Cozaar ndi antihypertensive mankhwala omwe ali m'gulu la angiotensin antagonists. Mankhwalawa amagwiritsidwa ntchito kuti magazi azithamanga, komanso kupewa matenda a stroko komanso mtima.
Dzinalo Losayenerana
Dzinalo losavomerezeka lamankhwala padziko lonse lapansi (INN) la mankhwalawa ndi losartan.
Cozaar ndi antihypertensive mankhwala omwe ali m'gulu la angiotensin antagonists.
ATX
Khodi ya ATX (gulu la mankhwala anatomical-achire): C09CA01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka monga mapiritsi. Pakiti imodzi mumakhala mapiritsi oyera 7, 14 kapena 28. Mankhwalawa amaperekedwa mu 2 Mlingo. Mapiritsi okhala ndi 50 mg yogwira ntchito ndi oval, omwe ali pachiwopsezo ndikulemba 952, ndipo mapiritsi okhala ndi mulingo wa 100 mg ndi ooneka ngati dontho, akulembeka 960 ndipo alibe zoopsa.
Kapangidwe ka Cozaar:
- Potaziyamu losartan (yogwira pophika).
- Microcrystalline cellulose.
- Wowuma pregelatinized.
- Hyprolose
- Titanium dioxide
- Hypromellose.
- Lactose Monohydrate.
- Magnesium wakuba.
- Carnauba sera.
Mankhwala amapezeka monga mapiritsi. Pakiti imodzi mumakhala mapiritsi oyera 7, 14 kapena 28.
Zotsatira za pharmacological
Losartan ndiwotsutsa wa angiotensin receptors 2. Angiotensin ndi timadzi timene timayambitsa vasoconstriction (vasoconstriction) komanso kuthamanga kwa magazi. Losartan amasiya kugwira ntchito kwa timadzi timeneti.
Thupi limakhala ndi hypotensive zotsatira zake ndipo silimakhudza shuga wamagazi, dongosolo lodziyimira pang'onopang'ono komanso mawonekedwe. Kutupa mukamamwa mankhwalawa sikuwoneka.
Mwakutero, kuchuluka kwa sodium mu mkodzo kumatha kuwonjezeka ndipo chimbudzi cha uric acid ndi impso chitha kuchuluka. Mphamvu ya mankhwalawa imachulukana ndipo zimatengera mlingo (50 kapena 100 mg wa losartan potaziyamu).
Pharmacokinetics
Ikaperekedwa, chinthu chogwira ntchito chimalowa mwachangu m'mimba. The bioavailability wa losartan ndi 33%. Nthawi yakukwanira ndende ya plasma ndi ola limodzi.
Losartan amadwala kagayidwe koyamba. Pankhaniyi, metabolite yogwira imapangidwa, yomwe imafika pazitali zambiri pambuyo pa maola 3-4. Losartan ndi metabolite amamangiriza bwino magaziin (99%). Zinthu sizingadutse chotchinga-magazi.
Ikaperekedwa, chinthu chogwira ntchito chimalowa mwachangu m'mimba.
Mankhwala amathandizidwa ndi impso zonse osasinthika komanso ma metabolites. Mlingo umodzi wa mankhwalawa sutsogolera kuchulukana kwa zinthu m'magazi, sizikhudza kusefukira kwamadzi ndi mphamvu ya kutuluka kwa plasma. Losartan ndi metabolites ake amadzunjikira m'thupi ndikugwiritsa ntchito nthawi yayitali.
Zizindikiro zogwiritsidwa ntchito
Madokotala amapereka mankhwala awa pazochitika zotsatirazi:
- Matenda oopsa. Chizindikiro chogwiritsidwa ntchito ndi mtundu wa matenda omwe ali pachimake komanso matenda.
- Proteinuria (mapuloteni ambiri mumkodzo), omwe amachokera kumbuyo kwa matenda amtundu wa 2 shuga. Kudya kwa Cozaar kumapereka chitetezo cha impso.
