Dokotala yekha ndi amene amagwiritsidwa ntchito poika mankhwala othandizira odwala matenda ashuga, kusankhidwa kwake kumayambitsa zovuta chifukwa cha zovuta komanso contraindication.
Mankhwala ochepetsa shuga, monga Metformin ndi Maninil, amasiyana mu kagwiritsidwe kake ka mphamvu ndi mphamvu ya zotsatira za hypoglycemic.
Izi ndichifukwa chosiyana ndi mankhwala, lingalirani mawonekedwe awo ndi kusiyana kwake.
Kupanga
Metformin ndi chinthu chochokera ku ma guruuanides angapo omwe amachepetsa shuga m'magazi mwa kuletsa mayamwidwe ake m'chiwindi.
Maninyl akuphatikiza ndi zinthu glibenclamide, zomwe zimapezeka mu m'badwo wachiwiri ndi kuchepetsa shuga. Mankhwala amapangidwa kokha m'mapiritsi okhala ndi mitundu yosiyanasiyana ya zosakaniza zogwira ntchito.
Zotsatira za pharmacological
Mfundo za Metformin ndikupewa gluconeogeneis. Thupi limayambitsa enzyme yapadera m'chiwindi chomwe chimalepheretsa kulowa kwina kwa glucose kulowa m'magazi. Mankhwalawa amalepheretsa kusintha kwamafuta acids ndikulimbikitsa kukhatikiza kwawo, kumalepheretsa mayamwidwe a shuga m'matumbo.
Poyerekeza ndi ena othandizira a hypoglycemic, mankhwalawa amathandiza kwambiri kupewa matenda a matenda a shuga. Pogwiritsa ntchito mwadongosolo, mankhwalawa amalepheretsa kulemera, ndipo pakudya, amathandizira kuchepetsa.
Mapiritsi a Metformin
Mankhwala amalepheretsa kukula kwa insulin ndipo amathandizira kulowa kwa shuga m'magazi a anthu. Ndi kuchepa kwa insulin m'magazi, chinthucho sikuwonetsa katundu wa hypoglycemic.
Maninyl amathandizira kupanga insulini mu kapamba chifukwa kutsekedwa kwa njira zam potaziyamu m'maselo a beta. Zomwe zili mu potionsum ions zikuchulukirachulukira, zomwe zimapatsa kapamba chizindikiritso cha kuphatikizira insulin yatsopano.
Mankhwalawa amatha kuwonjezera mayankho a metabolic ku mahomoni, amachepetsa chiopsezo cha nephropathy komanso kufa. Mphamvu yamapangidwe sikugwirizana ndi kuchuluka kwa shuga m'magazi, motero mankhwalawa amagwira ntchito ngakhale ndi standardoglycemia.
Zizindikiro
Metformin imayikidwa ngati othandizira hypoglycemic makamaka matenda a shuga a 2.
Mu matenda 1 a matenda ashuga, mankhwala atha kutumikiridwa ngati njira yolepheretsa kukula kwa matenda a shuga.
Mankhwala a hypoglycemic amatha kugwiritsidwa ntchito ngati polycystic ovary, ngati hyperinsulinemia ndi kulolera kwa glucose zimayang'aniridwa.
Glibenclamide imagwiritsidwa ntchito kokha mtundu wa 2 shuga mellitus, mukamagwiritsa ntchito zakudya zoyenera komanso katundu wokwanira sizotheka kuchepetsa shuga.
Kodi ndingatenge limodzi?
Kuti muganizire za kuphatikiza kwa mankhwalawa, muyenera kuganizira mawonekedwe a zakumwa zawo komanso momwe zimagwirira ntchito zomwe zimagwira.Kuchulukitsa kwa shuga kwa glibenclamide kumadalira mlingo: wokulirapo, umakhudzidwa kwambiri ndi kapamba.
Mukakhudzidwa ndi chinthu chogwira ntchito, insulin yowonjezera imayamba kupanga, chifukwa chake kusankha kwa Maninil kofunikira kumatsimikiziridwa ndi shuga la magazi.
Popereka mankhwala, dokotala amayenera kupereka malangizo pazakudya ndikuyenera kudziwa kuchuluka kwa chakudya chamagulu muzakudya. Pa gawo loyambirira, chithandizo chimayamba ndi mlingo wotsika kwambiri, ndipo pambuyo pa makonzedwe, zovuta za matenda ashuga zimawonedwa.
Ngati ndi kotheka, onjezerani kuchuluka kwa mankhwalawo. Imwani mankhwalawa 1-2 kawiri pa tsiku, zomwe zimachitika ndi mankhwala osachepera maola 12.
Kuti muwonjezere kuchuluka kwa hypoglycemic ndikuchepetsa kudya kwa magazi m'magazi, makuponi a Maninil omwe ali ndi Metformin amatha.
Kuphatikiza kwa mankhwalawa kumagwiritsidwa ntchito pomwe ndizosatheka kukwaniritsa zofunikira zochizira.
