Hypoglycemic mankhwala Galvus Met - malangizo, gwiritsani ntchito

Galvus Met ndi mankhwala ophatikiza a hypoglycemic omwe amachepetsa kuchuluka kwa shuga m'magazi.

Amagwiritsidwa ntchito pochiza matenda amtundu wa 2 kukhazikitsa bata ndipo nthawi zambiri thupi limavomereza.

Zambiri pazamankhwala

Chifukwa chowonetsedwa ndi vildagliptin (chinthu chogwira ntchito), zovuta zowononga za peptidase enzyme zimachepetsedwa, ndipo kapangidwe ka glucagon-ngati peptide-1 ndi HIP kumangowonjezera.

Kuchuluka kwa zinthuzi mthupi kumakhala kwakukulu kuposa kwabwinobwino, Vildagliptin imasintha ntchito ya maselo a beta mogwirizana ndi shuga, zomwe zimapangitsa kuti mahomoni azikhala ndi shuga.

Dziwani kuti kuwonjezeka kwa zochitika za beta-cell kumadalira kwathunthu kuwonongeka kwawo. Pachifukwa ichi, mwa anthu omwe ali ndi shuga othamanga, vildagliptin ilibe vuto pa kapangidwe ka insulin.

Chithandizo chogwira mankhwalawa chimawonjezera glucagon-ngati peptide-1 ndikuwonjezera mphamvu ya maselo a alpha ku glucose. Zotsatira zake, kuphatikiza kwa glucagon kumawonjezeka. Kutsika kwa kuchuluka kwake mkati mwakudya kumapangitsa kuti chiwopsezo cha zotumphukira za cell chikhale ndi mahomoni omwe amatsitsa shuga.

Kuphatikizika, mawonekedwe omasulidwa

Mankhwalawa ali ngati mapiritsi, omwe amaphatikizidwa. Imodzi ili ndi zinthu ziwiri zomwe zikugwira: Vildagliptin (50 mg) ndi Metformin, yomwe ili ndi milingo itatu - 500 mg, 850 mg ndi 1000 mg.

Kuphatikiza pa iwo, mapangidwe a mankhwala monga:

• magnesium stearic acid;
• hydroxypropyl cellulose;
• hydroxypropyl methyl cellulose;
• talc;
• titanium dioxide;
• chitsulo oxide chikasu kapena chofiira.

Mapiritsi amaikidwa m'matumba a zidutswa khumi. Phukusili lili ndi matuza atatu.

Pharmacology ndi pharmacokinetics

Kuchepetsa shuga kwa mankhwalawa kumadziwika chifukwa cha zomwe zimachitika pawiri:

• Vildagliptin - imawonjezera zochitika za maselo a pancreatic motsutsana ndi shuga wamagazi, zomwe zimapangitsa kuti chiwonjezeke cha insulin chikhale;
• Metformin - imachepetsa kuchuluka kwa shuga m'thupi mwa kuchepetsa kuchuluka kwa chakudya, kumachepetsa kuphatika kwa shuga ndi ma cell a chiwindi ndikuwongolera kugwiritsidwa ntchito ndi zotumphukira.

Mankhwalawa amagwiritsidwa ntchito kuchititsa kuchepa kwamphamvu kwa shuga m'thupi. Komanso, nthawi zina, mapangidwe a hypoglycemia amadziwika.

Zinapezeka kuti kudya sikumakhudza kuthamanga ndi kuchuluka kwa mankhwalawa, koma kugwiritsidwa ntchito kwa zinthu zomwe zimagwira kumachepa pang'ono, ngakhale zonse zimatengera mlingo wa mankhwalawo.

Kuyamwa kwa mankhwala osokoneza bongo kumathamanga kwambiri. Ngati mumwa mankhwalawa musanadye, kupezeka kwake m'mwazi kumatha kupezeka mkati mwa ola limodzi ndi theka. Mu thupi, mankhwalawa amasinthidwa kukhala ma metabolites omwe amadzazidwa mkodzo ndi ndowe.