- Kupewa myocardial infarction ndi stroke. Anthu omwe ali ndi matenda oopsa oopsa kapena hypertrophy ya kumanzere kwamtima kwamtima ali pachiwopsezochi.
- Kulephera kwamtima kosalekeza. Mankhwalawa amadziwitsidwa ngati kutenga ACE zoletsa sikungatheke kapena sikupereka achire.
- Kulephera kwina. Mankhwalawa amagwiritsidwa ntchito m'magawo omaliza a matenda awa.
Contraindication
Zoyipa zotsutsana ndi kugwiritsa ntchito mapiritsi ndi:
- tsankho la munthu;
- matenda akulu a chiwindi;
- lactose tsankho;
- kuchepa kwa lactase;
- glucose-galactose malabsorption (malabsorption a monosaccharides m'mimba mwake).
Ndi chisamaliro
Pali ma pathologies angapo momwe kugwiritsa ntchito mankhwalawa kumatheka motsogozedwa ndi dokotala.
Mosamala, mankhwalawa amatchulidwa motere:
- kuphatikiza kwamphamvu kwamitsempha yamafupa;
- nthawi pambuyo opaleshoni impso;
- mitral aortic malformations;
- milingo yambiri ya potaziyamu m'magazi;
- mitundu yoopsa ya aimpso ndi mtima kulephera;
- CHD (matenda a mtima);
- matenda amisala;
- Edema ya Quincke;
- kuchepa kwa pathological pozungulira magazi (BCC);
- Hypertrophy khoma lakumanzere kapena kumanja kwamitsempha yamtima.
Momwe mungatenge Cozaar?
Mapiritsi amatengedwa pakamwa ndi madzi pang'ono. Kudya sikukhudza kutha kwa mankhwalawa.
Kuchepetsa kuthamanga kwa magazi, wodwalayo amapatsidwa 50 mg wa losartan patsiku. A kutchulidwa achire zotsatira zimawonedwa pambuyo 3-4 milungu makonzedwe. Ndi osakwanira mankhwala, mlingo ukuwonjezeka mpaka 100 mg yogwira ntchito.
Pamaso pa matenda a mtima olephera, mlingo woyambira wa tsiku ndi tsiku ndi 12,5 mg. Pambuyo pa sabata, mlingo umakulitsidwa pang'onopang'ono katatu, kubweretsa kwa 100 mg patsiku (ngati kuli kofunikira).
Odwala omwe ali ndi BCC yotsika amapatsidwa theka la piritsi ya Cozaar (ndi 50 mg wa losartan potaziyamu) patsiku. Dokotala akhoza kuonjezera mlingo pokhapokha ngati mukuchiritsika.
Ndi matenda ashuga
Mtundu wachiwiri wa matenda a shuga, mankhwalawa amamuikira muyezo, koma Aliskiren ndi oletsedwa. Amaloledwa kumwa mankhwalawo pogwiritsa ntchito mankhwala a hypoglycemic (okhala ndi insulin, glitazones ndi glucosidase inhibitors).
Mapiritsi amatengedwa pakamwa ndi madzi pang'ono.
Kodi ndingatenge madzulo?
M'mayendedwe ovomerezeka a Cozaar, palibe malamulo okhudzana ndi nthawi yomwe matengere mapiritsi. Komabe, madokotala ambiri amalimbikitsa kuti odwala awo amwe mapiritsi m'mawa, chifukwa matenda oopsa amathanso kuthamanga magazi m'mawa.
Ndingatenge nthawi yayitali bwanji?
Kutalika kwa chithandizo ndi masabata 3-6.
Kutsika kapena kuwonjezeka kwa nthawi imeneyi kumatsimikiziridwa ndi adokotala potengera momwe wodwalayo alili.
Zotsatira zoyipa
Mankhwalawa amavomerezedwa bwino ndi odwala omwe ali ndi matenda oopsa. Zotsatira zoyipa ndizosowa ndipo zimapita zokha.
Nthawi zambiri, odwala amadandaula za malaise wamba, kufooka, kutopa kwambiri ndi kugona.
