Odwala omwe ali ndi vuto la lipid metabolism nthawi zambiri amakhala ndi chisankho, chiti ndibwino - Atorvastatin kapena Rosuvastatin? Ngakhale Rosuvastatin yakhala ikugwiritsidwa ntchito kwambiri posachedwa, sizingatheke kuyankha funsoli, chifukwa mankhwalawa ali ndi zabwino komanso zovuta zake.
Mankhwalawa onse ayenera kumwedwa kuti apatsidwe ma pathologies monga osakanikirana kapena homozygous hypercholesterolemia (kuchuluka LDL), hypertriglyceridemia (triglycerol ochulukirapo) ndi atherosulinosis (kuchepa kwa lumen kwa mitsempha yamagazi chifukwa cha subsidence ya cholesterol plaques). Amagwiritsidwanso ntchito kupewa zovuta za atherosulinosis - matenda oopsa, matenda a mtima, kugunda kwa mtima ndi matenda a mtima.
Popeza pali kusiyana pakati pa ma contraindication, zochita zoyipa, pharmacokinetics ndi pharmacodynamics, ndikofunikira kudziwa kuti ndi mankhwala ati othandiza komanso otetezeka.
Kodi ma statins ndi ati?
Statin imaphatikizapo gulu lalikulu la mankhwala omwe amachepetsa kuchuluka kwa LDL ndi VLDL m'magazi.
Muzochitika zamankhwala zamakono, ma statins sangathe kugawidwa popewa matenda a atherosulinosis, hypercholisterinemia (osakanikirana kapena homozygous), komanso matenda a mtima.
Mwambiri, mankhwalawa a gululi ali ndi zofanana zochizira, i.e. m'munsi LDL ndi VLDL. Komabe, chifukwa cha mitundu yosiyanasiyana yogwira ntchito komanso yothandizira, pali zosiyana zina zomwe ziyenera kukumbukiridwa kuti tipewe zovuta.
Statin nthawi zambiri amagawika I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) ndi m'badwo wa IV (Pitavastatin, Rosuvastatin).
Statin akhoza kukhala achilengedwe komanso opanga. Kwa katswiri, kusankha kwa mankhwala otsika kapena ochepa kwambiri kwa wodwala ndi gawo lofunikira.
Rosuvastatin ndi Atorvastatin nthawi zambiri amagwiritsidwa ntchito kutsitsa cholesterol. Aliyense wa mankhwalawa ali ndi mawonekedwe:
Rosuvastatin amatanthauza ma statins a m'badwo wachinayi. Wothandizila lipid-wotsitsa amapangidwa kwathunthu ndi pafupifupi Mlingo wothandizira. Zimapangidwa pansi pa zizindikiro zosiyanasiyana, mwachitsanzo, Krestor, Mertenil, Rosucard, Rosart, ndi zina zambiri.
Atorvastatin amatanthauza ma statins a m'badwo wachitatu. Monga momwe analogue ilili, imakhala ndi chiyambi chopangidwa, koma imakhala ndi mlingo waukulu wa zomwe zimagwira.
Pali maulumikizano amtundu wa mankhwala monga Atoris, Liprimar, Toovacard, Vazator, etc.
The mankhwala zikuchokera mankhwala
Mankhwala onsewa amapezeka piritsi. Rosuvastatin imapangidwa mumagulu angapo - 5, 10 ndi 20 mg ofanana. Atorvastatin imamasulidwa mu gawo la 10,20,40 ndi 80 mg yogwira mankhwala. Pansipa pali tebulo loyerekeza magawo othandizira aomwe amadziwika ndi ma statins.
| Rosuvastatin | Atorvastatin (Atorvastatin) |
| Hypromellose, wowuma, titanium dioxide, crospovidone, cellcrystalline cellulose, triacetin, magnesium stearate, silicon dioxide, titanium dioxide, utoto wa carmine. | Lactose monohydrate, croscarmellose sodium, titanium dioxide, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, microcrystalline cellulose, |
Kusiyana kwakukulu pakati pa Rosuvastatin ndi Atorvastatin ndizinthu zawo zachilengedwe. Ubwino wa rosuvastatin ndikuti umasweka mosavuta m'madzi amadzi ndi madzi ena, i.e. ndi hydrophilic. Atorvastatin ali ndi gawo lina: limasungunuka m'mafuta, i.e. ndi lipophilic.