Mankhwala owonjezera a antiidiabetes ayenera kuthandizidwa ndi dokotala. Kuphatikiza ndi mankhwala ena, mphamvu ya glibenclamide m'thupi imalimbikitsidwa.
Zabwino ndi ziti?
Mukamapereka mankhwala othandizira a hypoglycemic, amawongoleredwa ndi kufunika kochizira, momwe amagwirira ntchito pazinthu zomwe zikuchitika, zotsutsana zomwe zikugwiritsidwa ntchito pakalipano.
Metformin kapena Maninil
Chizindikiro cha Metformin ndikuti kuchuluka kwa hypoglycemic pa thupi sikukhudzana ndi kuchuluka kwa insulin. Mfundo ya mankhwalawa ndi kupewetsa kuchuluka kwa shuga.
Metformin ndi amodzi mwa mankhwala ochepa omwe chiopsezo chotenga hypoglycemia ndi chocheperako. Kuphatikiza pa maonekedwe a matumbo, mankhwalawa alibe zotsatira zoyipa. Lactic acidosis imatha kuchitika ndi bongo wambiri komanso vuto la impso.
Maninil
Chifukwa chake, pakupanga kwachilendo kwa mahomoni a peptide ndi kapamba, koma ndi kukana kwambiri kwa insulin, Metformin ndiyabwino.
Zoyipa zake ndi monga kuti greatuanide sangathe kuchepetsa shuga ndikusowa kwa insulin mthupi. Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumalepheretsa mayamwidwe a vitamini B12, omwe pambuyo pake amatha kuyambitsa kukula kwa myalgia ndi magazi.
Glibenclamide ndi mankhwala okhawo a 2 a matenda ashuga, pomwe mapiritsi ena ochepetsa shuga sikokwanira.
Sulfonylurea derivative (glibenclamide) imakhala ndi zoyipa zingapo:
- ngati kuchuluka kwa zomwe zimagwiritsidwa ntchito kuzidutsa, hypoglycemia imayamba;
- kulemera;
- kupweteka kwa molumikizana
- mutu
- kuchuluka kwa chidwi pakuwala;
- malungo
- chimbudzi;
- kutopa kwambiri;
- proteinuria (mapuloteni amawoneka mkodzo);
- cholestatic syndrome;
- thupi lawo siligwirizana;
- kukodza pafupipafupi.
Mndandanda wa zotsutsana ndi mankhwala ndizofanana, kupatula kuti glibenclamide ndizoletsedwa kutenga ndi shuga yodalira insulin.
Metformin, Maninil silingagwiritsidwe ntchito ngati:
- matenda a shuga;
- mimba
- mkaka wa m`mawere;
- kuphwanya chiwindi ndi impso;
- mawonekedwe a ketoacidosis;
- Hypersensitivity.
Glibenclamide ingagwiritsidwe ntchito mosamala mu zakumwa zoledzeretsa, zomwe kwa greatuanide ndizolepheretsa.
Kuphatikiza apo, Metformin idathetsedwa masiku awiri asanafike komanso pambuyo pa x-ray, ngati pakadakhala poyambitsa kusiyana.
Maninil kapena Amaryl
Amaryl ndi hypoglycemic yozikidwa pa sulfonylureas a m'badwo wa III. Muli yogwira pophika - glimepiride. Mfundo yakuchitapo kanthu ndikulimbikitsa kumasulidwa kwa insulin ya insulin ndi kapamba.
Mapiritsi a Amaryl
Mosiyana ndi Maninil, Amaryl ali ndi zina zowonjezera - mankhwalawo amalepheretsa gluconeogeneis. Mphamvu ya hypoglycemic ya Amaril imatchulidwa kwambiri ndipo ndi maola osachepera 24.
Maninil ndi Amaril sangathe kulembedwa mtundu wa shuga wodalira insulin. Mukamasankha mtundu wa Amaril ndi chithandizo chotsatira, kuwerenga kwa shuga pamagazi kuyenera kukumbukiridwa, chifukwa pali mwayi wopanga hypoglycemia.
Mawonekedwe olakwika ogwiritsa ntchito mankhwala ndi contraindication sikuti ndi osiyana. Kupatula kwake ndi vuto lotaya kugaya chakudya mu Amaril, lomwe limagwirizanitsidwa ndi njira yoletsa gluconeogenesis ndi mankhwalawa.
Makanema okhudzana nawo
Makina a kuchitapo kanthu, mawonekedwe amamasulidwe ndi zovuta zina zogwiritsira ntchito Metformin mu kanema:
Maninil ndi Amaryl ali ndi hypoglycemic kwambiri, koma amakhala ndi mndandanda wazotsatira zoyipa. Ngati kukondoweza kwapancreatic sikofunikira pakupanga insulin,
Metformin ili ndi mwayi woonekeratu. Kukula kwakukulu kumachepetsa chiopsezo cha atherosulinosis, sikuti kumabweretsa kulemera ndikulepheretsa kukula kwa matenda a mtima. Zotsatira zoyipa zamagetsi zomwe zimachitika chifukwa cha kutenga biguanide zimadutsa mofulumira.
