa uchidakwa wambiri, kukonzekera kwa pakamwa kwa mapiritsi kapena makapisozi ndikuwongolera angiocardil mu jakisoni ndikotheka.
Ndi matenda ashuga
Mankhwala atha kutumizidwa kwa odwala matenda ashuga. Meldonium imatha kutsitsa shuga wamagazi popanda kuwonjezera kuchuluka kwa insulin. Kulandila kwake kumakupatsani mwayi woletsa kusokonekera kwa endothelial, kuchepa kwa chidwi, kukula kwa acidosis. Kugwiritsanso ntchito kwa angiocardyl ndi mankhwala monga metformin, kumathandizira mphamvu ya hypoglycemic ya mankhwala onse awiri.
Zotsatira zoyipa za angiocardyl
Mankhwalawa amaloledwa ndi odwala, koma nthawi zina mawonekedwe a matupi awo sagwirizana ndi:
- zotupa, urticaria;
- erythema;
- Khungu;
- kukula kwa puffness.
Mukamayesa magazi, kuwonjezereka kwa kuchuluka kwa maselo oyera a eosinophilic. Nthawi zina, odwala amadandaula kuti zasokonekera.
Matumbo
Kugunda kwam'mimba nthawi zina kumachitika, kusasangalala kapena kupweteka kwa epigastrium kumamveka, ndipo kumverera kwodzaza kumabuka m'mimba. Wodwalayo akhoza kudwala.
Pakati mantha dongosolo
Zina mwazomwe zimachitika, nkhawa, kuchuluka kwa mkwiyo, kukhumudwa kwambiri, komanso kusowa tulo ndizotheka.
Kuchokera pamtima
Kupsinjika kumatha kusiyanasiyana. Kawirikawiri sawona kuchuluka kwa mtima.
Zokhudza mphamvu pakuwongolera njira
Palibe zambiri pazotsatira zoyipa za mankhwalawa pazomwe zimatha kuyendetsa magalimoto ndi maginito ovuta. Koma chifukwa chakuwoneka ngati mitundu yosiyanasiyana ya mankhwalawa imachitika panthawi ya chithandizo ndi Angiocardil, tikulimbikitsidwa kuti tisamachite zinthu ngati izi.
Mukamamwa Angiocardil, kupanikizika kumatha kusintha mbali imodzi kapena inayi, kuwonjezeka kwa kugunda kwa mtima sikumadziwika.
Malangizo apadera
Mu chiwonetsero chachikulu cha coronary syndrome, kukonzekera kwa meldoni sikukondedwa, kugwiritsa ntchito kwawo ndikosankha.
Gwiritsani ntchito mu ukalamba
Mankhwalawa amatha kuyambitsa tachycardia. Chifukwa chake, liyenera kugwiritsidwa ntchito polemekeza okalamba mosamala, pothandizidwa ndi mankhwala, komanso momwe chiwindi ndi impso za wodwalayo zilili.
Kupatsa ana
Mphamvu ya angiocardil mwa ana sinakhazikitsidwe. Zambiri pa chitetezo chakugwiritsa ntchito kwa ana zilinso zosowa. Chifukwa chake, mankhwalawa saikidwa kwa odwala osakwana zaka 18. Malire a kutenga meldonium mwanjira ya madzi ndi zaka 12.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Zotsatira za angiocardil pakukula kwa mwana wosabadwa sizinafotokozedwe bwino. Pa chifukwa ichi, amayi apakati ayenera kukana kubereka. Palibe umboni kuti mankhwalawa amatha kudutsa mkaka wa m'mawere. Pakadutsa njira yoperekera chithandizo, mayiyo ayenera kusiya kaye kuyamwitsa ndi angiocardil kwakanthawi.
The ntchito aimpso kuwonongeka
Pamaso pa impso pathologies, mankhwalawa mosamala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kuperewera kwa hepatatic kumabweretsa kuchepa kwa kagayidwe ka meldonium ndikuwonjezereka kwa ndende yake ya plasma. Chifukwa chake, odwala omwe ali ndi matenda a chiwindi ayenera kuyang'aniridwa mwapadera, makamaka ndi chithandizo chautali ndi angiocardil.
Mankhwala ochulukirapo a Angiocardil
Kuchuluka kwa mankhwalawa kumawonetsedwa:
- kuthamanga kwa magazi;
- tachycardia;
- kupweteka mutu;
- kusweka;
- chizungulire.
Ngati zizindikiro zotere zikuwoneka, pitani kuchipatala. Chithandizo cha mankhwala osokoneza bongo chikuyenera kuthetseratu zomwe zilipo.
Kuchita ndi mankhwala ena
Meldonium kuphatikiza ndi mtima glycosides, mankhwala osokoneza bongo a antihypertensive ndi mankhwala omwe amachititsa kukula kwa ziwiya zam'mimba, zimathandizira zotsatira za mankhwalawa. Pali chiopsezo chokhala ndi hypotonic reaction yomwe imayendetsedwa ndi tachycardia, chifukwa chake, kusamala kuyenera kutsatiridwa popereka Angiocardil limodzi ndi adrenergic blockers, nitroglycerin ndi zotumphukira zamagazi otulutsa ma vasodilators, antihypertensive mankhwala, calcium blockers.