Kutengera izi, mphamvu ya Rosuvastatin imangodalira maselo a chiwindi parenchyma, ndi Atorvastatin - ku kapangidwe ka ubongo.
Pharmacokinetics ndi pharmacodynamics - kusiyana
Poyamba pa magawo a mapiritsi, pali kusiyana pakati pa mayamwidwe. Chifukwa chake, kugwiritsa ntchito Rosuvastatin sikudalira nthawi yamasana kapena chakudya. Atorvastatin sayenera kudyedwa nthawi yomweyo ndi chakudya, monga izi zimakhudza mayamwidwe a chigawocho. Zambiri zomwe zili mu Atorvastatin zimatheka pambuyo pa maola 1-2, ndi Rosuvastatin - atatha maola 5.
Kusiyana kwina pakati pa ma statins ndi kagayidwe kake. Mthupi la munthu, Atorvastatin amasinthidwa kukhala mawonekedwe osagwira ntchito pogwiritsa ntchito ma enzymes a chiwindi. Chifukwa chake, ntchito ya mankhwalawa imakhudzana mwachindunji ndi kugwira ntchito kwa chiwindi.
Zimakhudzidwanso ndi mankhwala omwe amagwiritsidwa ntchito nthawi yomweyo ndi atorvastatin. Mafuta ake, m'malo mwake, chifukwa cha kutsika kwake, sikuti amachita ndi mankhwala ena. Ngakhale izi sizimamupulumutsa iye kuchokera kukhalapo koyipa.
Atorvastatin amapukusidwa makamaka ndi bile.
Mosiyana ndi ma statins ambiri, Rosuvastatin pafupifupi samapangidwira m'chiwindi: zoposa 90% za zinthu zimachotsedwa osasinthika ndi matumbo ndipo ndi 5-10% yokha impso.
Contraindication ndi zoyipa zimachitika
Kukhalapo kwa contraindication ndi zoipa zochita ndi zinthu zofunika posankha bwino kwambiri mankhwala. Awa ndi matenda akuluakulu ndi mikhalidwe yomwe kugwiritsa ntchito mankhwalawa kumaletsedwa, komanso zovuta zina.
| Contraindication | |
| Rosuvastatin | Atorvastatin |
| Zomverera payekha. Mimba komanso kuyamwa. Zowonongeka kwa hepatocytes ndi ma enzymes okwera. Ana ndi achinyamata ochepera zaka 18. Myopathy kapena kudziwikiratu kwa izo. Chithandizo chokwanira ndi cyclosporine ndi fibrate. Kulephera kwamlomo. Uchidakwa wambiri Myotoxicity mukutenga zina za HMG-CoA reductase inhibitors. Kugwiritsa ntchito ma virus obisika a HIV. Oimira mtundu wa Mongoloid (mlingo wochepera wololedwa). | Hypersensitivity kumagawo. Kuchuluka kwa chiwindi michere. Kubereka kwa ana komanso nthawi yayitali. Ana ndi achinyamata ochepera zaka 18, kupatula chithandizo cha heterozygous cholowa cholowa hypercholesterolemia. Kuperewera kwa njira zakulera. Kugwiritsa ntchito ma virus obisika a HIV. Matenda a chiwindi. |
| Zotsatira zoyipa | |