Matumbo
Kuchokera m'mimba momwemo
- kusanza ndi kusanza
- kutsegula m'mimba
- kupweteka m'mimba
- kudzimbidwa;
- matenda a chiwindi (kawirikawiri).
Hematopoietic ziwalo
Mwina chitukuko cha thrombocytopenia (ochepa maselo a m'magazi).
Pakati mantha dongosolo
Zotsatira zoyipa zamagetsi zamkati zimawonetsedwa ndi kupweteka kwa mutu komanso chizungulire. Odwala ena amadandaula za dysgeusia (kutaya kukoma).
Kuchokera ku minculoskeletal system
Kuchokera ku minculoskeletal system, myalgia kapena arthralgia imawonedwa.
Kuchokera ku kupuma
Kukhosomola kotheka.
Pa khungu
Khungu, zotupa, kuyamwa, ndi ming'oma zimatha kuonekera pakhungu.
Kuchokera ku genitourinary system
Palibe vuto lililonse pa impso. Odwala ena akuti kuchepa kwa libido.
Kuchokera pamtima
Zotsatira zoyipa za mtima zimasowa. Mwina kuwoneka kwa tachycardia ndi hypotension kwa odwala omwe ali ndi bcc.
Matupi omaliza
Ndi chidwi chogwira ntchito yogwira kapena yogwira mankhwala, anaphylactic mantha, angioedema ndi matupi awo amasiyana pakhungu amatha.
Zokhudza mphamvu pakuwongolera njira
Mphamvu ya Cozaar pakuwongolera njira sizinakhazikitsidwe mokwanira. Koma mukamagwiritsa ntchito chida ichi, kuoneka kwa zotsatira zoyipa ngati chizungulire komanso kufooka ndikotheka. Chifukwa chake, madokotala ambiri amalimbikitsa kuti musayendetse magalimoto pamankhwala.
Malangizo apadera
Zinapezeka kuti angiotensin antagonists alibe kutchulidwa kochiritsa mwa anthu amtundu wa Negroid. Odwala a mu mpikisano uyu samapereka mankhwala ndi losartan chifukwa chochepa kwambiri.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Amayi oyembekezera amakhala oletsedwa kumwa mankhwalawo.
Chifukwa cha kuchepa kwa maphunziro pakulowa kwa losartan mkaka wa m'mawere, kugwiritsa ntchito Cozaar panthawi yotsatsira sikulimbikitsidwa.
Kusankhidwa kwa Cozaar kwa ana
Mankhwalawa mankhwala pambuyo 18 zaka. Ana saloledwa kuti azigwiritsa ntchito.
Amayi oyembekezera amakhala oletsedwa kumwa mankhwalawo.
Gwiritsani ntchito mu ukalamba
Mankhwalawa amalekeredwa bwino ndi achinyamata komanso okalamba. Palibe kudalira kwazithandizo zamunthu pazaka zomwe zapezeka.
The ntchito aimpso kuwonongeka
Woopsa aimpso, mankhwala ayenera kumwedwa kuyang'aniridwa ndi achipatala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kwa matenda a chiwindi, mankhwalawa amagwiritsidwa ntchito mosamala. Odwala cirrhosis, kuchuluka kwa losartan m'magazi kumawonedwa. Mlingo wa tsiku ndi tsiku wa odwala otere umachepetsedwa.
Bongo
Milandu yambiri imakhala yachilendo kwambiri, chifukwa mapiritsiwa amachitika ndipo samakundana m'thupi limodzi.
Zizindikiro za bongo mwangozi ndi:
- hypotension (kutsitsa kuthamanga kwa magazi pansi pazonse);
- tachycardia kapena bradycardia (palpitations);
- kusanza ndi kusanza.
Zizindikiro izi zikayamba kuwoneka, kupweteka kwam'mimba ndikofunikira. Kenako wodwalayo amamulembera monga mankhwala.
Ndi mankhwala osokoneza bongo a bradycardia amachitika.
Kuchita ndi mankhwala ena
Mothandizidwa ndi fluconazole amatha kuchepetsa kuchuluka kwa yogwira metabolite wa losartan m'magazi.