Zizindikiro ndi contraindication

Chizindikiro chachikulu chogwiritsidwa ntchito ndi mtundu wa 2 shuga.

Pali zochitika zingapo pamene muyenera kugwiritsa ntchito chida ichi:

• mu mawonekedwe a monotherapy;
• pa chithandizo cha Vildagliptin ndi Metformin, omwe amagwiritsidwa ntchito ngati mankhwala athunthu;
• kugwiritsa ntchito mankhwalawa limodzi ndi othandizira omwe amachepetsa shuga ya magazi ndipo ali ndi sulfanyl urea;
• kugwiritsa ntchito mankhwalawa limodzi ndi insulin;
• Kugwiritsa ntchito mankhwalawa ngati chofunikira pothandizira pa matenda a shuga a 2, pomwe zakudya zopanda thanzi sizikuthandizanso.

Zotsatira zakumwa mankhwalawa zimawunikidwa ndi kuchepa kwakukhazikika kwa kuchuluka kwa shuga m'magazi.

Mowa kugwiritsa ntchito mankhwala sayenera:

• tsankho kwa odwala kapena chidwi chachikulu ndi zigawo za chipangizo chachipatala;
• mtundu 1 shuga;
• Pamaso pa opareshoni ndi kudutsa kwa ma x-ray, njira yodziwitsa matenda ake;
• ndi kuphwanya kagayidwe, ma ketones akapezeka m'magazi;
• chiwindi ntchito kuwonongeka ndi kulephera;
• aakulu kapena pachimake mawonekedwe a mtima kapena kupuma;
• poyizoni woledzera;
• zakudya zochepa zama calorie;
• mimba ndi mkaka wa m`mawere.

Musanayambe kumwa mapiritsi, muyenera kuonetsetsa kuti palibe zotsutsana.

Malangizo ogwiritsira ntchito

Mankhwalawa ayenera kumwedwa pakamwa ponse osatafuna.

Kuti muwonjezere zovuta zoyambira, ndibwino kumwa mankhwalawo panthawi ya chakudya.

Dokotala amakhazikitsa muyeso wofunikira kwa wodwala aliyense, kuyambira pa lingaliro lake la kuchuluka kwa kuchuluka kwa shuga, omwe wodwalayo adalandira chithandizo chamankhwala komanso ngati zinali zothandiza.

Mlingo wofanana ndi piritsi limodzi kawiri patsiku, m'mawa ndi madzulo. Ngati mlingo umakhala kamodzi patsiku, ndiye kuti muyenera kumwa mankhwalawa m'mawa.

Malangizo apadera

Simuyenera kumwa mankhwalawa chifukwa cha kukanika kwambiri kwa chiwindi, chifukwa cha kuchuluka kwa michere ya thupi.

Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa panthawi yapakati komanso munthawi ya mkaka wa m'mawere, chifukwa palibe zotsatira zenizeni pazotsatira zomwe zimagwira pa mluza.

Komabe, ngati kagayidwe kazakudya kagayidwe kachakudya mu thupi loyembekezera kamasokonekera mukamamwa mankhwalawo, ndiye kuti pamakhala chiwopsezo cha kubereka kwachilendo kwa mwana wosabadwayo.

Odwala opitirira zaka 65 sadzafunika kusintha mlingo.

Ngati tikulankhula za ana, popeza zotsatira ndi chitetezo chofunikira sizinawululidwe pamayesero azachipatala, sizikulimbikitsidwa kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi zaka zosakwana ambiri.

Pali malangizo apadera angapo, ngati muwatsatira, ndiye kuti mupewe zoyipa zomwe mungagwiritse ntchito mankhwalawa:

• mankhwalawa sichilowa m'malo mwa insulin, yomwe iyenera kukumbukiridwa kwa odwala omwe ali ndi matenda a shuga 1;
• pakugwiritsa ntchito mankhwalawa, muyenera kupenda kuchuluka kwa shuga mthupi;
• osachepera kamodzi pamwezi, amafunika kuyang'ana momwe impso, chiwindi ndi kuchuluka kwa lactic acid;
• munthawi yogwiritsira ntchito mankhwalawa ndizoletsedwa kumamwa zakumwa zoledzeretsa, chifukwa izi zimatha kuyambitsa kupanga lactic acidosis;
• Mankhwala amatha kuchepetsa mayamwidwe a vitamini B12, omwe amakhumudwitsa kukula kwa magazi m'thupi.

