Mapiritsi a Glibomet amapangidwira makamaka kwa odwala omwe ali ndi insulin-omwe amadalira shuga mellitus (mtundu II). Kuphatikiza kwakukulu kumakupatsani mwayi wokwanira wogwira mankhwalawa.
Dzinalo Losayenerana
Metformin + glibenclamide (metformin + glibenclamide).
ATX
A10BD02.
Glibomet imapezeka mu mawonekedwe a mapiritsi mu chipolopolo.
Kutulutsa mafomu ndi kapangidwe kake
Mapiritsi a chipolopolo. Zosakaniza zogwira piritsi limodzi: 2.5 mg glibenclamide, 400 mg metformin hydrochloride. Zinthu zina:
- ma cellcose a microcrystalline;
- wowuma chimanga;
- magnesium wakuba;
- talc;
- diethyl phthalate;
- cellulose acetate;
- colloidal silicon dioxide.
Zotsatira za pharmacological
Mankhwalawa ndi angapo ophatikizira mankhwala a hypoglycemic. Ili ndi extrapancreatic ndi pancreatic kwenikweni.
Glidenclamine ndi mtundu wa 2-sulfonylurea wochokera. Imayambitsa kupanga insulini pochita monga ma beta receptors a kapamba, imakulitsa insulin kukana maselo a kapamba ndipo imakulitsa kutulutsidwa kwa insulini komanso zochita za insulini poyerekeza ndi kuyamwa kwa shuga ndi minyewa, imachepetsa njira ya lipolytic m'magulu a minofu ya adipose.
Metformin ndi biguanide. Katunduyo amathandizira kumva kuphatikizika kwa minofu kumapangidwe amtundu wa insulin, amachepetsa kuchuluka kwa shuga m'magawo am'mimba ndipo amalepheretsa gluconeogeneis. Zotsatira zake, metabolidi ya lipid imapangidwa modabwitsa, ndipo kulemera kwa thupi mwa odwala matenda ashuga kumachepetsedwa.
Mankhwalawa ndi angapo ophatikizira mankhwala a hypoglycemic. Ili ndi extrapancreatic ndi pancreatic kwenikweni.
Pharmacokinetics
Glibenclamide kwathunthu ndipo imatengedwa mwachangu ndi makoma a mgonero. Nthawi yoti mufikire Cmax ndiyambira 60 mpaka 120 mphindi. Imapukusidwa ndi bile ndi impso pafupifupi voliyumu imodzi. Hafu ya moyo umasiyanasiyana pakati pa maola 5 mpaka 10.
Metformin imadziwikanso ndi matumbo ake. Thupi siligwa. Amachotsa impso m'mawonekedwe awo oyambirirawo. Kutha kwa theka moyo kumafika 7 maola.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amagwiritsidwa ntchito pochiza matenda amishuga a 2 a shuga.
Mankhwalawa amagwiritsidwa ntchito pochiza matenda a shuga a mtundu wachiwiri.
Contraindication
- kwambiri pathologies omwe amatsagana ndi kuwonongeka mu ntchito ya impso / chiwindi kapena hypoxic phenomena;
- tsankho;
- kukanika kwambiri kwa chiwindi;
- matenda ashuga / mtima;
- nthawi yoyamwitsa ndi / kapena pakati (mosamala);
- matenda a shuga a ketoacidosis;
- kwambiri hypoglycemia;
- lactic acidosis;
- lembani 1 shuga yodalira matenda a shuga.
Momwe mungatenge Glibomet
Mapiritsi amatengedwa pakamwa. Kudya kumathandiza kuyamwa kwa mankhwalawo. Mlingo amatchulidwa payekha, poganizira plasma ndende ya shuga m'magazi ndi kukula kwa chakudya kagayidwe kachakudya.
Mlingo amatchulidwa payekha, poganizira plasma ndende ya shuga m'magazi ndi kukula kwa chakudya kagayidwe kachakudya.
Kumwa mankhwala a shuga
Pulogalamu yoyamba ya mankhwalawa imayamba kuchokera pa mapiritsi 1 mpaka 3 patsiku, ndiye kuti mwambowu umakulitsidwa pang'onopang'ono mpaka kubwezeredwa kwamphamvu kwa matenda. Pazipita tsiku lililonse mankhwalawa mapiritsi 5 patsiku.
Zotsatira zoyipa za Glybomet
Matumbo
- hepatitis;
- cholestatic jaundice;
- kusanza
- kuphwanya kwam'mimba;
- pang'ono nseru.
Hematopoietic ziwalo
- kutsika kwa misempha yamagazi ofiira, maselo oyera am'magazi ndi ma protein (osowa);
- megaloblastic / hemolytic anemia.
Pakati mantha dongosolo
- kuchepa kwa chidwi;
- paresis (nthawi zina);
- kusokonekera kwa magalimoto;
- mutu.
Kuchokera kumbali ya kagayidwe
- pamakhala chiwopsezo cha kukhala ndi hypoglycemia.
Pa khungu
- Hypersensitivity mpaka kuwala (kawirikawiri),
Matupi omaliza
- zotupa
- kutupa;
- matupi awo sagwirizana;
- kuchuluka kwa kutentha;
- kupweteka kwa minofu ndi minyewa.
Mankhwalawa amatha kupweteketsa minofu ndi mafupa.
Zokhudza mphamvu pakuwongolera njira
Panthawi yomwe mumamwa mapiritsiwa, mumatha kukhala ndi hypoglycemia, chifukwa chake muyenera kupewa kuwongolera makina ndi makina.
