Fraxiparin wa mankhwala a Antithrombotic: malangizo, ntchito, mtengo, ndemanga

Fraxiparin ndi mankhwala othandiza omwe ali ndi mawonekedwe owonekera mwachangu, omwe amachokera ku nadroparin.

Akatswiri amapereka mankhwalawa kwa odwala awo ngati prophylaxis kapena chithandizo chovuta cha thrombotic pathologies mwa anthu omwe amakonda magazi.

Mankhwalawa adapangira kuti azigwiritsa ntchito mankhwalawa. Pakadali pano, thromboembolism imadziwika kuti ndi imodzi mwazifoopsa kwambiri kwa anthu. Kutseka m'madzi mu mtsempha kumayambitsa matenda a mtima kapena ischemia, yomwe nthawi zambiri imayambitsa kulumala kapena ngakhale kufa.

Ngakhale akatswiri azachipatala apanga mankhwala amakono ambiri kuti athetse matenda awa, Fraxiparin amadziwika kuti ndi othandiza kwambiri, ndi mankhwala omwe mungapeze malangizo.

Zizindikiro zogwiritsidwa ntchito

Nthawi zambiri, Fraxiparin amalembedwa kwa odwala omwe akumana ndi zovuta zotsatirazi:

• mawonekedwe osakhazikika a angina pectoris;
• thromboembolism ya digiri iliyonse (blockage yayikulu yamitsempha yamagazi yofunika ndi thrombus);
• myocardial infarction popanda mtundu wa Q (kuteteza ndi kuchiza pambuyo pake);
• kulowererapo kwa mafupa ndi ma opaleshoni omwe amachitidwa kwa odwala omwe ali ndi kupuma kapena kulephera kwa mtima (kuletsa kubwereranso mwatsopano);
• kupewa magazi kuwonongeka kwa odwala amene amafunikira hemodialysis.

Mlingo ndi makonzedwe

Opanga mankhwala a Fraxiparin amawonetsa kuti mankhwalawa amatumizidwa mosiyanasiyana m'mimba pokhapokha pa supine. Nthawi zina, kuyamwa kwa mankhwala amtundu wachikazi ndikololedwa.

Pofuna kupewa kutayika kwa mankhwalawa, osayesa kuchotsa thovu lakumanzere mu syringe isanafike. Singano iyenera kuyikika kokha kokha pakhungu laling'ono, lomwe liyenera kupangidwa mwaluso ndi zala zitatu za dzanja laulere. Malowo a jakisoni sayenera kuzilimbitsa ndikusintha.

Jakisoni Fraxiparin 0,3 ml

Pofuna kupewa chitukuko cha thromboembolism mu opanga opaleshoni, muyezo wa mankhwalawa ndi 0,3 ml. Poyamba, mankhwalawa amaperekedwa kwa wodwala maola 4 asanayambe ntchito, ndipo kamodzi patsiku.

Kuchita bwino kwa mankhwalawa kumayenera kupitilira sabata limodzi, nthawi zambiri wodwala amamuika jakisoni wa Fraxiparin mpaka wodwala atamuthandizira kupita kuchipatala. Kuti muthandizenso wodwala pambuyo pa vuto la mtima kapena vuto la angina losakhazikika, 0,6 ml ya mankhwalawa amatumizidwa kamodzi katatu patsiku.

Kuchiza kuyenera kukhala pafupifupi sabata limodzi. Pankhaniyi, jakisoni woyamba amaperekedwa kudzera m'mitsempha, ndipo onse omwe amatsatira - subcutaneally. Mlingo umatengera zomwe wodwala akuonetsa. Panthawi ya mafupa a mankhwalawa, Fraxiparin imayendetsedwa mosiyanasiyana modzaza wodwala (50 makilogalamu - 0,5 ml, 70 makilogalamu - 0,6 ml, 80 makilogalamu - 0,7 ml, 100 kg - 0,8 ml, oposa 100 makilogalamu - 0,9 ml).