Pamankhwala, mankhwala amangogulidwa ndi mankhwala.

Zotsatira zoyipa ndi bongo

Kugwiritsa ntchito mapiritsi kungapangitse kukonzekera kwa zovuta za mankhwala, ndipo izi zimakhudza ziwalo ndi machitidwe awa:

1. Matumbo oyenda - amayamba kudwala, pamakhala kupweteka pamimba, madzi am'mimba amaponyedwa m'munsi mwa esophagus, kutupa kwa kapamba kumatheka, kulumikizidwa kwazitsulo kumatha kuwonekera pakamwa, vitamini B akuyamba kuyamwa kwambiri.
2. Machitidwe amanjenje - kupweteka, chizungulire, manja akunjenjemera.
3. Chiwindi ndi ndulu - chiwindi.
4. Musculoskeletal system - kupweteka m'malo, nthawi zina.
5. Njira za metabolism - zimawonjezera kuchuluka kwa uric acid ndi acidity magazi.
6. Ziwengo - zotupa padziko khungu ndi kuyabwa, urticaria. Ndikothekanso kukulitsa zizindikiro zowopsa za thupi lawo siligwirizana, zomwe zimafotokozedwa ngati angioedema Quincke kapena anaphylactic.
7. Nthawi zina, zizindikiro za hypoglycemia zimachitika, monga, kunjenjemera kwa malekezero apamwamba, "thukuta lozizira". Pankhaniyi, kukhathamiritsa kwa zakudya zamafuta (tiyi wokoma, confectionery) ndikulimbikitsidwa.

Ngati zotsatila za mankhwalawa zimayamba kukhazikika, ndiye kuti tifunika kusiya kugwiritsa ntchito mankhwalawa ndikupita kuchipatala.

Kuyanjana Ndi Mankhwala Ndi Analogi

Ngati mumagwiritsa ntchito Galvus Met ndi mankhwala ena, ndizotheka kukulitsa zovuta zam'magazi kapena kuwonjezera / kuchepetsa mphamvu ya mankhwala omwe mumagwiritsidwa ntchito.

Pogwiritsa ntchito nthawi yomweyo ndi Furosemide, kuchuluka kwa magazi a chiwonetsero chachiwiri kumachuluka, koma kuchuluka kwa koyambirira kumachepa.

Kutenga Nifedipine pa mankhwala kumabweretsa kuyamwa kwambiri, kuchulukitsidwa ndi impso, komanso kuwonjezeka kwa ndende ya Metformin m'magazi.

Ngati agwiritsidwa ntchito ndi glibenclamide, ndiye kuti kugwirizanitsa kwakumapeto kumayamba kuchepa.

Sitikulimbikitsidwa kuti titengedwe limodzi ndi Donazol, chifukwa imakhala ndi hyperglycemic. Ngati kuphatikiza kwa mankhwalawa ndikofunikira chifukwa chachipatala, ndiye kuti muyenera kusintha kuchuluka kwa Metformin ndikuwonetsetsa kuchuluka kwa shuga m'magazi.

Mankhwala a diuretic, contracitive, glucocosteroid, calcium blockers, Phenothiazine - akagwiritsidwa ntchito limodzi ndi Galvus Met, amatha kuyambitsa hypoglycemia. Kugwiritsa ntchito osachepera 100 mg a Chlorpromazine pamodzi ndi Galvus Met patsiku, mutha kuwonjezera glycemia, komanso kuchepetsa kupanga insulin.