Pogwiritsa ntchito Cozaar, ndizoletsedwa kutenga potaziyamu-spure diuretics (Spironolactone, Amiloride), komanso zakudya zamagulu omwe ali ndi potaziyamu chifukwa choopsa cha hyperkalemia.
Kuphatikiza kwa Cozaar ndi ma antihypertensives ena (Captopril, Telmisartan), vasodilators (Vincamine, Cavinton, Wasonite) ndi NSAIDs (Nurofen, Paracetamol) sikulimbikitsidwa. Kuphatikizika kumeneku kumabweretsa mtolo waukulu kwa impso, chiwindi ndi mtima.
Kuyenderana ndi mowa
Pa mankhwala, amaloledwa kumwa mowa kawirikawiri komanso pang'ono. Kumwa mowa mwauchidakwa pogwiritsa ntchito mankhwalawa kungayambitse matenda owopsa a chiwindi.
Analogi
Ma fanizo odziwika komanso otchipa a Cozaar ndi:
- Losartan.
- Vasotens.
- Lozarel.
- Blocktran.
- Lozap.
- Lorista.
- Renicard.
Mankhwalawa ali ndi chinthu chimodzi - potaziyamu losartan.
Zotsatira za tchuthi Kosaara kuchokera ku pharmacy
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala amapatsidwa mankhwala. Sungagulidwe popanda mankhwala a dokotala.
Mtengo wa Cozaar
Mtengo wa mankhwalawo m'mafakitala aku Russia ndi ma ruble a 120-150 (mapiritsi a 50 mg) ndi ma ruble a 180-210 (mapiritsi a 100 mg).
Zosungidwa zamankhwala
Kusungirako kumachitika m'malo amdima pa kutentha osaposa + 25 ° C. Mankhwala ayenera kutetezedwa kwa ana.
Tsiku lotha ntchito
Mankhwalawa ndi oyenera kwa zaka zitatu.
Wopanga Cozaar
Wopanga ndi Merck Sharp & Dohme (UK).
Ndemanga za Cozaar
Onse a mtima ndi odwala amathandizadi mankhwalawa.
Mloza wa anzagi wa Cozaar.
Madokotala
Alexandra, wazaka 42, wazachipatala, wa St.
Mankhwala ali ndi kupitiriza hypotensive kwenikweni. Ndimapereka mankhwala kwa odwala ambiri opanikizika. Pochita, sindinawone zotsatira zoyipa.
Dmitry, wazaka 38, katswiri wazamtima, Chelyabinsk
Ndakhala ndikugwira ntchito ya mtima kwa zaka 13. Mankhwalawa ndi chisankho chabwino kwa odwala omwe ali ndi matenda oopsa komanso kulephera kwa mtima. Ndikupangira izi kwa odwala ambiri kupewa matenda a mtima ndi sitiroko.
Odwala
Elena, wazaka 55, Moscow
Kwa nthawi yayitali ndakhala ndikuvutika ndi matenda oopsa. Dokotalayo adawauza mapiritsiwo mu muyeso wochepa. Ndimamva bwino patatha milungu iwiri yoyang'anira. Tsopano ndikupitiliza kumwa mankhwala kuti ndikhale ndi nkhawa.
Stanislav, wazaka 61, Krasnodar
Ndimamwa mapiritsi awa kuti ndichiritse kulephera kwa mtima. Ndinkakonda kutenga ACE inhibitors, koma adasiya kuthandizira. Ndaphunzira za Cozaar kuchokera kwa a mtima wanga. Ndakhala ndikumwa mankhwalawa kwa milungu itatu ndipo ndikumva bwino. Zotsatira zoyipa sizimachitika.
Alexey, wazaka 47, Volgograd
Ndinayamba kumwa mankhwalawa monga momwe adanenera dotolo kuti andichepetse. Mankhwalawa amandigwira. Kupsinjika kunabweranso kwazonse pambuyo pa sabata la kudya kwambiri ndipo sikunawonjezeke. Ubwino wa Cozaar ulinso mtengo wotsika.