Malangizo apadera
Mukamagwiritsa ntchito mankhwalawa, munthu ayenera kutsatira malangizo a dokotala molingana ndi njira ndi Mlingo. Kuphatikiza apo, munthawi ya chithandizo, ndikofunikira kutsatira zakudya, kukhazikitsa dongosolo la zochitika zolimbitsa thupi ndikuwonetsetsa kuchuluka kwa magazi.
Kuchulukitsa kwa metformin kumapangitsa kuti chiwopsezo cha lactic acid chiwonjezeke m'magazi, zomwe zimapangitsa kuti pakhale ngozi ngati lactic acidosis. Chifukwa chake, mukamamwa mankhwalawa, zinthu zomwe zili pachiwopsezo monga kusala kudya kwanthawi yayitali, matenda a shuga, uchidakwa komanso zina zilizonse zokhudzana ndi hypoxia siziyenera kuphatikizidwa.
Popewa lactic acidosis, kusala kudya kwa nthawi yayitali kuyenera kupewedwa pakumwa mankhwala a Glibomet.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Zoletsedwa. Kwa nthawi ya chithandizo kuchokera kuyamwitsa ayenera kukana.
Mankhwala a Glybomet a ana
Mapiritsi sagwiritsidwa ntchito pochiza odwala omwe ali ndi zaka zosakwana 18.
Gwiritsani ntchito mu ukalamba
Kusintha kwa Mlingo sikofunikira.
The ntchito aimpso kuwonongeka
Ndi munthawi yomweyo makonzedwe a okodzetsa komanso mankhwala a antihypertensive, tiyenera kusamala. Kuphatikiza apo, clearinine chilolezo chiyenera kuyang'aniridwa kwa odwala omwe ali ndi vuto la impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Odwala omwe akuvutika ndi chiwindi ntchito ayenera kugwiritsa ntchito mankhwalawa mosamala.
Odwala omwe akuvutika ndi chiwindi ntchito ayenera kugwiritsa ntchito mankhwalawa mosamala.
Glybomet Mankhwala osokoneza bongo
Zizindikiro Za Khalidwe: Pali chiopsezo cha hypoglycemia ndi lactic acidosis. Izi pathologies zimawonetsedwa ndi zizindikiro zotsatirazi:
- kusanza
- ulesi;
- mphwayi
- kutsika kwa kuthamanga kwa magazi;
- kuphwanya kayendedwe ka malo;
- thukuta
- kuchuluka kwa mtima;
- kutsekeka kwa khungu;
- kugwedezeka
- nseru
- bradyarrhythmia (Reflex);
- kusapeza bwino pamimba;
- zosokoneza tulo;
- Kuda nkhawa
- kugona
Ndi kukayikira kulikonse kwa lactic acidosis ndi hypoglycemia, wodwala amafunikira kuchipatala mwachangu.
Ndi mtundu wofatsa wa hypoglycemia, muyenera kudya kachidutswa kakang'ono ka shuga kapena kumwera chakumwa chokometsera. Izi zidzasinthasintha magwiridwe antchito a kapamba.
Njira yothandizira kwambiri ndi njira ya hemodialysis.
Kuchita ndi mankhwala ena
Beta-blockers, allopurinol, oxytetracycline ndi dicumarol zimawonjezera ntchito ya hypoglycemic ya mankhwala omwe akufunsidwa.
Kuphatikizika ndi cimetidine ndi zotumphukira zina za sulfonylurea kumawonjezera chiopsezo cha lactic acidosis.
Kuyenderana ndi mowa
Mowa wophatikizana ndi mankhwalawa ungayambitse hypoglycemia ndi mikhalidwe yofanana ndi disulfiram. Chifukwa chake, pa nthawi ya chithandizo ayenera kusiya kuphatikiza kwawo.
Mowa wophatikizana ndi mankhwalawa ungayambitse hypoglycemia ndi mikhalidwe yofanana ndi disulfiram.
Analogi
Malangizo omwe angakhale othandizira:
- Siofor;
- Metformin;
- Gluconorm;
- Metglib;
- Mphamvu ya Metglib;
- Glucovans;
- Gluconorm Plus.
Kupita kwina mankhwala
Mapiritsi othandizira.
Mapiritsi othandizira.
Mtengo wa Glibomet
M'mafakitala ku Russia, mapiritsi okhala ndi mafutawa amatenga ndalama pakati pa ma ruble 330-360. Pazithunzi za makatoni 4 okhala ndi mapiritsi 10 aliwonse ndi malangizo ogwiritsira ntchito.
Zosungidwa zamankhwala
Zowoneka bwino: malo owuma, osadetsedwa ndi ana, kutentha sikuyenera kupitirira + 25 ° C.
Tsiku lotha ntchito
Osapitilira miyezi 36. Osamamwa mapiritsi omwe adatha.
Wopanga
Kampani yaku Germany "Berlin-Chemie Menarini Gulu / AG".
Ndemanga ya Glibomet
Nadezhda Khovrina, wazaka 40, Moscow
Dokotala asanandipatse mankhwala amkamwa awa, ndimagwiritsa ntchito Glucofage. Komabe, sizinapindule ndi iye. Mapiritsi awa mwachangu komanso moyenera amachepetsa shuga. Izi zimatsimikiziridwa ndi kusanthula.
Galina Guseva, wazaka 45, St. Petersburg
Ndakhala ndikumwa mankhwalawo kwa nthawi yayitali. Zotsatira zikupitilira, kutchulidwa. Posachedwa ndidapita kwa adotolo kuti ndikaone ngati zingaphatikizidwe ndi mankhwala azizilombo, chifukwa ndimakayikira za helminthiasis. Dokotalayo anavomera kuti amlandire nthawi yomweyo. Tsopano nditha kugona mwamtendere.