Mukamagwiritsa ntchito radiopaque wothandizira ndi ayodini pakumwa, lactic acidosis imayamba kupanga, yomwe imathandizidwa ndi kulephera kwa aimpso. Ngati mumwa mankhwala omwe amakhala ndi ethyl mowa nthawi yomweyo, ngozi ya lactic acidosis imakulanso.

Galvus Met ali ndi fanizo lotsatirali popanga zoweta: Avandamet, Glimecomb ndi Combogliz Prolong.

Avanta imakhala ndi zinthu ziwiri zogwira ntchito - Rosiglitazone ndi Metformin. Mankhwalawa amagwiritsidwa ntchito pochiza matenda enaake omwe amadzisokoneza. Rosiglitazone imathandizira chidwi cha maselo kuti apange insulin, ndipo Metformin imachepetsa kaphatikizidwe ka shuga ndi chiwindi.

Glimecomb imapangidwa ndi Metformin ndi Glyclazide, yomwe imakupatsani mwayi wokhazikika wa shuga. Imavomerezeka kuti igwiritsidwe ntchito ndi mtundu wa matenda a shuga omwe amadalira inshuwaransi, chikomokere, kuyamwa, etc.

Comboglyz Prolong imakhala ndi Metformin ndi Saxagliptin. Amagwiritsidwa ntchito kuthana ndi matenda a shuga a 2, pomwe sizingatheke kuchepetsa shuga mwazakudya ndi zochitika zolimbitsa thupi. Iwo ali osavomerezeka kuti azigwiritsa ntchito mosaloledwa pazinthu zomwe zili momwemo, odwala matenda a shuga, ana, pakakhala nthawi yobereka.

Maganizo a akatswiri ndi odwala

Malinga ndi ndemanga za madotolo ndi odwala za Galvus Met, titha kunena kuti mankhwalawa ndi othandizira kuchepetsa shuga. Zotsatira zoyipa ndizosowa kwambiri ndipo zimayimitsidwa ndi kuchepa kwa mlingo wa mankhwalawo.

Mankhwalawa ndi a gulu la mankhwala IDDP-4, adalembetsedwa ku Russia ngati mankhwala a mtundu 2 matenda a shuga. Ndiwothandiza komanso ndi yotetezeka, yolekeredwa bwino ndi odwala matenda ashuga, siyambitsa kulemera. Galvus Met imaloledwa kugwiritsidwa ntchito ndi kuchepa kwa impso, komwe sikungakhale kwapamwamba pochiza okalamba.

Olga, endocrinologist

Mankhwala okhazikika. Zimawonetsa zotsatira zabwino pakuwongolera shuga.

Lyudmila, wazamaphunziro

Type 2 shuga mellitus adapezeka zaka khumi zapitazo. Ndinayesetsa kumwa mankhwala ambiri, koma sizinandithandizire kwambiri. Kenako adotolo adalangiza Galvus. Ndidatenga kawiri patsiku ndipo posakhalitsa shuga adayamba kukhala wabwinobwino, koma zotsatira zoyipa za mankhwalawo zidawonekera, monga, kupweteka mutu komanso totupa. Dokotala adalimbikitsa kuti asinthane ndi mlingo wa 50 mg, izi zidathandiza. Pakadali pano, matendawo ndiabwino, pafupifupi kuyiwalako za matendawa.

Maria, wazaka 35, Noginsk

Zoposa zaka khumi ndi zisanu akhala akudwala matenda ashuga. Kwa nthawi yayitali, mankhwalawo sanabweretse zotsatira zabwino mpaka dokotala atalimbikitsa kugula Galvus Met. Chida chachikulu, mlingo umodzi patsiku ndi wokwanira kuteteza shuga. Ndipo ngakhale mtengo uli wokwera kwambiri, sindakana mankhwala, ndiwothandiza kwambiri.

Nikolay, wazaka 61, Vorkuta

Zolemba kanema kuchokera kwa Dr. Malysheva zokhudzana ndi zinthu zomwe zingakhale zothandiza ku mankhwala a shuga:

Mankhwalawa atha kugulidwa ku mankhwala aliwonse. Mtengo umachokera ku rubles 1180-1400., Kutengera dera.