Jakisoni woyamba amachitika maola 12 asanachite opareshoni, ndipo wotsatira pambuyo pa nthawi yomweyo atatha opareshoni. Kuti muthandizenso mankhwala, wodwala ayenera kugwiritsa ntchito Fraxiparin kamodzi patsiku. Kutalika kwa mankhwala osachepera masiku 10.

Zotsatira zoyipa

Odwala ambiri amalola jakisoni wokhazikika wa Fraxiparin, koma nthawi zina, kuwonetseredwa kwa kupweteka kovuta kwa thupi ndikotheka:

• kutuluka magazi mwadzidzidzi;
• redness, mapangidwe ang'onoang'ono oyamwitsa, hematomas, komanso kuyabwa m'malo a jakisoni;
• anaphylactic mantha;
• thrombocytopenia (kuphatikizapo chitetezo cha m'thupi);
• venous thrombosis;
• eosinophilia;
• mawonetseredwe a thupi lawo siligwirizana;
• priapism;
• Hyperkalemia

Pankhaniyi, wodwalayo ayenera kulumikizana ndi dokotala, kuti achulukitse chithunzi chonse chachipatala.

Malangizo apadera

Ngakhale kuti maphunziro angapo asayansi sanawululure za teratogenic, ndibwino kukana kutenga Fraxiparin mu trimester yoyamba ya mimba.

Pa trimester yachiwiri ndi yachitatu, mankhwalawa amatha kugwiritsidwa ntchito pokhapokha malinga ndi malingaliro a adokotala kuti apange mapangidwe a thrombosis.

Njira yochiritsira yathunthu pankhaniyi ndi yoletsedwa. Ngati vutoli limaphatikizapo kugwiritsa ntchito mankhwala opha ululu, wodwalayo ayenera kukana chithandizo ndi heparin osachepera maola 12 asanafike njira zamankhwala.

Madokotala amati mbali zonse za mankhwalawo ndizotetezeka kwathunthu kwa amayi omwe atsatira IVF. Chifukwa chakuti lero pali mitundu yambiri ya analogues, Fraxiparin imalembedwa kwa odwala pokhapokha ngati ali ndi chiopsezo chokhala ndi matenda opatsirana.

Mwachitsanzo, ngati mkazi wawonjezera magazi.

Ngati matenda amkati amkati, matenda oopsa kapena zilonda zam'mimba zapezeka, wodwalayo ayenera kudziwitsa dokotalayo za izi.

Zowonadi, pankhaniyi, ndikofunikira kutenga Fraxiparin mosamala kwambiri, popeza kufa kwa mwana wosabadwa ndi kusokonezeka kwamimba ndikotheka. Payokha, ndikofunikira kudziwa kuti azimayi ena amatha kupatsidwa mankhwala ogwiritsira ntchito nthawi yonse yoyembekezera ngati prophylaxis wodalirika, pamene kuphwanya kwakukulu pakuwonekera kwa placenta kwadziwika.

Koma, palibe chifukwa chomwe mungasankhire nokha, nthawi zonse muyenera kufunsa akatswiri. Mankhwala amatha kuperekedwa pokhapokha ngati mayeso onse ofunikira a coagulability ndi anticoagulability a magazi atachitika.

Kuphatikiza apo, Fraxiparin imathandizira kupewa kusintha kwakukulu kwa matenda:

• intrauterine imfa ya mwana;
• mimba ikutha;
• kukula kwa intrauterine kwa mwana;
• kuzungulira kwa placenta;
• preeclampsia;
• chik-placental kusakwanira.

Fraxiparin ikhoza kusokoneza kupanga aldosterone, zomwe zimapangitsa kuti pakhale mtundu wina wa hyperkalemia.

Izi ndizofunikira makamaka kwa odwala omwe magazi awo amadzuka a potaziyamu, kapena metabolic acidosis kapena chifuwa chosalephera apezeka. Odwala otere amafunika kuwunika mosamala ndi akatswiri.