| Mutu, mavuto amgwirizano, malaise wamba. Kukula kwa proteinuria ndi hematuria. Zotupa pakhungu, ming'oma, kuyabwa. Zovuta zamkati mwa minofu ndi mafupa. Dyspepsia, chopondapo chopondapo, kutupa kwa kapamba (kapamba). Matenda a shuga osagwirizana ndi insulin. Kukula kwa mabere mwa abambo. Kukhalapo kwa chifuwa chowuma, kufupika kwa mpweya. Stevens-Johnson Syndrome. | Kukula kwa nasopharyngitis, kwamikodzo matenda opatsirana. Kupezeka kwa thrombocytopenia. Hypo- ndi hyperglycemia, anorexia. Ululu pamutu, paresthesia, chitukuko cha zotumphukira zamitsempha, Hypesthesia, amnesia, chizungulire, dysgeusia. Kumva kuwonongeka, tinnitus, kuwonongeka kwa mawonekedwe. Zilonda zapakhosi. Dyspeptic disorder, belching, epigastric ululu, kukula kwa kapamba. Urticaria, zotupa pakhungu, edema ya Quincke. Maonekedwe a gynecomastia. Matenda osiyanasiyana a musculoskeletal system. Hepatitis, chiwindi kulephera, cholestasis. Hyperthermia, asthenia, malaise. Kuchulukitsa kwa ma enzymes a chiwindi, QC ndi kuwunika koyenera kwa leukocytes mu mkodzo. |
Kugwiritsa Ntchito Maganizo Abwino
Ntchito yayikulu ya mankhwala a statin ndikuchepetsa kuchuluka kwa LDL m'magazi ndikuwonjezera kuchuluka kwa HDL.
Chifukwa chake, kusankha pakati pa Atorvastatin ndi Rosuvastatin, tiyenera kuyerekezera momwe amachepetsa cholesterol.
Kafukufuku waposachedwa watsimikizira kuti rosuvastatin ndi mankhwala othandiza kwambiri.
Zotsatira zakuchipatala zafotokozedwera pansipa:
- Pokhala ndi Mlingo wofanana wamankhwala, Rosuvastatin amachepetsa cholesterol ya LDL ndi 10% bwino kwambiri kuposa analogue yake. Ubwino uwu umalola kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi hypercholesterolemia.
- The pafupipafupi chitukuko cha mtima mavuto ndi isanayambike wakupha zotsatira kwambiri mu Atorvastatin.
- Vutoli limayambira modabwitsa.
Kuyerekeza mphamvu yakuchepetsa kuchuluka kwa cholesterol "yoyipa" kumatsimikizira kuti Rosuvastatin ndi mankhwala othandiza kwambiri. Komabe, munthu sayenera kuyiwala za zinthu monga kukhalapo kwa contraindication, mavuto ndi mtengo wake. Poyerekeza mitengo ya mankhwalawa imaperekedwa patebulopo.
| Mlingo, kuchuluka kwa mapiritsi | Rosuvastatin | Atorvastatin |
| 5mg No. 30 | 335 rub | - |
| 10mg No. 30 | 360 ma ruble | 125 rub |
| 20mg No. 30 | 485 RUB | 150 rub |
| 40mg No. 30 | - | 245 RUB |
| 80mg No. 30 | - | 490 rub |
Chifukwa chake, atorvastatin ndi analogue yotsika mtengo yomwe anthu ochepa ndalama sangakwanitse.
Ndi zomwe odwala amaganiza za mankhwala osokoneza bongo - Rosuvastatin amalekeredwa bwino komanso popanda mavuto. Ikatengedwa, cholesterol yoyipa imachepetsedwa
Kuyerekezera kwa mankhwalawa kumathandiza kuzindikira kuti pakadali pano pa chitukuko cha mankhwala, malo oyamba pakati pa mapiritsi abwino kwambiri a cholesterol amatenga ma statins a m'badwo wachinayi, kuphatikiza Rosuvastatin.
Pankhani ya mankhwala Rosuvastatin ndi mawonekedwe ake afotokozedwa mu kanema munkhaniyi.