Meldonium kuphatikiza ndi mtima glycosides, mankhwala osokoneza bongo a antihypertensive ndi mankhwala omwe amachititsa kukula kwa ziwiya zam'mimba, zimathandizira zotsatira za mankhwalawa.
Kuphatikiza kwa mankhwala omwe amafunsidwa ndi magulu oterewa ndi zovomerezeka:
- antiplatelet othandizira;
- bronchodilators;
- okodzetsa;
- anticoagulants;
- mankhwala a antianginal;
- antiarrhythmic mankhwala.
Kuyenderana ndi mowa
Panthawi ya chithandizo, muyenera kukana kumwa zakumwa zoledzeretsa komanso zakumwa zoledzeretsa.
Analogi
Meldonium ndi gawo la mankhwala omwe ali ndi mayina osiyanasiyana azamalonda:
- Kapikor;
- Olvazole;
- Idrinol;
- Mildronate;
- Meldonium Organics;
- Cardionate;
- Pakatikati;
- Medatern;
- Mildrocard ndi ena
Kupita kwina mankhwala
Kugulitsa katundu ndizochepa.
Mankhwala ena omwe amaphatikizapo meldonium, mwachitsanzo, Idrinol, akhoza kukhala fanizo la angiocardil.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala amaperekedwa ndi mankhwala.
Mtengo
Mtengo wa angiocardyl umachokera kuma ruble 262. kwa ma ampoules 10.
Zosungidwa zamankhwala
Mankhwalawa amayenera kukhala mumdima pa kutentha kwa +15 mpaka + 25 ° C. Muyenera kuchepetsa ana kuti azitha kupeza mankhwala osokoneza bongo ndikuletsa kuti chinyezi chisalowe pamapiritsi ndi makapisozi.
Tsiku lotha ntchito
Njira yothetsera jakisoni ndioyenera zaka 2 kuyambira tsiku lopangira. Alumali moyo wamkamwa mawonekedwe a mankhwalawa ndi zaka 4. Kugwiritsa ntchito zinthu zomwe zatha ndikuletsedwa.
Wopanga
Wopanga ku Russia - Novosibkhimpharm OJSC, ku Latvia - Grindeks JSC.
Ndemanga
Amelina A.N., katswiri wamkulu, Voronezh
Mankhwalawa ndi othandiza komanso osakwera mtengo. Nthawi zambiri ndimalembera odwala anga nthawi yakukonzanso. Zimakupatsani mwayi wopeza mphamvu panthawi yayifupi kwambiri. Pazaka zambiri zatsimikizira chitetezo chake. Zotsatira zoyipa ndizosowa kwambiri.
Valentine, wazaka 34, Penza
Ndimagwira ntchito pafupifupi masiku asanu ndi awiri pa sabata; sindinakhale patchuthi kwa zaka zambiri. Madzulo ndikugwada, ndimafunikanso kukhala ndi maonekedwe, chifukwa pafupifupi sindimadzuka patebulo. Njira yothetsera vutoli idabwera ngati Angiocardil. Ndimamva mphamvu zochulukirachulukira, ngati kuti ndili mwana zaka khumi ndi ziwiri. Tsopano ndimapita kwa simulators katatu pa sabata ndipo nthawi yomweyo sindinatope kwenikweni.
Daria, wazaka 52, Moscow
Anachitidwa opaleshoni ya mtima. Kudwalaku kudali kotalikirapo komanso kowawa, ndinali wokhumudwa nthawi zonse. Kusankhidwa kwa Angiocardil kunapereka zotsatira zabwino zosayembekezeka.Anayamba kukhala wosangalala kwambiri, ndipo nkhawa zake zinatheratu.
Anastasia, wazaka 31, Ekaterinburg
Anakhala akuphunzira 2 ndi chithandizo cha angiocardil ndi masabata atatu. Masiku angapo oyamba panali mseru pang'ono mutatenga makapisozi, ndiye kuti palibe zotsatira zosafunikira zomwe zidadziwika. Osangomwa mankhwalawa madzulo, apo ayi zimakhala zovuta kugona. Zotsatira zake zidakondwera. Sakhala ndi nkhawa pamtima, yomwe nthawi zambiri imakhala ikugunda, ndimatha kupita kumtunda wa 5 popanda kupuma pang'ono ndikugona mokwanira maola 5-6.
Alexey, wazaka 39, Evpatoria
Ndinagula makapisozi amayi, kusintha kwabwino kumaonedwa nthawi yomweyo. Tsiku lotsatira, anayimba foni ndikuthokoza mankhwalawo. Amati kupuma kumakhala kosavuta, kumveka m'mutu komanso kusangalatsa mtima. Tikuyembekezera zotsatira zina zamankhwala.