Contraindication

Mankhwalawa amaletsedwa mwamphamvu kwa odwala omwe apezeka ndi matenda otsatirawa:

• tsankho kuti calcium nadroparin;
• kuvulala pamutu;
• kwambiri aimpso kapena chiwindi kulephera;
• kuchuluka kwa magazi;
• opaleshoni yaubongo;
• endocarditis;
• pafupipafupi intracranial hemorrhage;
• opaleshoni yamaso yam'mbuyomu;
• mtundu wa kuwonongeka kwa ziwalo zamkati (mwachitsanzo: ulcerative colitis).

Mosamala kwambiri, mutha kugwiritsa ntchito mankhwalawa pamaso pa zotsatirazi:

• dystrophy (odwala osakwana 40 kg);
• matenda oopsa;
• zilonda zam'mimbamo;
• kugwiritsa ntchito munthawi yomweyo mankhwala omwe amachititsa mwayi wokhetsa magazi;
• kuphwanya kwachilengedwe kufalikira kwa magazi mu retina kapena choroid.

Malo osungira

Ndikofunikira kusunga mankhwalawo pamalo osiyanitsidwa ndi ana, pamtunda wozungulira wa + 18 ° C mpaka + 30 ° C. Kuwonetsedwa kosavomerezeka kwa ma heterita ndi dzuwa mwachindunji. Moyo wa alumali ndi zaka zitatu. Amapezeka m'mafakitala kokha ndi mankhwala.

Mtengo

Inde, odwala onse ali ndi nkhawa ndi dongosolo la zachuma, chifukwa chithandizo chotere sichingakhale chotsika mtengo.

Mtengo wapakati wa Fraxiparin umasiyanasiyana kuchokera ku ma ruble 300 pach syringe imodzi ndi mpaka ma ruble 3000 a phukusi lonse, lomwe lili ndi jakisoni 10.

Koma anthu omwe adakumana ndi zovuta zowawa amadziwa kuti thanzi ndiye chinthu chofunikira kwambiri. Kuphatikiza apo, nthawi zambiri, odwala amakhala ndi jakisoni wokwanira 5-10.

Analogi

Misika yogulitsa mankhwala yakunja ndi yakunja imapereka mitundu ingapo yapamwamba kwambiri ya Fraxiparin. Onsewa ali m'gulu lomwelo la mankhwala, komanso ali ndi kachitidwe kena kofananira pama kachitidwe ka thupi.

Mankhwala otsatirawa amatchuka kwambiri:

• Clexane;
• Arikstra;
• Zopanda kanthu;
• Heparin sodium;
• Zibor 3500;
• Chibwano;
• Sinkumar;
• Warfarin;
• Bendera;
• Heparin.

Ndemanga

Odwala ambiri ali ndi nkhawa kuti hematomas owawa amapangira jakisoni.

Koma, zoona zake, izi zimagwirizanitsidwa ndi kugwiritsa ntchito jakisoni osafunikira.

Pankhaniyi, muyenera kulumikizana ndi katswiri ndikumupempha kuti afotokozere mwatsatanetsatane njira ya jekeseni. Mukaphunzira kugwiritsa ntchito mankhwalawa moyenera, simudzakumana ndi zoterezi. Mwambiri, odwala onse amakhutira ndi zotsatira za njira yochizira.

Makanema okhudzana nawo

Obstetrician-gynecologist pa gawo la matenda a thrombophilia ndi chitetezo chamthupi pakulakwitsa:

Pomaliza, titha kunena kuti Fraxiparin ndi mankhwala amakono ogwirira ntchito omwe akhala akugwiritsidwa ntchito mwachangu kwa nthawi yayitali. Amadziwika ndi ntchito yabwino, mawonekedwe owoneka bwino komanso kuwunika kambiri.

Chifukwa cha izi, odwala ambiri adatha kubwezeretsanso ntchito ya thupi lonse, kusintha thanzi lawo ndikubwerera m'moyo wawo wakale.